Dcdc2 (doublecortin domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dcdc2 (doublecortin domain containing 2) Rattus norvegicus
Analyze
Symbol: Dcdc2
Name: doublecortin domain containing 2
RGD ID: 1310227
Description: Enables kinesin binding activity. Involved in neuron migration. Located in kinocilium. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to human DCDC2 (doublecortin domain containing 2); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: doublecortin domain-containing protein 2; LOC291130
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,274,009 - 40,459,757 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,274,009 - 40,458,790 (-)EnsemblGRCr8
mRatBN7.21739,845,952 - 40,031,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1739,927,688 - 40,098,839 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,531,733 - 41,702,890 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01739,813,149 - 39,984,339 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01741,838,201 - 42,031,265 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)Ensemblrn6Rnor6.0
Rnor_5.01743,711,172 - 43,899,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41746,899,656 - 47,090,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,500,732 - 39,668,377 (-)NCBICelera
RGSC_v3.11746,907,816 - 47,107,277 (-)NCBI
Cytogenetic Map17p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (IBA,IEA,ISO,ISS)
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA)
kinocilium  (IBA,IDA,IEA)
microtubule  (IBA)
microtubule organizing center  (IBA)
mitotic spindle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat. Burbridge TJ, etal., Neuroscience. 2008 Mar 27;152(3):723-33. doi: 10.1016/j.neuroscience.2008.01.020. Epub 2008 Jan 19.
2. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. Cope N, etal., Neuroimage. 2012 Oct 15;63(1):148-56. doi: 10.1016/j.neuroimage.2012.06.037. Epub 2012 Jun 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis. Girard M, etal., Hum Mutat. 2016 Oct;37(10):1025-9. doi: 10.1002/humu.23031. Epub 2016 Aug 24.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation. Grati M, etal., Hum Mol Genet. 2015 May 1;24(9):2482-91. doi: 10.1093/hmg/ddv009. Epub 2015 Jan 18.
7. Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. Lind PA, etal., Eur J Hum Genet. 2010 Jun;18(6):668-73. doi: 10.1038/ejhg.2009.237. Epub 2010 Jan 13.
8. Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples. Mascheretti S, etal., J Child Psychol Psychiatry. 2017 Jan;58(1):75-82. doi: 10.1111/jcpp.12612. Epub 2016 Aug 8.
9. Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. Massinen S, etal., PLoS One. 2011;6(6):e20580. doi: 10.1371/journal.pone.0020580. Epub 2011 Jun 16.
10. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Meng H, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8. Epub 2005 Nov 8.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Truong DT, etal., Genes Brain Behav. 2014 Nov;13(8):802-11. doi: 10.1111/gbb.12170. Epub 2014 Sep 3.
16. The role of gene DCDC2 in German dyslexics. Wilcke A, etal., Ann Dyslexia. 2009 Jun;59(1):1-11. doi: 10.1007/s11881-008-0020-7. Epub 2009 Feb 24.
17. Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population. Zhang Y, etal., PLoS One. 2016 Apr 21;11(4):e0153603. doi: 10.1371/journal.pone.0153603. eCollection 2016.
Additional References at PubMed
PMID:16869982   PMID:16989952   PMID:20236041   PMID:21689730   PMID:21883923   PMID:24094509   PMID:25557784   PMID:26250775  


Genomics

Comparative Map Data
Dcdc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,274,009 - 40,459,757 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,274,009 - 40,458,790 (-)EnsemblGRCr8
mRatBN7.21739,845,952 - 40,031,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1739,927,688 - 40,098,839 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,531,733 - 41,702,890 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01739,813,149 - 39,984,339 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01741,838,201 - 42,031,265 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)Ensemblrn6Rnor6.0
Rnor_5.01743,711,172 - 43,899,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41746,899,656 - 47,090,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,500,732 - 39,668,377 (-)NCBICelera
RGSC_v3.11746,907,816 - 47,107,277 (-)NCBI
Cytogenetic Map17p11NCBI
DCDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,171,755 - 24,383,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,171,755 - 24,360,249 (-)Ensemblhg38GRCh38
GRCh37624,171,983 - 24,383,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,279,962 - 24,466,259 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34624,282,502 - 24,466,259NCBI
Celera625,405,284 - 25,591,655 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,122,011 - 24,332,773 (-)NCBIHuRef
CHM1_1624,174,677 - 24,387,757 (-)NCBICHM1_1
T2T-CHM13v2.0624,043,591 - 24,253,315 (-)NCBIT2T-CHM13v2.0
Dcdc2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,239,126 - 25,394,689 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,239,987 - 25,394,689 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381325,055,273 - 25,210,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1325,056,004 - 25,210,706 (+)Ensemblmm10GRCm38
MGSCv371325,147,873 - 25,302,575 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361325,063,469 - 25,128,988 (+)NCBIMGSCv36mm8
Celera1325,282,677 - 25,437,377 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.89NCBI
Dcdc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,607,925 - 2,778,799 (+)Ensembl
ChiLan1.0NW_0049554832,608,063 - 2,783,872 (+)NCBIChiLan1.0ChiLan1.0
DCDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2538,810,522 - 38,999,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1634,812,140 - 34,999,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,001,971 - 24,186,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,337,188 - 24,520,082 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,337,188 - 24,520,082 (-)EnsemblpanPan2panpan1.1
DCDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,264,484 - 22,422,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,266,282 - 22,422,776 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3522,230,688 - 22,391,502 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03522,383,951 - 22,544,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,386,481 - 22,544,780 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,189,453 - 22,350,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,237,980 - 22,398,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03523,667,022 - 23,834,441 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dcdc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,885,162 - 3,021,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671605,084 - 736,674 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936671605,114 - 736,217 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,048,088 - 19,219,075 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1719,044,229 - 19,219,055 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,197,245 - 20,368,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,880,282 - 48,065,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,881,346 - 48,066,436 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604424,107,394 - 24,298,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcdc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,644,248 - 2,809,787 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247562,644,287 - 2,813,908 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dcdc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11444,083,809 - 44,242,558 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dcdc2
1384 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:827
Count of miRNA genes:319
Interacting mature miRNAs:447
Transcripts:ENSRNOT00000068021
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat

Markers in Region
RH138880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21739,846,023 - 39,846,251 (+)MAPPERmRatBN7.2
Rnor_6.01741,838,273 - 41,838,500NCBIRnor6.0
Rnor_5.01743,711,244 - 43,711,471UniSTSRnor5.0
RGSC_v3.41746,899,728 - 46,899,955UniSTSRGSC3.4
Celera1739,500,804 - 39,501,031UniSTS
Cytogenetic Map17p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 50 143 91 90 59 24 59 6 262 99 4 127 81 92 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000068021   ⟹   ENSRNOP00000060289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,274,009 - 40,458,790 (-)Ensembl
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)Ensembl
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097082   ⟹   ENSRNOP00000077657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,274,009 - 40,458,790 (-)Ensembl
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)Ensembl
RefSeq Acc Id: NM_001106110   ⟹   NP_001099580
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,458,790 (-)NCBI
mRatBN7.21739,845,952 - 40,030,743 (-)NCBI
Rnor_6.01741,838,201 - 42,031,265 (-)NCBI
Rnor_5.01743,711,172 - 43,899,961 (-)NCBI
RGSC_v3.41746,899,656 - 47,090,283 (-)RGD
Celera1739,500,732 - 39,668,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095509   ⟹   XP_038951437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,459,756 (-)NCBI
mRatBN7.21739,845,952 - 40,031,781 (-)NCBI
RefSeq Acc Id: XM_039095510   ⟹   XP_038951438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,459,757 (-)NCBI
mRatBN7.21739,845,952 - 40,031,781 (-)NCBI
RefSeq Acc Id: XM_039095511   ⟹   XP_038951439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,449,110 (-)NCBI
mRatBN7.21739,845,952 - 40,021,067 (-)NCBI
RefSeq Acc Id: NP_001099580   ⟸   NM_001106110
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060289   ⟸   ENSRNOT00000068021
RefSeq Acc Id: XP_038951437   ⟸   XM_039095509
- Peptide Label: isoform X1
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951438   ⟸   XM_039095510
- Peptide Label: isoform X1
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951439   ⟸   XM_039095511
- Peptide Label: isoform X2
- UniProtKB: A6KLE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077657   ⟸   ENSRNOT00000097082
Protein Domains
Doublecortin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZR10-F1-model_v2 AlphaFold D3ZR10 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310227 AgrOrtholog
BioCyc Gene G2FUF-9430 BioCyc
Ensembl Genes ENSRNOG00000017511 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068021 ENTREZGENE
  ENSRNOT00000068021.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.230 UniProtKB/Swiss-Prot
InterPro DCDC2 UniProtKB/Swiss-Prot
  Doublecortin_dom UniProtKB/Swiss-Prot
  Doublecortin_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:291130 UniProtKB/Swiss-Prot
NCBI Gene 291130 ENTREZGENE
PANTHER DOUBLECORTIN DOMAIN CONTAINING 2 UniProtKB/Swiss-Prot
  PTHR23004:SF5 UniProtKB/Swiss-Prot
Pfam DCX UniProtKB/Swiss-Prot
PhenoGen Dcdc2 PhenoGen
PROSITE PS50309 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017511 RatGTEx
SMART DCX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF89837 UniProtKB/Swiss-Prot
UniProt A0A8I5YBZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6KLE2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR10 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Dcdc2  doublecortin domain containing 2  Dcdc2_predicted  doublecortin domain containing 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Dcdc2_predicted  doublecortin domain containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED