Cnot2 (CCR4-NOT transcription complex, subunit 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cnot2 (CCR4-NOT transcription complex, subunit 2) Rattus norvegicus
Analyze
Symbol: Cnot2
Name: CCR4-NOT transcription complex, subunit 2
RGD ID: 1311672
Description: Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of RNA metabolic process. Predicted to be located in cytoplasm. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2); PARTICIPATES IN microRNA pathway; RNA degradation pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCR4-NOT transcription complex subunit 2; LOC299805
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,016,447 - 54,117,511 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl754,016,447 - 54,107,960 (-)EnsemblGRCr8
mRatBN7.2752,130,445 - 52,222,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,130,441 - 52,223,575 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx754,037,151 - 54,128,665 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,240,245 - 56,331,759 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,018,227 - 56,109,741 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,526,105 - 59,617,307 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,527,124 - 59,587,385 (-)Ensemblrn6Rnor6.0
Rnor_5.0759,537,579 - 59,628,786 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4755,823,982 - 55,880,812 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera748,914,667 - 48,971,519 (-)NCBICelera
RGSC_v3.1755,844,724 - 55,901,542 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
CCR4-NOT complex  (IEA,ISO)
CCR4-NOT core complex  (IBA,IEA)
cytoplasm  (IEA,ISO)
cytosol  (IEA)
nucleus  (IEA)
P-body  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E and Winkler GS, Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.
Additional References at PubMed
PMID:12477932   PMID:14707134   PMID:16712523   PMID:16778766   PMID:19558367   PMID:19946888   PMID:21299754   PMID:22367759  


Genomics

Comparative Map Data
Cnot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,016,447 - 54,117,511 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl754,016,447 - 54,107,960 (-)EnsemblGRCr8
mRatBN7.2752,130,445 - 52,222,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,130,441 - 52,223,575 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx754,037,151 - 54,128,665 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,240,245 - 56,331,759 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,018,227 - 56,109,741 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,526,105 - 59,617,307 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,527,124 - 59,587,385 (-)Ensemblrn6Rnor6.0
Rnor_5.0759,537,579 - 59,628,786 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4755,823,982 - 55,880,812 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera748,914,667 - 48,971,519 (-)NCBICelera
RGSC_v3.1755,844,724 - 55,901,542 (-)NCBI
Cytogenetic Map7q22NCBI
CNOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381270,243,018 - 70,354,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1270,243,002 - 70,354,993 (+)Ensemblhg38GRCh38
GRCh371270,636,798 - 70,748,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,923,044 - 69,035,040 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341268,923,488 - 69,033,960NCBI
Celera1270,300,448 - 70,412,447 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1267,686,934 - 67,798,932 (+)NCBIHuRef
CHM1_11270,606,077 - 70,718,081 (+)NCBICHM1_1
T2T-CHM13v2.01270,222,411 - 70,334,463 (+)NCBIT2T-CHM13v2.0
Cnot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,321,065 - 116,418,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,321,066 - 116,417,416 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810116,485,160 - 116,581,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,485,161 - 116,581,511 (-)Ensemblmm10GRCm38
MGSCv3710115,922,217 - 116,018,567 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610115,889,276 - 115,985,621 (-)NCBIMGSCv36mm8
Celera10118,426,741 - 118,523,052 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1064.76NCBI
Cnot2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,451,414 - 10,547,229 (+)Ensembl
ChiLan1.0NW_00495540510,451,414 - 10,547,229 (+)NCBIChiLan1.0ChiLan1.0
CNOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21078,258,520 - 78,370,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11278,255,483 - 78,367,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01267,753,703 - 67,865,375 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11270,520,722 - 70,633,149 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,520,722 - 70,633,149 (+)EnsemblpanPan2panpan1.1
CNOT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,057,269 - 12,174,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,009,762 - 12,172,427 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1011,995,863 - 12,112,451 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01012,188,879 - 12,305,324 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,141,268 - 12,305,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,055,404 - 12,171,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01012,302,721 - 12,419,265 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01012,426,002 - 12,542,252 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cnot2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494546,069,715 - 46,170,762 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365457,938,934 - 8,042,117 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365457,938,934 - 8,040,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl534,426,394 - 34,549,310 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1534,470,911 - 34,548,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,132,108 - 37,207,783 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11165,823,294 - 65,932,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1165,861,353 - 65,934,042 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037179,752,841 - 179,862,945 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnot2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475027,430,575 - 27,529,081 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475027,433,671 - 27,529,545 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cnot2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11194,637,396 - 194,728,411 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cnot2
1088 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:124
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000066396
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH144030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,138,261 - 52,138,425 (+)MAPPERmRatBN7.2
Rnor_6.0759,533,922 - 59,534,085NCBIRnor6.0
Rnor_5.0759,545,396 - 59,545,559UniSTSRnor5.0
RGSC_v3.4755,827,349 - 55,827,512UniSTSRGSC3.4
Celera748,918,034 - 48,918,197UniSTS
RH 3.4 Map7481.5UniSTS
Cytogenetic Map7q22UniSTS
RH140338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,149,611 - 52,149,762 (+)MAPPERmRatBN7.2
Rnor_6.0759,545,272 - 59,545,422NCBIRnor6.0
Rnor_5.0759,556,746 - 59,556,896UniSTSRnor5.0
RGSC_v3.4755,838,699 - 55,838,849UniSTSRGSC3.4
Celera748,929,384 - 48,929,534UniSTS
RH 3.4 Map7503.6UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000066396   ⟹   ENSRNOP00000061277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,020,910 - 54,077,727 (-)Ensembl
mRatBN7.2 Ensembl752,134,908 - 52,191,729 (-)Ensembl
Rnor_6.0 Ensembl759,530,568 - 59,587,385 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085836   ⟹   ENSRNOP00000075690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,131,074 - 52,221,608 (-)Ensembl
Rnor_6.0 Ensembl759,532,641 - 59,547,174 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091427   ⟹   ENSRNOP00000074023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,022,862 - 54,107,960 (-)Ensembl
mRatBN7.2 Ensembl752,136,860 - 52,221,617 (-)Ensembl
Rnor_6.0 Ensembl759,527,124 - 59,587,382 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100132   ⟹   ENSRNOP00000078367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,016,447 - 54,107,960 (-)Ensembl
mRatBN7.2 Ensembl752,130,594 - 52,221,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104908   ⟹   ENSRNOP00000084380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,016,447 - 54,107,960 (-)Ensembl
mRatBN7.2 Ensembl752,130,441 - 52,221,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114739   ⟹   ENSRNOP00000077944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,016,447 - 54,107,960 (-)Ensembl
mRatBN7.2 Ensembl752,130,443 - 52,221,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118688   ⟹   ENSRNOP00000095291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,130,594 - 52,223,575 (-)Ensembl
RefSeq Acc Id: NM_001399553   ⟹   NP_001386482
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399554   ⟹   NP_001386483
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399555   ⟹   NP_001386484
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399556   ⟹   NP_001386485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: XM_006241369   ⟹   XP_006241431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,453 - 52,222,327 (-)NCBI
Rnor_6.0759,526,105 - 59,617,297 (-)NCBI
Rnor_5.0759,537,579 - 59,628,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594741   ⟹   XP_017450230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,448 - 52,222,327 (-)NCBI
Rnor_6.0759,526,105 - 59,617,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078717   ⟹   XP_038934645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,312 (-)NCBI
mRatBN7.2752,130,453 - 52,221,318 (-)NCBI
RefSeq Acc Id: XM_039078720   ⟹   XP_038934648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,453 - 52,222,326 (-)NCBI
RefSeq Acc Id: XM_039078728   ⟹   XP_038934656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,328 (-)NCBI
RefSeq Acc Id: XM_039078730   ⟹   XP_038934658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,327 (-)NCBI
RefSeq Acc Id: XM_039078732   ⟹   XP_038934660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,328 (-)NCBI
RefSeq Acc Id: XM_039078735   ⟹   XP_038934663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,030,719 (-)NCBI
mRatBN7.2752,131,062 - 52,145,999 (-)NCBI
RefSeq Acc Id: XM_063263224   ⟹   XP_063119294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,057,225 (-)NCBI
RefSeq Acc Id: XM_063263225   ⟹   XP_063119295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,030,621 - 54,117,511 (-)NCBI
RefSeq Acc Id: XM_063263226   ⟹   XP_063119296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,030,621 - 54,117,511 (-)NCBI
RefSeq Acc Id: XP_006241431   ⟸   XM_006241369
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AJD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450230   ⟸   XM_017594741
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZXR1 (UniProtKB/TrEMBL),   A6IGN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074023   ⟸   ENSRNOT00000091427
Ensembl Acc Id: ENSRNOP00000061277   ⟸   ENSRNOT00000066396
Ensembl Acc Id: ENSRNOP00000075690   ⟸   ENSRNOT00000085836
RefSeq Acc Id: XP_038934648   ⟸   XM_039078720
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KB82 (UniProtKB/TrEMBL),   A0A8I6AJD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934645   ⟸   XM_039078717
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934660   ⟸   XM_039078732
- Peptide Label: isoform X8
- UniProtKB: A6IGN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934656   ⟸   XM_039078728
- Peptide Label: isoform X6
- UniProtKB: A6IGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934658   ⟸   XM_039078730
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZKS1 (UniProtKB/TrEMBL),   A6IGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934663   ⟸   XM_039078735
- Peptide Label: isoform X11
- UniProtKB: A6IGP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084380   ⟸   ENSRNOT00000104908
Ensembl Acc Id: ENSRNOP00000095291   ⟸   ENSRNOT00000118688
Ensembl Acc Id: ENSRNOP00000077944   ⟸   ENSRNOT00000114739
Ensembl Acc Id: ENSRNOP00000078367   ⟸   ENSRNOT00000100132
RefSeq Acc Id: NP_001386485   ⟸   NM_001399556
- Peptide Label: isoform 4
- UniProtKB: A6IGP1 (UniProtKB/TrEMBL),   A6IGN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386482   ⟸   NM_001399553
- Peptide Label: Isoform 1
- UniProtKB: A0A8I5Y9U2 (UniProtKB/TrEMBL),   A0A8I6AJD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386483   ⟸   NM_001399554
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AJD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386484   ⟸   NM_001399555
- Peptide Label: isoform 3
- UniProtKB: A0A0G2KB82 (UniProtKB/TrEMBL),   A0A8I6AJD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119294   ⟸   XM_063263224
- Peptide Label: isoform X5
- UniProtKB: A6IGP0 (UniProtKB/TrEMBL),   A6IGN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119295   ⟸   XM_063263225
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063119296   ⟸   XM_063263226
- Peptide Label: isoform X10
Protein Domains
NOT2/NOT3/NOT5 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K717-F1-model_v2 AlphaFold A0A0G2K717 1-540 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311672 AgrOrtholog
BioCyc Gene G2FUF-34033 BioCyc
Ensembl Genes ENSRNOG00000004909 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066396 ENTREZGENE
  ENSRNOT00000066396.4 UniProtKB/TrEMBL
  ENSRNOT00000091427.3 UniProtKB/TrEMBL
  ENSRNOT00000100132 ENTREZGENE
  ENSRNOT00000100132.2 UniProtKB/TrEMBL
  ENSRNOT00000104908 ENTREZGENE
  ENSRNOT00000104908.2 UniProtKB/TrEMBL
  ENSRNOT00000114739 ENTREZGENE
  ENSRNOT00000114739.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.1020 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313082 IMAGE-MGC_LOAD
InterPro CCR4-NOT_su2/3/5_N_sf UniProtKB/TrEMBL
  NOT UniProtKB/TrEMBL
  Not2/3/5 UniProtKB/TrEMBL
MGC_CLONE MGC:105588 IMAGE-MGC_LOAD
NCBI Gene 299805 ENTREZGENE
PANTHER PTHR23326 UniProtKB/TrEMBL
Pfam NOT2_3_5 UniProtKB/TrEMBL
PhenoGen Cnot2 PhenoGen
RatGTEx ENSRNOG00000004909 RatGTEx
UniProt A0A0G2K717_RAT UniProtKB/TrEMBL
  A0A0G2KB82 ENTREZGENE
  A0A8I5Y9U2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJD1 ENTREZGENE
  A6IGN0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN2 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN5 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP2 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPJ8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cnot2  CCR4-NOT transcription complex, subunit 2  Cnot2_predicted  CCR4-NOT transcription complex, subunit 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cnot2_predicted  CCR4-NOT transcription complex, subunit 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED