PTPN3 (protein tyrosine phosphatase non-receptor type 3) - Rat Genome Database

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Gene: PTPN3 (protein tyrosine phosphatase non-receptor type 3) Chlorocebus sabaeus
Analyze
Symbol: PTPN3
Name: protein tyrosine phosphatase non-receptor type 3
RGD ID: 18561692
Description: ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal protein binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN liver regeneration (ortholog); ASSOCIATED WITH diastolic heart failure (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11230,048,941 - 30,168,816 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1230,083,128 - 30,171,473 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11230,048,941 - 30,168,816 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1230,083,128 - 30,171,473 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PTPN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389109,375,694 - 109,538,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9109,375,466 - 109,498,313 (-)EnsemblGRCh38hg38GRCh38
GRCh379112,137,974 - 112,260,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369111,180,337 - 111,265,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 349109,220,072 - 109,305,289NCBI
Celera982,637,279 - 82,759,899 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef981,738,137 - 81,860,645 (-)NCBIHuRef
CHM1_19112,284,708 - 112,407,241 (-)NCBICHM1_1
T2T-CHM13v2.09121,545,088 - 121,707,765 (-)NCBIT2T-CHM13v2.0
Ptpn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,190,841 - 57,339,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,190,841 - 57,301,837 (-)EnsemblGRCm39 Ensembl
GRCm38457,190,841 - 57,339,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,190,841 - 57,301,837 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,203,713 - 57,314,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36457,284,895 - 57,394,944 (-)NCBIMGSCv36mm8
Celera457,101,096 - 57,212,390 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.66NCBI
Ptpn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8576,703,687 - 76,822,584 (-)NCBIGRCr8
mRatBN7.2571,908,520 - 72,027,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl571,911,135 - 72,065,443 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0574,248,996 - 74,368,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl574,248,996 - 74,368,186 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0578,399,259 - 78,528,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,106,880 - 75,222,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,111,995 - 75,139,197 (-)NCBI
Celera570,758,167 - 70,876,826 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ptpn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541917,493,518 - 17,645,477 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541917,560,664 - 17,645,420 (+)NCBIChiLan1.0ChiLan1.0
PTPN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,908,994 - 30,031,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1929,911,359 - 30,031,626 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0980,528,896 - 80,651,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19108,699,761 - 108,787,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9108,699,761 - 108,787,464 (-)Ensemblpanpan1.1panPan2
PTPN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11164,486,293 - 64,595,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1164,489,446 - 64,630,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1162,886,334 - 63,029,951 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01165,619,500 - 65,763,908 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1165,619,501 - 65,764,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11164,139,495 - 64,283,404 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01164,160,914 - 64,305,281 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01164,851,489 - 64,995,173 (-)NCBIUU_Cfam_GSD_1.0
Ptpn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947179,719,264 - 179,830,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365593,436,651 - 3,547,275 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365593,436,114 - 3,547,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,418,133 - 250,540,480 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,418,131 - 250,583,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Ptpn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247582,011,732 - 2,170,348 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247582,011,998 - 2,170,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 3
Low 33 12 46
Below cutoff 5 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009844   ⟹   ENSCSAP00000007953
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1230,083,128 - 30,171,473 (+)Ensembl
RefSeq Acc Id: XM_007968467   ⟹   XP_007966658
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11230,048,941 - 30,168,816 (+)NCBI
Vero_WHO_p1.0NW_02366603512,548,998 - 12,668,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007968469   ⟹   XP_007966660
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11230,048,941 - 30,168,816 (+)NCBI
Vero_WHO_p1.0NW_02366603512,548,998 - 12,668,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007968470   ⟹   XP_007966661
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11230,049,589 - 30,168,816 (+)NCBI
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007968472   ⟹   XP_007966663
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11230,092,692 - 30,168,816 (+)NCBI
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,926 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037983397   ⟹   XP_037839325
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603512,548,993 - 12,668,933 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007966658   ⟸   XM_007968467
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007966660   ⟸   XM_007968469
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007966661   ⟸   XM_007968470
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007966663   ⟸   XM_007968472
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007953   ⟸   ENSCSAT00000009844
RefSeq Acc Id: XP_037839325   ⟸   XM_037983397
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RH64 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011753 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009844.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  PTPN3/4_FERM_C UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-3/4 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PTPN3 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr3 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0D9RH64 ENTREZGENE, UniProtKB/TrEMBL