Ndrg1 (N-myc downstream regulated 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ndrg1 (N-myc downstream regulated 1) Rattus norvegicus
Analyze
Symbol: Ndrg1
Name: N-myc downstream regulated 1
RGD ID: 1307303
Description: Predicted to enable several functions, including nickel cation binding activity; small GTPase binding activity; and tubulin binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hypoxia; and peripheral nervous system myelin maintenance. Predicted to act upstream of or within mast cell activation. Predicted to be located in several cellular components, including adherens junction; microtubule cytoskeleton; and recycling endosome membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299923; N-myc downstream regulated gene 1; N-myc downstream-regulated gene 1 protein; Ndr1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,573,526 - 100,614,902 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7100,573,523 - 100,614,913 (-)EnsemblGRCr8
mRatBN7.2798,684,487 - 98,725,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7100,449,304 - 100,490,614 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,650,974 - 102,692,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,570,302 - 102,611,611 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,734,326 - 107,775,701 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,734,323 - 107,775,714 (-)Ensemblrn6Rnor6.0
Rnor_5.07107,683,921 - 107,725,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47104,302,038 - 104,344,842 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera795,235,424 - 95,272,338 (-)NCBICelera
RGSC_v3.17104,336,268 - 104,379,072 (-)NCBI
Cytogenetic Map7q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
benzyl isothiocyanate  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
ferric oxide  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
metformin  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IEA,ISO)
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
microtubule  (IEA,ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)
recycling endosome membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, etal., Neuron. 2012 Mar 22;73(6):1127-42. doi: 10.1016/j.neuron.2012.01.019. Epub 2012 Mar 21.
Additional References at PubMed
PMID:9766676   PMID:12432451   PMID:12477932   PMID:12804568   PMID:15082788   PMID:15247272   PMID:15489334   PMID:17442733   PMID:17634366   PMID:17786215   PMID:18582504   PMID:19056867  
PMID:20810912   PMID:23376485   PMID:23555679   PMID:25468996   PMID:28131823   PMID:30053369   PMID:37356737  


Genomics

Comparative Map Data
Ndrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,573,526 - 100,614,902 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7100,573,523 - 100,614,913 (-)EnsemblGRCr8
mRatBN7.2798,684,487 - 98,725,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7100,449,304 - 100,490,614 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,650,974 - 102,692,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,570,302 - 102,611,611 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,734,326 - 107,775,701 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,734,323 - 107,775,714 (-)Ensemblrn6Rnor6.0
Rnor_5.07107,683,921 - 107,725,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47104,302,038 - 104,344,842 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera795,235,424 - 95,272,338 (-)NCBICelera
RGSC_v3.17104,336,268 - 104,379,072 (-)NCBI
Cytogenetic Map7q33NCBI
NDRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388133,237,175 - 133,297,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8133,237,175 - 133,302,022 (-)Ensemblhg38GRCh38
GRCh378134,249,418 - 134,309,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,318,596 - 134,378,680 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348134,318,595 - 134,378,680NCBI
Celera8130,427,338 - 130,487,468 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8129,569,158 - 129,629,277 (-)NCBIHuRef
CHM1_18134,290,434 - 134,350,564 (-)NCBICHM1_1
T2T-CHM13v2.08134,361,278 - 134,421,339 (-)NCBIT2T-CHM13v2.0
Ndrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,801,167 - 66,841,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,801,167 - 66,841,489 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381566,929,318 - 66,969,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,929,318 - 66,969,640 (-)Ensemblmm10GRCm38
MGSCv371566,760,880 - 66,801,203 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361566,758,991 - 66,799,308 (-)NCBIMGSCv36mm8
Celera1568,461,993 - 68,502,305 (-)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
Ndrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,786,850 - 7,836,922 (-)Ensembl
ChiLan1.0NW_0049554617,787,068 - 7,836,380 (-)NCBIChiLan1.0ChiLan1.0
NDRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,626,425 - 150,686,809 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18126,140,834 - 126,201,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,891,918 - 129,952,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,866,245 - 132,926,514 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,866,245 - 132,926,514 (-)EnsemblpanPan2panpan1.1
NDRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,689,294 - 29,745,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,650,444 - 29,746,382 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1329,668,427 - 29,710,107 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01330,048,859 - 30,105,421 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1330,050,503 - 30,092,259 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11329,777,136 - 29,818,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01329,876,514 - 29,918,203 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01330,226,181 - 30,267,635 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ndrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,625,163 - 8,676,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,051,015 - 16,102,585 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,051,291 - 16,102,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,014,446 - 8,069,335 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.148,014,445 - 8,069,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.247,894,536 - 7,930,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,668,012 - 127,727,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8127,667,981 - 127,719,011 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603912,373,846 - 12,433,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473522,734,228 - 22,782,347 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473522,734,365 - 22,782,247 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ndrg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11241,045,135 - 241,086,590 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ndrg1
216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:151
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000010811
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH130193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,684,539 - 98,684,725 (+)MAPPERmRatBN7.2
Rnor_6.07107,734,376 - 107,734,561NCBIRnor6.0
Rnor_5.07107,683,974 - 107,684,159UniSTSRnor5.0
RGSC_v3.47104,302,088 - 104,302,273UniSTSRGSC3.4
Celera795,235,474 - 95,235,659UniSTS
RH 3.4 Map7681.9UniSTS
Cytogenetic Map7q33UniSTS
RH130261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,684,571 - 98,684,776 (+)MAPPERmRatBN7.2
Rnor_6.07107,734,408 - 107,734,612NCBIRnor6.0
Rnor_5.07107,684,006 - 107,684,210UniSTSRnor5.0
RGSC_v3.47104,302,120 - 104,302,324UniSTSRGSC3.4
Celera795,235,506 - 95,235,710UniSTS
RH 3.4 Map7681.6UniSTS
Cytogenetic Map7q33UniSTS
RH131717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,687,539 - 98,687,742 (+)MAPPERmRatBN7.2
Rnor_6.07107,737,376 - 107,737,578NCBIRnor6.0
Rnor_5.07107,686,974 - 107,687,176UniSTSRnor5.0
RGSC_v3.47104,305,088 - 104,305,290UniSTSRGSC3.4
Celera795,238,474 - 95,238,676UniSTS
RH 3.4 Map7680.8UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010811   ⟹   ENSRNOP00000010811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,734,323 - 107,775,712 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093189   ⟹   ENSRNOP00000076191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7100,573,523 - 100,607,352 (-)Ensembl
mRatBN7.2 Ensembl798,684,487 - 98,718,270 (-)Ensembl
Rnor_6.0 Ensembl7107,746,596 - 107,768,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093322   ⟹   ENSRNOP00000076179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7100,573,523 - 100,614,913 (-)Ensembl
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,746,640 - 107,774,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093459   ⟹   ENSRNOP00000076093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7100,573,523 - 100,614,913 (-)Ensembl
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,744,491 - 107,775,714 (-)Ensembl
RefSeq Acc Id: NM_001011991   ⟹   NP_001011991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,573,526 - 100,614,902 (-)NCBI
mRatBN7.2798,684,490 - 98,725,869 (-)NCBI
Rnor_6.07107,734,326 - 107,775,701 (-)NCBI
Rnor_5.07107,683,921 - 107,725,300 (-)NCBI
RGSC_v3.47104,302,038 - 104,344,842 (-)RGD
Celera795,235,424 - 95,272,338 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078783   ⟹   XP_038934711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,573,526 - 100,607,292 (-)NCBI
mRatBN7.2798,684,487 - 98,718,234 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001011991 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934711 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81898 (Get FASTA)   NCBI Sequence Viewer  
  AAS78638 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010811.5
  ENSRNOP00000076093
  ENSRNOP00000076191
GenBank Protein Q6JE36 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011991   ⟸   NM_001011991
- UniProtKB: Q6JE36 (UniProtKB/Swiss-Prot),   A0A1W2Q686 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076179   ⟸   ENSRNOT00000093322
Ensembl Acc Id: ENSRNOP00000076093   ⟸   ENSRNOT00000093459
Ensembl Acc Id: ENSRNOP00000010811   ⟸   ENSRNOT00000010811
Ensembl Acc Id: ENSRNOP00000076191   ⟸   ENSRNOT00000093189
RefSeq Acc Id: XP_038934711   ⟸   XM_039078783
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q6A2 (UniProtKB/TrEMBL),   A0A1W2Q686 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6JE36-F1-model_v2 AlphaFold Q6JE36 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695366
Promoter ID:EPDNEW_R5891
Type:multiple initiation site
Name:Ndrg1_1
Description:N-myc downstream regulated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07107,775,712 - 107,775,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307303 AgrOrtholog
BioCyc Gene G2FUF-33118 BioCyc
Ensembl Genes ENSRNOG00000007393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010811.8 UniProtKB/Swiss-Prot
  ENSRNOT00000093189 ENTREZGENE
  ENSRNOT00000093459 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110455 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  NDRG UniProtKB/Swiss-Prot
KEGG Report rno:299923 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93814 IMAGE-MGC_LOAD
NCBI Gene 299923 ENTREZGENE
PANTHER PTHR11034 UniProtKB/Swiss-Prot
Pfam Ndr UniProtKB/Swiss-Prot
PhenoGen Ndrg1 PhenoGen
RatGTEx ENSRNOG00000007393 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A1W2Q609_RAT UniProtKB/TrEMBL
  A0A1W2Q686 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6A2 ENTREZGENE, UniProtKB/TrEMBL
  NDRG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Ndrg1  N-myc downstream regulated 1  Ndrg1  N-myc downstream regulated gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-29 Ndrg1  N-myc downstream regulated gene 1  Ndrg1  N-myc downstream regulated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-18 Ndrg1  N-myc downstream regulated 1  Ndrg1  N-myc downstream regulated gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ndrg1  N-myc downstream regulated gene 1  Ndrg1_predicted  N-myc downstream regulated gene 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ndrg1_predicted  N-myc downstream regulated gene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED