PSENEN (presenilin enhancer, gamma-secretase subunit) - Rat Genome Database

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Gene: PSENEN (presenilin enhancer, gamma-secretase subunit) Pan paniscus
Analyze
Symbol: PSENEN
Name: presenilin enhancer, gamma-secretase subunit
RGD ID: 11772845
Description: ENCODES a protein that exhibits endopeptidase activator activity (inferred); enzyme binding (inferred); INVOLVED IN Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH Brugada syndrome 5 (ortholog); dystonia (ortholog); Familial Acne Inversa 2 (ortholog); FOUND IN gamma-secretase complex (ortholog); presynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; presenilin enhancer gamma-secretase subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,725,157 - 43,726,595 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,409,662 - 41,411,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PSENEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,725,157 - 43,726,595 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,409,662 - 41,411,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensemblpanpan1.1panPan2
PSENEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,745,651 - 35,747,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,745,600 - 35,747,519 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,236,552 - 36,238,420 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,928,334 - 40,929,743 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,928,333 - 40,929,743NCBI
Celera1932,949,971 - 32,951,380 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,741,466 - 32,743,044 (+)NCBIHuRef
CHM1_11936,237,788 - 36,239,366 (+)NCBICHM1_1
T2T-CHM13v2.01938,290,961 - 38,292,828 (+)NCBIT2T-CHM13v2.0
Psenen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,261,290 - 30,263,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,261,288 - 30,263,052 (-)EnsemblGRCm39 Ensembl
GRCm38730,561,865 - 30,563,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,561,863 - 30,563,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,346,884 - 31,348,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,270,625 - 30,271,944 (-)NCBIMGSCv36mm8
Celera725,153,627 - 25,154,945 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.6NCBI
Psenen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,942,348 - 94,943,545 (-)NCBIGRCr8
mRatBN7.2185,814,905 - 85,816,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,231,624 - 91,232,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,697,789 - 99,698,999 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,989,904 - 92,991,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
Psenen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,805,153 - 2,806,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,805,153 - 2,806,573 (-)NCBIChiLan1.0ChiLan1.0
PSENEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,887,155 - 116,888,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,886,972 - 116,888,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,292,416 - 116,293,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,490,131 - 117,491,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,489,948 - 117,491,434 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,053,507 - 117,054,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,677,128 - 116,678,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,732,508 - 117,733,796 (-)NCBIUU_Cfam_GSD_1.0
Psenen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570576,722 - 578,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSENEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,627,906 - 40,629,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSENEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,655,162 - 30,656,587 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,655,243 - 30,656,584 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,446,437 - 8,447,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psenen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,053,114 - 10,054,411 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,053,085 - 10,054,411 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000041983   ⟹   ENSPPAP00000019228
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000041985   ⟹   ENSPPAP00000019230
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,410,016 - 41,410,932 (+)Ensembl
RefSeq Acc Id: XM_003816165   ⟹   XP_003816213
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBI
NHGRI_mPanPan11943,725,157 - 43,726,595 (+)NCBI
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBI
PanPan1.11941,409,662 - 41,411,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063599562   ⟹   XP_063455632
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003816213 (Get FASTA)   NCBI Sequence Viewer  
  XP_063455632 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000019228
  ENSPPAP00000019228.1
  ENSPPAP00000019230.1
Reference Protein Sequences
RefSeq Acc Id: XP_003816213   ⟸   XM_003816165
- UniProtKB: A0A2R9APY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000019228   ⟸   ENSPPAT00000041983
RefSeq Acc Id: ENSPPAP00000019230   ⟸   ENSPPAT00000041985
RefSeq Acc Id: XP_063455632   ⟸   XM_063599562
- UniProtKB: A0A2R9APY8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032790 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000041983.1 UniProtKB/TrEMBL
  ENSPPAT00000041985.1 UniProtKB/TrEMBL
InterPro Gamma_Secretase_Asp_P_PEN2 UniProtKB/TrEMBL
KEGG Report pps:100974103 UniProtKB/TrEMBL
NCBI Gene PSENEN ENTREZGENE
PANTHER GAMMA-SECRETASE SUBUNIT PEN-2 UniProtKB/TrEMBL
  PTHR16318 UniProtKB/TrEMBL
Pfam PEN-2 UniProtKB/TrEMBL
UniProt A0A2R9APY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ATZ0_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 PSENEN  presenilin enhancer, gamma-secretase subunit    presenilin enhancer gamma-secretase subunit  Symbol and/or name change 5135510 APPROVED