Pkp2 (plakophilin 2) - Rat Genome Database

Name: Pkp2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pkp2 (plakophilin 2) Rattus norvegicus

Analyze

Symbol:

Pkp2 (Ensembl: AABR07034767.1)

Name:

plakophilin 2

RGD ID:

1306533

Description:

Predicted to enable several functions, including alpha-catenin binding activity; intermediate filament binding activity; and protein kinase C binding activity. Involved in several processes, including cardiac muscle cell action potential; cell-cell junction organization; and regulation of bicellular tight junction assembly. Located in adherens junction and intercalated disc. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC287925; plakophilin-2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PKP2 (plakophilin 2)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Pkp2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pkp2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PKP2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PKP2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pkp2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PKP2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PKP2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pkp2 (plakophilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CCL26 (C-C motif chemokine ligand 26)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PKP2 (plakophilin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pkp2 (plakophilin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pkp2 (plakophilin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	98,165,974 - 98,231,916 (-)	NCBI		GRCr8
mRatBN7.2	11	84,661,783 - 84,727,730 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	84,661,783 - 84,727,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	93,393,755 - 93,459,584 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	86,054,906 - 86,120,731 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	85,108,508 - 85,174,333 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,912,163 - 88,972,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	11	91,966,047 - 92,031,277 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	86,553,493 - 86,584,425 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,497,846 - 86,625,018 (+)	NCBI
Celera	11	83,407,295 - 83,471,505 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy (ISO)

arrhythmogenic right ventricular dysplasia 1 (ISO)

arrhythmogenic right ventricular dysplasia 9 (ISO)

atrial fibrillation (ISO)

Becker muscular dystrophy (ISO)

Brugada syndrome (ISO)

cardiac amyloidosis (ISO)

Cardiac Arrhythmias (ISO)

Cardiac Conduction Defect (ISO)

cardiomyopathy (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1A (ISO)

dilated cardiomyopathy 1B (ISO)

dilated cardiomyopathy 1H (ISO)

dilated cardiomyopathy 1S (ISO)

dilated cardiomyopathy 3B (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

Duchenne muscular dystrophy (ISO)

Familial Amyloid Polyneuropathies (ISO)

familial hypertrophic cardiomyopathy (ISO)

genetic disease (ISO)

Heart Block (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

left ventricular noncompaction (ISO)

Left Ventricular Noncompaction 1 (ISO)

long QT syndrome (ISO)

Sudden Cardiac Death (ISO)

Sudden Death (ISO)

Sudden Unexpected Nocturnal Death Syndrome (ISO)

transthyretin amyloidosis (ISO)

Ventricular Fibrillation (ISO)

Ventricular Fibrillation, Paroxysmal Familial, 1 (ISO)

Ventricular Premature Complexes (ISO)

Ventricular Tachycardia (ISO)

X-linked dilated cardiomyopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

caffeine (ISO)

calcitriol (ISO)

cantharidin (ISO)

capecitabine (ISO)

carbon nanotube (ISO)

carmustine (EXP)

cisplatin (ISO)

cocaine (EXP)

coumarin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cytarabine (ISO)

dextran sulfate (ISO)

diethylstilbestrol (EXP,ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxifluridine (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

genistein (ISO)

glafenine (EXP)

glycidol (EXP)

hydroquinone (ISO)

kainic acid (ISO)

ketoconazole (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methamphetamine (EXP)

methimazole (EXP)

methotrexate (EXP)

methylmercury chloride (ISO)

mifepristone (EXP)

nitrofen (EXP)

p-chloromercuribenzoic acid (ISO)

paclitaxel (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

tioguanine (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction maintenance (IMP)

bundle of His cell-Purkinje myocyte adhesion involved in cell communication (ISO)

cardiac muscle cell action potential (IMP)

cardiac muscle cell action potential involved in contraction (ISO)

cell-cell adhesion (IBA,ISO)

cell-cell signaling involved in cardiac conduction (ISO)

desmosome assembly (ISO)

desmosome organization (IBA)

gap junction assembly (IMP)

heart development (IBA,ISO)

intermediate filament bundle assembly (IBA,ISO)

lipid homeostasis (IMP)

maintenance of animal organ identity (ISO)

maintenance of protein localization at cell tip (ISO,ISS)

negative regulation of cell migration (IMP)

negative regulation of cell population proliferation (IMP)

positive regulation of cell adhesion (IMP)

protein localization to plasma membrane (IBA,ISO)

regulation of bicellular tight junction assembly (IMP)

regulation of cell-substrate adhesion (ISO)

regulation of heart rate by cardiac conduction (ISO)

regulation of substrate adhesion-dependent cell spreading (ISO)

regulation of ventricular cardiac muscle cell action potential (ISO)

ventricular cardiac muscle cell action potential (ISO)

ventricular cardiac muscle tissue morphogenesis (ISO)

Cellular Component

adherens junction (IBA,IDA)

cell junction (IDA,ISO)

cell tip (IEA)

cell-cell junction (ISO)

cytoplasm (IBA,ISO)

desmosome (IDA,ISO)

intercalated disc (IBA,IDA,ISO)

intermediate filament (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

alpha-catenin binding (ISO)

cadherin binding (IBA)

intermediate filament binding (ISO)

molecular adaptor activity (ISO)

protein binding (IPI,ISO)

protein kinase C binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.	Dubash AD, etal., J Cell Biol. 2016 Feb 15;212(4):425-38. doi: 10.1083/jcb.201507018. Epub 2016 Feb 8.
2.	The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins.	Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.	Gehmlich K, etal., Cardiovasc Res. 2011 Apr 1;90(1):77-87. doi: 10.1093/cvr/cvq353. Epub 2010 Nov 9.
5.	A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions.	Gehmlich K, etal., Heart Rhythm. 2011 May;8(5):711-8. doi: 10.1016/j.hrthm.2011.01.010. Epub 2011 Jan 7.
6.	Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.	Gerull B, etal., Nat Genet. 2004 Nov;36(11):1162-4. Epub 2004 Oct 17.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk.	Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
9.	Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics.	Li MW, etal., Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10213-8. Epub 2009 Jun 9.
10.	Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts.	Matthes SA, etal., Cell Commun Adhes. 2011 Aug;18(4):73-84. Epub 2011 Oct 10.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.	Moncayo-Arlandi J, etal., Hum Mol Genet. 2016 Sep 1;25(17):3676-3688. doi: 10.1093/hmg/ddw213. Epub 2016 Jul 12.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells.	Oxford EM, etal., Circ Res. 2007 Sep 28;101(7):703-11. Epub 2007 Aug 2.
15.	The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes.	Pieperhoff S, etal., Eur J Cell Biol. 2008 Jul;87(7):399-411. Epub 2008 Feb 7.
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.	Sato PY, etal., Circ Res. 2009 Sep 11;105(6):523-6. Epub 2009 Aug 6.
21.	Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc.	Sato PY, etal., Circ Res. 2011 Jul 8;109(2):193-201. Epub 2011 May 26.
22.	Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis.	Tang EI, etal., Spermatogenesis. 2012 Apr 1;2(2):117-126.
23.	Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy.	van Tintelen JP, etal., Circulation. 2006 Apr 4;113(13):1650-8. Epub 2006 Mar 27.

Additional References at PubMed

PMID:9864371	PMID:10852826	PMID:12477932	PMID:15479741	PMID:16917092	PMID:17535849	PMID:17980246	PMID:18474624	PMID:20859650	PMID:21296051	PMID:22274697	PMID:22781308
PMID:22889254	PMID:23136403	PMID:23863954	PMID:25225333	PMID:25468996

Genomics

Comparative Map Data

Pkp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	98,165,974 - 98,231,916 (-)	NCBI		GRCr8
mRatBN7.2	11	84,661,783 - 84,727,730 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	84,661,783 - 84,727,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	93,393,755 - 93,459,584 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	86,054,906 - 86,120,731 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	85,108,508 - 85,174,333 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,912,163 - 88,972,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	11	91,966,047 - 92,031,277 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	86,553,493 - 86,584,425 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	86,497,846 - 86,625,018 (+)	NCBI
Celera	11	83,407,295 - 83,471,505 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

PKP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	32,790,755 - 32,896,777 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	32,790,745 - 32,896,798 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	32,943,689 - 33,049,711 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	32,834,947 - 32,941,047 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	32,834,953 - 32,940,993	NCBI
Celera	12	12,764,378 - 12,870,162 (-)	NCBI		Celera
Cytogenetic Map	12	p11.21	NCBI
HuRef	12	32,696,154 - 32,802,035 (-)	NCBI		HuRef
CHM1_1	12	32,910,199 - 33,015,916 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	32,667,065 - 32,772,770 (-)	NCBI		T2T-CHM13v2.0

Pkp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,031,209 - 16,090,576 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,031,182 - 16,090,576 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	16,213,345 - 16,272,712 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	16,213,318 - 16,272,712 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	16,213,438 - 16,272,805 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	16,126,923 - 16,186,290 (+)	NCBI		MGSCv36	mm8
Celera	16	16,784,266 - 16,843,631 (+)	NCBI		Celera
Cytogenetic Map	16	A2	NCBI
cM Map	16	10.09	NCBI

Pkp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	2,878,081 - 2,958,404 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955505	2,878,001 - 2,959,299 (+)	NCBI	ChiLan1.0	ChiLan1.0

PKP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	63,850,924 - 63,957,419 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	63,847,328 - 63,953,815 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	53,322,227 - 53,428,747 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	55,925,514 - 56,030,996 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	55,925,174 - 56,030,998 (+)	Ensembl	panpan1.1		panPan2

PKP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	16,023,186 - 16,109,978 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	16,023,224 - 16,109,603 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	30,317,043 - 30,404,388 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	16,202,157 - 16,290,541 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	16,185,310 - 16,290,531 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	16,015,227 - 16,100,629 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	16,043,378 - 16,131,741 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	30,463,876 - 30,551,090 (-)	NCBI		UU_Cfam_GSD_1.0

Pkp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	76,625,035 - 76,699,086 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936607	3,458,073 - 3,532,543 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936607	3,458,406 - 3,530,066 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	41,424,845 - 41,508,868 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	41,424,687 - 41,509,590 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	44,676,288 - 44,708,684 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	32,225,743 - 32,333,951 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	32,225,600 - 32,333,615 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	2,557,970 - 2,670,195 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	3,261,390 - 3,342,850 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	3,261,446 - 3,344,204 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pkp2
381 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	43
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000002498
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat

Markers in Region

RH127356

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	84,704,540 - 84,704,747 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	88,949,309 - 88,949,515	NCBI	Rnor6.0
Rnor_5.0	11	92,008,373 - 92,008,579	UniSTS	Rnor5.0
Celera	11	83,448,227 - 83,448,433	UniSTS
Cytogenetic Map	6	q31	UniSTS
Cytogenetic Map	11	q23	UniSTS

AI556444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	84,661,799 - 84,662,011 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	88,912,180 - 88,912,391	NCBI	Rnor6.0
Rnor_5.0	11	91,966,064 - 91,966,275	UniSTS	Rnor5.0
RGSC_v3.4	11	86,584,197 - 86,584,408	UniSTS	RGSC3.4
Celera	11	83,407,312 - 83,407,523	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC092602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002498 ⟹ ENSRNOP00000002498

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	84,661,783 - 84,727,730 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103562 ⟹ ENSRNOP00000088522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	84,661,783 - 84,727,730 (-)	Ensembl

RefSeq Acc Id:

NM_001100499 ⟹ NP_001093969

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	98,165,974 - 98,231,916 (-)	NCBI
mRatBN7.2	11	84,661,783 - 84,727,730 (-)	NCBI
Rnor_6.0	11	88,912,163 - 88,972,213 (-)	NCBI
Rnor_5.0	11	91,966,047 - 92,031,277 (-)	NCBI
RGSC_v3.4	11	86,553,493 - 86,584,425 (+)	RGD
Celera	11	83,407,295 - 83,471,505 (-)	RGD

Sequence:

show sequence

GTCCTGGCAGTCCTTTCCTGGTCACCTTGCGGACGCCATGGCGATCCCAGGCTCACTGGGCGAG
TGTGGTTACATCCGGACCGTGCTGGGCCAGCAGATCCTGGGTCACCTGGACAGCTCCAGCCTGG
CCTTGCCCTCCGAGGCCAGGCTGAGGCTAGCGGGCAGCAGCGGCCGCGGCGACCCGGTGGCCCG
GAGCCAGCGGATCCAGGAGCAGGTGCAGCAAACCCTGGCTCGCCGGGGCCGGAGCTCTGTAGTC
GGCGGGAACCTTCACCGAACCAGCAGTGTTCCTGAGTATGTCTACAAGCTGCACTTGGTTGAGA
ATGACTTTGTTGGAAGGCAGTCACCTGCCGCTAGGGACTATGACATGCTTAAGGCTGGAGTGAC
TGCCACTTACGGAAGTCGTTGGGGGAGAGGAACAGCACAGTATAGTTCGCAGAAGTCAGTAGAG
GAGAGATCCTGGAGGCAGCCCCTGAGGAGACTTGAGATTTCCCCAGATAGCAGCCCGGAGAGAG
CCCACTATGGGCACAGCGAATACCAATATGCCTGGCGGAGCCATGTGGTGCCTGGTGGGCGCCT
TACCCTTCCACGCTATGCTCGCTCAGAGATCCTGGGCCTGCGCCAGACTGGCACAGCCCGAAGG
GCACCTGGGTGCGGGTCAGTCAGCGATGCTGTCTTTGACAATGGCCCGCTTAACCCCACCATAC
CCACCCACCCTCCTGGCACCAGCCACAGCGCAGGCAGCCTGCTGGAGGAGACCACTGTGCGTGT
GAGCCAGGCTCGATTTCAGGGCCTGCAGAGCAGAGCCGGCCGCTCCTCCTGGCCCCGGAGCTCA
GTCCACAGTACCTTGCGGGAGTCAGGAAGAATGCTGCCCACCGCAGGCCAGGCTGCGGTGGGCA
GCGGGGATGCGCATCGGGACAGGAGCGCCTTCGCTGACTCCCAGCTCGGGAATGCAGACTTAGA
GATGACCTTGGAGCGAGCTGTGAATATGCTGGATGCAGACCATGTACCACTGTCCAAGATCTCT
GCTGCGGCTACCTTCATACAGCATGAGAGCTTCCAAAAATCTGAAGCACGGAAAAGGGTCAATC
AACTTCAAGGCATCCCTAAACTTCTGCAGCTGCTCAAAGTTCAGAATGAAGACGTTCAGCGGGC
TGTGTGTGGGGCCCTGAGAAATTTGGTATTTGAAGACAATGATAACAAGTTGGAGGTCGCTGAA
CTGAATGGAGTGCCTCGGCTGCTGCAGGTGCTGAAGCAAACCAGAGACTTGGAGACAAAGAAGC
AAATAACAGGTTTGCTCTGGAACTTGTCCTCTAGTGATAAACTCAAGCATCTCATGATAACAGA
AGCCTTGCTCACCTTGACAGAGAGTGTCATCATCCCCTTCTCAGGGTGGCCTGAAGGAGACTAC
CCCAAAGCCAATGGCTTGCTTGATTTTGATATATTCTACAATGTCACTGGATGCCTAAGAAACA
TGAGCTCCGCTGGCCCTGATGGGAGGAAGGTGATGAGGAGGTGTGATGGTCTCATTGATTCATT
GGTCCATTACGTCAGAGGAACCATTGCAGACTACCAGCCAGATGATAAGGCCACAGAGAACTGC
GTATGCATTCTTCATAACCTCTCCTACCAGCTGGAGGCTGAGCTCCCAGAGAAATATTCCCAGA
GTATCTACATGCAAAACCGGAATATCCAGACCAACAGTAACAAAAGCATCGGGTGTTTTGGCAG
CCGGAGTAGAAAAGTAAAGGAGCAATACCAAGACACGCCGATGCCAGAGGAAAGGAGCAGTCCC
CGTGGCATTGAGTGGCTGTGGCATTCCATTGTGATAAGGATGTATTTGTCCTTAATTGCCAAGA
GTTCCCGAAACTATACCCAAGAGGCATCATTGGGAGCTCTCCAGAACCTCACAGCAGGAAGCGG
CCCGATACCCACATCGGTAGCTCGCATGGTTGTCCAGAAGGAAAATGGTCTTCAGCACACCCGG
AAGATGCTGCACGTGGGTGATCCCAGTGTGAAAAAGACTGCAGTCTCCCTGCTGAGGAATTTGT
CACGGAATCTTTCTCTGCAGAATGAAATTGCTAAAGAAACTCTACCAGATTTGGTTTCTATAAT
TCCTGACACAGTCCCAAGTACTGACCTCCTCATTGAAACTACAGCTTCTGCTTGCTATACGTTG
AACAATTTAATGCAAAATAGTTACCAGAATGCACGAGACCTTCTGAACACTGGAGGGCTGCAGA
AAATTATGACCATCAGCATAGGAGAAGGCTATGCCCCCAACAAGGCCAGCAAAGCTGCCTCTGT
CCTCCTGTACTCTCTGTGGGCACACACCGAGCTCCATAATGCCTACAAGAAGGCTCAGTTTAAG
AAGACGGACTTCGTCAACAGCCGGACTGCCAAGGCCTCCCACTCCCTTAAAGACTAATAAGGAG
AAGACGACTCAGGAACTCCAGCTTCACAATTCTCCACTGAAAAAATAAAACAAAAAACAAAAAA
CAAAAAAAAAATCCCCAAAGAAAACACCTATTTTTCTACTAACTGACCCAAGAAACCTCAAAAA
GCATGCTTTGTTTATACTCTTTTCTATTTTCATCCCCCAAATCTAGTAACGAATATCTGAATAT
GATTTTGTTAGACATCCTGGAGACTTGCCAGGTCGCACCAGTGTGGAATCCGTGTTCCCTGTGC
AGATGATGGGCATCAGTATCCAGGCTTATGTACACCCATGTGGGTGCTCATCGGAGGAATCTGA
GGAAGCCTAGTCACTTGTCTGCATGTCACCTCCTTAGTGAGCCAGAGGTGTGTGTGCACCAGTG
CTGCACAGGACCCAAGTGCAGGAATAAAGCTTTGATGGCAGATCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001093969	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92602	(Get FASTA)	NCBI Sequence Viewer
	EDL77846	(Get FASTA)	NCBI Sequence Viewer
	EDL77847	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002498.7
	ENSRNOP00000088522
	ENSRNOP00000088522.1
GenBank Protein	F1M7L9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001093969 ⟸ NM_001100499

- Sequence:

show sequence

MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTL
ARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKAGVTATYGSRWGRGTA
QYSSQKSVEERSWRQPLRRLEISPDSSPERAHYGHSEYQYAWRSHVVPGGRLTLPRYARSEILG
LRQTGTARRAPGCGSVSDAVFDNGPLNPTIPTHPPGTSHSAGSLLEETTVRVSQARFQGLQSRA
GRSSWPRSSVHSTLRESGRMLPTAGQAAVGSGDAHRDRSAFADSQLGNADLEMTLERAVNMLDA
DHVPLSKISAAATFIQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFED
NDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIP
FSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQ
PDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDT
PMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQ
KENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIE
TTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELH
NAYKKAQFKKTDFVNSRTAKASHSLKD

hide sequence

RefSeq Acc Id:

ENSRNOP00000002498 ⟸ ENSRNOT00000002498

RefSeq Acc Id:

ENSRNOP00000088522 ⟸ ENSRNOT00000103562

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M7L9-F1-model_v2	AlphaFold	F1M7L9	1-792	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306533	AgrOrtholog
BioCyc Gene	G2FUF-20549	BioCyc
Ensembl Genes	ENSRNOG00000001825	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002498.8	UniProtKB/Swiss-Prot
	ENSRNOT00000103562	ENTREZGENE
	ENSRNOT00000103562.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7305258	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Armadillo	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Plakophilin/d_Catenin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:287925	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109189	IMAGE-MGC_LOAD
NCBI Gene	287925	ENTREZGENE
PANTHER	PLAKOPHILIN-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLAKOPHILLIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Arm	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pkp2	PhenoGen
PROSITE	ARM_REPEAT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001825	RatGTEx
SMART	ARM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	ARM repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JSR0_RAT	UniProtKB/TrEMBL
	F1M7L9	ENTREZGENE, UniProtKB/Swiss-Prot
	Q562C0_RAT	UniProtKB/TrEMBL
UniProt Secondary	A0A8I6A597	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Pkp2	plakophilin 2	Pkp2_predicted	plakophilin 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Pkp2_predicted	plakophilin 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)