Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of NHSL1 mRNA | CTD | PMID:28960355 | 17alpha-ethynylestradiol | multiple interactions | ISO | Nhsl1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NHSL1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of NHSL1 mRNA | CTD | PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:19095052 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Nhsl1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NHSL1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NHSL1 mRNA | CTD | PMID:21570461 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of NHSL1 mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Nhsl1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of NHSL1 promoter | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of NHSL1 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Nhsl1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of NHSL1 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of NHSL1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of NHSL1 mRNA | CTD | PMID:24780913 | aflatoxin B1 | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of NHSL1 mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases methylation | ISO | NHSL1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of NHSL1 gene | CTD | PMID:27153756 | aldrin | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Aldrin results in increased expression of NHSL1 mRNA | CTD | PMID:18579281 | all-trans-retinoic acid | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of NHSL1 mRNA | CTD | PMID:33167477 | antirheumatic drug | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of NHSL1 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of NHSL1 mRNA | CTD | PMID:19770486 and PMID:21569818 | benzo[a]pyrene | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of NHSL1 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | NHSL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NHSL1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | NHSL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of NHSL1 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | NHSL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of NHSL1 exon | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20382639 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NHSL1 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol A | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of NHSL1 mRNA | CTD | PMID:32156529 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of NHSL1 protein | CTD | PMID:28903499 | buta-1,3-diene | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of NHSL1 mRNA | CTD | PMID:29038090 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of NHSL1 mRNA | CTD | PMID:33453195 | caffeine | affects phosphorylation | ISO | NHSL1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of NHSL1 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of NHSL1 mRNA | CTD | PMID:25979313 | choline | multiple interactions | ISO | Nhsl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NHSL1 gene | CTD | PMID:20938992 | chrysene | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | chrysene results in increased expression of NHSL1 mRNA | CTD | PMID:26377693 | cisplatin | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of NHSL1 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of NHSL1 mRNA | CTD | PMID:27392435 | crocidolite asbestos | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of NHSL1 mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of NHSL1 mRNA | CTD | PMID:20106945 and PMID:21632981 | cyclosporin A | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of NHSL1 mRNA | CTD | PMID:25562108 | cypermethrin | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | cypermethrin results in increased expression of NHSL1 mRNA | CTD | PMID:29020013 | dicrotophos | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of NHSL1 mRNA | CTD | PMID:28302478 | dioxygen | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of NHSL1 mRNA | CTD | PMID:24205000 | dorsomorphin | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | epoxiconazole | affects expression | ISO | Nhsl1 (Mus musculus) | 6480464 | epoxiconazole affects the expression of NHSL1 mRNA | CTD | PMID:35436446 | ethanol | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Ethanol results in increased expression of NHSL1 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Nhsl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NHSL1 gene | CTD | PMID:20938992 | FR900359 | affects phosphorylation | ISO | NHSL1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of NHSL1 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of NHSL1 gene | CTD | PMID:31601247 | glycidyl methacrylate | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | glycidyl methacrylate results in increased expression of NHSL1 protein | CTD | PMID:36641056 | indometacin | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of NHSL1 mRNA | CTD | PMID:16984733 | ivermectin | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NHSL1 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Nhsl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NHSL1 gene | CTD | PMID:20938992 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of NHSL1 gene | CTD | PMID:35440735 | methyl methanesulfonate | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of NHSL1 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of NHSL1 mRNA | CTD | PMID:26272509 | methylmercury chloride | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NHSL1 mRNA | CTD | PMID:27188386 | paracetamol | affects expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of NHSL1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of NHSL1 mRNA | CTD | PMID:29067470 | paracetamol | decreases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of NHSL1 mRNA | CTD | PMID:21420995 | perfluorohexanesulfonic acid | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of NHSL1 mRNA | CTD | PMID:37995155 | perfluorooctanoic acid | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of NHSL1 mRNA and perfluorooctanoic acid results in increased expression of NHSL1 protein | CTD | PMID:26879310 and PMID:36326898 | phenylmercury acetate | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of NHSL1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NHSL1 mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of NHSL1 mRNA | CTD | PMID:17426115 | potassium dichromate | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of NHSL1 mRNA | CTD | PMID:23608068 | SB 431542 | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | serpentine asbestos | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Asbestos and Serpentine results in increased expression of NHSL1 mRNA | CTD | PMID:21148743 | sotorasib | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL1 mRNA | CTD | PMID:36139627 | sulforaphane | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | sulforaphane results in increased expression of NHSL1 mRNA | CTD | PMID:31838189 | testosterone | affects expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Testosterone affects the expression of NHSL1 mRNA | CTD | PMID:20403060 | titanium dioxide | increases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of NHSL1 mRNA | CTD | PMID:29264374 | trametinib | multiple interactions | ISO | NHSL1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL1 mRNA | CTD | PMID:36139627 | triclosan | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Triclosan results in increased expression of NHSL1 mRNA | CTD | PMID:30510588 | trimellitic anhydride | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of NHSL1 mRNA | CTD | PMID:19042947 | triptonide | decreases expression | ISO | Nhsl1 (Mus musculus) | 6480464 | triptonide results in decreased expression of NHSL1 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | Nhsl1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of NHSL1 mRNA | CTD | PMID:17963808 | vincristine | increases expression | ISO | NHSL1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of NHSL1 mRNA | CTD | PMID:23649840 | |