FIS1 (fission, mitochondrial 1) - Rat Genome Database

Name: FIS1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: FIS1 (fission, mitochondrial 1) Pan paniscus

Analyze

Symbol:

FIS1

Name:

fission, mitochondrial 1

RGD ID:

11795070

Description:

ENCODES a protein that exhibits lipid binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN autophagy of mitochondrion (ortholog); cellular response to glucose stimulus (ortholog); cellular response to lipid (ortholog); PARTICIPATES IN mitochondria fission pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); chronic kidney disease (ortholog); FOUND IN mitochondrial outer membrane (ortholog); peroxisomal membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fission 1 (mitochondrial outer membrane) homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FIS1 (fission, mitochondrial 1)	NCBI	Ortholog
Mus musculus (house mouse):	Fis1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fis1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fis1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FIS1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fis1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FIS1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FIS1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fis1 (fission, mitochondrial 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	119,252,931 - 119,260,623 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	167,517,560 - 167,523,003 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	93,381,058 - 93,386,483 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	106,621,211 - 106,626,612 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	106,621,211 - 106,626,683 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Alzheimer's disease (ISO)

chronic kidney disease (ISO)

dental fluorosis (ISO)

Heart Injuries (ISO)

Insulin Resistance (ISO)

Lung Injury (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

neuronal ceroid lipofuscinosis 1 (ISO)

pleomorphic xanthoastrocytoma (ISO)

Pulmonary Edema of Mountaineers (ISO)

rhinitis (ISO)

Sarcopenia (ISO)

Spinal Cord Compression (ISO)

Spinal Cord Injuries (ISO)

steatotic liver disease (ISO)

Ventricular Remodeling (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy of mitochondrion (ISO)

cellular response to glucose stimulus (ISO)

cellular response to lipid (ISO)

cellular response to peptide (ISO)

cellular response to toxic substance (ISO)

mitochondrial fission (IEA)

mitochondrial fragmentation involved in apoptotic process (IEA,ISO)

mitochondrial fusion (IEA)

mitochondrion organization (IEA,ISO)

negative regulation of ATP metabolic process (IEA)

negative regulation of endoplasmic reticulum calcium ion concentration (IEA)

negative regulation of fatty acid transport (IEA)

peroxisome fission (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of intrinsic apoptotic signaling pathway (IEA)

positive regulation of mitochondrial calcium ion concentration (IEA)

positive regulation of mitochondrial fission (IEA,ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of protein targeting to membrane (IEA)

protein targeting to mitochondrion (IEA)

regulation of mitochondrion organization (IEA)

release of cytochrome c from mitochondria (IEA)

response to endoplasmic reticulum stress (ISO)

response to flavonoid (ISO)

response to fluoride (ISO)

response to hypobaric hypoxia (ISO)

response to muscle activity (ISO)

response to nutrient levels (ISO)

Cellular Component

endoplasmic reticulum (IEA)

membrane (IEA)

mitochondrial outer membrane (IEA,ISO)

mitochondrion (IEA)

peroxisomal membrane (IEA,ISO)

peroxisome (IEA)

protein-containing complex (IEA)

Molecular Function

identical protein binding (IEA)

lipid binding (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondria fission pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FIS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	119,252,931 - 119,260,623 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	167,517,560 - 167,523,003 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	93,381,058 - 93,386,483 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	106,621,211 - 106,626,612 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	106,621,211 - 106,626,683 (-)	Ensembl	panpan1.1		panPan2

FIS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	101,239,472 - 101,245,081 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	101,239,458 - 101,252,316 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	100,882,753 - 100,888,362 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	100,669,613 - 100,675,091 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	100,476,327 - 100,481,801	NCBI
Celera	7	95,892,051 - 95,897,529 (-)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	95,475,936 - 95,481,415 (-)	NCBI		HuRef
CHM1_1	7	100,813,303 - 100,818,781 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	102,562,935 - 102,568,544 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	100,241,280 - 100,246,758 (-)	NCBI

Fis1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	136,982,129 - 136,995,088 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	136,982,129 - 136,995,088 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	136,953,275 - 136,966,234 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	136,953,275 - 136,966,234 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	137,429,145 - 137,442,104 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	137,246,713 - 137,250,859 (+)	NCBI		MGSCv36	mm8
Celera	5	133,969,492 - 133,982,284 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.06	NCBI

Fis1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	25,345,239 - 25,360,135 (-)	NCBI		GRCr8
mRatBN7.2	12	19,708,560 - 19,723,392 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	19,708,558 - 19,723,377 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	20,847,143 - 20,862,230 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	21,459,848 - 21,474,937 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	20,524,895 - 20,540,015 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	22,750,485 - 22,765,324 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	22,750,485 - 22,765,308 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	24,760,051 - 24,774,751 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	20,806,840 - 20,821,766 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	20,807,273 - 20,811,373 (+)	NCBI
Celera	12	21,483,983 - 21,498,749 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Fis1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	16,038,221 - 16,060,623 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	16,057,158 - 16,060,623 (+)	NCBI	ChiLan1.0	ChiLan1.0

FIS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	8,642,014 - 8,645,812 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	8,642,039 - 8,648,851 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	10,339,369 - 10,343,166 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	8,461,512 - 8,465,308 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	8,458,742 - 8,465,308 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	8,417,290 - 8,421,077 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	8,392,322 - 8,396,123 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	8,557,014 - 8,560,797 (+)	NCBI		UU_Cfam_GSD_1.0

Fis1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	132,919,990 - 132,923,784 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	1,112,742 - 1,116,518 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	1,112,746 - 1,116,521 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FIS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,937,453 - 8,946,955 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	8,938,250 - 8,942,102 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FIS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	11,934,848 - 11,940,230 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	11,934,821 - 11,941,901 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	4,412,698 - 4,418,083 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fis1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,052,820 - 16,057,098 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	16,052,777 - 16,056,438 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008959246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000049407 ⟹ ENSPPAP00000026573

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	106,621,211 - 106,626,612 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000049413 ⟹ ENSPPAP00000026579

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	106,621,406 - 106,626,683 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000049416 ⟹ ENSPPAP00000026582

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	106,621,759 - 106,626,518 (-)	Ensembl

RefSeq Acc Id:

XM_008959246 ⟹ XP_008957494

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	119,252,931 - 119,260,623 (-)	NCBI
NHGRI_mPanPan1	7	167,517,560 - 167,523,003 (-)	NCBI
Mhudiblu_PPA_v0	7	93,381,058 - 93,386,483 (-)	NCBI
PanPan1.1	7	106,621,211 - 106,626,612 (-)	NCBI

Sequence:

show sequence

GCCGGACGCCGGAAGTGGTTCTCCGCCCCTGCCACTGGGCCATGGAGACTGTGGCACAGTAGAC
TGTAGTGTGAGGCTCGCGGGGGCAGTGGCCATGGAGGCCGTGCTGAACGAGCTGGTGTCTGTGG
AGGACCTGCTGAAGTTTGAAAAGAAATTTCAGTCTGAGAAGGCAGCAGGCTCGGTGTCCAAGAG
CACGCAGTTTGAGTACGCCTGGTGCCTGGTGCGGAGCAAGTACAATGATGACATCCGTAAAGGC
ATCGTGCTGCTCGAGGAGCTGCTGCCCAAAGGGAGCAAGGAGGAACAGCGGGATTACGTCTTCT
ACCTGGCCGTGGGGAACTACCGGCTCAAGGAATACGAGAAGGCCTTAAAGTACGTCCGCGGGTT
GCTGCAGACAGAGCCCCAGAACAACCAGGCCAAGGAACTGGAGCGGCTCATTGACAAGGCCATG
AAGAAAGATGGACTCGTGGGCATGGCCATCGTGGGAGGCATGGCCCTGGGTGTGGCGGGACTGG
CCGGACTCATCGGACTTGCTGTGTCCAAGTCCAAATCCTGAAGGAGGCGCGGGAGCCCACGGAG
AACGCTCCAGGAGGGCCTGTCCATCCTCGCTGTCCTTTCCCTGTTCTCCCCCTGCACCCCTGTC
TCTATCCTCTGTGGCCTTCAGCTAACTTCTGCTCCCCTGAGACTCGTCCTTCAGCTCCATCATG
TGCTTTGGGATGAGTGTAAATAAAACGGGGCTGTGGCTTGGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008957494	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000026573
	ENSPPAP00000026573.1
	ENSPPAP00000026579.1
	ENSPPAP00000026582.1

RefSeq Acc Id:	XP_008957494 ⟸ XM_008959246
- UniProtKB:	A0A2R9BAE7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPK GSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAI VGGMALGVAGLAGLIGLAVSKSKS hide sequence

RefSeq Acc Id:

ENSPPAP00000026579 ⟸ ENSPPAT00000049413

RefSeq Acc Id:

ENSPPAP00000026582 ⟸ ENSPPAT00000049416

RefSeq Acc Id:

ENSPPAP00000026573 ⟸ ENSPPAT00000049407

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036372	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000049407.1	UniProtKB/TrEMBL
	ENSPPAT00000049413.1	UniProtKB/TrEMBL
	ENSPPAT00000049416.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
InterPro	Fis1	UniProtKB/TrEMBL
	Fis1_cytosol	UniProtKB/TrEMBL
	Fis1_TPR_C	UniProtKB/TrEMBL
	Fis1_TPR_N	UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100972410	UniProtKB/TrEMBL
NCBI Gene	FIS1	ENTREZGENE
PANTHER	MITOCHONDRIAL FISSION 1 PROTEIN	UniProtKB/TrEMBL
	PTHR13247	UniProtKB/TrEMBL
Pfam	Fis1_TPR_C	UniProtKB/TrEMBL
	Fis1_TPR_N	UniProtKB/TrEMBL
PIRSF	TPR_repeat_11_Fis1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/TrEMBL
UniProt	A0A2R9BAE7	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BAE9_PANPA	UniProtKB/TrEMBL
	A0A2R9BBU0_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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