Ern1 (endoplasmic reticulum to nucleus signaling 1) - Rat Genome Database

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Gene: Ern1 (endoplasmic reticulum to nucleus signaling 1) Rattus norvegicus
Analyze
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signaling 1
RGD ID: 1559716
Description: Predicted to enable several functions, including adenyl ribonucleotide binding activity; heat shock protein binding activity; and magnesium ion binding activity. Involved in cellular response to glucose stimulus and cellular response to hydrogen peroxide. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Predicted to be part of AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and IRE1-TRAF2-ASK1 complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,4-dithiothreitol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endoplasmic reticulum (ER) to nucleus signalling 1; LOC498013; RGD1559716; serine/threonine-protein kinase/endoribonuclease IRE1; similar to protein kinase/endoribonuclease(IRE1) alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,826,663 - 91,920,976 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,830,428 - 91,920,791 (-)EnsemblGRCr8
mRatBN7.21091,326,889 - 91,421,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,330,654 - 91,421,029 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,385,286 - 96,446,643 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,848,447 - 95,909,805 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,259,314 - 91,320,624 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abamectin  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-D-galactose  (EXP)
aluminium sulfate (anhydrous)  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amosite asbestos  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
aucubin  (ISO)
Azaspiracid  (ISO)
baicalein  (EXP)
baicalin  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calix[6]arene  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
choline  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dizocilpine maleate  (EXP)
doxorubicin  (EXP)
edaravone  (EXP)
elaidic acid  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
epoxomicin  (ISO)
erastin  (ISO)
ethanol  (ISO)
EUK-134  (ISO)
fentin chloride  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP)
gamma-aminobutyric acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
Guanabenz  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
isoliquiritigenin  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
lidocaine  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP,ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mithramycin  (ISO)
MitoTEMPO  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
montelukast  (ISO)
morusin  (ISO)
muscimol  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naltrexone  (ISO)
naringin  (EXP,ISO)
nicotine  (ISO)
Nivalenol  (ISO)
NMS-873  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
pirinixic acid  (EXP,ISO)
poly(guanylic acid)  (EXP)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
procymidone  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
ricolinostat  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
Salidroside  (ISO)
SCH 23390  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP)
sinapic acid  (EXP)
sincalide  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toxoflavin  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (ISO)
vemurafenib  (ISO)
vildagliptin  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
zerumbone  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma. Archer KJ, etal., Mol Genet Genomics. 2010 Apr;283(4):341-9. doi: 10.1007/s00438-010-0522-y. Epub 2010 Feb 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. Lipson KL, etal., PLoS One. 2008 Feb 20;3(2):e1648. doi: 10.1371/journal.pone.0001648.
4. Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis. Liu A, etal., Sci Rep. 2019 Dec 13;9(1):19043. doi: 10.1038/s41598-019-55557-1.
5. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
6. [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage]. Liu J, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Oct;33(10):1316-1322.
7. Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways. Liu XR, etal., Mol Med Rep. 2018 May;17(5):7258-7264. doi: 10.3892/mmr.2018.8751. Epub 2018 Mar 15.
8. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
9. Interleukin-6 production mediated by the IRE1-XBP1 pathway confers radioresistance in human papillomavirus-negative oropharyngeal carcinoma. Lyu X, etal., Cancer Sci. 2019 Aug;110(8):2471-2484. doi: 10.1111/cas.14094. Epub 2019 Jul 3.
10. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Marcu MG, etal., Mol Cell Biol. 2002 Dec;22(24):8506-13.
11. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
18. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Urano F, etal., Science. 2000 Jan 28;287(5453):664-6.
19. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
20. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
21. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
22. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
Additional References at PubMed
PMID:9637683   PMID:9755171   PMID:10882126   PMID:11146108   PMID:11430819   PMID:11779464   PMID:11779465   PMID:11850408   PMID:12637535   PMID:15601821   PMID:16973740   PMID:18281285  
PMID:19328063   PMID:19622636   PMID:19875812   PMID:20103773   PMID:20625543   PMID:20798350   PMID:21317875   PMID:21779001   PMID:21896783   PMID:22529213   PMID:23000344   PMID:23028046  
PMID:23103912   PMID:23529610   PMID:24180212   PMID:24508390   PMID:24936061   PMID:25011481   PMID:25164867   PMID:26315405   PMID:26711306   PMID:27655546   PMID:28114319   PMID:28436754  
PMID:29198525   PMID:30763911   PMID:31467308   PMID:32199617   PMID:32272965   PMID:32950473   PMID:33179109   PMID:35085541   PMID:38336929  


Genomics

Comparative Map Data
Ern1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,826,663 - 91,920,976 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,830,428 - 91,920,791 (-)EnsemblGRCr8
mRatBN7.21091,326,889 - 91,421,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,330,654 - 91,421,029 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,385,286 - 96,446,643 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,848,447 - 95,909,805 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,259,314 - 91,320,624 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ERN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,039,142 - 64,130,144 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,039,080 - 64,130,819 (-)Ensemblhg38GRCh38
GRCh371762,116,502 - 62,207,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,474,122 - 59,561,234 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1756,508,473 - 56,595,582 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,488,466 - 57,575,481 (-)NCBIHuRef
CHM1_11762,184,805 - 62,271,973 (-)NCBICHM1_1
T2T-CHM13v2.01764,909,877 - 65,000,874 (-)NCBIT2T-CHM13v2.0
Ern1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,285,474 - 106,378,701 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,285,476 - 106,378,678 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,397,620 - 106,487,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,394,650 - 106,487,852 (-)Ensemblmm10GRCm38
MGSCv3711106,258,934 - 106,349,110 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611106,213,710 - 106,303,886 (-)NCBIMGSCv36mm8
Celera11118,128,975 - 118,219,164 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1169.14NCBI
Ern1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,751,830 - 7,799,460 (+)Ensembl
ChiLan1.0NW_0049554787,720,664 - 7,803,662 (+)NCBIChiLan1.0ChiLan1.0
ERN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,222,161 - 80,313,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,042,461 - 85,133,625 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,132,889 - 58,224,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,226,949 - 63,317,825 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,226,949 - 63,317,825 (-)EnsemblpanPan2panpan1.1
ERN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,930,614 - 12,006,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,934,965 - 12,006,814 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha912,825,652 - 12,903,073 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,591,579 - 13,669,839 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,591,584 - 13,669,995 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,538,344 - 12,616,358 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,915,804 - 14,993,944 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,918,080 - 14,996,082 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ern1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,488,687 - 14,581,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,617,555 - 4,705,866 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,613,197 - 4,705,911 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,881,923 - 14,963,284 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11214,881,913 - 14,963,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,918,929 - 14,954,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,145,080 - 57,233,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,145,191 - 57,236,230 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607727,756,105 - 27,847,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ern1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,525,235 - 1,625,893 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248491,521,996 - 1,625,878 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ern1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,633,725 - 72,724,357 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ern1
851 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000017371
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
BI280353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,326,927 - 91,327,112 (+)MAPPERmRatBN7.2
Rnor_6.01094,588,594 - 94,588,778NCBIRnor6.0
Rnor_5.01094,336,679 - 94,336,863UniSTSRnor5.0
RGSC_v3.41095,790,762 - 95,790,946UniSTSRGSC3.4
Celera1090,000,206 - 90,000,390UniSTS
RH 3.4 Map10981.4UniSTS
Cytogenetic Map10q32.1UniSTS
AA866270  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81091,936,558 - 91,936,754 (+)Marker Load Pipeline
mRatBN7.21091,436,797 - 91,436,993 (+)MAPPERmRatBN7.2
Rnor_6.01094,698,131 - 94,698,326NCBIRnor6.0
Rnor_5.01094,446,111 - 94,446,306UniSTSRnor5.0
RGSC_v3.41096,001,780 - 96,001,975UniSTSRGSC3.4
Celera1090,109,459 - 90,109,654UniSTS
RH 3.4 Map10973.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017371   ⟹   ENSRNOP00000017371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,830,428 - 91,891,648 (-)Ensembl
mRatBN7.2 Ensembl1091,330,654 - 91,391,879 (-)Ensembl
Rnor_6.0 Ensembl1094,592,320 - 94,652,658 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085736   ⟹   ENSRNOP00000072244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,830,438 - 91,920,791 (-)Ensembl
mRatBN7.2 Ensembl1091,330,664 - 91,421,029 (-)Ensembl
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107730   ⟹   ENSRNOP00000079836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,865,996 - 91,920,791 (-)Ensembl
mRatBN7.2 Ensembl1091,366,224 - 91,421,029 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108922   ⟹   ENSRNOP00000086547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,365,169 - 91,421,029 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116974   ⟹   ENSRNOP00000093755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,830,428 - 91,905,741 (-)Ensembl
mRatBN7.2 Ensembl1091,330,654 - 91,389,792 (-)Ensembl
RefSeq Acc Id: NM_001191926   ⟹   NP_001178855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,830,428 - 91,891,648 (-)NCBI
mRatBN7.21091,330,654 - 91,391,879 (-)NCBI
Rnor_6.01094,592,320 - 94,652,658 (-)NCBI
Rnor_5.01094,336,640 - 94,429,967 (-)NCBI
Celera1090,003,932 - 90,064,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247634   ⟹   XP_006247696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,920,976 (-)NCBI
mRatBN7.21091,326,889 - 91,421,200 (-)NCBI
Rnor_6.01094,588,555 - 94,682,072 (-)NCBI
Rnor_5.01094,336,640 - 94,429,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597474   ⟹   XP_017452963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,903,527 (-)NCBI
mRatBN7.21091,326,889 - 91,421,201 (-)NCBI
Rnor_6.01094,588,555 - 94,681,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086647   ⟹   XP_038942575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,894,819 (-)NCBI
mRatBN7.21091,326,889 - 91,395,048 (-)NCBI
RefSeq Acc Id: XM_063269670   ⟹   XP_063125740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,826,663 - 91,866,112 (-)NCBI
RefSeq Acc Id: NP_001178855   ⟸   NM_001191926
- Sequence:
RefSeq Acc Id: XP_006247696   ⟸   XM_006247634
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2H4 (UniProtKB/TrEMBL),   A6HK45 (UniProtKB/TrEMBL),   A0A8I6AJE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452963   ⟸   XM_017597474
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AJE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017371   ⟸   ENSRNOT00000017371
Ensembl Acc Id: ENSRNOP00000072244   ⟸   ENSRNOT00000085736
RefSeq Acc Id: XP_038942575   ⟸   XM_039086647
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJE4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079836   ⟸   ENSRNOT00000107730
Ensembl Acc Id: ENSRNOP00000093755   ⟸   ENSRNOT00000116974
Ensembl Acc Id: ENSRNOP00000086547   ⟸   ENSRNOT00000108922
RefSeq Acc Id: XP_063125740   ⟸   XM_063269670
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AJE4 (UniProtKB/TrEMBL)
Protein Domains
KEN   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2H4-F1-model_v2 AlphaFold A0A0G2K2H4 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697849
Promoter ID:EPDNEW_R8370
Type:single initiation site
Name:Ern1_1
Description:endoplasmic reticulum to nucleus signaling 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,681,912 - 94,681,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559716 AgrOrtholog
BioCyc Gene G2FUF-22944 BioCyc
Ensembl Genes ENSRNOG00000012864 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017371.7 UniProtKB/TrEMBL
  ENSRNOT00000085736 ENTREZGENE
  ENSRNOT00000085736.3 UniProtKB/TrEMBL
  ENSRNOT00000107730.2 UniProtKB/TrEMBL
  ENSRNOT00000116974 ENTREZGENE
  ENSRNOT00000116974.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.180 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IRE1/2-like UniProtKB/TrEMBL
  KEN_RNase_activator UniProtKB/TrEMBL
  KEN_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PQQ_beta_propeller_repeat UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Quinonprotein_ADH-like UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498013 UniProtKB/TrEMBL
NCBI Gene 498013 ENTREZGENE
PANTHER PTHR13954 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Ribonuc_2-5A UniProtKB/TrEMBL
PhenoGen Ern1 PhenoGen
PROSITE KEN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012864 RatGTEx
SMART PQQ UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  Quin_alc_DH_like UniProtKB/TrEMBL
UniProt A0A0G2K2H4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPE4_RAT UniProtKB/TrEMBL
  A0A8I6AJE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HK45 ENTREZGENE, UniProtKB/TrEMBL
  F1LSY7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-29 Ern1  endoplasmic reticulum to nucleus signaling 1  Ern1  endoplasmic reticulum (ER) to nucleus signalling 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Ern1  endoplasmic reticulum (ER) to nucleus signalling 1  RGD1559716_predicted  similar to protein kinase/endoribonuclease(IRE1) alpha (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559716_predicted  similar to protein kinase/endoribonuclease(IRE1) alpha (predicted)  LOC498013  similar to protein kinase/endoribonuclease(IRE1) alpha  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498013  similar to protein kinase/endoribonuclease(IRE1) alpha      Symbol and Name status set to provisional 70820 PROVISIONAL