Cul2 (cullin 2) - Rat Genome Database

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Gene: Cul2 (cullin 2) Rattus norvegicus
Analyze
Symbol: Cul2
Name: cullin 2
RGD ID: 1310644
Description: Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of VCB complex. Orthologous to human CUL2 (cullin 2); PARTICIPATES IN hypoxia inducible factor pathway; neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cullin-2; LOC361258
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,864,274 - 58,905,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1758,864,274 - 58,905,132 (-)EnsemblGRCr8
mRatBN7.21754,169,093 - 54,210,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,169,086 - 54,209,968 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1757,335,609 - 57,376,784 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,338,647 - 61,379,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,496,476 - 55,537,755 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,952,480 - 56,992,716 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,952,480 - 56,992,694 (-)Ensemblrn6Rnor6.0
Rnor_5.01754,986,452 - 55,026,674 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41762,701,289 - 62,741,344 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1750,150,407 - 50,190,272 (-)NCBICelera
RGSC_v3.11762,712,162 - 62,752,367 (-)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetamide  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
citalopram  (EXP)
clozapine  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
doxorubicin  (ISO)
Erionite  (ISO)
folic acid  (ISO)
genistein  (ISO)
ivermectin  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel dichloride  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, etal., J Cell Physiol. 2010 Mar;222(3):635-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Kamura T, etal., Science. 1999 Apr 23;284(5414):657-61.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Ohh M, etal., EMBO Rep. 2002 Feb;3(2):177-82. Epub 2002 Jan 29.
7. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, etal., Oncogene. 2004 Mar 15;23(11):1985-97.
8. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Pause A, etal., Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
Additional References at PubMed
PMID:15601820   PMID:16129783   PMID:17636018  


Genomics

Comparative Map Data
Cul2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,864,274 - 58,905,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1758,864,274 - 58,905,132 (-)EnsemblGRCr8
mRatBN7.21754,169,093 - 54,210,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,169,086 - 54,209,968 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1757,335,609 - 57,376,784 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,338,647 - 61,379,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,496,476 - 55,537,755 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,952,480 - 56,992,716 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,952,480 - 56,992,694 (-)Ensemblrn6Rnor6.0
Rnor_5.01754,986,452 - 55,026,674 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41762,701,289 - 62,741,344 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1750,150,407 - 50,190,272 (-)NCBICelera
RGSC_v3.11762,712,162 - 62,752,367 (-)NCBI
Cytogenetic Map17q12.1NCBI
CUL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381035,008,551 - 35,127,006 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1035,008,504 - 35,127,006 (-)Ensemblhg38GRCh38
GRCh371035,297,479 - 35,379,542 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361035,338,804 - 35,419,300 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341035,338,813 - 35,419,300NCBI
Celera1035,064,147 - 35,144,640 (-)NCBICelera
Cytogenetic Map10p11.21NCBI
HuRef1035,016,158 - 35,098,233 (-)NCBIHuRef
CHM1_11035,298,728 - 35,380,758 (-)NCBICHM1_1
T2T-CHM13v2.01035,037,104 - 35,155,467 (-)NCBIT2T-CHM13v2.0
Cul2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39183,382,970 - 3,436,700 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl183,382,988 - 3,436,377 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38183,382,970 - 3,436,700 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl183,382,988 - 3,436,377 (+)Ensemblmm10GRCm38
MGSCv37183,383,223 - 3,436,698 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36183,383,029 - 3,436,372 (+)NCBIMGSCv36mm8
Celera183,432,713 - 3,487,378 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.21NCBI
Cul2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554622,580,117 - 2,661,561 (+)Ensembl
ChiLan1.0NW_0049554622,580,117 - 2,659,849 (+)NCBIChiLan1.0ChiLan1.0
CUL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2847,649,997 - 47,730,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11047,655,268 - 47,736,246 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01035,127,771 - 35,210,108 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11035,705,442 - 35,787,248 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1035,704,964 - 35,787,014 (-)EnsemblpanPan2panpan1.1
CUL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121,830,046 - 1,994,418 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl21,897,309 - 2,175,909 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha21,920,061 - 2,084,989 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.022,111,788 - 2,276,949 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22,178,615 - 2,278,532 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121,883,731 - 2,049,588 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021,926,447 - 2,092,740 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022,050,312 - 2,216,547 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cul2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934413,810,807 - 13,908,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365743,309,941 - 3,408,370 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365743,310,304 - 3,408,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1057,700,683 - 57,799,264 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11057,700,667 - 57,829,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21063,254,465 - 63,302,289 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1934,294,885 - 34,381,140 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl934,294,362 - 34,364,122 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605643,445,984 - 43,532,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248056,992,546 - 7,094,855 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cul2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11429,881,456 - 29,907,632 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cul2
193 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:744
Count of miRNA genes:296
Interacting mature miRNAs:382
Transcripts:ENSRNOT00000066805
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
AI598891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21754,169,152 - 54,169,257 (+)MAPPERmRatBN7.2
Rnor_6.01756,952,547 - 56,952,651NCBIRnor6.0
Rnor_5.01754,986,519 - 54,986,623UniSTSRnor5.0
RGSC_v3.41762,701,356 - 62,701,460UniSTSRGSC3.4
Celera1750,150,474 - 50,150,578UniSTS
RH 3.4 Map17554.7UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066805   ⟹   ENSRNOP00000061765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1758,864,274 - 58,905,132 (-)Ensembl
mRatBN7.2 Ensembl1754,169,086 - 54,209,968 (-)Ensembl
Rnor_6.0 Ensembl1756,952,480 - 56,992,489 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079607   ⟹   ENSRNOP00000074075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1758,865,656 - 58,905,132 (-)Ensembl
mRatBN7.2 Ensembl1754,170,475 - 54,209,968 (-)Ensembl
Rnor_6.0 Ensembl1756,952,485 - 56,992,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106539   ⟹   ENSRNOP00000089738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1754,170,284 - 54,209,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108140   ⟹   ENSRNOP00000081844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1758,864,274 - 58,905,132 (-)Ensembl
mRatBN7.2 Ensembl1754,170,040 - 54,209,931 (-)Ensembl
RefSeq Acc Id: NM_001399213   ⟹   NP_001386142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,864,274 - 58,905,132 (-)NCBI
mRatBN7.21754,169,093 - 54,209,952 (-)NCBI
RefSeq Acc Id: XM_006254073   ⟹   XP_006254135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,865,217 - 58,905,447 (-)NCBI
mRatBN7.21754,169,093 - 54,210,197 (-)NCBI
Rnor_6.01756,952,487 - 56,992,716 (-)NCBI
Rnor_5.01754,986,452 - 55,026,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600628   ⟹   XP_017456117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,865,217 - 58,905,150 (-)NCBI
mRatBN7.21754,169,093 - 54,209,974 (-)NCBI
Rnor_6.01756,952,487 - 56,992,491 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006254135   ⟸   XM_006254073
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G8I6 (UniProtKB/TrEMBL),   A6K9G9 (UniProtKB/TrEMBL),   D4A0H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456117   ⟸   XM_017600628
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G8I6 (UniProtKB/TrEMBL),   A6K9G9 (UniProtKB/TrEMBL),   D4A0H4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074075   ⟸   ENSRNOT00000079607
Ensembl Acc Id: ENSRNOP00000061765   ⟸   ENSRNOT00000066805
Ensembl Acc Id: ENSRNOP00000089738   ⟸   ENSRNOT00000106539
Ensembl Acc Id: ENSRNOP00000081844   ⟸   ENSRNOT00000108140
RefSeq Acc Id: NP_001386142   ⟸   NM_001399213
- UniProtKB: A0A8I6G8I6 (UniProtKB/TrEMBL),   A6K9G9 (UniProtKB/TrEMBL),   D4A0H4 (UniProtKB/TrEMBL)
Protein Domains
Cullin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K761-F1-model_v2 AlphaFold A0A0G2K761 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700529
Promoter ID:EPDNEW_R11052
Type:multiple initiation site
Name:Cul2_1
Description:cullin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01756,992,455 - 56,992,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310644 AgrOrtholog
BioCyc Gene G2FUF-8992 BioCyc
Ensembl Genes ENSRNOG00000015292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066805 ENTREZGENE
  ENSRNOT00000066805.4 UniProtKB/TrEMBL
  ENSRNOT00000079607 ENTREZGENE
  ENSRNOT00000079607.3 UniProtKB/TrEMBL
  ENSRNOT00000108140.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.280.240 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
  Cullin, Chain C, Domain 2 UniProtKB/TrEMBL
InterPro Cullin UniProtKB/TrEMBL
  Cullin_CS UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/TrEMBL
  Cullin_repeat-like_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 361258 ENTREZGENE
PANTHER PTHR11932 UniProtKB/TrEMBL
Pfam Cullin UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
PhenoGen Cul2 PhenoGen
PROSITE CULLIN_1 UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015292 RatGTEx
SMART CULLIN UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
Superfamily-SCOP Cullin_homology UniProtKB/TrEMBL
  Cullin_repeat-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2K761_RAT UniProtKB/TrEMBL
  A0A8I6G8I6 ENTREZGENE, UniProtKB/TrEMBL
  A6K9G9 ENTREZGENE, UniProtKB/TrEMBL
  D4A0H4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cul2  cullin 2   Cul2_predicted  cullin 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cul2_predicted  cullin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED