Ctnna1 (catenin alpha 1) - Rat Genome Database

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Gene: Ctnna1 (catenin alpha 1) Rattus norvegicus
Analyze
Symbol: Ctnna1
Name: catenin alpha 1
RGD ID: 1359485
Description: Enables beta-catenin binding activity. Involved in several processes, including gap junction assembly; gonad development; and response to estrogen. Located in acrosomal vesicle and adherens junction. Biomarker of esophageal cancer and lung carcinoma. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1; catenin alpha-1-like; catenin, alpha 1; Catna1; LOC100911326; MGC93767; uncharacterized LOC100911326
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,002,330 - 27,135,009 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1826,999,820 - 27,135,007 (+)EnsemblGRCr8
mRatBN7.21826,728,246 - 26,860,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,728,485 - 26,860,910 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1826,855,902 - 26,988,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,618,824 - 27,751,220 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,953,728 - 27,086,125 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,923,229 - 28,055,972 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,923,572 - 28,055,960 (+)Ensemblrn6Rnor6.0
Rnor_5.01827,633,009 - 27,766,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41827,629,915 - 27,769,360 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1826,463,736 - 26,596,152 (+)NCBICelera
RGSC_v3.11827,656,560 - 27,796,004 (+)NCBI
Cytogenetic Map18p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
glafenine  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
jaspamide  (EXP)
L-ethionine  (EXP)
latrunculin A  (EXP)
lead nitrate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylazoxymethanol  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nitrates  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfur dioxide  (ISO)
sunitinib  (ISO)
taraxasterol  (ISO)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IDA)
actin cytoskeleton  (IEA)
adherens junction  (IBA,IDA,IEA,ISO)
catenin complex  (IBA,IEA,ISO)
cell junction  (IEA,ISO)
cell-cell junction  (IDA,IEA,ISO)
cytoskeleton  (IEA)
flotillin complex  (IEA,ISO)
intercalated disc  (IEA,ISO)
lamellipodium  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO)
zonula adherens  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Reduced alpha- and beta-catenin expression predicts shortened survival in local prostate cancer. Aaltomaa S, etal., Anticancer Res. 2005 Nov-Dec;25(6C):4707-12.
2. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Blanco D, etal., Lab Invest. 2004 Aug;84(8):999-1012.
3. Cadherins and cadherin-associated molecules in the developing and maturing rat testis. Byers SW, etal., Endocrinology. 1994 Feb;134(2):630-9.
4. E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma. Carico E, etal., Gynecol Oncol. 2001 Feb;80(2):156-61.
5. Expression of E-cadherin, alpha-catenin and beta-catenin in normal ovarian surface epithelium and epithelial ovarian cancers. Davies BR, etal., Histopathology. 1998 Jan;32(1):69-80.
6. Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development. DeBellefeuille S, etal., Endocrinology. 2003 Nov;144(11):5040-9. doi: 10.1210/en.2002-0139. Epub 2003 Aug 13.
7. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen K, etal., J Neuropathol Exp Neurol 2002 Oct;61(10):903-13.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
10. Cell-cell junctions between mammalian (human and rat) hepatic stellate cells. Higashi N, etal., Cell Tissue Res. 2004 Jul;317(1):35-43. Epub 2004 Jun 10.
11. Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats. Jung KY, etal., Mech Ageing Dev. 2004 Jun;125(6):445-53.
12. The prognostic value of E-cadherin, alpha-, beta-, and gamma-catenin in urothelial cancer of the upper urinary tract. Kashibuchi K, etal., Eur Urol. 2006 May;49(5):839-45; discussion 845. Epub 2006 Jan 6.
13. The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy. Kashibuchi K, etal., Int J Urol. 2007 Sep;14(9):789-94.
14. Altered localization of E-cadherin and alpha-catenin in rat esophageal tumors. Khare L, etal., Int J Oncol. 1999 Jan;14(1):33-40.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival. Nakopoulou L, etal., Histopathology. 2002 Jun;40(6):536-46.
17. Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis. Park D, etal., APMIS. 2007 Jan;115(1):52-65.
18. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Piedra J, etal., Mol Cell Biol. 2003 Apr;23(7):2287-97.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. Scholten AN, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1379-85.
25. Decreased expression of alpha-catenin is associated with poor prognosis of patients with localized renal cell carcinoma. Shimazui T, etal., Int J Cancer. 1997 Oct 21;74(5):523-8.
26. Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis. Sobarzo CM, etal., Reprod Toxicol. 2006 Jul;22(1):77-86. Epub 2006 May 5.
27. The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. Sorkin BC, etal., J Histochem Cytochem. 2000 Mar;48(3):397-406.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. E-cadherin-catenin complex in the rat ovary: cell-specific expression during folliculogenesis and luteal formation. Sundfeldt K, etal., J Reprod Fertil. 2000 Mar;118(2):375-85.
30. An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Tomlinson JS, etal., Cancer Res. 2001 Jul 1;61(13):5231-41.
31. Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells. Uehara K and Uehara A, Histochem Cell Biol. 2008 Jan;129(1):95-103. Epub 2007 Sep 25.
32. The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. van Oort IM, etal., Prostate. 2007 Sep 15;67(13):1432-8.
33. Role of catenins in the development of gap junctions in rat cardiomyocytes. Wu JC, etal., J Cell Biochem. 2003 Mar 1;88(4):823-35.
34. [Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis] Zhang RD, etal., Zhonghua Nan Ke Xue. 2006 May;12(5):394-6, 400.
Additional References at PubMed
PMID:7650039   PMID:7890674   PMID:8853988   PMID:9700171   PMID:10460003   PMID:10868478   PMID:11025210   PMID:11795944   PMID:12695331   PMID:12734196   PMID:14657280   PMID:15775979  
PMID:16510873   PMID:16543460   PMID:17535849   PMID:17989230   PMID:18195371   PMID:19129494   PMID:19805073   PMID:21399649   PMID:21423176   PMID:22411810   PMID:22658674   PMID:23292143  
PMID:23417122   PMID:24046456   PMID:24973089   PMID:25468996   PMID:25931508   PMID:26377600   PMID:26514267   PMID:27782092   PMID:28051089   PMID:30361391  


Genomics

Comparative Map Data
Ctnna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,002,330 - 27,135,009 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1826,999,820 - 27,135,007 (+)EnsemblGRCr8
mRatBN7.21826,728,246 - 26,860,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,728,485 - 26,860,910 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1826,855,902 - 26,988,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,618,824 - 27,751,220 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,953,728 - 27,086,125 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,923,229 - 28,055,972 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,923,572 - 28,055,960 (+)Ensemblrn6Rnor6.0
Rnor_5.01827,633,009 - 27,766,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41827,629,915 - 27,769,360 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1826,463,736 - 26,596,152 (+)NCBICelera
RGSC_v3.11827,656,560 - 27,796,004 (+)NCBI
Cytogenetic Map18p11NCBI
CTNNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,753,425 - 138,935,034 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,610,967 - 138,935,039 (+)Ensemblhg38GRCh38
GRCh375138,089,114 - 138,270,723 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,117,006 - 138,298,622 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345138,117,005 - 138,298,621NCBI
Celera5134,210,957 - 134,392,494 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,278,985 - 133,460,517 (+)NCBIHuRef
CHM1_15137,521,762 - 137,703,280 (+)NCBICHM1_1
T2T-CHM13v2.05139,279,620 - 139,461,169 (+)NCBIT2T-CHM13v2.0
Ctnna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,251,955 - 35,387,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,251,912 - 35,387,832 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381835,118,902 - 35,254,776 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,118,859 - 35,254,779 (+)Ensemblmm10GRCm38
MGSCv371835,278,566 - 35,414,429 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361835,244,886 - 35,380,749 (+)NCBIMGSCv36mm8
Celera1835,608,364 - 35,710,407 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.89NCBI
Ctnna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,592,229 - 1,754,689 (-)Ensembl
ChiLan1.0NW_0049554181,592,555 - 1,754,423 (-)NCBIChiLan1.0ChiLan1.0
CTNNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24134,030,560 - 134,208,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15132,170,119 - 132,348,741 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05134,134,944 - 134,313,239 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,261,883 - 140,438,854 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,261,883 - 140,438,547 (+)EnsemblpanPan2panpan1.1
CTNNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,273,322 - 26,459,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,143,013 - 26,459,091 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1125,040,958 - 25,226,366 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01127,129,159 - 27,315,090 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,999,426 - 27,328,806 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,836,828 - 26,022,382 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,658,855 - 25,844,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,323,192 - 26,509,271 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctnna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,575,485 - 153,790,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,865,820 - 8,037,935 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,865,907 - 8,036,020 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTNNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,682,371 - 140,871,334 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12140,682,776 - 140,869,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,440,632 - 146,624,719 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTNNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,423,504 - 41,599,458 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,447,675 - 41,600,190 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603436,284,586 - 36,461,261 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctnna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,512,481 - 31,700,340 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctnna1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1159,099,331 - 9,228,329 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctnna1
513 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:203
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000008041
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81827,076,756 - 27,076,914 (+)Marker Load Pipeline
mRatBN7.21826,802,654 - 26,802,812 (+)MAPPERmRatBN7.2
Rnor_6.01827,997,695 - 27,997,852NCBIRnor6.0
Rnor_5.01827,707,131 - 27,707,288UniSTSRnor5.0
RGSC_v3.41827,706,319 - 27,706,476UniSTSRGSC3.4
Celera1826,537,814 - 26,537,971UniSTS
Cytogenetic Map18p11UniSTS
BB129880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,819,936 - 26,820,027 (+)MAPPERmRatBN7.2
Rnor_6.01828,014,998 - 28,015,088NCBIRnor6.0
Rnor_5.01827,724,807 - 27,724,897UniSTSRnor5.0
RGSC_v3.41827,724,838 - 27,724,928UniSTSRGSC3.4
Celera1826,555,095 - 26,555,185UniSTS
Cytogenetic Map18p11UniSTS
RH127326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2468,141,841 - 68,142,025 (+)MAPPERmRatBN7.2
mRatBN7.21826,859,830 - 26,860,014 (+)MAPPERmRatBN7.2
Rnor_6.01828,054,887 - 28,055,070NCBIRnor6.0
Rnor_6.0467,151,096 - 67,151,279NCBIRnor6.0
Rnor_5.01827,764,990 - 27,765,173UniSTSRnor5.0
RGSC_v3.4466,874,130 - 66,874,313UniSTSRGSC3.4
RGSC_v3.41827,768,281 - 27,768,464UniSTSRGSC3.4
Celera1826,595,073 - 26,595,256UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map18p11UniSTS
RH129529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,860,469 - 26,860,666 (+)MAPPERmRatBN7.2
mRatBN7.2468,142,479 - 68,142,676 (+)MAPPERmRatBN7.2
Rnor_6.01828,055,526 - 28,055,722NCBIRnor6.0
Rnor_6.0467,151,734 - 67,151,930NCBIRnor6.0
Rnor_5.0466,958,195 - 66,958,391UniSTSRnor5.0
Rnor_5.01827,765,629 - 27,765,825UniSTSRnor5.0
RGSC_v3.41827,768,920 - 27,769,116UniSTSRGSC3.4
RGSC_v3.4466,874,768 - 66,874,964UniSTSRGSC3.4
Celera1826,595,712 - 26,595,908UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map18p11UniSTS
RH132461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,817,053 - 26,817,235 (+)MAPPERmRatBN7.2
Rnor_6.01828,012,115 - 28,012,296NCBIRnor6.0
Rnor_5.01827,721,874 - 27,722,055UniSTSRnor5.0
RGSC_v3.41827,721,955 - 27,722,136UniSTSRGSC3.4
Celera1826,552,212 - 26,552,393UniSTS
RH 3.4 Map18372.8UniSTS
Cytogenetic Map18p11UniSTS
RH135258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,800,545 - 26,800,748 (+)MAPPERmRatBN7.2
Rnor_6.01827,995,586 - 27,995,788NCBIRnor6.0
Rnor_5.01827,705,022 - 27,705,224UniSTSRnor5.0
RGSC_v3.41827,704,210 - 27,704,412UniSTSRGSC3.4
Celera1826,535,705 - 26,535,907UniSTS
RH 3.4 Map18366.7UniSTS
Cytogenetic Map18p11UniSTS
AI230960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,804,183 - 26,804,400 (+)MAPPERmRatBN7.2
Rnor_6.01827,999,225 - 27,999,441NCBIRnor6.0
Rnor_5.01827,708,661 - 27,708,877UniSTSRnor5.0
RGSC_v3.41827,707,849 - 27,708,065UniSTSRGSC3.4
Celera1826,539,344 - 26,539,560UniSTS
RH 3.4 Map18372.9UniSTS
Cytogenetic Map18p11UniSTS
AI851755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,817,980 - 26,818,087 (+)MAPPERmRatBN7.2
Rnor_6.01828,013,042 - 28,013,148NCBIRnor6.0
Rnor_5.01827,722,851 - 27,722,957UniSTSRnor5.0
RGSC_v3.41827,722,882 - 27,722,988UniSTSRGSC3.4
Celera1826,553,139 - 26,553,245UniSTS
Cytogenetic Map18p11UniSTS
Lrrtm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,821,028 - 26,821,665 (+)MAPPERmRatBN7.2
Rnor_6.01828,016,090 - 28,016,726NCBIRnor6.0
Rnor_5.01827,725,899 - 27,726,535UniSTSRnor5.0
RGSC_v3.41827,725,930 - 27,726,566UniSTSRGSC3.4
Celera1826,556,187 - 26,556,823UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008041   ⟹   ENSRNOP00000008041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,999,820 - 27,135,007 (+)Ensembl
mRatBN7.2 Ensembl1826,728,485 - 26,860,910 (+)Ensembl
Rnor_6.0 Ensembl1827,923,572 - 28,055,960 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080999   ⟹   ENSRNOP00000070637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1827,956,429 - 28,054,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136251   ⟹   ENSRNOP00000102115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1827,002,813 - 27,135,007 (+)Ensembl
RefSeq Acc Id: NM_001007145   ⟹   NP_001007146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,002,600 - 27,135,009 (+)NCBI
mRatBN7.21826,728,518 - 26,860,910 (+)NCBI
Rnor_6.01827,923,572 - 28,055,966 (+)NCBI
Rnor_5.01827,633,009 - 27,766,069 (+)NCBI
RGSC_v3.41827,629,915 - 27,769,360 (+)RGD
Celera1826,463,736 - 26,596,152 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772037   ⟹   XP_008770259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,097,235 - 27,135,009 (+)NCBI
mRatBN7.21826,823,011 - 26,860,911 (+)NCBI
Rnor_6.01828,018,122 - 28,055,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600964   ⟹   XP_017456453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,002,330 - 27,135,009 (+)NCBI
mRatBN7.21826,728,246 - 26,860,911 (+)NCBI
Rnor_6.01827,923,229 - 28,055,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600965   ⟹   XP_017456454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,105,963 - 27,135,009 (+)NCBI
mRatBN7.21826,831,911 - 26,860,911 (+)NCBI
Rnor_6.01828,026,935 - 28,055,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096868   ⟹   XP_038952796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,002,841 - 27,135,009 (+)NCBI
mRatBN7.21826,729,071 - 26,860,911 (+)NCBI
RefSeq Acc Id: XM_039096869   ⟹   XP_038952797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,116,818 - 27,135,009 (+)NCBI
mRatBN7.21826,843,222 - 26,860,911 (+)NCBI
RefSeq Acc Id: NP_001007146   ⟸   NM_001007145
- UniProtKB: Q5U302 (UniProtKB/TrEMBL),   F7F7X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770259   ⟸   XM_008772037
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456453   ⟸   XM_017600964
- Peptide Label: isoform X1
- UniProtKB: Q5U302 (UniProtKB/TrEMBL),   F7F7X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456454   ⟸   XM_017600965
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000008041   ⟸   ENSRNOT00000008041
Ensembl Acc Id: ENSRNOP00000070637   ⟸   ENSRNOT00000080999
RefSeq Acc Id: XP_038952796   ⟸   XM_039096868
- Peptide Label: isoform X1
- UniProtKB: Q5U302 (UniProtKB/TrEMBL),   F7F7X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952797   ⟸   XM_039096869
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000102115   ⟸   ENSRNOT00000136251

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U302-F1-model_v2 AlphaFold Q5U302 1-908 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700706
Promoter ID:EPDNEW_R11229
Type:single initiation site
Name:Ctnna1_1
Description:catenin alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01827,923,534 - 27,923,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359485 AgrOrtholog
BioCyc Gene G2FUF-7920 BioCyc
Ensembl Genes ENSRNOG00000005796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008041 ENTREZGENE
  ENSRNOT00000008041.9 UniProtKB/TrEMBL
  ENSRNOT00000136251 ENTREZGENE
  ENSRNOT00000136251.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2510 UniProtKB/TrEMBL
  Alpha-catenin/vinculin-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108824 IMAGE-MGC_LOAD
InterPro Alpha-catenin/vinculin-like_sf UniProtKB/TrEMBL
  Alpha_catenin UniProtKB/TrEMBL
  Vinculin/catenin UniProtKB/TrEMBL
  Vinculin_CS UniProtKB/TrEMBL
KEGG Report rno:307505 UniProtKB/TrEMBL
MGC_CLONE MGC:93767 IMAGE-MGC_LOAD
NCBI Gene 307505 ENTREZGENE
PANTHER ALPHA CATENIN UniProtKB/TrEMBL
  PTHR18914:SF24 UniProtKB/TrEMBL
Pfam Vinculin UniProtKB/TrEMBL
PhenoGen Ctnna1 PhenoGen
PRINTS ALPHACATENIN UniProtKB/TrEMBL
PROSITE VINCULIN_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005796 RatGTEx
Superfamily-SCOP Vinculin/catenin UniProtKB/TrEMBL
UniProt A0ABK0LLC8_RAT UniProtKB/TrEMBL
  F7F7X1 ENTREZGENE, UniProtKB/TrEMBL
  Q5U302 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ctnna1  catenin alpha 1  LOC100911326  uncharacterized LOC100911326  Data merged from RGD:6493437 737654 PROVISIONAL
2015-11-25 Ctnna1  catenin alpha 1  Ctnna1  catenin (cadherin-associated protein), alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-19 Ctnna1  catenin (cadherin-associated protein), alpha 1  Ctnna1  catenin (cadherin-associated protein), alpha 1, 102kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911326  uncharacterized LOC100911326      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-01-10 Ctnna1  catenin (cadherin-associated protein), alpha 1, 102kDa  Ctnna1  catenin (cadherin associated protein), alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-11 Ctnna1  catenin (cadherin associated protein), alpha 1  Catna1  catenin (cadherin-associated protein), alpha 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-30 Catna1  catenin (cadherin-associated protein), alpha 1    catenin (cadherin-associated protein), alpha 1, 102kDa  Name updated 1299863 APPROVED
2005-07-29 Catna1  catenin (cadherin-associated protein), alpha 1, 102kDa      Symbol and Name status set to provisional 70820 PROVISIONAL