Dcdc2 (doublecortin domain containing 2)

Gene: Dcdc2 (doublecortin domain containing 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Dcdc2

Name:

doublecortin domain containing 2

RGD ID:

12518255

Description:

ENCODES a protein that exhibits kinesin binding (ortholog); INVOLVED IN dendrite morphogenesis (ortholog); neuron migration (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal recessive nonsyndromic deafness 66 (ortholog); chylomicron retention disease (ortholog); FOUND IN synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

doublecortin domain-containing protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	2,885,162 - 3,021,294 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936671	605,084 - 736,674 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936671	605,114 - 736,217 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

attention deficit hyperactivity disorder (ISO)

autosomal recessive nonsyndromic deafness 66 (ISO)

chylomicron retention disease (ISO)

dyslexia (ISO)

genetic disease (ISO)

nephronophthisis 19 (ISO)

nonsyndromic deafness (ISO)

sclerosing cholangitis (ISO)

succinic semialdehyde dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (IEA)

dendrite morphogenesis (IEA,ISO)

intracellular signal transduction (IEA)

neuron migration (IEA,ISO)

neuronal action potential (ISO)

positive regulation of smoothened signaling pathway (IEA)

regulation of cilium assembly (IEA)

regulation of Wnt signaling pathway (IEA)

sensory perception of sound (IEA,ISO)

synaptic transmission, glutamatergic (ISO)

visual learning (ISO)

Cellular Component

axoneme (IEA)

centriolar satellite (IEA)

cilium (IEA)

cytoplasm (IEA)

cytosol (IEA)

kinocilium (IEA)

microtubule (IEA)

microtubule cytoskeleton (IEA)

microtubule organizing center (IEA)

mitotic spindle (IEA)

synapse (ISO)

Molecular Function

kinesin binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dcdc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	2,885,162 - 3,021,294 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936671	605,084 - 736,674 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936671	605,114 - 736,217 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCDC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	24,171,755 - 24,383,292 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	24,171,755 - 24,358,059 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	24,171,983 - 24,383,520 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	24,279,962 - 24,466,259 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	24,282,502 - 24,466,259	NCBI
Celera	6	25,405,284 - 25,591,655 (-)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	24,122,011 - 24,332,773 (-)	NCBI		HuRef
CHM1_1	6	24,174,677 - 24,387,757 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	24,043,591 - 24,253,315 (-)	NCBI		T2T-CHM13v2.0

Dcdc2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	25,239,126 - 25,394,689 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	25,239,987 - 25,394,689 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	25,055,273 - 25,210,706 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	25,056,004 - 25,210,706 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	25,147,873 - 25,302,575 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	25,063,469 - 25,128,988 (+)	NCBI		MGSCv36	mm8
Celera	13	25,282,677 - 25,437,377 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	10.89	NCBI

Dcdc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	40,274,009 - 40,459,757 (-)	NCBI		GRCr8
mRatBN7.2	17	39,845,952 - 40,031,781 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	39,845,952 - 40,030,743 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	39,927,688 - 40,098,839 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	41,531,733 - 41,702,890 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	39,813,149 - 39,984,339 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	41,838,201 - 42,031,265 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	41,838,201 - 42,031,265 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	43,711,172 - 43,899,961 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	46,899,656 - 47,090,283 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	46,907,816 - 47,107,277 (-)	NCBI
Celera	17	39,500,732 - 39,668,377 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

Dcdc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955483	2,607,925 - 2,778,799 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955483	2,608,063 - 2,783,872 (+)	NCBI	ChiLan1.0	ChiLan1.0

DCDC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	38,810,522 - 38,999,931 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	34,812,140 - 34,999,414 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	24,001,971 - 24,186,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	24,337,188 - 24,520,082 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	24,337,188 - 24,520,082 (-)	Ensembl	panpan1.1		panPan2

DCDC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	22,264,484 - 22,422,769 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	22,266,282 - 22,422,776 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	22,230,688 - 22,391,502 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	22,383,951 - 22,544,907 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	22,386,481 - 22,544,780 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	22,189,453 - 22,350,407 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	22,237,980 - 22,398,987 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	23,667,022 - 23,834,441 (-)	NCBI		UU_Cfam_GSD_1.0

DCDC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	19,048,088 - 19,219,075 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	19,044,229 - 19,219,055 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	20,197,245 - 20,368,857 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCDC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	47,880,282 - 48,065,686 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	47,881,346 - 48,066,436 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	24,107,394 - 24,298,206 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dcdc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	2,644,248 - 2,809,787 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	2,644,287 - 2,813,908 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005732532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000021106 ⟹ ENSSTOP00000016365

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936671	605,084 - 736,674 (-)	Ensembl

RefSeq Acc Id:

XM_005337022 ⟹ XP_005337079

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	2,885,162 - 3,016,089 (+)	NCBI
SpeTri2.0	NW_004936671	605,114 - 736,217 (-)	NCBI

Sequence:

show sequence

GGGGGCAGAAAACGAGCCTCCGCCTGGAGCCAGCTGGGGAGGCGTCCCGCGGGAAAATGAGCGG
CAGCAGCGCCAGGTCCAGCCACCTGTCCCAGCCGGTGGTGAAGAGCGTGTTGGTGTATCGCAAC
GGGGACCCGTTCTTCGCGGGGCGCCGCGTGGTCATCCATGAGAAGAAGGTGTCCAGCTTCGACG
TCTTCCTGAAGGAGGTGACCGGCGGCGTTCAGGCGCCCTTCGGGGCGGTCAGGAACATCTACAC
CCCGCGGACCGGCCACCGCATCCGGAAGCTGGACCAGATCGAGAGCGGGGGCAACTACGTGGCG
GGGGGCCAGGAGGCCTTCAAGAAACTCAATTACTTGGACATAGGAGAAATCAAGAAAAGACCAA
TGGAAGTTGTTAATACAGAGGTCAAACCAGTGACCCACAGCAAGATCAACGTGTCCGCCCGCTT
TAGGAAACCCCTGCAGGAGCCCTGCACCATTTTCTTGATTGCCAACGGGGACCTCATAAGCCCA
GCCTCTCGCCTCCTCATCCCCAGGAAAGCCCTGAGTCAGTGGGACCACGTGCTGCAAATGGCCA
CAGAAAAAATACCTCTCCGGAGCGGGGCTGTCCACAGACTCTATACCCTAGAAGGGAAGCTGGT
GGAGAGCGGGGCAGAGCTGGAGAACGGGCAGTTCTACGTGGCTGTGGGCAGAGATAGGTTTAAG
AGGCTGCCGTACAGTGAGTTGCTCTTTGACAAGTCGGCGATGCGAAGGCCTTATGGTCAGAAAG
CCTCTTCACTACCTCCTATCGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCAGTC
TAAGTCGACAGTTGGGTCCAGTGACAACTCGTCTCCTCAGCCTCTGAAGAGGAAAGGGAAAAAA
GAAGTCGCAAATTCAGAGAAATCAAGGAAGTCGAAACAAAATGTCAAGTTGAAGAATACACAAG
AAACGCTGCCCGACAGTGATGAAGGCATTTTCAAAGCTGGAGAAGAGAGGTCTGAAATGCGGGG
GGCAGCAGAAGTCCAAGAAGATGAAGACACTCGGGTCGAGATCCCAGTGGATCAGAGGCCAGCA
GAGATGGTCGATGAGGAAGAAGATGAGGAGAAAACCAACAAAGATGCAGAACAGAAAGAAGACT
TTTCAGAAATGAATGGCCAAGTGGAAGATGAGGCCGGTGGGGGCGCTGCCGATGTCCCTGAGCA
AGTGGAGGAGATCCCCGATCCCAGGGAGGAGAACCCCGGTCCTGCTCGGGTCAACGGAGGCACG
GACGAAGAAAATGGCGAGGAGCTGGACCAGGTTAATGAGGAGCTGCAGGCGGCAGCGGAGGAGG
AAAGACAGTCTCCAGCCGGGGCGGGCAGTGGACAAGACGAGGCTGATGTGGACCCTCAGAGGCC
ACCGAGGCCAGAAGTGAAGGTCACGAGTCCTCAGGAAAACGGGAGCAACGAGCAGAGCAAGGAC
TACGCTGTGGTGGCATAGATGGGGACTAAGAGCGAGGACTAAGAGCGAGGACTCGGAGTTCGAG
AACGGAGCCGTGACCCTGAGCAGTGGGCGCATCGTTCTTGCTAAACCTGGTGAGGCAAGACGGT
GGGACCCTCCCTGTGGAATTTCACGATCAGAGGCCTCTGTGGAAGGCCAGATGACTCTCAGTAG
CTACTAAAAGAGAACGACGCGTGCTTTACGGCATGTGTTTTTATGTCACTTAGAAGATTTGAAT
AAGAGGGACAGAGAAGAATCTGCGGTGGACAGTCGGCCACTTATGTTTGTAAGGATAGAAGGAT
GGAATCACTCCCATTGCATTCGTTATTGTAAATTTAGGAATGACAGTAGTAGACGGCAGCTTGT
TCTAGAGCATTTATCTAAGAAAGCATAGAATTTTAAAGAATCGGTAATAGGAAAACATGTTATT
TTCTTAAAGCAATAAACTTTTGAATGAAAACGGTTGCGATTTAGTTTCAGAGGTAACTTGGAGA
TGGCAGGAGGTCAGCATGTTTCTTTGGCTGGTGGACCTTCCTGTCTTTCCTCCTCTTAAGCCAG
ACTCCACTCGAGGGCATCCAGGTGGAGTGCATCTGCTCTGGTAGGGGGAGCATTCATTGGAGGT
GTCTCAGGTGGACACTCTACTTGTTGCCCTGGGCACCAGGAAGGGCAGCCCTCAGGAAGGAGCG
GGGAAGGAAGGACAACTCGTGCTGCCCAGCAAATTCTGGAAATCCTATGGACTTCCGTGGGTCC
AGCCTCCCTTTACCAAGGATCCTTTCCTTCCCCCTCATGTGACTGTGTTGGAAAACCCAA

hide sequence

RefSeq Acc Id:

XR_005732532

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	2,885,162 - 3,021,294 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005337079	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000016365.2
GenBank Protein	KAG3288618	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337079 ⟸ XM_005337022

- UniProtKB:

I3MW70 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGSSARSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRN
IYTPRTGHRIRKLDQIESGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVTHSKINVS
ARFRKPLQEPCTIFLIANGDLISPASRLLIPRKALSQWDHVLQMATEKIPLRSGAVHRLYTLEG
KLVESGAELENGQFYVAVGRDRFKRLPYSELLFDKSAMRRPYGQKASSLPPIVGSRKSKGSGND
RQSKSTVGSSDNSSPQPLKRKGKKEVANSEKSRKSKQNVKLKNTQETLPDSDEGIFKAGEERSE
MRGAAEVQEDEDTRVEIPVDQRPAEMVDEEEDEEKTNKDAEQKEDFSEMNGQVEDEAGGGAADV
PEQVEEIPDPREENPGPARVNGGTDEENGEELDQVNEELQAAAEEERQSPAGAGSGQDEADVDP
QRPPRPEVKVTSPQENGSNEQSKDYAVVA

hide sequence

RefSeq Acc Id:

ENSSTOP00000016365 ⟸ ENSSTOT00000021106

Protein Domains

Doublecortin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022911	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021106.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.20.230	UniProtKB/TrEMBL
InterPro	DCDC2	UniProtKB/TrEMBL
	DCX/DCDC2-like	UniProtKB/TrEMBL
	Doublecortin_dom	UniProtKB/TrEMBL
	Doublecortin_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Dcdc2	ENTREZGENE
PANTHER	DOUBLECORTIN DOMAIN CONTAINING 2	UniProtKB/TrEMBL
	PTHR23004:SF5	UniProtKB/TrEMBL
Pfam	DCX	UniProtKB/TrEMBL
PROSITE	PS50309	UniProtKB/TrEMBL
SMART	DCX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF89837	UniProtKB/TrEMBL
UniProt	I3MW70	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM