Rbx1 (ring-box 1) - Rat Genome Database

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Gene: Rbx1 (ring-box 1) Rattus norvegicus
Analyze
Symbol: Rbx1
Name: ring-box 1
RGD ID: 1308453
Description: Predicted to enable several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including positive regulation of protein metabolic process; protein modification by small protein conjugation; and regulation of signal transduction. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of metabolic process; and regulation of intracellular signal transduction. Part of VCB complex. Orthologous to human RBX1 (ring-box 1); PARTICIPATES IN hypoxia inducible factor pathway; neddylation pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase RBX1; LOC300084; MGC116275; ring-box 1, E3 ubiquitin protein ligase; ring-box 1-like; RING-box protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,870,893 - 114,881,194 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,870,972 - 114,881,191 (+)EnsemblGRCr8
mRatBN7.27112,976,863 - 113,001,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,753,189 - 114,763,404 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,976,687 - 116,986,902 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,946,098 - 116,956,313 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,700,849 - 122,710,907 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)Ensemblrn6Rnor6.0
Rnor_5.07122,677,395 - 122,687,076 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,794,976 - 119,805,104 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,310,166 - 109,320,235 (+)NCBICelera
RGSC_v3.17119,828,667 - 119,836,146 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calycosin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
deguelin  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
escitalopram  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
heme b  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
maneb  (ISO)
methimazole  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
sertraline  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
solanesol  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to UV  (ISO)
DNA damage response  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of response to oxidative stress  (IEA,ISO)
negative regulation of type I interferon production  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein autoubiquitination  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of TORC1 signaling  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein catabolic process  (ISO)
protein K27-linked ubiquitination  (IEA,ISO)
protein K48-linked ubiquitination  (IEA,ISO)
protein monoubiquitination  (IEA,ISO)
protein neddylation  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
protein ubiquitination  (IBA,IEA,ISO)
RNA polymerase II transcription initiation surveillance  (IEA,ISO)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
signal transduction in response to DNA damage  (IEA,ISO)
spermatogenesis  (IEA,ISO)
T cell activation  (IEA,ISO)
transcription-coupled nucleotide-excision repair  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO)
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Kamura T, etal., Genes Dev. 2004 Dec 15;18(24):3055-65.
4. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. Kamura T, etal., J Biol Chem. 2001 Aug 10;276(32):29748-53. Epub 2001 May 30.
5. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Kamura T, etal., Science. 1999 Apr 23;284(5414):657-61.
6. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
7. Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. Megumi Y, etal., Genes Cells. 2005 Jul;10(7):679-91.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Ohh M, etal., EMBO Rep. 2002 Feb;3(2):177-82. Epub 2002 Jan 29.
10. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, etal., Oncogene. 2004 Mar 15;23(11):1985-97.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
16. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Zheng N, etal., Nature. 2002 Apr 18;416(6882):703-9.
Additional References at PubMed
PMID:10230407   PMID:11956208   PMID:12140560   PMID:12477932   PMID:12732143   PMID:14528312   PMID:14739464   PMID:15103331   PMID:15983046   PMID:16880526   PMID:17085480   PMID:17543862  
PMID:17636018   PMID:18498745   PMID:18794347   PMID:19028597   PMID:19250909   PMID:20129063   PMID:20223979   PMID:20389280   PMID:21343341   PMID:21572392   PMID:22358839   PMID:22405651  
PMID:23263282   PMID:25585578   PMID:29593216  


Genomics

Comparative Map Data
Rbx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,870,893 - 114,881,194 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,870,972 - 114,881,191 (+)EnsemblGRCr8
mRatBN7.27112,976,863 - 113,001,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,753,189 - 114,763,404 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,976,687 - 116,986,902 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,946,098 - 116,956,313 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,700,849 - 122,710,907 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)Ensemblrn6Rnor6.0
Rnor_5.07122,677,395 - 122,687,076 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,794,976 - 119,805,104 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,310,166 - 109,320,235 (+)NCBICelera
RGSC_v3.17119,828,667 - 119,836,146 (+)NCBI
Cytogenetic Map7q34NCBI
RBX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,951,378 - 40,973,309 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,951,277 - 40,973,539 (+)Ensemblhg38GRCh38
GRCh372241,347,382 - 41,369,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,677,331 - 39,698,614 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342239,671,884 - 39,693,168NCBI
Celera2225,151,059 - 25,172,347 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,308,951 - 24,330,592 (+)NCBIHuRef
CHM1_12241,306,113 - 41,327,855 (+)NCBICHM1_1
T2T-CHM13v2.02241,423,571 - 41,445,506 (+)NCBIT2T-CHM13v2.0
Rbx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,350,517 - 81,360,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,350,497 - 81,360,570 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,466,316 - 81,476,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,466,296 - 81,476,369 (+)Ensemblmm10GRCm38
MGSCv371581,296,746 - 81,306,799 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,293,628 - 81,303,619 (+)NCBIMGSCv36mm8
Celera1583,584,172 - 83,594,608 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.11NCBI
Rbx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,579,759 - 26,592,980 (+)Ensembl
ChiLan1.0NW_00495541326,579,759 - 26,592,980 (+)NCBIChiLan1.0ChiLan1.0
RBX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,781,027 - 50,802,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,480,935 - 53,503,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,845,351 - 21,866,627 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,941,405 - 39,962,175 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,941,405 - 39,962,175 (+)EnsemblpanPan2panpan1.1
RBX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,265,733 - 24,280,253 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,266,408 - 24,280,235 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1024,200,859 - 24,214,782 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01025,014,111 - 25,028,037 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,013,516 - 25,028,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,729,691 - 24,743,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,050,324 - 25,064,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,224,699 - 25,238,847 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,861,902 - 7,880,482 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492873,576 - 890,835 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492872,316 - 890,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,500,490 - 7,515,370 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,500,492 - 7,515,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RBX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,500,361 - 23,521,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,500,356 - 23,522,723 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045101,955,371 - 101,977,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,546,959 - 7,560,668 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247527,547,702 - 7,560,605 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rbx1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,217,666 - 251,227,565 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rbx1
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:140
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000025979
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH135115  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07122,710,269 - 122,710,460NCBIRnor6.0
RH 3.4 Map7882.2UniSTS
Cytogenetic Map7q34UniSTS
RH137490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,996,536 - 112,996,742 (+)MAPPERmRatBN7.2
Rnor_6.07122,706,572 - 122,706,777NCBIRnor6.0
Rnor_5.07122,682,583 - 122,682,788UniSTSRnor5.0
RGSC_v3.47119,799,479 - 119,799,684UniSTSRGSC3.4
Celera7109,315,848 - 109,316,053UniSTS
Cytogenetic Map7q34UniSTS
RH131226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,000,747 - 113,000,930 (+)MAPPERmRatBN7.2
Rnor_6.07122,710,604 - 122,710,786NCBIRnor6.0
Rnor_5.07122,686,773 - 122,686,955UniSTSRnor5.0
RGSC_v3.47119,804,801 - 119,804,983UniSTSRGSC3.4
Celera7109,319,932 - 109,320,114UniSTS
RH 3.4 Map7878.9UniSTS
Cytogenetic Map7q34UniSTS
RH142947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,992,368 - 112,992,491 (+)MAPPERmRatBN7.2
Rnor_6.07122,702,383 - 122,702,505NCBIRnor6.0
Rnor_5.07122,678,929 - 122,679,051UniSTSRnor5.0
Celera7109,311,700 - 109,311,822UniSTS
RH 3.4 Map7880.6UniSTS
Cytogenetic Map7q34UniSTS
RH137754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,991,861 - 112,992,039 (+)MAPPERmRatBN7.2
Rnor_6.07122,701,876 - 122,702,053NCBIRnor6.0
Rnor_5.07122,678,422 - 122,678,599UniSTSRnor5.0
Celera7109,311,193 - 109,311,370UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000086603   ⟹   ENSRNOP00000069049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,870,972 - 114,881,191 (+)Ensembl
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)Ensembl
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)Ensembl
RefSeq Acc Id: NM_001034135   ⟹   NP_001029307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,870,979 - 114,881,194 (+)NCBI
mRatBN7.27112,990,835 - 113,001,051 (+)NCBI
Rnor_6.07122,700,849 - 122,710,907 (+)NCBI
Rnor_5.07122,677,395 - 122,687,076 (+)NCBI
RGSC_v3.47119,794,976 - 119,805,104 (+)RGD
Celera7109,310,166 - 109,320,235 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078842   ⟹   XP_038934770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,870,893 - 114,881,194 (+)NCBI
mRatBN7.27112,990,797 - 113,001,051 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001029307 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934770 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00259 (Get FASTA)   NCBI Sequence Viewer  
  EDM15720 (Get FASTA)   NCBI Sequence Viewer  
  EDM15721 (Get FASTA)   NCBI Sequence Viewer  
  EDM15722 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069049.3
RefSeq Acc Id: NP_001029307   ⟸   NM_001034135
- UniProtKB: Q498D8 (UniProtKB/TrEMBL),   A0A0G2JUC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069049   ⟸   ENSRNOT00000086603
RefSeq Acc Id: XP_038934770   ⟸   XM_039078842
- Peptide Label: isoform X1
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498D8-F1-model_v2 AlphaFold Q498D8 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695511
Promoter ID:EPDNEW_R6036
Type:multiple initiation site
Name:Rbx1_1
Description:ring-box 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,700,840 - 122,700,900EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308453 AgrOrtholog
BioCyc Gene G2FUF-32677 BioCyc
Ensembl Genes ENSRNOG00000058914 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086603.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7444286 IMAGE-MGC_LOAD
InterPro RING-box_E3_Ubiquitin_Ligase UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_H2 UniProtKB/TrEMBL
KEGG Report rno:300084 UniProtKB/TrEMBL
MGC_CLONE MGC:116275 IMAGE-MGC_LOAD
NCBI Gene 300084 ENTREZGENE
PANTHER RING BOX UniProtKB/TrEMBL
Pfam zf-rbx1 UniProtKB/TrEMBL
PhenoGen Rbx1 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058914 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0G2JUC8 ENTREZGENE, UniProtKB/TrEMBL
  A6HT00_RAT UniProtKB/TrEMBL
  A6HT01_RAT UniProtKB/TrEMBL
  A6HT02_RAT UniProtKB/TrEMBL
  Q498D8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Rbx1  ring-box 1  Rbx1  ring-box 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Rbx1  ring-box 1, E3 ubiquitin protein ligase  LOC100363742  ring-box 1-like  Data merged from RGD:2322409 1643240 APPROVED
2012-10-10 Rbx1  ring-box 1, E3 ubiquitin protein ligase  Rbx1  ring-box 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363742  ring-box 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Rbx1  ring-box 1  Rbx1_predicted  ring-box 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rbx1_predicted  ring-box 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED