PSENEN (presenilin enhancer, gamma-secretase subunit) - Rat Genome Database

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Gene: PSENEN (presenilin enhancer, gamma-secretase subunit) Sus scrofa
Analyze
Symbol: PSENEN
Name: presenilin enhancer, gamma-secretase subunit
RGD ID: 13871367
Description: ENCODES a protein that exhibits endopeptidase activator activity (inferred); enzyme binding (inferred); INVOLVED IN Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH Brugada syndrome 5 (ortholog); dystonia (ortholog); Familial Acne Inversa 2 (ortholog); FOUND IN gamma-secretase complex (ortholog); presynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gamma-secretase subunit PEN-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,627,906 - 40,629,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PSENEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,627,906 - 40,629,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSENEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,745,651 - 35,747,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,745,600 - 35,747,519 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,236,552 - 36,238,420 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,928,334 - 40,929,743 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,928,333 - 40,929,743NCBI
Celera1932,949,971 - 32,951,380 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,741,466 - 32,743,044 (+)NCBIHuRef
CHM1_11936,237,788 - 36,239,366 (+)NCBICHM1_1
T2T-CHM13v2.01938,290,961 - 38,292,828 (+)NCBIT2T-CHM13v2.0
Psenen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,261,290 - 30,263,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,261,288 - 30,263,052 (-)EnsemblGRCm39 Ensembl
GRCm38730,561,865 - 30,563,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,561,863 - 30,563,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,346,884 - 31,348,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,270,625 - 30,271,944 (-)NCBIMGSCv36mm8
Celera725,153,627 - 25,154,945 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.6NCBI
Psenen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,942,348 - 94,943,545 (-)NCBIGRCr8
mRatBN7.2185,814,905 - 85,816,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,231,624 - 91,232,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,697,789 - 99,698,999 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,989,904 - 92,991,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
Psenen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,805,153 - 2,806,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,805,153 - 2,806,573 (-)NCBIChiLan1.0ChiLan1.0
PSENEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,739,832 - 41,741,270 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,725,157 - 43,726,595 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,409,662 - 41,411,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensemblpanpan1.1panPan2
PSENEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,887,155 - 116,888,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,886,972 - 116,888,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,292,416 - 116,293,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,490,131 - 117,491,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,489,948 - 117,491,434 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,053,507 - 117,054,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,677,128 - 116,678,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,732,508 - 117,733,796 (-)NCBIUU_Cfam_GSD_1.0
Psenen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570576,722 - 578,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSENEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,655,162 - 30,656,587 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,655,243 - 30,656,584 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,446,437 - 8,447,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psenen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,053,114 - 10,054,411 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,053,085 - 10,054,411 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSENEN
29 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 22 2 3 3
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000062978   ⟹   ENSSSCP00000047698
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076086   ⟹   ENSSSCP00000065592
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl645,172,799 - 45,177,203 (+)Ensembl
RefSeq Acc Id: XM_003127056   ⟹   XP_003127104
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003127057   ⟹   XP_003127105
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1645,172,443 - 45,174,112 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003127104   ⟸   XM_003127056
- UniProtKB: A0A287AUA7 (UniProtKB/TrEMBL),   A0A4X1TJQ9 (UniProtKB/TrEMBL),   A0A8D0UV39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003127105   ⟸   XM_003127057
- UniProtKB: A0A287AUA7 (UniProtKB/TrEMBL),   A0A4X1TJQ9 (UniProtKB/TrEMBL),   A0A8D0UV39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065592   ⟸   ENSSSCT00000076086
RefSeq Acc Id: ENSSSCP00000047698   ⟸   ENSSSCT00000062978


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032059 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005037588 UniProtKB/TrEMBL
  ENSSSCG00015038135 UniProtKB/TrEMBL
  ENSSSCG00025053272 UniProtKB/TrEMBL
  ENSSSCG00030023551 UniProtKB/TrEMBL
  ENSSSCG00035026537 UniProtKB/TrEMBL
  ENSSSCG00040071679 UniProtKB/TrEMBL
  ENSSSCG00045028741 UniProtKB/TrEMBL
  ENSSSCG00050017627 UniProtKB/TrEMBL
  ENSSSCG00055026902 UniProtKB/TrEMBL
  ENSSSCG00060063595 UniProtKB/TrEMBL
  ENSSSCG00065062654 UniProtKB/TrEMBL
  ENSSSCG00070009437 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000062978 ENTREZGENE
  ENSSSCT00000062978.2 UniProtKB/TrEMBL
  ENSSSCT00005060076.1 UniProtKB/TrEMBL
  ENSSSCT00005060104.1 UniProtKB/TrEMBL
  ENSSSCT00005060129.1 UniProtKB/TrEMBL
  ENSSSCT00015050706.1 UniProtKB/TrEMBL
  ENSSSCT00015050885.1 UniProtKB/TrEMBL
  ENSSSCT00025072859.1 UniProtKB/TrEMBL
  ENSSSCT00025072928.1 UniProtKB/TrEMBL
  ENSSSCT00025072994.1 UniProtKB/TrEMBL
  ENSSSCT00030032706.1 UniProtKB/TrEMBL
  ENSSSCT00030032717.1 UniProtKB/TrEMBL
  ENSSSCT00030032724.1 UniProtKB/TrEMBL
  ENSSSCT00035035015.1 UniProtKB/TrEMBL
  ENSSSCT00035035023.1 UniProtKB/TrEMBL
  ENSSSCT00040098524.1 UniProtKB/TrEMBL
  ENSSSCT00040098564.1 UniProtKB/TrEMBL
  ENSSSCT00045048991.1 UniProtKB/TrEMBL
  ENSSSCT00045049049.1 UniProtKB/TrEMBL
  ENSSSCT00050023964.1 UniProtKB/TrEMBL
  ENSSSCT00050023975.1 UniProtKB/TrEMBL
  ENSSSCT00050023983.1 UniProtKB/TrEMBL
  ENSSSCT00055053172.1 UniProtKB/TrEMBL
  ENSSSCT00055053226.1 UniProtKB/TrEMBL
  ENSSSCT00060086746.1 UniProtKB/TrEMBL
  ENSSSCT00060086768.1 UniProtKB/TrEMBL
  ENSSSCT00060086777.1 UniProtKB/TrEMBL
  ENSSSCT00065085946.1 UniProtKB/TrEMBL
  ENSSSCT00065085957.1 UniProtKB/TrEMBL
  ENSSSCT00070018300.1 UniProtKB/TrEMBL
  ENSSSCT00070018307.1 UniProtKB/TrEMBL
InterPro Gamma_Secretase_Asp_P_PEN2 UniProtKB/TrEMBL
KEGG Report ssc:100518735 UniProtKB/TrEMBL
NCBI Gene PSENEN ENTREZGENE
PANTHER GAMMA-SECRETASE SUBUNIT PEN-2 UniProtKB/TrEMBL
  PTHR16318 UniProtKB/TrEMBL
Pfam PEN-2 UniProtKB/TrEMBL
UniProt A0A287AUA7 ENTREZGENE
  A0A4X1TJQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TJR5_PIG UniProtKB/TrEMBL
  A0A8D0UV39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W1G2_PIG UniProtKB/TrEMBL
  A0A8D0W1Q6_PIG UniProtKB/TrEMBL
  A0A8D1ZNB0_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287AUA7 UniProtKB/TrEMBL