F11 (coagulation factor XI) - Rat Genome Database

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Pathways
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Gene: F11 (coagulation factor XI) Canis lupus familiaris
Analyze
Symbol: F11
Name: coagulation factor XI
RGD ID: 12188308
Description: ENCODES a protein that exhibits identical protein binding (ortholog); serine-type aminopeptidase activity (ortholog); INVOLVED IN regulation of blood coagulation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH factor XI deficiency; autistic disorder (ortholog); Cerebral Hemorrhage (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: plasma thromboplastin antecedent
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,469,609 - 44,492,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,956,542 - 44,972,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,683,089 - 46,700,923 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,683,106 - 46,700,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,652,096 - 44,668,510 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,264,846 - 45,281,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,395,778 - 45,412,243 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
F11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,469,609 - 44,492,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,956,542 - 44,972,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,683,089 - 46,700,923 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,683,106 - 46,700,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,652,096 - 44,668,510 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,264,846 - 45,281,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,395,778 - 45,412,243 (-)NCBIUU_Cfam_GSD_1.0
F11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,266,189 - 186,289,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,266,189 - 186,289,681 (+)EnsemblGRCh38hg38GRCh38
GRCh374187,187,343 - 187,210,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,424,112 - 187,447,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 344187,562,426 - 187,585,083NCBI
Celera4184,511,477 - 184,537,546 (+)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4182,938,469 - 182,962,233 (+)NCBIHuRef
CHM1_14187,163,556 - 187,187,273 (+)NCBICHM1_1
T2T-CHM13v2.04189,606,162 - 189,629,664 (+)NCBIT2T-CHM13v2.0
F11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,693,696 - 45,715,092 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,694,211 - 45,715,068 (-)EnsemblGRCm39 Ensembl
GRCm38845,240,659 - 45,262,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,241,174 - 45,262,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,326,524 - 46,347,385 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,739,987 - 46,760,848 (-)NCBIMGSCv36mm8
Celera847,928,261 - 47,949,034 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.14NCBI
F11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,720,502 - 53,741,547 (+)NCBIGRCr8
mRatBN7.21646,987,988 - 47,009,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,986,107 - 47,008,437 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,378,899 - 52,400,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,756,360 - 55,778,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,018,291 - 51,040,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,179,458 - 50,201,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,179,458 - 50,201,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,902,415 - 49,924,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,276,330 - 50,298,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,287,001 - 50,298,978 (+)NCBI
Celera1644,976,615 - 44,998,530 (+)NCBICelera
Cytogenetic Map16q11NCBI
F11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,811,380 - 22,830,563 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,811,211 - 22,830,281 (-)NCBIChiLan1.0ChiLan1.0
F11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23184,008,843 - 184,033,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,357,677 - 184,381,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,436,865 - 178,459,568 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,643,733 - 190,666,512 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,643,733 - 190,666,512 (+)Ensemblpanpan1.1panPan2
LOC101967202
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,886,563 - 34,903,578 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,205,539 - 3,219,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,205,539 - 3,223,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,046,002 - 9,073,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,045,990 - 9,073,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,180,026 - 132,207,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,180,336 - 132,208,155 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,505,568 - 112,530,733 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476917,094,169 - 17,115,222 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476917,093,643 - 17,115,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F11
221 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011775   ⟹   ENSCAFP00000010914
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,469,632 - 44,487,120 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000011815   ⟹   ENSCAFP00000010953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,492,977 - 44,516,531 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000011851   ⟹   ENSCAFP00000010988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063618   ⟹   ENSCAFP00000064005
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,469,632 - 44,487,098 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071904   ⟹   ENSCAFP00000048322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,469,632 - 44,516,482 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034051   ⟹   ENSCAFP00845026653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1646,683,106 - 46,700,880 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034175   ⟹   ENSCAFP00845026753
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1646,683,106 - 46,698,120 (-)Ensembl
RefSeq Acc Id: NM_001135123   ⟹   NP_001128595
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11644,469,827 - 44,486,258 (-)NCBI
Dog10K_Boxer_Tasha1644,956,542 - 44,972,975 (-)NCBI
ROS_Cfam_1.01646,683,296 - 46,699,768 (-)NCBI
UMICH_Zoey_3.11644,652,096 - 44,668,510 (-)NCBI
UNSW_CanFamBas_1.01645,264,846 - 45,281,307 (-)NCBI
UU_Cfam_GSD_1.01645,395,778 - 45,412,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038688866   ⟹   XP_038544794
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01646,683,089 - 46,700,923 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001128595   ⟸   NM_001135123
- Peptide Label: precursor
- UniProtKB: B5LX43 (UniProtKB/TrEMBL),   A0A8C0NKV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010988   ⟸   ENSCAFT00000011851
RefSeq Acc Id: ENSCAFP00000010953   ⟸   ENSCAFT00000011815
RefSeq Acc Id: ENSCAFP00000010914   ⟸   ENSCAFT00000011775
RefSeq Acc Id: ENSCAFP00000064005   ⟸   ENSCAFT00000063618
RefSeq Acc Id: ENSCAFP00000048322   ⟸   ENSCAFT00000071904
RefSeq Acc Id: XP_038544794   ⟸   XM_038688866
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NKK8 (UniProtKB/TrEMBL),   A0A8I3P9T1 (UniProtKB/TrEMBL),   A0A8C0NKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026753   ⟸   ENSCAFT00845034175
RefSeq Acc Id: ENSCAFP00845026653   ⟸   ENSCAFT00845034051
Protein Domains
Apple   Peptidase S1

Promoters
RGD ID:13686123
Promoter ID:EPDNEW_C4193
Type:multiple initiation site
Name:F11_1
Description:coagulation factor XI
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11644,487,173 - 44,487,233EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007348 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017665 UniProtKB/TrEMBL
  ENSCAFG00040009600 UniProtKB/TrEMBL
  ENSCAFG00845019228 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011775.5 UniProtKB/TrEMBL
  ENSCAFT00030032757.1 UniProtKB/TrEMBL
  ENSCAFT00030032903.1 UniProtKB/TrEMBL
  ENSCAFT00040017886.1 UniProtKB/TrEMBL
  ENSCAFT00845034051 ENTREZGENE
  ENSCAFT00845034051.1 UniProtKB/TrEMBL
  ENSCAFT00845034175 ENTREZGENE
  ENSCAFT00845034175.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  Hepatocyte Growth Factor UniProtKB/TrEMBL
InterPro Apple UniProtKB/TrEMBL
  Pan_app UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report cfa:475623 UniProtKB/TrEMBL
NCBI Gene F11 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  HYALIN UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE 3-LIKE UniProtKB/TrEMBL
Pfam PAN_1 UniProtKB/TrEMBL
  PAN_4 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PRINTS APPLEDOMAIN UniProtKB/TrEMBL
  CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE APPLE UniProtKB/TrEMBL
  PAN UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART APPLE UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0NKK8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NKV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NYS2_CANLF UniProtKB/TrEMBL
  A0A8I3P9T1 ENTREZGENE, UniProtKB/TrEMBL
  B5LX43 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40544 ENTREZGENE