Fis1 (fission, mitochondrial 1) - Rat Genome Database

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Gene: Fis1 (fission, mitochondrial 1) Rattus norvegicus
Analyze
Symbol: Fis1
Name: fission, mitochondrial 1
RGD ID: 1306668
Description: Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in several processes, including cellular response to peptide; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrial outer membrane and peroxisomal membrane. Biomarker of dental fluorosis; kidney failure (multiple); myocardial infarction; rhinitis; and steatotic liver disease. Orthologous to human FIS1 (fission, mitochondrial 1); PARTICIPATES IN mitochondria fission pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fis1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); LOC288584; mitochondrial fission 1 protein; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; Ttc11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,345,239 - 25,360,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,345,239 - 25,349,335 (-)EnsemblGRCr8
mRatBN7.21219,708,560 - 19,723,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,708,558 - 19,723,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,847,143 - 20,862,230 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,459,848 - 21,474,937 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,524,895 - 20,540,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,750,485 - 22,765,324 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,750,485 - 22,765,308 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,760,051 - 24,774,751 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,806,840 - 20,821,766 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,483,983 - 21,498,749 (-)NCBICelera
RGSC_v3.11220,807,273 - 20,811,373 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-DAMP(1+)  (EXP)
4-phenylbutyric acid  (EXP,ISO)
acrolein  (EXP)
aldehydo-D-glucose  (EXP,ISO)
angiotensin II  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbidopa  (ISO)
carnosic acid  (ISO)
Carnosol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cytochalasin B  (EXP)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP)
diuron  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folpet  (ISO)
fructose  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lanthanum trichloride  (EXP)
lenvatinib  (EXP)
lipoic acid  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
metformin  (EXP)
methidathion  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nitrogen dioxide  (ISO)
nocodazole  (EXP)
okadaic acid  (EXP)
oleic acid  (ISO)
oxidopamine  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phlorizin  (ISO)
ponasterone A  (EXP)
Pseudolaric acid B  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
sarpogrelate  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spermine  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trans-cinnamic acid  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial outer membrane  (IBA,IDA,IEA,ISO,ISS)
mitochondrion  (IEA,ISO)
peroxisomal membrane  (IBA,IDA,IEA,ISO,ISS)
peroxisome  (IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
3. Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
4. Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung. Chitra L and Boopathy R, Respir Physiol Neurobiol. 2014 Feb 1;192:74-84. doi: 10.1016/j.resp.2013.12.007. Epub 2013 Dec 17.
5. Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model. Córdova-Dávalos L, etal., Epilepsy Res. 2016 Jul;123:11-9. doi: 10.1016/j.eplepsyres.2016.03.007. Epub 2016 Mar 29.
6. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
7. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. Dagda RK, etal., J Biol Chem. 2008 Dec 26;283(52):36241-8. Epub 2008 Oct 21.
8. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. Disatnik MH, etal., J Am Heart Assoc. 2013 Oct 8;2(5):e000461. doi: 10.1161/JAHA.113.000461.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
12. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. Hom JR, etal., J Cell Physiol. 2007 Aug;212(2):498-508.
13. Autophagy signaling in skeletal muscle of infarcted rats. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
14. Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein. Jofuku A, etal., Biochem Biophys Res Commun. 2005 Jul 29;333(2):650-9.
15. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
16. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Koch A, etal., Mol Biol Cell. 2005 Nov;16(11):5077-86. Epub 2005 Aug 17.
17. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
18. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
19. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
20. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. Liu Q, etal., PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.
21. The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain. Lou DD, etal., Arch Toxicol. 2013 Mar;87(3):449-57. doi: 10.1007/s00204-012-0942-z. Epub 2012 Sep 25.
22. Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Marton O, etal., Pflugers Arch. 2015 Apr;467(4):779-88. doi: 10.1007/s00424-014-1554-7. Epub 2014 Jun 19.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
25. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
26. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Parra V, etal., Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4.
27. Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells. Plácido AI, etal., Mol Neurobiol. 2017 Jan;54(1):154-168. doi: 10.1007/s12035-015-9640-1. Epub 2016 Jan 5.
28. The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress. Qin SL, etal., J Trace Elem Med Biol. 2015 Jan;29:263-8. doi: 10.1016/j.jtemb.2014.06.001. Epub 2014 Jun 9.
29. GOA pipeline RGD automated data pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
32. Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury. Wang Y, etal., Neuroscience. 2015 Mar 19;289:224-32. doi: 10.1016/j.neuroscience.2014.12.061. Epub 2015 Jan 13.
33. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
34. High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects. Yu J, etal., Acta Physiol (Oxf). 2016 Sep 29. doi: 10.1111/apha.12812.
35. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
36. Dihydromyricetin improves physical performance under simulated high altitude. Zou D, etal., Med Sci Sports Exerc. 2014 Nov;46(11):2077-84. doi: 10.1249/MSS.0000000000000336.
Additional References at PubMed
PMID:11596118   PMID:12477932   PMID:14651853   PMID:14996942   PMID:15057822   PMID:16118244   PMID:17035996   PMID:17408615   PMID:17545159   PMID:18353969   PMID:18515060   PMID:18614015  
PMID:18782765   PMID:18832378   PMID:18845145   PMID:19864424   PMID:19946888   PMID:20178365   PMID:20451243   PMID:20826455   PMID:21149567   PMID:21183955   PMID:22800520   PMID:22871113  
PMID:23283981   PMID:23921378   PMID:28265681  


Genomics

Comparative Map Data
Fis1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,345,239 - 25,360,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,345,239 - 25,349,335 (-)EnsemblGRCr8
mRatBN7.21219,708,560 - 19,723,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,708,558 - 19,723,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,847,143 - 20,862,230 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,459,848 - 21,474,937 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,524,895 - 20,540,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,750,485 - 22,765,324 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,750,485 - 22,765,308 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,760,051 - 24,774,751 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,806,840 - 20,821,766 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,483,983 - 21,498,749 (-)NCBICelera
RGSC_v3.11220,807,273 - 20,811,373 (+)NCBI
Cytogenetic Map12q12NCBI
FIS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,239,472 - 101,245,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,239,458 - 101,252,316 (-)Ensemblhg38GRCh38
GRCh377100,882,753 - 100,888,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,669,613 - 100,675,091 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347100,476,327 - 100,481,801NCBI
Celera795,892,051 - 95,897,529 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,475,936 - 95,481,415 (-)NCBIHuRef
CHM1_17100,813,303 - 100,818,781 (-)NCBICHM1_1
T2T-CHM13v2.07102,562,935 - 102,568,544 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,241,280 - 100,246,758 (-)NCBI
Fis1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,982,129 - 136,995,088 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,982,129 - 136,995,088 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385136,953,275 - 136,966,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,953,275 - 136,966,234 (+)Ensemblmm10GRCm38
MGSCv375137,429,145 - 137,442,104 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365137,246,713 - 137,250,859 (+)NCBIMGSCv36mm8
Celera5133,969,492 - 133,982,284 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.06NCBI
Fis1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,038,221 - 16,060,623 (+)Ensembl
ChiLan1.0NW_00495545616,057,158 - 16,060,623 (+)NCBIChiLan1.0ChiLan1.0
FIS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,252,931 - 119,260,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,517,560 - 167,523,003 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,381,058 - 93,386,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,621,211 - 106,626,612 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,621,211 - 106,626,683 (-)EnsemblpanPan2panpan1.1
FIS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,642,014 - 8,645,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,642,039 - 8,648,851 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha610,339,369 - 10,343,166 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.068,461,512 - 8,465,308 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,458,742 - 8,465,308 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,417,290 - 8,421,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,392,322 - 8,396,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,557,014 - 8,560,797 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fis1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,919,990 - 132,923,784 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,112,742 - 1,116,518 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,112,746 - 1,116,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,937,453 - 8,946,955 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.138,938,250 - 8,942,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FIS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12811,934,848 - 11,940,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2811,934,821 - 11,941,901 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660704,412,698 - 4,418,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fis1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,052,820 - 16,057,098 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474016,052,777 - 16,056,438 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fis1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11617,053,579 - 17,068,682 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fis1
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:153
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000001924, ENSRNOT00000063901
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH142325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,708,602 - 19,708,801 (+)MAPPERmRatBN7.2
Rnor_6.01222,750,530 - 22,750,728NCBIRnor6.0
Rnor_5.01224,760,096 - 24,760,294UniSTSRnor5.0
RGSC_v3.41220,821,523 - 20,821,721UniSTSRGSC3.4
Celera1221,484,028 - 21,484,226UniSTS
RH 3.4 Map12277.7UniSTS
Cytogenetic Map12q12UniSTS
RH142876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,722,278 - 19,722,440 (+)MAPPERmRatBN7.2
Rnor_6.01222,764,211 - 22,764,372NCBIRnor6.0
Rnor_5.01224,773,650 - 24,773,811UniSTSRnor5.0
RGSC_v3.41220,807,763 - 20,807,924UniSTSRGSC3.4
Celera1221,497,666 - 21,497,827UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001924   ⟹   ENSRNOP00000001924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,708,567 - 19,712,897 (-)Ensembl
Rnor_6.0 Ensembl1222,750,708 - 22,754,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000063901   ⟹   ENSRNOP00000061895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,345,242 - 25,349,335 (-)Ensembl
mRatBN7.2 Ensembl1219,708,563 - 19,723,377 (-)Ensembl
Rnor_6.0 Ensembl1222,750,490 - 22,765,308 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083471   ⟹   ENSRNOP00000075023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,345,239 - 25,348,789 (-)Ensembl
mRatBN7.2 Ensembl1219,708,558 - 19,712,043 (-)Ensembl
Rnor_6.0 Ensembl1222,750,485 - 22,765,295 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107414   ⟹   ENSRNOP00000086280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,708,563 - 19,712,897 (-)Ensembl
RefSeq Acc Id: NM_001105919   ⟹   NP_001099389
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,345,239 - 25,360,043 (-)NCBI
mRatBN7.21219,708,560 - 19,723,367 (-)NCBI
Rnor_6.01222,750,485 - 22,765,295 (-)NCBI
Rnor_5.01224,760,051 - 24,774,751 (-)NCBI
RGSC_v3.41220,806,840 - 20,821,766 (+)RGD
Celera1221,483,983 - 21,498,749 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401051   ⟹   NP_001387980
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,345,239 - 25,349,332 (-)NCBI
mRatBN7.21219,708,560 - 19,712,653 (-)NCBI
RefSeq Acc Id: XM_006249121   ⟹   XP_006249183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,345,239 - 25,353,333 (-)NCBI
mRatBN7.21219,708,885 - 19,712,805 (-)NCBI
Rnor_6.01222,750,812 - 22,754,813 (-)NCBI
Rnor_5.01224,760,051 - 24,774,751 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249122   ⟹   XP_006249184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,345,239 - 25,360,135 (-)NCBI
mRatBN7.21219,708,560 - 19,723,392 (-)NCBI
Rnor_6.01222,750,487 - 22,765,324 (-)NCBI
Rnor_5.01224,760,051 - 24,774,751 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001099389   ⟸   NM_001105919
- Peptide Label: isoform 1
- UniProtKB: A0A8L2URI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249184   ⟸   XM_006249122
- Peptide Label: isoform X2
- UniProtKB: P84817 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249183   ⟸   XM_006249121
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A509 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061895   ⟸   ENSRNOT00000063901
Ensembl Acc Id: ENSRNOP00000075023   ⟸   ENSRNOT00000083471
Ensembl Acc Id: ENSRNOP00000001924   ⟸   ENSRNOT00000001924
Ensembl Acc Id: ENSRNOP00000086280   ⟸   ENSRNOT00000107414
RefSeq Acc Id: NP_001387980   ⟸   NM_001401051
- Peptide Label: isoform 2
- UniProtKB: P84817 (UniProtKB/Swiss-Prot),   B2RZ80 (UniProtKB/Swiss-Prot),   D4A5K3 (UniProtKB/Swiss-Prot),   A6J062 (UniProtKB/TrEMBL),   A0A8L2URI1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84817-F1-model_v2 AlphaFold P84817 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698536
Promoter ID:EPDNEW_R9056
Type:multiple initiation site
Name:Fis1_1
Description:fission, mitochondrial 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9057  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,754,569 - 22,754,629EPDNEW
RGD ID:13698532
Promoter ID:EPDNEW_R9057
Type:initiation region
Name:Fis1_2
Description:fission, mitochondrial 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9056  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,765,298 - 22,765,358EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306668 AgrOrtholog
BioCyc Gene G2FUF-19668 BioCyc
Ensembl Genes ENSRNOG00000001420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001924.9 UniProtKB/Swiss-Prot
  ENSRNOT00000063901 ENTREZGENE
  ENSRNOT00000063901.4 UniProtKB/Swiss-Prot
  ENSRNOT00000083471 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9098277 IMAGE-MGC_LOAD
InterPro Fis1 UniProtKB/Swiss-Prot
  Fis1_cytosol UniProtKB/Swiss-Prot
  Fis1_TPR_C UniProtKB/Swiss-Prot
  Fis1_TPR_N UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:288584 UniProtKB/Swiss-Prot
MGC_CLONE MGC:189358 IMAGE-MGC_LOAD
NCBI Gene 288584 ENTREZGENE
PANTHER MITOCHONDRIAL FISSION 1 PROTEIN UniProtKB/Swiss-Prot
  PTHR13247 UniProtKB/Swiss-Prot
Pfam Fis1_TPR_C UniProtKB/Swiss-Prot
  Fis1_TPR_N UniProtKB/Swiss-Prot
PhenoGen Fis1 PhenoGen
PIRSF TPR_repeat_11_Fis1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001420 RatGTEx
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I6A509 ENTREZGENE
  A0A8L2URI1 ENTREZGENE, UniProtKB/TrEMBL
  A6J062 ENTREZGENE, UniProtKB/TrEMBL
  A6J063_RAT UniProtKB/TrEMBL
  B2RZ80 ENTREZGENE
  D4A5K3 ENTREZGENE
  FIS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RZ80 UniProtKB/Swiss-Prot
  D4A5K3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Fis1  fission, mitochondrial 1  Fis1  fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-29 Fis1  fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)  Fis1  fission 1 (mitochondrial outer membrane) homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Fis1  fission 1 (mitochondrial outer membrane) homolog (yeast)  Ttc11  tetratricopeptide repeat domain 11  Symbol and Name updated 1299863 APPROVED
2005-12-06 Ttc11  tetratricopeptide repeat domain 11  Ttc11_predicted  tetratricopeptide repeat domain 11 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ttc11_predicted  tetratricopeptide repeat domain 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED