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Gene: Lsg1 (large 60S subunit nuclear export GTPase 1) Rattus norvegicus

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Symbol:

Lsg1

Name:

large 60S subunit nuclear export GTPase 1

RGD ID:

1309089

Description:

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

large subunit GTPase 1 homolog; large subunit GTPase 1 homolog (S. cerevisiae); LOC103693591; LOC288029; RGD1309089; similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed; uncharacterized LOC103693591

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LSG1 (large 60S subunit nuclear export GTPase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LSG1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LSG1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LSG1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LSG1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Lsg1 (large 60S subunit nuclear export GTPase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LSG1 (large 60S subunit nuclear export GTPase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lsg1 (large 60S subunit nuclear export GTPase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C53H9.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LSG1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ns3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lsg1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	83,648,757 - 83,673,431 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	83,648,772 - 83,673,878 (+)	Ensembl				GRCr8
mRatBN7.2	11	70,132,919 - 70,168,526 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	70,143,847 - 70,168,518 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	78,987,948 - 79,012,569 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	71,625,685 - 71,650,297 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	70,677,053 - 70,701,674 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	73,693,862 - 73,723,457 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	73,693,814 - 73,723,501 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	76,764,254 - 76,793,849 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	72,026,815 - 72,051,401 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	90,030 - 114,648 (-)	NCBI		Celera
RGSC_v3.1	11	72,084,403 - 72,108,989 (+)	NCBI
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain Injuries (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amphotericin B (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

fenvalerate (EXP)

flutamide (EXP)

FR900359 (ISO)

gentamycin (EXP,ISO)

methotrexate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenol red (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nuclear export (IEA,ISO,ISS)

protein transport (IEA)

ribosomal subunit export from nucleus (IBA)

Cellular Component

Cajal body (IEA,ISO,ISS)

cytoplasm (IEA)

cytosol (IBA,IEA,ISO)

endoplasmic reticulum (IEA,ISO,ISS)

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

GTP binding (IEA,ISO,ISS)

GTPase activity (IBA,IEA,ISO)

hydrolase activity (IEA)

nucleotide binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14499481	PMID:16209721	PMID:19946888

Genomics

Comparative Map Data

Lsg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	83,648,757 - 83,673,431 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	83,648,772 - 83,673,878 (+)	Ensembl				GRCr8
mRatBN7.2	11	70,132,919 - 70,168,526 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	70,143,847 - 70,168,518 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	78,987,948 - 79,012,569 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	71,625,685 - 71,650,297 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	70,677,053 - 70,701,674 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	73,693,862 - 73,723,457 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	73,693,814 - 73,723,501 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	76,764,254 - 76,793,849 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	72,026,815 - 72,051,401 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	90,030 - 114,648 (-)	NCBI		Celera
RGSC_v3.1	11	72,084,403 - 72,108,989 (+)	NCBI
Cytogenetic Map	11	q22	NCBI

LSG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	194,640,791 - 194,672,191 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	194,640,791 - 194,672,463 (-)	Ensembl			hg38	GRCh38
GRCh37	3	194,361,520 - 194,392,920 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	195,842,812 - 195,874,200 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	3	192,777,382 - 192,808,648 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	191,741,919 - 191,772,993 (-)	NCBI		HuRef
CHM1_1	3	194,324,597 - 194,355,945 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	197,339,420 - 197,370,401 (-)	NCBI		T2T-CHM13v2.0

Lsg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	30,380,187 - 30,406,430 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	30,379,312 - 30,406,410 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	30,561,369 - 30,587,612 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	30,560,494 - 30,587,592 (-)	Ensembl			mm10	GRCm38
MGSCv37	16	30,561,455 - 30,587,675 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	30,481,116 - 30,507,336 (-)	NCBI		MGSCv36	mm8
Celera	16	31,075,924 - 31,102,170 (-)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	21.34	NCBI

Lsg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955420	14,216,430 - 14,244,289 (+)	NCBI	ChiLan1.0	ChiLan1.0

LSG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	192,564,654 - 192,595,529 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	192,569,373 - 192,600,251 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	191,937,249 - 191,967,849 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	202,247,591 - 202,278,402 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	202,247,591 - 202,278,647 (-)	Ensembl			panPan2	panpan1.1

LSG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	31,078,384 - 31,117,093 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	31,087,349 - 31,117,095 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	31,116,439 - 31,147,559 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	31,344,794 - 31,375,922 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	31,344,792 - 31,375,910 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	31,138,718 - 31,169,817 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	31,173,857 - 31,204,743 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	31,800,009 - 31,831,365 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	124,062,830 - 124,101,062 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936711	148,798 - 186,716 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936711	148,748 - 186,978 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LSG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	131,623,534 - 131,657,046 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	131,623,530 - 131,653,930 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	141,224,934 - 141,257,701 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LSG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	88,729,016 - 88,758,421 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	88,729,031 - 88,759,102 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	62,417,762 - 62,447,298 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lsg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	63,218,107 - 63,241,964 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	63,218,010 - 63,243,028 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lsg1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	15,492,735 - 15,515,733 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lsg1
58 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	41
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000002354
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	73308487	96070872	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	58928336	99753367	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	79618519	99753367	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	73850894	99753367	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	58931822	92356038	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	54415391	96071021	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	82951028	96351019	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	57754837	96071021	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	67962184	99753367	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	73308315	99753367	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	68599321	96497754	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	69855943	99753367	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	51071021	96071021	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF452725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF452729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002354 ⟹ ENSRNOP00000002354

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	83,648,772 - 83,673,878 (+)	Ensembl
mRatBN7.2 Ensembl	11	70,143,859 - 70,168,518 (+)	Ensembl
Rnor_6.0 Ensembl	11	73,693,862 - 73,723,456 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081081 ⟹ ENSRNOP00000074962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	70,143,859 - 70,168,518 (+)	Ensembl
Rnor_6.0 Ensembl	11	73,693,814 - 73,723,501 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090940 ⟹ ENSRNOP00000071302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	83,648,772 - 83,673,298 (+)	Ensembl
mRatBN7.2 Ensembl	11	70,143,847 - 70,167,377 (+)	Ensembl
Rnor_6.0 Ensembl	11	73,693,877 - 73,723,187 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113183 ⟹ ENSRNOP00000095423

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	83,648,791 - 83,672,087 (+)	Ensembl
mRatBN7.2 Ensembl	11	70,143,888 - 70,167,178 (+)	Ensembl

RefSeq Acc Id:

NM_001013421 ⟹ NP_001013439

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	83,648,810 - 83,673,431 (+)	NCBI
mRatBN7.2	11	70,143,899 - 70,168,522 (+)	NCBI
Rnor_6.0	11	73,693,862 - 73,723,457 (+)	NCBI
Rnor_5.0	11	76,764,254 - 76,793,849 (+)	NCBI
RGSC_v3.4	11	72,026,815 - 72,051,401 (+)	RGD
Celera	11	90,030 - 114,648 (-)	RGD

Sequence:

show sequence

TGCTGATACGCTGTTATGGGCCGGAGAAGAGCGCCGGGTGGTGGGTCACTGGGTCGGGTACTTA
TCCGGCATCAGACTCAACGAAGCCGCAGTCACCGTCATACTGACTCCTGGCTGCATACGAGTGA
ACTCAATGATGGTTATGATTGGGGACGTCTGAATCTTCAGTCAGTGACGGAACAGAGCTCCCTC
GAGGACTTTCTTGCAACTGCAGAACTTGCAGGGACGGAGTTCGTGGCTGAGAAGCTTAATATTA
AGTTTGTGCCCCCTGAGGCTAGAACTGGACTGCTGTCTTTCGAGGAGAGCCAGAGAATTAAGAG
ACTCCATGAAGAAAACAGACAGTTCCTGTGTATACCAAGGAGACCAAATTGGGACAGAAAAACT
AGCCCTGAAGAACTGAAACAAGCAGAGAAAGATAACTTTCTAAAATGGAGGCGCCAGCTTGTCC
GGCTAGAAGAAGAACAGAAGTTGATATTGACTCCCTTTGAACGGAATTTGGACTTCTGGCGCCA
GCTCTGGAGGGTCATTGAGAGAAGTGATATTGTGGTCCAGATAGTAGATGCTCGGAACCCGCTC
CTGTTCAGATGTGAGGATTTGGAATGTTACGTGAAGGAGATAGATGCTGCCAAGGAGAATGTGA
TTCTGATAAACAAGGCAGACTTGTTGACTGCTGAGCAGAGGGTTGCCTGGGCTGTGCACTTTGA
GAAAGAAGGTGTGAAGGTTATCTTCTGGTCAGCTTTGGCAGAAACCGTTCACCTAAATGGTGAC
TCTAAGGATGAAGTAAACAGTGTTGCTGGAGAAGCCAACAGCTCTGAGTCTGAAGACTCCAGTT
TGGACGGGAATGAAATTCCACACAGAGACTTGTTCTTGCTTAGTGAGGAGTCCGAAAGTGACGA
TGACGACAGTGAGTATGAGGACTGTCAGGAGGACGAGGAGGAAGATTGGCAGACGTGTTCTGAA
GAAGATAGCAATCCTGAGGAGGGGCAGGAGGAAGGGGGCTGTGATCGGGACCAGAAGGAACACG
GTCCTGAGGATTCTGAGGCTCAGAGCAGAGCATCACCAGAAAATTCACAGATGAGCAACAAGAG
CCATCTGGTCTCGAAGCAGGAGTTACTAGAGCTCTTCAAGAAACTCCACACTGGGAAGAAGGTG
AAAGACGGACAGCTGACTGTAGGGCTGGTGGGCTACCCTAATGTTGGTAAGAGCTCAACCATCA
ACACCATCATGGGCAACAAGAAAGTATCGGTGTCTGCCACGCCAGGCCACACCAAGCATTTCCA
GACCCTGTACGTGGAGCCAGGCCTCTGTCTGTGTGACTGCCCCGGCCTGGTGATGCCATCTTTT
GTGTCTACCAAAGCAGAGATGATTTGCAGTGGGATCCTCCCTATCGACCAGATGAGAGATCACG
TTCCGCCTGTATCACTAGTTTGCCAGAATATCCCGAGGCGAGTTTTAGAAGCTACCTATGGCAT
TAACATTATAAAGCCTGGAGAAGATGAAGACCCCTACCGACCTCCGACCTCAGAAGAGCTGTTG
ACAGCTTATGGATGCATGCGGGGATTCATGACAGCACACGGACAGCCAGACCAGCCTCGGTCTG
CACGATACATCCTGAAGGACTACGTCAGAGGTAAACTTCTGTATTGTCACCCTCCTCCTGGAAA
AGACCCTGTGGCATTCCAGCATCAACACAGGCAACTCCTAGAGAACAAAATAAAAGGTGAAGAA
CTGAGGCTTCAGCCAGGCAAAACCCAAAAAGCCAAACAGGTTGAAAATGTAGTCGACAAGACTT
TTTTCCATCAGGAGAATGTCAGAGCATTGACCAAAGGGGTCCAGGCTGTCATGGGTTACAAGCC
CGGGAGTGGCCTGGTGACTGCAGCTGCTGCGAGTGCTGAGAACGTACCTGGGAAGCCCTGGAAA
AAACACGGTAACAGAAACAAAAAAGAGAAAAGCCGCAGGCTCTACAGGCACCTGGATGTGTGAG
CTTGGCTGAAGAGAAATGGCAGCTGCACTGTGCGGGTGGACAAGGACTGAGGCCACCGCTGCCT
GTGCTGCACCCCAGACAACAGCGCTGTGGACTGGACCCTGCTCTTGTGGAGCACTCGCCCCCGG
AAGTCACCTTCGGAAGCACCTGAGGTGGCTACAGTAGTCATGAGGTGCCCCAGAAGTCTCCTGC
AGGAGGATGATGGATGTGTGTATAAACATACAGATACATAATAACTTTGAGGTTTTGTTATTAA
AATTAATTTGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088110 ⟹ XP_038944038

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	83,648,757 - 83,669,889 (+)	NCBI
mRatBN7.2	11	70,132,919 - 70,164,977 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013439	(Get FASTA)	NCBI Sequence Viewer
	XP_038944038	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91338	(Get FASTA)	NCBI Sequence Viewer
	EDL82932	(Get FASTA)	NCBI Sequence Viewer
	EDL82933	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002354
	ENSRNOP00000002354.5
GenBank Protein	Q5BJT6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013439 ⟸ NM_001013421

- UniProtKB:

Q5BJT6 (UniProtKB/Swiss-Prot), A0A8L2R9T6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGRRRAPGGGSLGRVLIRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLEDFLA
TAELAGTEFVAEKLNIKFVPPEARTGLLSFEESQRIKRLHEENRQFLCIPRRPNWDRKTSPEEL
KQAEKDNFLKWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCE
DLECYVKEIDAAKENVILINKADLLTAEQRVAWAVHFEKEGVKVIFWSALAETVHLNGDSKDEV
NSVAGEANSSESEDSSLDGNEIPHRDLFLLSEESESDDDDSEYEDCQEDEEEDWQTCSEEDSNP
EEGQEEGGCDRDQKEHGPEDSEAQSRASPENSQMSNKSHLVSKQELLELFKKLHTGKKVKDGQL
TVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKA
EMICSGILPIDQMRDHVPPVSLVCQNIPRRVLEATYGINIIKPGEDEDPYRPPTSEELLTAYGC
MRGFMTAHGQPDQPRSARYILKDYVRGKLLYCHPPPGKDPVAFQHQHRQLLENKIKGEELRLQP
GKTQKAKQVENVVDKTFFHQENVRALTKGVQAVMGYKPGSGLVTAAAASAENVPGKPWKKHGNR
NKKEKSRRLYRHLDV

hide sequence

Ensembl Acc Id:

ENSRNOP00000071302 ⟸ ENSRNOT00000090940

Ensembl Acc Id:

ENSRNOP00000002354 ⟸ ENSRNOT00000002354

Ensembl Acc Id:

ENSRNOP00000074962 ⟸ ENSRNOT00000081081

RefSeq Acc Id:	XP_038944038 ⟸ XM_039088110
- Peptide Label:	isoform X1
- UniProtKB:	A6KTZ4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095423 ⟸ ENSRNOT00000113183

Protein Domains

CP-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5BJT6-F1-model_v2	AlphaFold	Q5BJT6	1-655	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698226

Promoter ID:

EPDNEW_R8750

Type:

multiple initiation site

Name:

Lsg1_1

Description:

large 60S subunit nuclear export GTPase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	73,693,839 - 73,693,899	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309089	AgrOrtholog
BioCyc Gene	G2FUF-21021	BioCyc
Ensembl Genes	ENSRNOG00000001727	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002354	ENTREZGENE
	ENSRNOT00000002354.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7113447	IMAGE-MGC_LOAD
	IMAGE:7315079	IMAGE-MGC_LOAD
InterPro	G_CP_dom	UniProtKB/Swiss-Prot
	GNL1-like	UniProtKB/Swiss-Prot
	GTP_binding_domain	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:288029	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109338	IMAGE-MGC_LOAD
	MGC:93933	IMAGE-MGC_LOAD
NCBI Gene	288029	ENTREZGENE
PANTHER	LARGE SUBUNIT GTPASE 1 HOMOLOG	UniProtKB/Swiss-Prot
	PTHR45709	UniProtKB/Swiss-Prot
Pfam	MMR_HSR1	UniProtKB/Swiss-Prot
PhenoGen	Lsg1	PhenoGen
PRINTS	GTP1OBG	UniProtKB/Swiss-Prot
PROSITE	G_CP	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001727	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6AND5_RAT	UniProtKB/TrEMBL
	A0A8L2R5G8_RAT	UniProtKB/TrEMBL
	A0A8L2R9T6	ENTREZGENE
	A6KTZ4	ENTREZGENE, UniProtKB/TrEMBL
	A6KTZ5_RAT	UniProtKB/TrEMBL
	LSG1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Lsg1	large 60S subunit nuclear export GTPase 1	LOC103693591	uncharacterized LOC103693591	Data merged from RGD:9421620	737654	PROVISIONAL
2014-08-25	LOC103693591	uncharacterized LOC103693591			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-11-19	Lsg1	large 60S subunit nuclear export GTPase 1	Lsg1	large subunit GTPase 1 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Lsg1	large subunit GTPase 1 homolog (S. cerevisiae)	RGD1309089	similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1309089	similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed	RGD1309089_predicted	similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309089_predicted	similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed (predicted)	LOC288029_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC288029_predicted	similar to DNA segment, Chr 16, Brigham & Womens Genetics 1547 expressed (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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