Srsf2 (serine and arginine rich splicing factor 2) - Rat Genome Database

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Gene: Srsf2 (serine and arginine rich splicing factor 2) Rattus norvegicus
Analyze
Symbol: Srsf2
Name: serine and arginine rich splicing factor 2
RGD ID: 1359422
Description: Enables protein kinase C binding activity. Involved in response to vitamin E. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC73009; SC-35; serine/arginine-rich splicing factor 2; Sfrs2; similar to splicing factor, arginine/serine-rich 2; splicing component, 35 kDa; splicing factor SC35; splicing factor, arginine/serine-rich 2; splicing factor, arginine/serine-rich 2 (SC-35)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,550,962 - 102,554,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,553,072 - 102,554,141 (-)EnsemblGRCr8
mRatBN7.210102,052,158 - 102,055,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10107,156,134 - 107,159,309 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,619,223 - 106,622,399 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,972,989 - 101,976,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,792,779 - 105,795,986 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)Ensemblrn6Rnor6.0
Rnor_5.010105,451,332 - 105,454,538 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,954,365 - 106,956,807 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,620,618 - 100,623,797 (-)NCBICelera
RGSC_v3.110106,968,870 - 106,971,311 (-)NCBI
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic UMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
artesunate  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butan-2-one  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress. Bryantsev AL, etal., Exp Cell Res. 2007 Jan 1;313(1):195-209. Epub 2006 Oct 13.
2. Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue. Cataldi A, etal., Anat Rec (Hoboken). 2009 Aug;292(8):1135-42. doi: 10.1002/ar.20936.
3. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
4. A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors. Edmond V, etal., Cell Cycle. 2013 Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. Gout S, etal., PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10.
8. Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors. Je EM, etal., Int J Cancer. 2013 Jul;133(1):260-5. doi: 10.1002/ijc.28011. Epub 2013 Feb 5.
9. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
10. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Luo C, etal., Cancer Res. 2017 Mar 1;77(5):1168-1178. doi: 10.1158/0008-5472.CAN-16-1919. Epub 2017 Jan 12.
11. Aging and vitamin E deficiency are responsible for altered RNA pathways. Malatesta M, etal., Ann N Y Acad Sci. 2004 Jun;1019:379-82.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states. Sahlas DJ, etal., J Cell Sci. 1993 Jun;105 ( Pt 2):347-57.
18. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Sharma S, etal., Mol Cancer Ther. 2011 Sep;10(9):1751-9. doi: 10.1158/1535-7163.MCT-11-0248. Epub 2011 Jul 15.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients. Wang P, etal., Cancer Biomark. 2018 Feb 14;21(3):681-687. doi: 10.3233/CBM-170770.
21. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Zaidi SK, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14852-7. Epub 2003 Dec 1.
22. Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development. Zara S, etal., J Biol Regul Homeost Agents. 2009 Jan-Mar;23(1):45-54.
23. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice. Zhang C, etal., Commun Biol. 2020 May 5;3(1):210. doi: 10.1038/s42003-020-0893-5.
24. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Zhang SJ, etal., Blood. 2012 May 10;119(19):4480-5. doi: 10.1182/blood-2011-11-390252. Epub 2012 Mar 19.
