Ptpn3 (protein tyrosine phosphatase, non-receptor type 3) - Rat Genome Database

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Pathways
Gene: Ptpn3 (protein tyrosine phosphatase, non-receptor type 3) Rattus norvegicus
Analyze
Symbol: Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
RGD ID: 1311363
Description: Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Involved in liver regeneration. Predicted to be located in cytoskeleton and plasma membrane. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362524; tyrosine-protein phosphatase non-receptor type 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8576,703,687 - 76,822,584 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl576,703,687 - 76,860,470 (-)EnsemblGRCr8
mRatBN7.2571,908,520 - 72,027,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl571,911,135 - 72,065,443 (-)EnsemblmRatBN7.2
Rnor_6.0574,248,996 - 74,368,167 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl574,248,996 - 74,368,186 (-)Ensemblrn6Rnor6.0
Rnor_5.0578,399,259 - 78,528,991 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4575,106,880 - 75,222,735 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera570,758,167 - 70,876,826 (-)NCBICelera
RGSC_v3.1575,111,995 - 75,139,197 (-)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzohydrazide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin A  (ISO)
cannabidiol  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
indometacin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-nitrosodiethylamine  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pirfenidone  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. Kitamura T, etal., Jpn J Cancer Res. 1995 Sep;86(9):811-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10364224   PMID:10940933   PMID:12207026   PMID:16930557   PMID:19167335  


Genomics

Comparative Map Data
Ptpn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8576,703,687 - 76,822,584 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl576,703,687 - 76,860,470 (-)EnsemblGRCr8
mRatBN7.2571,908,520 - 72,027,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl571,911,135 - 72,065,443 (-)EnsemblmRatBN7.2
Rnor_6.0574,248,996 - 74,368,167 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl574,248,996 - 74,368,186 (-)Ensemblrn6Rnor6.0
Rnor_5.0578,399,259 - 78,528,991 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4575,106,880 - 75,222,735 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera570,758,167 - 70,876,826 (-)NCBICelera
RGSC_v3.1575,111,995 - 75,139,197 (-)NCBI
Cytogenetic Map5q24NCBI
PTPN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389109,375,694 - 109,538,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9109,375,466 - 109,498,333 (-)Ensemblhg38GRCh38
GRCh379112,137,974 - 112,260,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369111,180,337 - 111,265,557 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349109,220,072 - 109,305,289NCBI
Celera982,637,279 - 82,759,899 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef981,738,137 - 81,860,645 (-)NCBIHuRef
CHM1_19112,284,708 - 112,407,241 (-)NCBICHM1_1
T2T-CHM13v2.09121,545,088 - 121,707,765 (-)NCBIT2T-CHM13v2.0
Ptpn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,190,841 - 57,339,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,190,841 - 57,301,837 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38457,190,841 - 57,339,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,190,841 - 57,301,837 (-)Ensemblmm10GRCm38
MGSCv37457,203,713 - 57,314,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36457,284,895 - 57,394,944 (-)NCBIMGSCv36mm8
Celera457,101,096 - 57,212,390 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.66NCBI
Ptpn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541917,493,518 - 17,645,477 (+)Ensembl
ChiLan1.0NW_00495541917,560,664 - 17,645,420 (+)NCBIChiLan1.0ChiLan1.0
PTPN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,908,994 - 30,031,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1929,911,359 - 30,031,626 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0980,528,896 - 80,651,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19108,699,761 - 108,787,464 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9108,699,761 - 108,787,464 (-)EnsemblpanPan2panpan1.1
PTPN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11164,486,293 - 64,595,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1164,489,446 - 64,630,004 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1162,886,334 - 63,029,951 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01165,619,500 - 65,763,908 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1165,619,501 - 65,764,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11164,139,495 - 64,283,404 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01164,160,914 - 64,305,281 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01164,851,489 - 64,995,173 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947179,719,264 - 179,830,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365593,436,651 - 3,547,275 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365593,436,114 - 3,547,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,418,133 - 250,540,480 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11250,418,131 - 250,583,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTPN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11230,048,941 - 30,168,816 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1230,083,128 - 30,171,473 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247582,011,732 - 2,170,348 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247582,011,998 - 2,170,096 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptpn3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1194,303,104 - 94,417,599 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptpn3
503 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:559
Count of miRNA genes:254
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000059627
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Mit17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,963,533 - 71,963,668 (+)MAPPERmRatBN7.2
Rnor_6.0574,304,359 - 74,304,493NCBIRnor6.0
Rnor_5.0578,454,425 - 78,454,559UniSTSRnor5.0
RGSC_v3.4575,159,411 - 75,159,546RGDRGSC3.4
RGSC_v3.4575,159,412 - 75,159,546UniSTSRGSC3.4
Celera570,813,108 - 70,813,242UniSTS
RGSC_v3.1575,164,525 - 75,164,659RGD
RH 3.4 Map5487.8UniSTS
RH 3.4 Map5487.8RGD
RH 2.0 Map5371.2RGD
Cytogenetic Map5q24UniSTS
D5Rat182  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,963,532 - 71,963,722 (+)MAPPERmRatBN7.2
Rnor_6.0574,304,358 - 74,304,547NCBIRnor6.0
Rnor_5.0578,454,424 - 78,454,613UniSTSRnor5.0
RGSC_v3.4575,159,410 - 75,159,600RGDRGSC3.4
RGSC_v3.4575,159,411 - 75,159,600UniSTSRGSC3.4
Celera570,813,107 - 70,813,296UniSTS
RGSC_v3.1575,164,413 - 75,164,721RGD
FHH x ACI Map536.89RGD
FHH x ACI Map536.89UniSTS
Cytogenetic Map5q24UniSTS
RH141861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,908,518 - 71,908,725 (+)MAPPERmRatBN7.2
Rnor_6.0574,248,995 - 74,249,201NCBIRnor6.0
Rnor_5.0578,399,258 - 78,399,464UniSTSRnor5.0
RGSC_v3.4575,104,609 - 75,104,815UniSTSRGSC3.4
Celera570,758,166 - 70,758,372UniSTS
RH 3.4 Map5483.5UniSTS
Cytogenetic Map5q24UniSTS
RH132655  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,960,402 - 71,960,593 (+)MAPPERmRatBN7.2
Rnor_6.0574,301,229 - 74,301,419NCBIRnor6.0
Rnor_5.0578,451,295 - 78,451,485UniSTSRnor5.0
RGSC_v3.4575,156,347 - 75,156,537UniSTSRGSC3.4
Celera570,810,035 - 70,810,225UniSTS
RH 3.4 Map5484.6UniSTS
Cytogenetic Map5q24UniSTS
AI555271  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,911,367 - 71,911,552 (+)MAPPERmRatBN7.2
Rnor_6.0574,251,844 - 74,252,028NCBIRnor6.0
Rnor_5.0578,402,107 - 78,402,291UniSTSRnor5.0
RGSC_v3.4575,107,458 - 75,107,642UniSTSRGSC3.4
Celera570,761,015 - 70,761,199UniSTS
RH 3.4 Map5486.1UniSTS
Cytogenetic Map5q24UniSTS
AU049242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,963,570 - 71,963,711 (+)MAPPERmRatBN7.2
Rnor_6.0574,304,396 - 74,304,536NCBIRnor6.0
Rnor_5.0578,454,462 - 78,454,602UniSTSRnor5.0
RGSC_v3.4575,159,449 - 75,159,589UniSTSRGSC3.4
Celera570,813,145 - 70,813,285UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 146 91 90 59 29 59 6 293 129 11 125 81 92 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001055793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001059757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC092605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000059627   ⟹   ENSRNOP00000056382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,821,764 (-)Ensembl
mRatBN7.2 Ensembl571,911,135 - 72,026,586 (-)Ensembl
Rnor_6.0 Ensembl574,250,453 - 74,368,186 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076106   ⟹   ENSRNOP00000068051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,821,940 (-)Ensembl
mRatBN7.2 Ensembl571,911,135 - 72,026,586 (-)Ensembl
Rnor_6.0 Ensembl574,248,996 - 74,367,267 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076705   ⟹   ENSRNOP00000068252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,821,940 (-)Ensembl
mRatBN7.2 Ensembl571,911,135 - 72,026,492 (-)Ensembl
Rnor_6.0 Ensembl574,252,602 - 74,366,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096667   ⟹   ENSRNOP00000081216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,860,470 (-)Ensembl
mRatBN7.2 Ensembl571,911,135 - 72,065,443 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104839   ⟹   ENSRNOP00000077016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,821,221 (-)Ensembl
mRatBN7.2 Ensembl571,911,135 - 72,025,696 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141448   ⟹   ENSRNOP00000101587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,821,940 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158623   ⟹   ENSRNOP00000101241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,802,441 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164426   ⟹   ENSRNOP00000104527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl576,703,687 - 76,834,284 (-)Ensembl
RefSeq Acc Id: NM_001100754   ⟹   NP_001094224
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,821,221 (-)NCBI
RefSeq Acc Id: XM_001059757   ⟹   XP_001059757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,821,763 (-)NCBI
mRatBN7.2571,908,520 - 72,026,608 (-)NCBI
Rnor_6.0574,248,996 - 74,367,571 (-)NCBI
Rnor_5.0578,399,259 - 78,528,991 (-)NCBI
RGSC_v3.4575,106,880 - 75,222,735 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763740   ⟹   XP_008761962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,765,452 (-)NCBI
mRatBN7.2571,910,793 - 71,970,317 (-)NCBI
Rnor_6.0574,251,269 - 74,311,597 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593736   ⟹   XP_017449225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,822,584 (-)NCBI
mRatBN7.2571,910,793 - 72,027,323 (-)NCBI
Rnor_6.0574,251,269 - 74,368,167 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111038   ⟹   XP_038966966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,800,540 (-)NCBI
mRatBN7.2571,910,793 - 72,005,372 (-)NCBI
RefSeq Acc Id: XM_063287932   ⟹   XP_063144002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,703,687 - 76,802,244 (-)NCBI
RefSeq Acc Id: XP_001059757   ⟸   XM_001059757
- Peptide Label: isoform X1
- UniProtKB: F1LQQ5 (UniProtKB/TrEMBL),   A6KDS9 (UniProtKB/TrEMBL),   A0A096MJA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761962   ⟸   XM_008763740
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017449225   ⟸   XM_017593736
- Peptide Label: isoform X3
- UniProtKB: A0A8I5YBL2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056382   ⟸   ENSRNOT00000059627
Ensembl Acc Id: ENSRNOP00000068051   ⟸   ENSRNOT00000076106
Ensembl Acc Id: ENSRNOP00000068252   ⟸   ENSRNOT00000076705
RefSeq Acc Id: XP_038966966   ⟸   XM_039111038
- Peptide Label: isoform X3
- UniProtKB: A0A8I5YBL2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077016   ⟸   ENSRNOT00000104839
Ensembl Acc Id: ENSRNOP00000081216   ⟸   ENSRNOT00000096667
RefSeq Acc Id: NP_001094224   ⟸   NM_001100754
- UniProtKB: A0A8I5YBL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144002   ⟸   XM_063287932
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101587   ⟸   ENSRNOT00000141448
Ensembl Acc Id: ENSRNOP00000101241   ⟸   ENSRNOT00000158623
Ensembl Acc Id: ENSRNOP00000104527   ⟸   ENSRNOT00000164426
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQQ5-F1-model_v2 AlphaFold F1LQQ5 1-1018 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693759
Promoter ID:EPDNEW_R4282
Type:multiple initiation site
Name:Ptpn3_1
Description:protein tyrosine phosphatase, non-receptor type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4283  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0574,366,841 - 74,366,901EPDNEW
RGD ID:13693760
Promoter ID:EPDNEW_R4283
Type:initiation region
Name:Ptpn3_2
Description:protein tyrosine phosphatase, non-receptor type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4282  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0574,367,253 - 74,367,313EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311363 AgrOrtholog
BioCyc Gene G2FUF-41211 BioCyc
Ensembl Genes ENSRNOG00000011425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059627.6 UniProtKB/TrEMBL
  ENSRNOT00000076106.4 UniProtKB/TrEMBL
  ENSRNOT00000076705 ENTREZGENE
  ENSRNOT00000076705.3 UniProtKB/TrEMBL
  ENSRNOT00000096667.2 UniProtKB/TrEMBL
  ENSRNOT00000104839 ENTREZGENE
  ENSRNOT00000104839.2 UniProtKB/TrEMBL
  ENSRNOT00000141448.1 UniProtKB/TrEMBL
  ENSRNOT00000158623 ENTREZGENE
  ENSRNOT00000158623.1 UniProtKB/TrEMBL
  ENSRNOT00000164426.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308722 IMAGE-MGC_LOAD
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPN3/4_FERM_C UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-3/4 UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:362524 UniProtKB/TrEMBL
MGC_CLONE MGC:109219 IMAGE-MGC_LOAD
NCBI Gene 362524 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpn3 PhenoGen
PIRSF Tyr-Ptase_nr3 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011425 RatGTEx
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A096MJA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MJT2_RAT UniProtKB/TrEMBL
  A0A8I5YBL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUL2_RAT UniProtKB/TrEMBL
  A0ABK0L0K4_RAT UniProtKB/TrEMBL
  A0ABK0L8D6_RAT UniProtKB/TrEMBL
  A0ABK0LNI7_RAT UniProtKB/TrEMBL
  A6KDS9 ENTREZGENE, UniProtKB/TrEMBL
  F1LQQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q562B7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Ptpn3  protein tyrosine phosphatase, non-receptor type 3  Ptpn3_predicted  protein tyrosine phosphatase, non-receptor type 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ptpn3_predicted  protein tyrosine phosphatase, non-receptor type 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED