Pkp2 (plakophilin 2) - Rat Genome Database

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Gene: Pkp2 (plakophilin 2) Rattus norvegicus
Analyze
Symbol: Pkp2
Name: plakophilin 2
RGD ID: 1306533
Description: Predicted to enable several functions, including alpha-catenin binding activity; cadherin binding activity; and protein kinase C binding activity. Involved in several processes, including cardiac muscle cell action potential; cell-cell junction organization; and regulation of bicellular tight junction assembly. Located in adherens junction; desmosome; and intercalated disc. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287925; plakophilin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,165,974 - 98,231,916 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,165,974 - 98,231,916 (-)EnsemblGRCr8
mRatBN7.21184,661,783 - 84,727,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,661,783 - 84,727,730 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,393,755 - 93,459,584 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,054,906 - 86,120,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,108,508 - 85,174,333 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,912,163 - 88,972,213 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,966,047 - 92,031,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,553,493 - 86,584,425 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,407,295 - 83,471,505 (-)NCBICelera
RGSC_v3.11186,497,846 - 86,625,018 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
erianin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
glafenine  (EXP)
glycidol  (EXP)
hydroquinone  (ISO)
kainic acid  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
nitrofen  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IBA,IDA)
anchoring junction  (IEA)
cell junction  (IDA,ISO)
cell tip  (IEA)
cell-cell junction  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
desmosome  (IDA,IEA,ISO)
intercalated disc  (IBA,IDA,IEA,ISO)
intermediate filament  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. de Paiva Lima C, etal., J Neurogenet. 2017 Sep;31(3):170-177. doi: 10.1080/01677063.2017.1349121. Epub 2017 Jul 17.
2. Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. Dubash AD, etal., J Cell Biol. 2016 Feb 15;212(4):425-38. doi: 10.1083/jcb.201507018. Epub 2016 Feb 8.
3. The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Gehmlich K, etal., Cardiovasc Res. 2011 Apr 1;90(1):77-87. doi: 10.1093/cvr/cvq353. Epub 2010 Nov 9.
6. A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Gehmlich K, etal., Heart Rhythm. 2011 May;8(5):711-8. doi: 10.1016/j.hrthm.2011.01.010. Epub 2011 Jan 7.
7. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Gerull B, etal., Nat Genet. 2004 Nov;36(11):1162-4. Epub 2004 Oct 17.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
10. Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics. Li MW, etal., Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10213-8. Epub 2009 Jun 9.
11. Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts. Matthes SA, etal., Cell Commun Adhes. 2011 Aug;18(4):73-84. Epub 2011 Oct 10.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model. Moncayo-Arlandi J, etal., Hum Mol Genet. 2016 Sep 1;25(17):3676-3688. doi: 10.1093/hmg/ddw213. Epub 2016 Jul 12.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Oxford EM, etal., Circ Res. 2007 Sep 28;101(7):703-11. Epub 2007 Aug 2.
16. The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes. Pieperhoff S, etal., Eur J Cell Biol. 2008 Jul;87(7):399-411. Epub 2008 Feb 7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Sato PY, etal., Circ Res. 2009 Sep 11;105(6):523-6. Epub 2009 Aug 6.
22. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Sato PY, etal., Circ Res. 2011 Jul 8;109(2):193-201. Epub 2011 May 26.
23. Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis. Tang EI, etal., Spermatogenesis. 2012 Apr 1;2(2):117-126.
24. Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy. van Tintelen JP, etal., Circulation. 2006 Apr 4;113(13):1650-8. Epub 2006 Mar 27.
Additional References at PubMed
PMID:9864371   PMID:10852826   PMID:12477932   PMID:15479741   PMID:16917092   PMID:17535849   PMID:17980246   PMID:18474624   PMID:20859650   PMID:21296051   PMID:22274697   PMID:22781308  
PMID:22889254   PMID:23136403   PMID:23863954   PMID:25225333   PMID:25468996  


Genomics

Comparative Map Data
Pkp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,165,974 - 98,231,916 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,165,974 - 98,231,916 (-)EnsemblGRCr8
mRatBN7.21184,661,783 - 84,727,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,661,783 - 84,727,730 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,393,755 - 93,459,584 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,054,906 - 86,120,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,108,508 - 85,174,333 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,912,163 - 88,972,213 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,966,047 - 92,031,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,553,493 - 86,584,425 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,407,295 - 83,471,505 (-)NCBICelera
RGSC_v3.11186,497,846 - 86,625,018 (+)NCBI
Cytogenetic Map11q23NCBI
PKP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,790,755 - 32,896,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,790,745 - 32,896,798 (-)Ensemblhg38GRCh38
GRCh371232,943,689 - 33,049,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,834,947 - 32,941,047 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341232,834,953 - 32,940,993NCBI
Celera1212,764,378 - 12,870,162 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,696,154 - 32,802,035 (-)NCBIHuRef
CHM1_11232,910,199 - 33,015,916 (-)NCBICHM1_1
T2T-CHM13v2.01232,667,065 - 32,772,770 (-)NCBIT2T-CHM13v2.0
Pkp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,031,209 - 16,090,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,031,182 - 16,090,576 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381616,213,345 - 16,272,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,213,318 - 16,272,712 (+)Ensemblmm10GRCm38
MGSCv371616,213,438 - 16,272,805 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361616,126,923 - 16,186,290 (+)NCBIMGSCv36mm8
Celera1616,784,266 - 16,843,631 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
Pkp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555052,878,081 - 2,958,404 (+)Ensembl
ChiLan1.0NW_0049555052,878,001 - 2,959,299 (+)NCBIChiLan1.0ChiLan1.0
PKP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21063,850,924 - 63,957,419 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11263,847,328 - 63,953,815 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,322,227 - 53,428,747 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11255,925,514 - 56,030,996 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1255,925,174 - 56,030,998 (+)EnsemblpanPan2panpan1.1
PKP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,023,186 - 16,109,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,023,224 - 16,109,603 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2730,317,043 - 30,404,388 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02716,202,157 - 16,290,541 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,185,310 - 16,290,531 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,015,227 - 16,100,629 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,043,378 - 16,131,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,463,876 - 30,551,090 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pkp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,625,035 - 76,699,086 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,458,073 - 3,532,543 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,458,406 - 3,530,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,424,845 - 41,508,868 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1541,424,687 - 41,509,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,676,288 - 44,708,684 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,225,743 - 32,333,951 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,225,600 - 32,333,615 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660692,557,970 - 2,670,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247783,261,390 - 3,342,850 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247783,261,446 - 3,344,204 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pkp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v141,477,735 - 1,548,364 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000002498
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
RH127356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,704,540 - 84,704,747 (+)MAPPERmRatBN7.2
Rnor_6.01188,949,309 - 88,949,515NCBIRnor6.0
Rnor_5.01192,008,373 - 92,008,579UniSTSRnor5.0
Celera1183,448,227 - 83,448,433UniSTS
Cytogenetic Map6q31UniSTS
Cytogenetic Map11q23UniSTS
AI556444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,661,799 - 84,662,011 (+)MAPPERmRatBN7.2
Rnor_6.01188,912,180 - 88,912,391NCBIRnor6.0
Rnor_5.01191,966,064 - 91,966,275UniSTSRnor5.0
RGSC_v3.41186,584,197 - 86,584,408UniSTSRGSC3.4
Celera1183,407,312 - 83,407,523UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 46 26 97 54 11 45 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002498   ⟹   ENSRNOP00000002498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,661,783 - 84,727,730 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103562   ⟹   ENSRNOP00000088522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,661,783 - 84,727,730 (-)Ensembl
RefSeq Acc Id: NM_001100499   ⟹   NP_001093969
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,165,974 - 98,231,916 (-)NCBI
mRatBN7.21184,661,783 - 84,727,730 (-)NCBI
Rnor_6.01188,912,163 - 88,972,213 (-)NCBI
Rnor_5.01191,966,047 - 92,031,277 (-)NCBI
RGSC_v3.41186,553,493 - 86,584,425 (+)RGD
Celera1183,407,295 - 83,471,505 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001093969 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH92602 (Get FASTA)   NCBI Sequence Viewer  
  EDL77846 (Get FASTA)   NCBI Sequence Viewer  
  EDL77847 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002498.7
  ENSRNOP00000088522
  ENSRNOP00000088522.1
GenBank Protein F1M7L9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093969   ⟸   NM_001100499
- Sequence:
Ensembl Acc Id: ENSRNOP00000002498   ⟸   ENSRNOT00000002498
Ensembl Acc Id: ENSRNOP00000088522   ⟸   ENSRNOT00000103562

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7L9-F1-model_v2 AlphaFold F1M7L9 1-792 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306533 AgrOrtholog
BioCyc Gene G2FUF-20549 BioCyc
Ensembl Genes ENSRNOG00000001825 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002498.8 UniProtKB/Swiss-Prot
  ENSRNOT00000103562 ENTREZGENE
  ENSRNOT00000103562.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305258 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  Plakophilin/d_Catenin UniProtKB/Swiss-Prot
KEGG Report rno:287925 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109189 IMAGE-MGC_LOAD
NCBI Gene 287925 ENTREZGENE
PANTHER PLAKOPHILIN-2 UniProtKB/Swiss-Prot
  PLAKOPHILLIN-RELATED UniProtKB/Swiss-Prot
Pfam Arm UniProtKB/Swiss-Prot
PhenoGen Pkp2 PhenoGen
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001825 RatGTEx
SMART ARM UniProtKB/Swiss-Prot
Superfamily-SCOP ARM repeat UniProtKB/Swiss-Prot
UniProt A6JSR0_RAT UniProtKB/TrEMBL
  F1M7L9 ENTREZGENE, UniProtKB/Swiss-Prot
  Q562C0_RAT UniProtKB/TrEMBL
UniProt Secondary A0A8I6A597 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pkp2  plakophilin 2  Pkp2_predicted  plakophilin 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pkp2_predicted  plakophilin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED