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Gene: F11 (coagulation factor XI) Rattus norvegicus

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Symbol:

F11

Name:

coagulation factor XI

RGD ID:

1309364

Description:

Enables serine-type aminopeptidase activity. Predicted to be involved in blood coagulation; plasminogen activation; and positive regulation of fibrinolysis. Predicted to act upstream of or within regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC290757; LRRGT00086

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	F11 (coagulation factor XI)	HGNC	Ensembl, HomoloGene, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101967202 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	F11 (coagulation factor XI)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	F11 (coagulation factor XI)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	F11 (coagulation factor XI)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klkb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	53,720,502 - 53,741,547 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	53,718,621 - 53,740,941 (+)	Ensembl				GRCr8
mRatBN7.2	16	46,987,988 - 47,009,015 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,986,107 - 47,008,437 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	52,378,899 - 52,400,805 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	55,756,360 - 55,778,414 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	51,018,291 - 51,040,195 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	50,179,458 - 50,201,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	50,179,458 - 50,201,698 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	49,902,415 - 49,924,601 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	50,276,330 - 50,298,903 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	44,976,615 - 44,998,530 (+)	NCBI		Celera
RGSC_v3.1	16	50,287,001 - 50,298,978 (+)	NCBI
Cytogenetic Map	16	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

factor X deficiency (ISO)

factor XI deficiency (ISO,ISS)

genetic disease (ISO)

hemorrhagic disease (ISO)

hypertension (ISO)

middle cerebral artery infarction (ISO)

Noonan syndrome (ISO)

Sepsis (IEP)

Spontaneous Abortions (ISO)

thrombocytopenia (ISO)

thrombosis (ISO)

Venous Thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

(S)-amphetamine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

amiodarone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcium dichloride (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (ISO)

endosulfan (EXP)

ethanol (ISO)

Ethyl icosapentate (EXP)

fenthion (ISO)

genistein (ISO)

hexadecanoic acid (ISO)

inulin (ISO)

kaolin (ISO)

methotrexate (ISO)

N-Nitrosopyrrolidine (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (ISO)

PCB138 (EXP)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

raloxifene (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

Triptolide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA,ISO)

blood coagulation, intrinsic pathway (ISO)

hemostasis (IEA)

plasminogen activation (IBA,IEA,ISO)

positive regulation of fibrinolysis (IBA,IEA,ISO)

proteolysis (IEA)

regulation of blood coagulation (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IDA,IEA,ISO)

serine-type endopeptidase complex (ISO)

Molecular Function

hydrolase activity (IEA)

identical protein binding (ISO)

peptidase activity (IEA)

protein binding (ISO)

serine-type aminopeptidase activity (IDA)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

coagulation cascade pathway (IDA,ISO)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

heparin pharmacodynamics pathway (ISO)

phenindione pharmacodynamics pathway (ISO)

reteplase pharmacodynamics pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations.	Asakai R, etal., Proc Natl Acad Sci U S A. 1989 Oct;86(20):7667-71.
2.	Noonan syndrome: partial factor XI deficiency.	de Haan M, etal., Am J Med Genet. 1988 Feb;29(2):277-82.
3.	A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis.	Espinola RG, etal., Am J Pathol. 2004 Sep;165(3):969-76.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis.	Kleinschnitz C, etal., J Exp Med. 2006 Mar 20;203(3):513-8. Epub 2006 Mar 13.
6.	Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis.	Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
7.	Genetic variants associated with deep vein thrombosis: the F11 locus.	Li Y, etal., J Thromb Haemost. 2009 Nov;7(11):1802-8. doi: 10.1111/j.1538-7836.2009.03544.x. Epub 2009 Jul 6.
8.	The F11 rs2289252 polymorphism is associated with FXI activity levels and APTT ratio in women with thrombosis.	Lunghi B, etal., Thromb Res. 2012 Sep;130(3):563-4. doi: 10.1016/j.thromres.2012.05.004. Epub 2012 May 25.
9.	High levels of coagulation factor XI as a risk factor for venous thrombosis.	Meijers JC, etal., N Engl J Med. 2000 Mar 9;342(10):696-701.
10.	Age-related changes in coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats.	Nobukata H, etal., Thromb Res. 2000 Jun 15;98(6):507-16.
11.	Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats.	Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
12.	Blood coagulation.	Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	A novel mutation that leads to a congenital factor XI deficiency in a Japanese family.	Sato E, etal., Am J Hematol. 2000 Apr;63(4):165-9.
19.	How it all starts: Initiation of the clotting cascade.	Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
20.	Activity of coagulation factor XI in patients with spontaneous miscarriage: the presence of risk alleles.	Sokol J, etal., J Obstet Gynaecol. 2015;35(6):621-4. doi: 10.3109/01443615.2014.991284. Epub 2014 Dec 17.
21.	Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families.	Ventura C, etal., Thromb Haemost. 2000 Nov;84(5):833-40.

Additional References at PubMed

PMID:89876	PMID:9169594	PMID:16699514	PMID:17884987	PMID:19056867	PMID:23376485

Genomics

Comparative Map Data

F11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	53,720,502 - 53,741,547 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	53,718,621 - 53,740,941 (+)	Ensembl				GRCr8
mRatBN7.2	16	46,987,988 - 47,009,015 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,986,107 - 47,008,437 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	52,378,899 - 52,400,805 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	55,756,360 - 55,778,414 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	51,018,291 - 51,040,195 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	50,179,458 - 50,201,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	50,179,458 - 50,201,698 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	49,902,415 - 49,924,601 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	50,276,330 - 50,298,903 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	44,976,615 - 44,998,530 (+)	NCBI		Celera
RGSC_v3.1	16	50,287,001 - 50,298,978 (+)	NCBI
Cytogenetic Map	16	q11	NCBI

F11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	186,266,189 - 186,290,710 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	186,260,159 - 186,291,273 (+)	Ensembl			hg38	GRCh38
GRCh37	4	187,187,343 - 187,210,835 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	187,424,112 - 187,447,829 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	187,562,426 - 187,585,083	NCBI
Celera	4	184,511,477 - 184,537,546 (+)	NCBI		Celera
Cytogenetic Map	4	q35.2	NCBI
HuRef	4	182,938,469 - 182,962,233 (+)	NCBI		HuRef
CHM1_1	4	187,163,556 - 187,187,273 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	189,606,162 - 189,630,690 (+)	NCBI		T2T-CHM13v2.0

F11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	45,693,696 - 45,715,092 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	45,694,211 - 45,715,068 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	45,240,659 - 45,262,055 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	45,241,174 - 45,262,031 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	46,326,524 - 46,347,385 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	46,739,987 - 46,760,848 (-)	NCBI		MGSCv36	mm8
Celera	8	47,928,261 - 47,949,034 (-)	NCBI		Celera
Cytogenetic Map	8	B1.1	NCBI
cM Map	8	25.14	NCBI

F11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	22,811,380 - 22,830,563 (-)	Ensembl
ChiLan1.0	NW_004955403	22,811,211 - 22,830,281 (-)	NCBI	ChiLan1.0	ChiLan1.0

F11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	184,008,843 - 184,033,166 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	184,357,677 - 184,381,996 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	178,436,865 - 178,459,568 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	190,643,733 - 190,666,512 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	190,643,733 - 190,666,512 (+)	Ensembl			panPan2	panpan1.1

F11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	44,469,609 - 44,492,833 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	44,469,632 - 44,540,292 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	44,956,542 - 44,972,975 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	46,683,089 - 46,700,923 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	46,683,106 - 46,700,880 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	44,652,096 - 44,668,510 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	45,264,846 - 45,281,307 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	45,395,778 - 45,412,243 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101967202
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	34,886,563 - 34,903,578 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936554	3,205,539 - 3,219,311 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936554	3,205,539 - 3,223,228 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

F11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	9,046,002 - 9,073,520 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	9,045,990 - 9,073,552 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

F11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	132,180,026 - 132,207,081 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	132,180,336 - 132,208,155 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	112,505,568 - 112,530,733 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	17,094,169 - 17,115,222 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624769	17,093,643 - 17,115,716 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in F11
177 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	103
Interacting mature miRNAs:	108
Transcripts:	ENSRNOT00000041946
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	36928782	81928782	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	28468701	73468701	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	32361043	77361043	Rat
631833	Sach2	Saccharin preference QTL 2	4	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake rate (CMO:0001613)	16	49757666	56898388	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	31058039	76058039	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	34398294	79398294	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	31885271	76885271	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	15905802	60905802	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	8	22	86	81	86	59	26	59	2	159	62	2	74	19	45	27	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001411666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY387072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000041946 ⟹ ENSRNOP00000044970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	53,718,621 - 53,740,941 (+)	Ensembl
mRatBN7.2 Ensembl	16	46,986,107 - 47,008,437 (+)	Ensembl
Rnor_6.0 Ensembl	16	50,179,458 - 50,201,373 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077662 ⟹ ENSRNOP00000073061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	53,720,469 - 53,740,941 (+)	Ensembl
mRatBN7.2 Ensembl	16	46,987,902 - 47,008,437 (+)	Ensembl
Rnor_6.0 Ensembl	16	50,181,316 - 50,201,698 (+)	Ensembl

RefSeq Acc Id:

NM_001411666 ⟹ NP_001398595

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	53,720,502 - 53,740,949 (+)	NCBI
mRatBN7.2	16	46,987,988 - 47,008,435 (+)	NCBI

RefSeq Acc Id:

XM_006253145 ⟹ XP_006253207

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	53,728,414 - 53,741,547 (+)	NCBI
mRatBN7.2	16	46,995,900 - 47,009,015 (+)	NCBI
Rnor_6.0	16	50,189,642 - 50,201,644 (+)	NCBI
Rnor_5.0	16	49,902,415 - 49,924,601 (+)	NCBI

Sequence:

show sequence

CACGTACTGCCAGCTGGTCTGCACACACCACCCACGTTGCTTGCTCTTCACGTTCATGGCTGAG
TCATCTTCTGACGATCCCACCAAATGAACAGGTTTGCCTGCATCCTGAAGGACAGTCTCACAGA
AACATTGCCGATGGTACACATGACAGGAGCGGTTTCTGGATATTCCTTCAAGCAATGCCCTCAG
CAATTAAGTGCTTGCAGCAAAAACGTGTACGTGAACCTGGACATGAAGGGCATGAACTATAACA
GTTCTGCCGTGAAGAATGCTCGAGAATGTCAGGAGAGATGCACCAACGATGCCCACTGCCAGTT
TTTCACATACGCAACGGGGCATTTTCCCAGTGTGGACCATCGTAAAATGTGTCTTTTGAAGTAC
ACCCAAATGGGGACGCCAACTTCAATAACAAAGCTCGACAGTGTGGTATCTGGATTTTCACTGA
AGTCCTGTGGGCTTTCGAACCTGGCTTGTATCAGGGACATTTTCCCGAACACCGTGCTTGCAGA
CCTTAACATTGACAGCGTGTTGGCCCCAGATGCTTTTGTCTGTCGTCGCATTTGCACGCATCAC
CCCACGTGCCTGTTTTTTACATTCTTTACCCAAGCGTGGCCAAAAGAATCCCAGAGACATCTTT
GCCTCCTTAAAACATCTGAAAGCGGATTTCCAAGCACACGCATCACAAAGAGCAACGCCCTTTC
CGGGTTCAGTCTCCAGCACTGCAGGCACAGCATCCCAGTATTCTGTCATCCGAACTTTTACAAC
GACACTGATTTCTTGGGAGAAGAACTGGACATCGTCGATGTGAAAGGCAAAGAATCCTGCCAGA
AAATGTGCTCTGACAACGTCCGCTGCCAGTTCTTTACCTATTATCCCTCTCGAGGATCTTGCAG
TGAGAGGAAGGGCAGATGTTACTTAAAGCTTTCTTCAAACGGATCTCCAACTAGAATACTTCAT
GGGAGGGGAGGCATCTCTGGATACACGCTGAGGCTGTGCAAAATGGATAATGTATGCACAACCA
AAATCAGGCCCAGGGTGTTCGGAGGAGCTGCGTCTGTTCACGGCGAGTGGCCATGGCAGGTGAC
CCTGCACACCACCCAGGGACACCTGTGTGGAGGCTCCATCATTGGAAACCGGTGGATATTGACA
GCGGCTCATTGTTTCTCTGGGACAGAGACACCTAAAACTCTGCGTGTCTACGGTGGTATTGTAA
ATCAATCAGAAATAAATGAAGATACCACTTTCTTCAGGGTTCAAGAAATGATAATTCATGATCA
ATATACATCGGCAGAAAGTGGGTTTGACATTGCCCTCTTAAAACTGGAACCGGCCATGAATTAC
ACAGATTTTCAGCGGCCAATATGCCTGCCTTCCAAAGGAGACAGAAACGTAGTTCACACAGAAT
GCTGGGTGACTGGATGGGGATACACAAAATCAAGAGATGAAGTACAAAGTACTCTCCAGAAAGC
CAAGGTACCATTGGTGTCGAATGAAGAATGTCAAACAAGATACAGAAAACATAAAATAACCAAC
AAGGTGATCTGTGCAGGATATAAGGAAGGAGGGAAGGATACGTGTAAGGGAGATTCTGGAGGGC
CCCTGTCCTGCAAACACAATGGGGTCTGGCACTTGGTGGGCATCACAAGCTGGGGTGAAGGCTG
CGGCCAGAAAGAGAGGCCGGGTGTCTACACCAACGTGGCCAAGTATGTGGACTGGATTTTGGAG
AAAACTCAGTCGGAATGAAAGAGTTCAACAGGTGTCATTTCGTGGCCCTGGAAGACTATTCCAC
AGAAGAGAGCATGATGTGTCTCATGAAGACACGGGGAAGCTGTATCTTCACTGTCAGGAACTGG
AGGGGCTTGATGTATGTAAGAACGCACAGAAAGAAAACTATTATTTTCAGAATTCCCGATCTGT
GAGAATCACAGGTTGCTTTCTGTATCCAGCTACTCTCAAGGAAACCAACACAACGAGGAGATTT
TTAAAATAAAAACACAGCAGATAAACTAGGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001398595	(Get FASTA)	NCBI Sequence Viewer
	XP_006253207	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ91042	(Get FASTA)	NCBI Sequence Viewer
	EDL78852	(Get FASTA)	NCBI Sequence Viewer
	EDL78853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000044970.1
	ENSRNOP00000073061
	ENSRNOP00000073061.3

RefSeq Acc Id:	XP_006253207 ⟸ XM_006253145
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K4I9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNRFACILKDSLTETLPMVHMTGAVSGYSFKQCPQQLSACSKNVYVNLDMKGMNYNSSAVKNAR ECQERCTNDAHCQFFTYATGHFPSVDHRKMCLLKYTQMGTPTSITKLDSVVSGFSLKSCGLSNL ACIRDIFPNTVLADLNIDSVLAPDAFVCRRICTHHPTCLFFTFFTQAWPKESQRHLCLLKTSES GFPSTRITKSNALSGFSLQHCRHSIPVFCHPNFYNDTDFLGEELDIVDVKGKESCQKMCSDNVR CQFFTYYPSRGSCSERKGRCYLKLSSNGSPTRILHGRGGISGYTLRLCKMDNVCTTKIRPRVFG GAASVHGEWPWQVTLHTTQGHLCGGSIIGNRWILTAAHCFSGTETPKTLRVYGGIVNQSEINED TTFFRVQEMIIHDQYTSAESGFDIALLKLEPAMNYTDFQRPICLPSKGDRNVVHTECWVTGWGY TKSRDEVQSTLQKAKVPLVSNEECQTRYRKHKITNKVICAGYKEGGKDTCKGDSGGPLSCKHNG VWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQSE hide sequence

Ensembl Acc Id:

ENSRNOP00000073061 ⟸ ENSRNOT00000077662

Ensembl Acc Id:

ENSRNOP00000044970 ⟸ ENSRNOT00000041946

RefSeq Acc Id:	NP_001398595 ⟸ NM_001411666
- Peptide Label:	precursor
- UniProtKB:	A0A0G2K4I9 (UniProtKB/TrEMBL)

Protein Domains

Apple Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K4I9-F1-model_v2	AlphaFold	A0A0G2K4I9	1-622	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700114

Promoter ID:

EPDNEW_R10635

Type:

initiation region

Name:

F11_1

Description:

coagulation factor XI

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	50,181,306 - 50,181,366	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309364	AgrOrtholog
BioCyc Gene	G2FUF-11310	BioCyc
Ensembl Genes	ENSRNOG00000013684	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000041946.4	UniProtKB/TrEMBL
	ENSRNOT00000077662	ENTREZGENE
	ENSRNOT00000077662.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	Hepatocyte Growth Factor	UniProtKB/TrEMBL
InterPro	Apple	UniProtKB/TrEMBL
	Pan_app	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Ser/Cys_Pept_Trypsin-like	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	290757	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	COAGULATION FACTOR XI	UniProtKB/TrEMBL
	HYALIN	UniProtKB/TrEMBL
	PTHR33946	UniProtKB/TrEMBL
Pfam	PAN_1	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	F11	PhenoGen
PRINTS	APPLEDOMAIN	UniProtKB/TrEMBL
	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	APPLE	UniProtKB/TrEMBL
	PAN	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013684	RatGTEx
SMART	APPLE	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	Hairpin loop containing domain-like	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
UniProt	A0A0G2K4I9	ENTREZGENE, UniProtKB/TrEMBL
	A6JPR9_RAT	UniProtKB/TrEMBL
	A6JPS0_RAT	UniProtKB/TrEMBL
	Q6TUF8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	F11	coagulation factor XI	F11_predicted	coagulation factor XI (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	F11_predicted	coagulation factor XI (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB