Psenen (presenilin enhancer gamma secretase subunit) - Rat Genome Database

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Gene: Psenen (presenilin enhancer gamma secretase subunit) Rattus norvegicus
Analyze
Symbol: Psenen
Name: presenilin enhancer gamma secretase subunit
RGD ID: 1312037
Description: Predicted to enable endopeptidase activator activity and enzyme binding activity. Predicted to be involved in several processes, including amyloid-beta formation; membrane protein proteolysis; and positive regulation of endopeptidase activity. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-schisandrin B; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-secretase subunit PEN-2; liver regeneration-related protein LRRGT00140; LOC292788; LRRGT00140 mRNA; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); presenilin enhancer protein 2; RGD1312037; similar to RIKEN cDNA 1700023M09
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,942,348 - 94,943,545 (-)NCBIGRCr8
mRatBN7.2185,814,905 - 85,816,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,231,624 - 91,232,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,697,789 - 99,698,999 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,989,904 - 92,991,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
2. Synaptic and endosomal localization of active gamma-secretase in rat brain. Frykman S, etal., PLoS One. 2010 Jan 28;5(1):e8948. doi: 10.1371/journal.pone.0008948.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. Hansson CA, etal., J Biol Chem 2004 Dec 3;279(49):51654-60. Epub 2004 Sep 28.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12660785   PMID:15274632   PMID:20130175   PMID:20236034   PMID:20333303   PMID:22771797   PMID:25043039   PMID:26280335  


Genomics

Comparative Map Data
Psenen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,942,348 - 94,943,545 (-)NCBIGRCr8
mRatBN7.2185,814,905 - 85,816,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,231,624 - 91,232,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,697,789 - 99,698,999 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,989,904 - 92,991,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
PSENEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,745,651 - 35,747,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,745,600 - 35,747,519 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,236,552 - 36,238,420 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,928,334 - 40,929,743 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,928,333 - 40,929,743NCBI
Celera1932,949,971 - 32,951,380 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,741,466 - 32,743,044 (+)NCBIHuRef
CHM1_11936,237,788 - 36,239,366 (+)NCBICHM1_1
T2T-CHM13v2.01938,290,961 - 38,292,828 (+)NCBIT2T-CHM13v2.0
Psenen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,261,290 - 30,263,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,261,288 - 30,263,052 (-)EnsemblGRCm39 Ensembl
GRCm38730,561,865 - 30,563,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,561,863 - 30,563,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,346,884 - 31,348,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,270,625 - 30,271,944 (-)NCBIMGSCv36mm8
Celera725,153,627 - 25,154,945 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.6NCBI
Psenen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,805,153 - 2,806,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,805,153 - 2,806,573 (-)NCBIChiLan1.0ChiLan1.0
PSENEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,725,157 - 43,726,595 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,409,662 - 41,411,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensemblpanpan1.1panPan2
PSENEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,887,155 - 116,888,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,886,972 - 116,888,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,292,416 - 116,293,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,490,131 - 117,491,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,489,948 - 117,491,434 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,053,507 - 117,054,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,677,128 - 116,678,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,732,508 - 117,733,796 (-)NCBIUU_Cfam_GSD_1.0
Psenen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570576,722 - 578,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSENEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,627,906 - 40,629,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSENEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,655,162 - 30,656,587 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,655,243 - 30,656,584 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,446,437 - 8,447,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psenen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,053,114 - 10,054,411 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,053,085 - 10,054,411 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Psenen
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000028438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH134336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,815,395 - 85,815,937 (+)MAPPERmRatBN7.2
Rnor_6.0189,016,585 - 89,017,126NCBIRnor6.0
Rnor_5.0190,171,400 - 90,171,941UniSTSRnor5.0
RGSC_v3.4185,607,543 - 85,608,084UniSTSRGSC3.4
Celera180,186,917 - 80,187,458UniSTS
RH 3.4 Map1844.0UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028438   ⟹   ENSRNOP00000028438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)Ensembl
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)Ensembl
RefSeq Acc Id: NM_001008764   ⟹   NP_001008764
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,942,348 - 94,943,545 (-)NCBI
mRatBN7.2185,814,905 - 85,816,101 (-)NCBI
Rnor_6.0189,016,093 - 89,017,290 (-)NCBI
Rnor_5.0190,170,908 - 90,172,275 (-)NCBI
RGSC_v3.4185,607,051 - 85,608,248 (-)RGD
Celera180,186,425 - 80,187,622 (-)RGD
Sequence:
RefSeq Acc Id: NP_001008764   ⟸   NM_001008764
- UniProtKB: Q6QI68 (UniProtKB/Swiss-Prot),   A6J9Z1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028438   ⟸   ENSRNOT00000028438

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QI68-F1-model_v2 AlphaFold Q6QI68 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689921
Promoter ID:EPDNEW_R446
Type:initiation region
Name:Psenen_1
Description:presenilin enhancer gamma secretase subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,017,334 - 89,017,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312037 AgrOrtholog
BioCyc Gene G2FUF-60097 BioCyc
Ensembl Genes ENSRNOG00000020941 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055031780 UniProtKB/Swiss-Prot
  ENSRNOG00060031330 UniProtKB/Swiss-Prot
  ENSRNOG00065032678 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028438.5 UniProtKB/Swiss-Prot
  ENSRNOT00055054984 UniProtKB/Swiss-Prot
  ENSRNOT00060054356 UniProtKB/Swiss-Prot
  ENSRNOT00065056203 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7377803 IMAGE-MGC_LOAD
InterPro Gamma_Secretase_Asp_P_PEN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112872 IMAGE-MGC_LOAD
NCBI Gene 292788 ENTREZGENE
PANTHER GAMMA-SECRETASE SUBUNIT PEN-2 UniProtKB/Swiss-Prot
  GAMMA-SECRETASE SUBUNIT PEN-2 UniProtKB/TrEMBL
  GAMMA-SECRETASE SUBUNIT PEN-2 UniProtKB/TrEMBL
  PTHR16318 UniProtKB/Swiss-Prot
Pfam PEN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psenen PhenoGen
RatGTEx ENSRNOG00000020941 RatGTEx
  ENSRNOG00055031780 RatGTEx
  ENSRNOG00060031330 RatGTEx
  ENSRNOG00065032678 RatGTEx
UniProt A6J9Y9_RAT UniProtKB/TrEMBL
  A6J9Z1 ENTREZGENE, UniProtKB/TrEMBL
  PEN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Psenen  presenilin enhancer gamma secretase subunit  Psenen  presenilin enhancer 2 homolog (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Psenen  presenilin enhancer 2 homolog (C. elegans)  RGD1312037  similar to RIKEN cDNA 1700023M09  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1312037  similar to RIKEN cDNA 1700023M09  RGD1312037_predicted  similar to RIKEN cDNA 1700023M09 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1312037_predicted  similar to RIKEN cDNA 1700023M09 (predicted)  LOC292788_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC292788_predicted  similar to RIKEN cDNA 1700023M09 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL