Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ksr1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of KSR1 mRNA | CTD | PMID:22206623 | Ksr1 | Rat | 17beta-estradiol | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of KSR1 mRNA | CTD | PMID:23094148 and PMID:31614463 | Ksr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ksr1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KSR1 promoter] | CTD | PMID:19654925 | Ksr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KSR1 mRNA | CTD | PMID:33387578 and PMID:34747641 | Ksr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KSR1 mRNA | CTD | PMID:32109520 | Ksr1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KSR1 mRNA | CTD | PMID:28973697 | Ksr1 | Rat | 4-vinylcyclohexene dioxide | affects expression | ISO | Ksr1 (Mus musculus) | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of KSR1 mRNA | CTD | PMID:20829426 | Ksr1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of KSR1 mRNA | CTD | PMID:28959563 | Ksr1 | Rat | aflatoxin B1 | increases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of KSR1 intron | CTD | PMID:30157460 | Ksr1 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of KSR1 exon | CTD | PMID:30157460 | Ksr1 | Rat | all-trans-retinoic acid | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KSR1 mRNA | CTD | PMID:33167477 | Ksr1 | Rat | aristolochic acid A | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KSR1 mRNA | CTD | PMID:33212167 | Ksr1 | Rat | arsenite(3-) | multiple interactions | ISO | KSR1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to KSR1 mRNA] | CTD | PMID:32406909 | Ksr1 | Rat | benzene | multiple interactions | ISO | Ksr1 (Mus musculus) | 6480464 | TRP53 protein inhibits the reaction [Benzene results in increased expression of KSR1] | CTD | PMID:15935813 | Ksr1 | Rat | benzo[a]pyrene | affects methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KSR1 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | Ksr1 | Rat | benzo[a]pyrene | increases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of KSR1 3' UTR | CTD | PMID:27901495 | Ksr1 | Rat | benzo[e]pyrene | increases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of KSR1 5' UTR | CTD | PMID:30157460 | Ksr1 | Rat | benzo[e]pyrene | decreases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of KSR1 exon and benzo(e)pyrene results in decreased methylation of KSR1 intron | CTD | PMID:30157460 | Ksr1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KSR1 mRNA | CTD | PMID:25181051 and PMID:30816183 | Ksr1 | Rat | cadmium dichloride | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of KSR1 mRNA | CTD | PMID:32512071 and PMID:38568856 | Ksr1 | Rat | caffeine | decreases phosphorylation | ISO | KSR1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of KSR1 protein | CTD | PMID:35688186 | Ksr1 | Rat | calcitriol | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of KSR1 mRNA | CTD | PMID:16002434 | Ksr1 | Rat | CGP 52608 | multiple interactions | ISO | KSR1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KSR1 gene] | CTD | PMID:28238834 | Ksr1 | Rat | cisplatin | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of KSR1 mRNA | CTD | PMID:27392435 | Ksr1 | Rat | clothianidin | decreases expression | ISO | KSR1 (Homo sapiens) | 6480464 | clothianidin results in decreased expression of KSR1 mRNA | CTD | PMID:31626844 | Ksr1 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KSR1 mRNA | CTD | PMID:26577399 | Ksr1 | Rat | Dibutyl phosphate | affects expression | ISO | KSR1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of KSR1 mRNA | CTD | PMID:37042841 | Ksr1 | Rat | dibutyl phthalate | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of KSR1 mRNA | CTD | PMID:21266533 | Ksr1 | Rat | dicrotophos | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of KSR1 mRNA | CTD | PMID:28302478 | Ksr1 | Rat | dorsomorphin | multiple interactions | ISO | KSR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA | CTD | PMID:27188386 | Ksr1 | Rat | doxorubicin | decreases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KSR1 mRNA | CTD | PMID:29803840 | Ksr1 | Rat | ethanol | affects expression | ISO | Ksr1 (Mus musculus) | 6480464 | Ethanol affects the expression of KSR1 mRNA | CTD | PMID:30319688 | Ksr1 | Rat | formaldehyde | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of KSR1 mRNA | CTD | PMID:23649840 | Ksr1 | Rat | FR900359 | increases phosphorylation | ISO | KSR1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of KSR1 protein | CTD | PMID:37730182 | Ksr1 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of KSR1 mRNA | CTD | PMID:25539665 | Ksr1 | Rat | genistein | increases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Genistein results in increased expression of KSR1 mRNA | CTD | PMID:32186404 | Ksr1 | Rat | leflunomide | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | leflunomide results in increased expression of KSR1 mRNA | CTD | PMID:28988120 | Ksr1 | Rat | methapyrilene | decreases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of KSR1 exon and Methapyrilene results in decreased methylation of KSR1 intron | CTD | PMID:30157460 | Ksr1 | Rat | methapyrilene | increases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of KSR1 5' UTR | CTD | PMID:30157460 | Ksr1 | Rat | methotrexate | decreases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of KSR1 mRNA | CTD | PMID:24449571 | Ksr1 | Rat | methoxychlor | increases methylation | EXP | | 6480464 | Methoxychlor results in increased methylation of KSR1 gene | CTD | PMID:23303685 | Ksr1 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of KSR1 gene | CTD | PMID:33148267 | Ksr1 | Rat | ozone | multiple interactions | ISO | Ksr1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of KSR1 mRNA | CTD | PMID:34911549 | Ksr1 | Rat | paracetamol | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KSR1 mRNA | CTD | PMID:29067470 | Ksr1 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of KSR1 gene | CTD | PMID:33148267 | Ksr1 | Rat | phenylmercury acetate | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of KSR1 mRNA | CTD | PMID:26272509 | Ksr1 | Rat | phenylmercury acetate | multiple interactions | ISO | KSR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA | CTD | PMID:27188386 | Ksr1 | Rat | pirinixic acid | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of KSR1 mRNA | CTD | PMID:17426115 | Ksr1 | Rat | quercetin | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Quercetin results in increased expression of KSR1 mRNA | CTD | PMID:27514524 | Ksr1 | Rat | SB 431542 | multiple interactions | ISO | KSR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA | CTD | PMID:27188386 | Ksr1 | Rat | silicon dioxide | decreases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of KSR1 mRNA | CTD | PMID:25895662 | Ksr1 | Rat | silver atom | increases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Silver results in increased expression of KSR1 mRNA | CTD | PMID:27131904 | Ksr1 | Rat | silver(0) | increases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Silver results in increased expression of KSR1 mRNA | CTD | PMID:27131904 | Ksr1 | Rat | sodium fluoride | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of KSR1 mRNA | CTD | PMID:27862939 | Ksr1 | Rat | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of KSR1 mRNA | CTD | PMID:19281266 | Ksr1 | Rat | sunitinib | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KSR1 mRNA | CTD | PMID:31533062 | Ksr1 | Rat | titanium dioxide | decreases methylation | ISO | Ksr1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of KSR1 gene and titanium dioxide results in decreased methylation of KSR1 promoter | CTD | PMID:35295148 | Ksr1 | Rat | tributylstannane | increases expression | ISO | Ksr1 (Mus musculus) | 6480464 | tributyltin results in increased expression of KSR1 mRNA | CTD | PMID:31939706 | Ksr1 | Rat | trichostatin A | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KSR1 mRNA | CTD | PMID:28542535 | Ksr1 | Rat | triphenyl phosphate | affects expression | ISO | KSR1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of KSR1 mRNA | CTD | PMID:37042841 | Ksr1 | Rat | troglitazone | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of KSR1 mRNA | CTD | PMID:28973697 | Ksr1 | Rat | trovafloxacin | decreases expression | ISO | Ksr1 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of KSR1 mRNA | CTD | PMID:35537566 | Ksr1 | Rat | valproic acid | increases methylation | ISO | KSR1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KSR1 gene | CTD | PMID:29154799 | Ksr1 | Rat | valproic acid | increases expression | ISO | KSR1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KSR1 mRNA | CTD | PMID:23179753 | Ksr1 | Rat | zinc atom | increases phosphorylation | ISO | Ksr1 (Mus musculus) | 6480464 | Zinc results in increased phosphorylation of KSR1 protein | CTD | PMID:14685271 | Ksr1 | Rat | zinc(0) | increases phosphorylation | ISO | Ksr1 (Mus musculus) | 6480464 | Zinc results in increased phosphorylation of KSR1 protein | CTD | PMID:14685271 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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