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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559716 Species: Rattus norvegicus RGD Object: Gene Symbol: Ern1 Name: endoplasmic reticulum to nucleus signaling 1

Acc ID: CHEBI:29699 Term: tunicamycin Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety. CasRN: 11089-65-9 Chemical ID: MESH:D014415

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1558600	6480464	CTD	Amiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein]	PMID:20015086
increases expression	ISO	RGD:1558600	6480464	CTD	Tunicamycin results in increased expression of ERN1 mRNA	PMID:17127020
increases expression	ISO	RGD:1605125	6480464	CTD	Tunicamycin results in increased expression of ERN1 protein	PMID:19139269
increases phosphorylation	ISO	RGD:1558600	6480464	CTD	Tunicamycin results in increased phosphorylation of ERN1 protein	PMID:22001960
increases expression	ISO	RGD:1558600	6480464	CTD	Tunicamycin results in increased expression of ERN1 mRNA	PMID:17127020 PMID:21432213