Iqgap1 (IQ motif containing GTPase activating protein 1) - Rat Genome Database

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Gene: Iqgap1 (IQ motif containing GTPase activating protein 1) Rattus norvegicus
Analyze
Symbol: Iqgap1
Name: IQ motif containing GTPase activating protein 1
RGD ID: 1311884
Description: Enables mitogen-activated protein kinase binding activity. Involved in several processes, including positive regulation of dendrite development; positive regulation of vascular associated smooth muscle cell migration; and regulation of cell junction assembly. Located in focal adhesion and growth cone. Part of protein-containing complex. Is active in postsynapse. Colocalizes with actin cytoskeleton and microtubule cytoskeleton. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361598; ras GTPase-activating-like protein IQGAP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,088,788 - 144,178,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,088,793 - 144,179,043 (-)EnsemblGRCr8
mRatBN7.21134,679,581 - 134,769,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,588,968 - 142,679,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,758,382 - 149,848,532 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,676,568 - 142,767,383 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,734,261 - 126,824,269 (-)NCBICelera
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
CGP 52608  (ISO)
choline  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dihydroartemisinin  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of spine density and morphology by IQGAP1 protein domains. Jausoro I, etal., PLoS One. 2013;8(2):e56574. doi: 10.1371/journal.pone.0056574. Epub 2013 Feb 18.
4. IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Johnson M, etal., Int J Biochem Cell Biol. 2011 Jan;43(1):65-73. doi: 10.1016/j.biocel.2010.09.014. Epub 2010 Sep 29.
5. IQGAP1 links PDGF receptor-beta signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury. Kohno T, etal., Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C591-600. doi: 10.1152/ajpcell.00011.2013. Epub 2013 May 8.
6. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36.
7. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. Li Z, etal., J Biol Chem. 2005 Apr 8;280(14):13871-8. Epub 2005 Jan 28.
8. IQGAP1 mediates angiotensin II-induced apoptosis of podocytes via the ERK1/2 MAPK signaling pathway. Liu Y, etal., Am J Nephrol. 2013;38(5):430-44. doi: 10.1159/000355970. Epub 2013 Nov 12.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Identification of an IQGAP1/AKAP79 complex in beta-cells. Nauert JB, etal., J Cell Biochem 2003 Sep 1;90(1):97-108.
11. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. Nuriya M, etal., J Neurochem. 2005 Oct;95(2):544-52. doi: 10.1111/j.1471-4159.2005.03410.x.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
17. CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. Swiech L, etal., J Neurosci. 2011 Mar 23;31(12):4555-68. doi: 10.1523/JNEUROSCI.6582-10.2011.
18. Hierarchical scaffolding of an ERK1/2 activation pathway. Vetterkind S, etal., Cell Commun Signal. 2013 Aug 29;11:65. doi: 10.1186/1478-811X-11-65.
19. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Yamaoka-Tojo M, etal., Circ Res. 2004 Aug 6;95(3):276-83. Epub 2004 Jun 24.
Additional References at PubMed
PMID:12377780   PMID:12477932   PMID:14516655   PMID:15121898   PMID:15166316   PMID:15263019   PMID:15389538   PMID:16369480   PMID:16380380   PMID:16510873   PMID:17137623   PMID:17563371  
PMID:18504258   PMID:18567582   PMID:18604197   PMID:19056867   PMID:19199708   PMID:20015863   PMID:20458337   PMID:21423176   PMID:21525035   PMID:21709260   PMID:22493426   PMID:22835851  
PMID:23376485   PMID:23533145   PMID:24625528   PMID:24841562   PMID:25468996   PMID:25554515   PMID:26242911   PMID:28839270   PMID:29033352   PMID:30257103   PMID:32364766   PMID:34147590  


Genomics

Comparative Map Data
Iqgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,088,788 - 144,178,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,088,793 - 144,179,043 (-)EnsemblGRCr8
mRatBN7.21134,679,581 - 134,769,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,588,968 - 142,679,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,758,382 - 149,848,532 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,676,568 - 142,767,383 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,734,261 - 126,824,269 (-)NCBICelera
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Cytogenetic Map1q31NCBI
IQGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,388,242 - 90,502,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,388,207 - 90,502,239 (+)Ensemblhg38GRCh38
GRCh371590,931,474 - 91,045,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,732,477 - 88,846,479 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341588,732,476 - 88,846,479NCBI
Celera1567,336,216 - 67,450,214 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,043,721 - 67,156,752 (+)NCBIHuRef
CHM1_11590,773,219 - 90,887,196 (+)NCBICHM1_1
T2T-CHM13v2.01588,144,255 - 88,258,256 (+)NCBIT2T-CHM13v2.0
Iqgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,361,331 - 80,453,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,361,331 - 80,475,722 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38780,711,583 - 80,815,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,711,583 - 80,825,974 (-)Ensemblmm10GRCm38
MGSCv37787,856,469 - 87,948,217 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36780,586,294 - 80,676,807 (-)NCBIMGSCv36mm8
Celera778,116,162 - 78,211,858 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.68NCBI
Iqgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,560,292 - 14,650,036 (+)Ensembl
ChiLan1.0NW_00495541614,558,628 - 14,652,031 (+)NCBIChiLan1.0ChiLan1.0
IQGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,935,362 - 80,049,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,634,820 - 83,748,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,276,762 - 88,390,721 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)EnsemblpanPan2panpan1.1
IQGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,683,869 - 53,791,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,683,791 - 53,792,186 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha356,321,230 - 56,429,279 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0354,099,750 - 54,207,801 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,098,495 - 54,207,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,618,792 - 53,726,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,830,202 - 53,938,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,170,507 - 54,278,357 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Iqgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,739,918 - 129,845,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,489,133 - 16,594,783 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,489,127 - 16,594,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,363,273 - 9,485,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl299,362,926 - 9,485,526 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605937,209,223 - 37,324,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqgap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,702,728 - 17,799,022 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476817,703,113 - 17,797,922 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Iqgap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12119,431,468 - 119,523,287 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Iqgap1
500 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:506
Count of miRNA genes:224
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000018021
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Got124  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01142,624,945 - 142,625,025NCBIRnor6.0
Rnor_5.01143,576,626 - 143,576,706UniSTSRnor5.0
RGSC_v3.41136,652,602 - 136,652,683RGDRGSC3.4
RGSC_v3.41136,652,603 - 136,652,683UniSTSRGSC3.4
Celera1126,833,500 - 126,833,582UniSTS
RGSC_v3.11136,731,009 - 136,731,089RGD
RH 3.4 Map11077.3RGD
RH 3.4 Map11077.3UniSTS
RH 2.0 Map1689.9RGD
Cytogenetic Map1q31UniSTS
RH129224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,679,647 - 134,679,852 (+)MAPPERmRatBN7.2
Rnor_6.01142,525,108 - 142,525,312NCBIRnor6.0
Rnor_5.01143,476,949 - 143,477,153UniSTSRnor5.0
RGSC_v3.41136,552,425 - 136,552,629UniSTSRGSC3.4
Celera1126,734,328 - 126,734,532UniSTS
RH 3.4 Map11075.5UniSTS
Cytogenetic Map1q31UniSTS
AU047418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,742,669 - 134,742,966 (+)MAPPERmRatBN7.2
Rnor_6.01142,588,533 - 142,588,829NCBIRnor6.0
Rnor_5.01143,540,374 - 143,540,670UniSTSRnor5.0
RGSC_v3.41136,615,441 - 136,615,737UniSTSRGSC3.4
Celera1126,797,222 - 126,797,518UniSTS
Cytogenetic Map1q31UniSTS
RH137092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,678,465 - 134,678,664 (+)MAPPERmRatBN7.2
Rnor_6.01142,523,926 - 142,524,124NCBIRnor6.0
Rnor_5.01143,475,767 - 143,475,965UniSTSRnor5.0
RGSC_v3.41136,551,243 - 136,551,441UniSTSRGSC3.4
Celera1126,733,146 - 126,733,344UniSTS
RH 3.4 Map11075.5UniSTS
Cytogenetic Map1q31UniSTS
AI011928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,678,462 - 134,678,748 (+)MAPPERmRatBN7.2
Rnor_6.01142,523,923 - 142,524,208NCBIRnor6.0
Rnor_5.01143,475,764 - 143,476,049UniSTSRnor5.0
RGSC_v3.41136,551,240 - 136,551,525UniSTSRGSC3.4
Celera1126,733,143 - 126,733,428UniSTS
RH 3.4 Map11075.7UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018021   ⟹   ENSRNOP00000018021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)Ensembl
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118439   ⟹   ENSRNOP00000093807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,088,793 - 144,179,043 (-)Ensembl
mRatBN7.2 Ensembl1134,679,586 - 134,767,547 (-)Ensembl
RefSeq Acc Id: NM_001108489   ⟹   NP_001101959
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,088,788 - 144,178,953 (-)NCBI
mRatBN7.21134,679,581 - 134,769,755 (-)NCBI
Rnor_6.01142,525,041 - 142,615,673 (-)NCBI
Rnor_5.01143,476,882 - 143,567,395 (-)NCBI
RGSC_v3.41136,552,358 - 136,642,545 (-)RGD
Celera1126,734,261 - 126,824,269 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082350   ⟹   XP_038938278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,105,668 - 144,178,989 (-)NCBI
mRatBN7.21134,696,450 - 134,769,776 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101959 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69057 (Get FASTA)   NCBI Sequence Viewer  
  EDM08654 (Get FASTA)   NCBI Sequence Viewer  
  EDM08655 (Get FASTA)   NCBI Sequence Viewer  
  EDM08656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093807
  ENSRNOP00000093807.2
RefSeq Acc Id: NP_001101959   ⟸   NM_001108489
- UniProtKB: G3V7Q7 (UniProtKB/TrEMBL),   A6JCC7 (UniProtKB/TrEMBL),   A0A8I6AJK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018021   ⟸   ENSRNOT00000018021
RefSeq Acc Id: XP_038938278   ⟸   XM_039082350
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093807   ⟸   ENSRNOT00000118439
Protein Domains
Calponin-homology (CH)   Ras-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7Q7-F1-model_v2 AlphaFold G3V7Q7 1-1657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690148
Promoter ID:EPDNEW_R673
Type:initiation region
Name:Iqgap1_1
Description:IQ motif containing GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,615,673 - 142,615,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311884 AgrOrtholog
BioCyc Gene G2FUF-58724 BioCyc
Ensembl Genes ENSRNOG00000012002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118439 ENTREZGENE
  ENSRNOT00000118439.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  GTPase Activation - p120gap, domain 1 UniProtKB/TrEMBL
  Myosin, subunit A UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:361598 UniProtKB/TrEMBL
NCBI Gene 361598 ENTREZGENE
PANTHER RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
PhenoGen Iqgap1 PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012002 RatGTEx
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  RGC domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AJK7 ENTREZGENE, UniProtKB/TrEMBL
  A6JCC7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFH1_RAT UniProtKB/TrEMBL
  G3V7Q7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Iqgap1  IQ motif containing GTPase activating protein 1   Iqgap1_predicted  IQ motif containing GTPase activating protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Iqgap1_predicted  IQ motif containing GTPase activating protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED