Irak2 (interleukin-1 receptor-associated kinase 2) - Rat Genome Database

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Gene: Irak2 (interleukin-1 receptor-associated kinase 2) Rattus norvegicus
Analyze
Symbol: Irak2
Name: interleukin-1 receptor-associated kinase 2
RGD ID: 1309584
Description: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and signaling adaptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of canonical NF-kappaB signal transduction; and regulation of cytokine-mediated signaling pathway. Predicted to act upstream of or within canonical NF-kappaB signal transduction; non-canonical NF-kappaB signal transduction; and toll-like receptor 4 signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin-1 receptor-associated kinase-like 2; IRAK-2; LOC362418
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,341,704 - 148,398,211 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4148,341,719 - 148,398,210 (+)EnsemblGRCr8
mRatBN7.24146,786,004 - 146,842,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,786,100 - 146,842,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4152,170,673 - 152,227,276 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,951,537 - 148,008,146 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,579,755 - 146,636,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,594,575 - 145,651,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,594,575 - 145,651,053 (+)Ensemblrn6Rnor6.0
Rnor_5.04208,890,974 - 208,947,453 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44149,543,029 - 149,599,463 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4135,340,439 - 135,396,939 (+)NCBICelera
RGSC_v3.14149,787,869 - 149,844,303 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium selenide  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferulic acid  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glyphosate  (EXP)
graphite  (EXP)
imiquimod  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium atom  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (TAS)
nucleus  (IBA)
plasma membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
Additional References at PubMed
PMID:10383454   PMID:12034707   PMID:12220507   PMID:12477932   PMID:15082713   PMID:15489334   PMID:18996842   PMID:19103603   PMID:26394923  


Genomics

Comparative Map Data
Irak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,341,704 - 148,398,211 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4148,341,719 - 148,398,210 (+)EnsemblGRCr8
mRatBN7.24146,786,004 - 146,842,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,786,100 - 146,842,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4152,170,673 - 152,227,276 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,951,537 - 148,008,146 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,579,755 - 146,636,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,594,575 - 145,651,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,594,575 - 145,651,053 (+)Ensemblrn6Rnor6.0
Rnor_5.04208,890,974 - 208,947,453 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44149,543,029 - 149,599,463 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4135,340,439 - 135,396,939 (+)NCBICelera
RGSC_v3.14149,787,869 - 149,844,303 (+)NCBI
Cytogenetic Map4q42NCBI
IRAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,164,919 - 10,243,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl310,164,863 - 10,243,756 (+)Ensemblhg38GRCh38
GRCh37310,206,603 - 10,285,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,181,563 - 10,260,427 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34310,181,562 - 10,260,427NCBI
Celera310,142,206 - 10,221,236 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef310,142,464 - 10,221,162 (+)NCBIHuRef
CHM1_1310,156,570 - 10,235,592 (+)NCBICHM1_1
T2T-CHM13v2.0310,157,816 - 10,237,049 (+)NCBIT2T-CHM13v2.0
Irak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,615,428 - 113,671,987 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,615,428 - 113,671,987 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386113,638,467 - 113,695,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,638,467 - 113,695,026 (+)Ensemblmm10GRCm38
MGSCv376113,588,461 - 113,645,020 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366113,604,280 - 113,660,528 (+)NCBIMGSCv36mm8
Celera6115,465,268 - 115,520,422 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.82NCBI
Irak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,585,827 - 1,653,197 (+)Ensembl
ChiLan1.0NW_0049555611,585,842 - 1,650,268 (+)NCBIChiLan1.0ChiLan1.0
IRAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2210,158,692 - 10,239,126 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1310,163,519 - 10,243,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0310,100,279 - 10,179,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1310,453,329 - 10,532,629 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,453,329 - 10,532,629 (+)EnsemblpanPan2panpan1.1
VHL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,206,616 - 8,211,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,206,616 - 8,211,323 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha208,240,602 - 8,245,270 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0208,235,897 - 8,240,567 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,234,824 - 8,240,587 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,958,176 - 7,962,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,303,525 - 8,308,231 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,277,313 - 8,281,981 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,776,320 - 15,835,825 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,073,889 - 3,129,408 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,073,910 - 3,129,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,350,606 - 66,416,827 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11366,350,606 - 66,416,834 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,509,351 - 73,515,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,204,600 - 46,279,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,204,893 - 46,278,260 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041120,261,210 - 120,339,634 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,294,431 - 5,348,481 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247315,294,464 - 5,348,426 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Irak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1632,841,469 - 32,898,597 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irak2
240 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:125
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000029819
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
D4Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,803,311 - 146,803,430 (+)MAPPERmRatBN7.2
Rnor_6.04145,611,768 - 145,611,886NCBIRnor6.0
Rnor_5.04208,908,167 - 208,908,285UniSTSRnor5.0
RGSC_v3.44149,560,221 - 149,560,340RGDRGSC3.4
RGSC_v3.44149,560,222 - 149,560,340UniSTSRGSC3.4
Celera4135,357,633 - 135,357,751UniSTS
RGSC_v3.14149,805,063 - 149,805,181RGD
RH 3.4 Map4942.7UniSTS
RH 3.4 Map4942.7RGD
SHRSP x BN Map471.41UniSTS
SHRSP x BN Map471.41RGD
FHH x ACI Map487.92RGD
Cytogenetic Map4q42UniSTS
RH134608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,842,135 - 146,842,322 (+)MAPPERmRatBN7.2
Rnor_6.04145,650,587 - 145,650,773NCBIRnor6.0
Rnor_5.04208,946,986 - 208,947,172UniSTSRnor5.0
RGSC_v3.44149,598,996 - 149,599,182UniSTSRGSC3.4
Celera4135,396,472 - 135,396,658UniSTS
RH 3.4 Map4948.4UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029819   ⟹   ENSRNOP00000034508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4148,341,719 - 148,398,210 (+)Ensembl
mRatBN7.2 Ensembl4146,786,100 - 146,842,598 (+)Ensembl
Rnor_6.0 Ensembl4145,594,575 - 145,651,053 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096002   ⟹   ENSRNOP00000082209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4148,341,767 - 148,398,210 (+)Ensembl
mRatBN7.2 Ensembl4146,786,153 - 146,842,602 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112620   ⟹   ENSRNOP00000097081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4148,341,719 - 148,398,210 (+)Ensembl
mRatBN7.2 Ensembl4146,786,100 - 146,842,598 (+)Ensembl
RefSeq Acc Id: NM_001025422   ⟹   NP_001020593
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,341,732 - 148,398,211 (+)NCBI
mRatBN7.24146,786,118 - 146,842,603 (+)NCBI
Rnor_6.04145,594,575 - 145,651,054 (+)NCBI
Rnor_5.04208,890,974 - 208,947,453 (+)NCBI
RGSC_v3.44149,543,029 - 149,599,463 (+)RGD
Celera4135,340,439 - 135,396,939 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107858   ⟹   XP_038963786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,341,704 - 148,398,208 (+)NCBI
mRatBN7.24146,786,004 - 146,842,615 (+)NCBI
RefSeq Acc Id: XM_063286304   ⟹   XP_063142374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,341,716 - 148,398,208 (+)NCBI
RefSeq Acc Id: NP_001020593   ⟸   NM_001025422
- UniProtKB: Q4QQS0 (UniProtKB/Swiss-Prot),   A6IBT6 (UniProtKB/TrEMBL),   A0A8I5ZWK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034508   ⟸   ENSRNOT00000029819
RefSeq Acc Id: XP_038963786   ⟸   XM_039107858
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ATU6 (UniProtKB/TrEMBL),   A0A8I5ZWK6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082209   ⟸   ENSRNOT00000096002
Ensembl Acc Id: ENSRNOP00000097081   ⟸   ENSRNOT00000112620
RefSeq Acc Id: XP_063142374   ⟸   XM_063286304
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWK6 (UniProtKB/TrEMBL)
Protein Domains
Death   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QQS0-F1-model_v2 AlphaFold Q4QQS0 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693312
Promoter ID:EPDNEW_R3835
Type:single initiation site
Name:Irak2_1
Description:interleukin-1 receptor-associated kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,594,590 - 145,594,650EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309584 AgrOrtholog
BioCyc Gene G2FUF-43369 BioCyc
Ensembl Genes ENSRNOG00000021817 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029819 ENTREZGENE
  ENSRNOT00000029819.5 UniProtKB/Swiss-Prot
  ENSRNOT00000096002 ENTREZGENE
  ENSRNOT00000112620 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458113 IMAGE-MGC_LOAD
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  Death_IRAK2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
KEGG Report rno:362418 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116221 IMAGE-MGC_LOAD
NCBI Gene 362418 ENTREZGENE
PANTHER INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE UniProtKB/Swiss-Prot
  PTHR24419:SF2 UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Irak2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021817 RatGTEx
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZWK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATU6 ENTREZGENE, UniProtKB/TrEMBL
  A6IBT6 ENTREZGENE, UniProtKB/TrEMBL
  A6IBT7_RAT UniProtKB/TrEMBL
  IRAK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Irak2  interleukin-1 receptor-associated kinase 2  Irak2_predicted  interleukin-1 receptor-associated kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Irak2_predicted  interleukin-1 receptor-associated kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED