GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Srsf2 | decreases acetylation | ISO | SRSF2 (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased acetylation of SRSF2 protein | PMID:21157427 | Srsf2 | increases expression | ISO | SRSF2 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of SRSF2 protein | PMID:21157427 | Srsf2 | increases phosphorylation | ISO | SRSF2 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased phosphorylation of SRSF2 protein | PMID:21157427 | Srsf2 | multiple interactions | ISO | SRSF2 (Homo sapiens) | 6480464 | CTD | [[Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA] which results in increased activity of CASP8 protein; [Cisplatin affects the localization of SRPK2 protein] which results in increased phosphorylation of SRSF2 protein; [Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA; Cisplatin inhibits the reaction [Piroxicam results in decreased expression of SRSF2 mRNA]; HDAC6 protein promotes the reaction [Cisplatin results in increased expression of SRSF2 protein] | PMID:21157427 PMID:21858171 | |
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