Additional References at PubMed
PMID:11641275   PMID:11683997   PMID:11739632   PMID:11827461   PMID:12799190   PMID:15489334   PMID:15564382   PMID:15652350   PMID:15798186   PMID:15988025   PMID:16376875   PMID:16854843  
PMID:17494991   PMID:19734146   PMID:20356838   PMID:21117027   PMID:21470964   PMID:21653549   PMID:21984414   PMID:22658674   PMID:22681889   PMID:22840402   PMID:23376485   PMID:23512658  
PMID:23562910   PMID:25896510   PMID:26013685   PMID:31505169  


Genomics

Comparative Map Data
Srsf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,550,962 - 102,554,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,553,072 - 102,554,141 (-)EnsemblGRCr8
mRatBN7.210102,052,158 - 102,055,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10107,156,134 - 107,159,309 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,619,223 - 106,622,399 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,972,989 - 101,976,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,792,779 - 105,795,986 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)Ensemblrn6Rnor6.0
Rnor_5.010105,451,332 - 105,454,538 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,954,365 - 106,956,807 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,620,618 - 100,623,797 (-)NCBICelera
RGSC_v3.110106,968,870 - 106,971,311 (-)NCBI
Cytogenetic Map10q32.2NCBI
SRSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,734,115 - 76,737,411 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,734,115 - 76,737,395 (-)Ensemblhg38GRCh38
GRCh371774,730,197 - 74,733,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,241,792 - 72,245,007 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341772,241,793 - 72,245,007NCBI
Celera1771,322,570 - 71,325,785 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1770,157,912 - 70,161,208 (-)NCBIHuRef
CHM1_11774,795,009 - 74,798,305 (-)NCBICHM1_1
T2T-CHM13v2.01777,631,102 - 77,634,398 (-)NCBIT2T-CHM13v2.0
Srsf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,740,723 - 116,744,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,740,727 - 116,743,920 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811116,849,897 - 116,853,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,849,901 - 116,853,094 (-)Ensemblmm10GRCm38
MGSCv3711116,711,211 - 116,714,408 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611116,665,997 - 116,669,172 (-)NCBIMGSCv36mm8
Celera11128,590,379 - 128,593,569 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.49NCBI
Srsf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,569,302 - 5,570,120 (+)Ensembl
ChiLan1.0NW_0049555065,569,280 - 5,572,164 (+)NCBIChiLan1.0ChiLan1.0
SRSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,782,655 - 92,786,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,608,369 - 97,612,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,809,931 - 70,813,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,375,957 - 76,379,258 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,375,957 - 76,379,759 (-)EnsemblpanPan2panpan1.1
SRSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,028,414 - 4,032,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,028,482 - 4,030,793 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha94,709,901 - 4,713,865 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.094,704,238 - 4,708,205 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,704,294 - 4,708,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,730,113 - 4,734,075 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.094,849,750 - 4,853,714 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.094,930,800 - 4,934,764 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srsf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,633,549 - 4,636,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,777,376 - 1,778,164 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,775,412 - 1,778,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl124,800,624 - 4,801,675 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1124,800,578 - 4,803,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,652,818 - 4,653,543 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11644,945,193 - 44,948,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1644,945,200 - 44,946,438 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607715,682,841 - 15,686,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,575,325 - 6,578,468 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248016,575,322 - 6,578,429 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srsf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1967,228,156 - 67,231,366 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srsf2
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:98
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000067739
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
D11Wsu175e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,052,252 - 102,052,476 (+)MAPPERmRatBN7.2
Rnor_6.010105,792,874 - 105,793,097NCBIRnor6.0
Rnor_5.010105,451,427 - 105,451,650UniSTSRnor5.0
RGSC_v3.410106,953,723 - 106,953,946UniSTSRGSC3.4
Celera10100,620,713 - 100,620,936UniSTS
Cytogenetic Map10q32.3UniSTS
D4S2570E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,055,017 - 102,055,124 (+)MAPPERmRatBN7.2
Rnor_6.010105,795,638 - 105,795,744NCBIRnor6.0
Rnor_5.010105,454,191 - 105,454,297UniSTSRnor5.0
RGSC_v3.410106,956,487 - 106,956,593UniSTSRGSC3.4
Celera10100,623,477 - 100,623,583UniSTS
Cytogenetic Map10q32.3UniSTS
RH139654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,051,833 - 102,052,049 (+)MAPPERmRatBN7.2
Rnor_6.010105,792,455 - 105,792,670NCBIRnor6.0
Rnor_5.010105,451,008 - 105,451,223UniSTSRnor5.0
RGSC_v3.410106,953,304 - 106,953,519UniSTSRGSC3.4
Celera10100,620,294 - 100,620,509UniSTS
Cytogenetic Map10q32.3UniSTS
UniSTS:275635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,052,885 - 102,053,630 (+)MAPPERmRatBN7.2
Rnor_6.010105,793,507 - 105,794,250NCBIRnor6.0
Rnor_5.010105,452,060 - 105,452,803UniSTSRnor5.0
RGSC_v3.410106,954,356 - 106,955,099UniSTSRGSC3.4
Celera10100,621,346 - 100,622,089UniSTS
Cytogenetic Map10q32.3UniSTS
UniSTS:479265  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr810102,553,117 - 102,553,951 (+)Marker Load Pipeline
mRatBN7.210102,054,314 - 102,055,148 (+)MAPPERmRatBN7.2
Rnor_6.010105,794,935 - 105,795,768NCBIRnor6.0
Rnor_5.010105,453,488 - 105,454,321UniSTSRnor5.0
RGSC_v3.410106,955,784 - 106,956,617UniSTSRGSC3.4
Celera10100,622,774 - 100,623,607UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067739   ⟹   ENSRNOP00000059012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,553,072 - 102,554,141 (-)Ensembl
mRatBN7.2 Ensembl10102,052,314 - 102,055,338 (-)Ensembl
Rnor_6.0 Ensembl10105,792,779 - 105,795,958 (-)Ensembl
RefSeq Acc Id: NM_001009720   ⟹   NP_001009720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,962 - 102,554,141 (-)NCBI
mRatBN7.210102,052,158 - 102,055,338 (-)NCBI
Rnor_6.010105,792,779 - 105,795,958 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
RGSC_v3.410106,954,365 - 106,956,807 (-)RGD
Celera10100,620,618 - 100,623,797 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247813   ⟹   XP_006247875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,986 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768382   ⟹   XP_008766604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,183 (-)NCBI
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,985 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489901
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
RefSeq Acc Id: XR_005489902
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,200 (-)NCBI
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
RefSeq Acc Id: XR_010055222
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
RefSeq Acc Id: XR_010055223
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
RefSeq Acc Id: XR_010055224
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
RefSeq Acc Id: XR_358012
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,550,977 - 102,554,168 (-)NCBI
mRatBN7.210102,052,160 - 102,055,365 (-)NCBI
Rnor_6.010105,792,794 - 105,795,986 (-)NCBI
Rnor_5.010105,451,332 - 105,454,538 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001009720   ⟸   NM_001009720
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot),   A6HL00 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247875   ⟸   XM_006247813
- Peptide Label: isoform X1
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot),   A6HL00 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766604   ⟸   XM_008768382
- Peptide Label: isoform X1
- UniProtKB: Q6PDU1 (UniProtKB/Swiss-Prot),   A6HL00 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059012   ⟸   ENSRNOT00000067739
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PDU1-F1-model_v2 AlphaFold Q6PDU1 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697927
Promoter ID:EPDNEW_R8452
Type:single initiation site
Name:Srsf2_1
Description:serine and arginine rich splicing factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,795,957 - 105,796,017EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359422 AgrOrtholog
BioCyc Gene G2FUF-22579 BioCyc
Ensembl Genes ENSRNOG00000000248 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067739 ENTREZGENE
  ENSRNOT00000067739.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889746 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RNA-bind/splicing_reg UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  RRM_dom_euk UniProtKB/Swiss-Prot
KEGG Report rno:494445 UniProtKB/Swiss-Prot
MGC_CLONE MGC:73009 IMAGE-MGC_LOAD
NCBI Gene 494445 ENTREZGENE
PANTHER GLYCINE-RICH RNA-BINDING PROTEIN RZ1A UniProtKB/Swiss-Prot
  SC35-LIKE SPLICING FACTOR UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srsf2 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000248 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
  RRM_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A6HL00 ENTREZGENE, UniProtKB/TrEMBL
  Q6PDU1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf2  serine and arginine rich splicing factor 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs2  splicing factor, arginine/serine-rich 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs2  splicing factor, arginine/serine-rich 2  Srsf2  serine/arginine-rich splicing factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf2  serine/arginine-rich splicing factor 2  Sfrs2  splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Sfrs2  splicing factor, arginine/serine-rich 2  Sfrs2  splicing factor, arginine/serine-rich 2 (SC-35)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Sfrs2  splicing factor, arginine/serine-rich 2 (SC-35)  Sfrs2  similar to splicing factor, arginine/serine-rich 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED