Ugt1a3 (UDP glycosyltransferase 1 family, polypeptide A3) - Rat Genome Database

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Gene: Ugt1a3 (UDP glycosyltransferase 1 family, polypeptide A3) Rattus norvegicus
Analyze
Symbol: Ugt1a3 (Ensembl: Ugt1a5)
Name: UDP glycosyltransferase 1 family, polypeptide A3 (Ensembl:UDP glucuronosyltransferase family 1 member A5)
RGD ID: 1549728
Description: Predicted to enable enzyme binding activity and glucuronosyltransferase activity. Involved in animal organ regeneration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human UGT1A5 (UDP glucuronosyltransferase family 1 member A5); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B3; UDP glycosyltransferase 1 family polypeptide A3; UDP glycosyltransferase 1 family polypeptide A4; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1A3; UDPGT; UDPGT 1-3; Ugt1; UGT1*3; UGT1-03; UGT1.3; Ugt1a4
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,228,134 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,780,328 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,204,156 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,340,349 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,708,528 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,274,707 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,961,922 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,070,247 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,341,626 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, etal., Pharm Res. 2005 Dec;22(12):2007-15. Epub 2005 Oct 21.
7. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:2112380   PMID:7608130   PMID:16141793  


Genomics

Comparative Map Data
Ugt1a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,228,134 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,780,328 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,204,156 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,340,349 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,708,528 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,274,707 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,961,922 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,070,247 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,341,626 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,712,907 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,712,907 - 233,773,300 (+)Ensemblhg38GRCh38
GRCh372234,621,553 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,286,377 - 234,346,684 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342234,403,637 - 234,463,945NCBI
Celera2228,342,257 - 228,402,577 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,421,632 - 226,481,779 (+)NCBIHuRef
CHM1_12234,627,452 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,201,556 - 234,261,929 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Ugt1a3
164 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Mco15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,718 - 88,787,007 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,097 - 95,281,383NCBIRnor6.0
Rnor_5.0994,968,312 - 94,968,598UniSTSRnor5.0
RGSC_v3.4987,076,637 - 87,076,923UniSTSRGSC3.4
Celera986,348,016 - 86,348,299UniSTS
Cytogenetic Map9q35UniSTS
D9Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,755 - 88,786,956 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,134 - 95,281,332NCBIRnor6.0
Rnor_5.0994,968,349 - 94,968,547UniSTSRnor5.0
RGSC_v3.4987,076,674 - 87,076,872UniSTSRGSC3.4
Celera986,348,053 - 86,348,248UniSTS
Cytogenetic Map9q35UniSTS
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8996,255,939 - 96,256,140 (+)Marker Load Pipeline
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
5 3 24 22 57 25 32 27 14 9 9

Sequence


RefSeq Acc Id: NM_201424   ⟹   NP_958827
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,228,134 - 96,256,264 (+)NCBI
mRatBN7.2988,780,328 - 88,808,465 (+)NCBI
Rnor_6.0995,274,707 - 95,302,822 (+)NCBI
Rnor_5.0994,961,922 - 94,990,037 (+)NCBI
RGSC_v3.4987,070,247 - 87,098,362 (+)RGD
Celera986,341,626 - 86,369,556 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_958827 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR95632 (Get FASTA)   NCBI Sequence Viewer  
  BAA07262 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046507
GenBank Protein Q64637 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_958827   ⟸   NM_201424
- Peptide Label: precursor
- UniProtKB: Q64637 (UniProtKB/Swiss-Prot),   Q6T5F1 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64637-F1-model_v2 AlphaFold Q64637 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549728 AgrOrtholog
BioCyc Gene G2FUF-26819 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045163 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
NCBI Gene 396551 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt1a3 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018740 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt F7EKA4_RAT UniProtKB/TrEMBL
  Q64637 ENTREZGENE
  Q6T5F1 ENTREZGENE, UniProtKB/TrEMBL
  UD13_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-22 Ugt1a3  UDP glycosyltransferase 1 family, polypeptide A3  Ugt1a3  UDP glycosyltransferase 1 family polypeptide A3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-08 Ugt1a3  UDP glycosyltransferase 1 family polypeptide A3  Ugt1a4  UDP glycosyltransferase 1 family polypeptide A4  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-09-15 Ugt1a4  UDP glycosyltransferase 1 family polypeptide A4      Symbol and Name status set to provisional 70820 PROVISIONAL