CCL26 (C-C motif chemokine ligand 26) - Rat Genome Database

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Gene: CCL26 (C-C motif chemokine ligand 26) Homo sapiens
Analyze
Symbol: CCL26
Name: C-C motif chemokine ligand 26
RGD ID: 1344177
HGNC Page HGNC:10625
Description: Enables CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of actin filament polymerization; and positive regulation of endothelial cell proliferation. Located in extracellular space. Implicated in asthma; eosinophilic esophagitis; and rhinitis. Biomarker of several diseases, including Churg-Strauss syndrome; dermatitis (multiple); eosinophilic esophagitis; eosinophilic gastroenteritis; and rhinitis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 26; CC chemokine IMAC; chemokine (C-C motif) ligand 26; chemokine N1; eotaxin-3; IMAC; macrophage inflammatory protein 4-alpha; MGC126714; MIP-4-alpha; MIP-4a; MIP-4alpha; SCYA26; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; small-inducible cytokine A26; thymic stroma chemokine-1; TSC-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,769,524 - 75,791,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,769,533 - 75,789,896 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,398,842 - 75,420,915 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,236,778 - 75,257,000 (-)NCBINCBI36Build 36hg18NCBI36
Build 34775,043,492 - 75,063,715NCBI
Celera770,266,590 - 70,286,812 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,484,790 - 70,505,408 (-)NCBIHuRef
CHM1_1775,328,822 - 75,349,108 (-)NCBICHM1_1
T2T-CHM13v2.0777,056,596 - 77,078,673 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,731,906 - 74,752,128 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge. Baumann R, etal., Am J Rhinol Allergy. 2013 Jul-Aug;27(4):266-72. doi: 10.2500/ajra.2013.27.3913.
2. Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Bhattacharya B, etal., Hum Pathol. 2007 Dec;38(12):1744-53. Epub 2007 Sep 27.
3. Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome. Caldwell JM, etal., J Allergy Clin Immunol. 2014 Nov;134(5):1114-24. doi: 10.1016/j.jaci.2014.07.026. Epub 2014 Sep 15.
4. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. Chae SC, etal., Biochem Biophys Res Commun. 2004 Jul 16;320(1):131-7.
5. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. Chae SC, etal., Immunogenetics. 2005 Jan;56(10):760-4. Epub 2004 Dec 4.
6. Nasal fluid release of eotaxin-3 and eotaxin-2 in persistent sinonasal eosinophilic inflammation. De Corso E, etal., Int Forum Allergy Rhinol. 2014 Aug;4(8):617-24. doi: 10.1002/alr.21348. Epub 2014 Jul 2.
7. Markers of eosinophilic inflammation and risk prediction in patients with coronary artery disease. Falcone C, etal., Eur J Clin Invest. 2006 Apr;36(4):211-7.
8. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
9. Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps. Gu Z, etal., J Otolaryngol Head Neck Surg. 2011 Feb;40(1):64-9.
10. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. Ji P, etal., Parasitol Res. 2015 Feb;114(2):613-24. doi: 10.1007/s00436-014-4223-z. Epub 2014 Nov 18.
11. Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Kagami S, etal., Clin Exp Immunol. 2003 Nov;134(2):309-13.
12. High levels of CCL26 in blister fluid and sera of patients with bullous pemphigoid. Kagami S, etal., J Invest Dermatol. 2012 Jan;132(1):249-51. doi: 10.1038/jid.2011.251. Epub 2011 Sep 1.
13. Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions. Kalomenidis I, etal., Chest. 2005 Jun;127(6):2094-100.
14. Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma. Larose MC, etal., J Allergy Clin Immunol. 2015 Oct;136(4):904-13. doi: 10.1016/j.jaci.2015.02.039. Epub 2015 May 1.
15. Genetic interactions model among Eotaxin gene polymorphisms in asthma. Lee JH, etal., J Hum Genet. 2008;53(10):867-75. Epub 2008 Aug 20.
16. Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Lucendo AJ, etal., Am J Gastroenterol. 2008 Sep;103(9):2184-93. doi: 10.1111/j.1572-0241.2008.01937.x.
17. Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Min JW, etal., Chest. 2005 Nov;128(5):3127-32.
18. Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. Miyagaki T, etal., J Invest Dermatol. 2010 Sep;130(9):2304-11. doi: 10.1038/jid.2010.128. Epub 2010 May 27.
19. PGD2 induces eotaxin-3 via PPARgamma from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. Nakahigashi K, etal., J Allergy Clin Immunol. 2012 Feb;129(2):536-43. doi: 10.1016/j.jaci.2011.11.034. Epub 2011 Dec 28.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study. Romano C, etal., Dig Liver Dis. 2014 Jul;46(7):590-5. doi: 10.1016/j.dld.2014.03.003. Epub 2014 Apr 3.
23. Puerarin attenuates airway inflammation by regulation of eotaxin-3. Wang J, etal., Immunol Lett. 2015 Feb;163(2):173-8. doi: 10.1016/j.imlet.2014.12.002. Epub 2014 Dec 19.
24. Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients. Yao T, etal., Laryngoscope. 2009 Jun;119(6):1053-9.
25. Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study. Zwerina J, etal., Rheumatology (Oxford). 2011 Oct;50(10):1823-7. doi: 10.1093/rheumatology/keq445. Epub 2011 Jan 25.
Additional References at PubMed
PMID:9847074   PMID:10373330   PMID:10415065   PMID:10488147   PMID:11329013   PMID:11425309   PMID:11544308   PMID:11748272   PMID:12061839   PMID:12192108   PMID:12477932   PMID:12689946  
PMID:12853948   PMID:12975309   PMID:15039444   PMID:15489334   PMID:15521376   PMID:15784470   PMID:15863444   PMID:16084752   PMID:16264039   PMID:16391516   PMID:16453027   PMID:16604488  
PMID:17073866   PMID:17490641   PMID:17541284   PMID:17703412   PMID:18055844   PMID:18774776   PMID:19141347   PMID:19141349   PMID:19203252   PMID:19258923   PMID:19331716   PMID:19379605  
PMID:19423540   PMID:19525930   PMID:19567623   PMID:20056178   PMID:20059579   PMID:20143648   PMID:20236835   PMID:20406964   PMID:20438785   PMID:20503287   PMID:20974991   PMID:21077277  
PMID:21325281   PMID:21493274   PMID:21832049   PMID:21873635   PMID:21985360   PMID:22226123   PMID:22580413   PMID:22739041   PMID:22846146   PMID:22946025   PMID:22948508   PMID:22952702  
PMID:23185525   PMID:23477905   PMID:23532518   PMID:23607908   PMID:24323578   PMID:24600981   PMID:24684589   PMID:25323950   PMID:25377782   PMID:26116899   PMID:26418908   PMID:26861136  
PMID:27228567   PMID:27300476   PMID:27621211   PMID:27664933   PMID:28089872   PMID:28381538   PMID:29051319   PMID:30197185   PMID:30468398   PMID:30583236   PMID:30778348   PMID:31209239  
PMID:32296183   PMID:32658051   PMID:33008138   PMID:33087148   PMID:33167029   PMID:33764366   PMID:33961781   PMID:34518591   PMID:35799778   PMID:36156375   PMID:36380370   PMID:36543402  
PMID:37200921   PMID:37933466   PMID:38270326  


Genomics

Comparative Map Data
CCL26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,769,524 - 75,791,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,769,533 - 75,789,896 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,398,842 - 75,420,915 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,236,778 - 75,257,000 (-)NCBINCBI36Build 36hg18NCBI36
Build 34775,043,492 - 75,063,715NCBI
Celera770,266,590 - 70,286,812 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,484,790 - 70,505,408 (-)NCBIHuRef
CHM1_1775,328,822 - 75,349,108 (-)NCBICHM1_1
T2T-CHM13v2.0777,056,596 - 77,078,673 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,731,906 - 74,752,128 (-)NCBI
Ccl26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,589,302 - 135,592,423 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,589,302 - 135,592,423 (-)EnsemblGRCm39 Ensembl
GRCm385135,560,448 - 135,563,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,560,448 - 135,563,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,036,318 - 136,039,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,845,075 - 135,848,196 (-)NCBIMGSCv36mm8
Celera5132,571,981 - 132,575,102 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.27NCBI
Ccl26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,745,972 - 26,750,924 (+)NCBIGRCr8
mRatBN7.21221,109,384 - 21,114,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,109,421 - 21,114,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,251,193 - 22,256,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,863,537 - 22,868,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,930,001 - 21,934,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,157,182 - 24,161,870 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,158,766 - 24,161,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,154,496 - 26,159,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,265,430 - 22,268,793 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1222,873,373 - 22,876,736 (+)NCBICelera
Cytogenetic Map12q12NCBI
Ccl26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545614,554,583 - 14,558,967 (-)NCBIChiLan1.0ChiLan1.0
CCL26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2694,180,602 - 94,184,888 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,445,240 - 142,449,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0768,230,804 - 68,251,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,221,846 - 82,242,874 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,221,846 - 82,242,874 (-)Ensemblpanpan1.1panPan2
CCL26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,151,352 - 7,154,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,151,212 - 7,154,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,848,112 - 8,851,272 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,971,954 - 6,975,124 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,971,814 - 6,981,222 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,941,498 - 6,944,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,904,900 - 6,908,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,068,177 - 7,071,344 (-)NCBIUU_Cfam_GSD_1.0
Ccl26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,619,608 - 131,626,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,414,850 - 2,416,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,414,948 - 2,416,922 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,381,306 - 10,385,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,381,306 - 10,385,677 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCL26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,036,177 - 10,038,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,036,337 - 10,038,875 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,400,433 - 6,403,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCL26
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q11.22-21.11(chr7:71225344-81735657)x1 copy number loss See cases [RCV000050709] Chr7:71225344..81735657 [GRCh38]
Chr7:70690330..81364973 [GRCh37]
Chr7:70328266..81202909 [NCBI36]
Chr7:7q11.22-21.11		 pathogenic
GRCh38/hg38 7q11.23(chr7:75526437-76499472)x1 copy number loss See cases [RCV000051302] Chr7:75526437..76499472 [GRCh38]
Chr7:75155767..76128789 [GRCh37]
Chr7:74993703..75966725 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.23(chr7:75567961-76584901)x1 copy number loss See cases [RCV000051303] Chr7:75567961..76584901 [GRCh38]
Chr7:75197265..76214218 [GRCh37]
Chr7:75035201..76052154 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.21-21.11(chr7:64560824-79186156)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052318]|See cases [RCV000052318] Chr7:64560824..79186156 [GRCh38]
Chr7:64021202..78815472 [GRCh37]
Chr7:63658637..78653408 [NCBI36]
Chr7:7q11.21-21.11		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.23(chr7:75769688-76066509)x1 copy number loss See cases [RCV000052686] Chr7:75769688..76066509 [GRCh38]
Chr7:75236942..75533763 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.22-11.23(chr7:69382353-77823832)x1 copy number loss See cases [RCV000054111] Chr7:69382353..77823832 [GRCh38]
Chr7:68847339..77453149 [GRCh37]
Chr7:68485275..77291085 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:73873420-83988860)x1 copy number loss See cases [RCV000054118] Chr7:73873420..83988860 [GRCh38]
Chr7:73992744..83618176 [GRCh37]
Chr7:72925686..83456112 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:75496701-78375575)x1 copy number loss See cases [RCV000054153] Chr7:75496701..78375575 [GRCh38]
Chr7:75126024..78004892 [GRCh37]
Chr7:74963960..77842828 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7q11.23(chr7:73352304-76722261)x1 copy number loss See cases [RCV000133638] Chr7:73352304..76722261 [GRCh38]
Chr7:72766313..76351578 [GRCh37]
Chr7:72404249..76189514 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.23(chr7:75432651-76418304)x1 copy number loss See cases [RCV000135520] Chr7:75432651..76418304 [GRCh38]
Chr7:75061927..76047621 [GRCh37]
Chr7:74899863..75885557 [NCBI36]
Chr7:7q11.23		 likely pathogenic
GRCh38/hg38 7q11.23(chr7:75529854-76611483)x1 copy number loss See cases [RCV000136113] Chr7:75529854..76611483 [GRCh38]
Chr7:75159180..76240800 [GRCh37]
Chr7:74997116..76078736 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.23(chr7:75568161-76584760)x1 copy number loss See cases [RCV000136550] Chr7:75568161..76584760 [GRCh38]
Chr7:75197465..76214077 [GRCh37]
Chr7:75035401..76052013 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.23(chr7:75529854-76626561)x3 copy number gain See cases [RCV000135929] Chr7:75529854..76626561 [GRCh38]
Chr7:75159180..76255878 [GRCh37]
Chr7:74997116..76093814 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.23-21.11(chr7:74377395-82031742)x1 copy number loss See cases [RCV000142381] Chr7:74377395..82031742 [GRCh38]
Chr7:73992744..81661058 [GRCh37]
Chr7:73429661..81498994 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7q11.22-21.11(chr7:72179092-79164071) copy number gain See cases [RCV000143454] Chr7:72179092..79164071 [GRCh38]
Chr7:71644077..78793387 [GRCh37]
Chr7:71282013..78631323 [NCBI36]
Chr7:7q11.22-21.11		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:73591993-75914797)x1 copy number loss See cases [RCV000240532] Chr7:73591993..75914797 [GRCh37]
Chr7:7q11.23		 likely pathogenic
GRCh37/hg19 7q11.23(chr7:75058408-77082896)x1 copy number loss See cases [RCV000449141] Chr7:75058408..77082896 [GRCh37]
Chr7:7q11.23		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:75155154-75729363)x1 copy number loss See cases [RCV000511396] Chr7:75155154..75729363 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:72456604-76007380)x1 copy number loss See cases [RCV000510782] Chr7:72456604..76007380 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:75360014-75426951)x1 copy number loss not provided [RCV000682770] Chr7:75360014..75426951 [GRCh37]
Chr7:7q11.23		 uncertain significance
Single allele deletion not provided [RCV000677988] Chr7:73591993..93683437 [GRCh37]
Chr7:7q11.23-21.3		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75384846-76279036)x3 copy number gain not provided [RCV000682872] Chr7:75384846..76279036 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75085013-75995207)x3 copy number gain not provided [RCV000682874] Chr7:75085013..75995207 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75082354-76007380)x1 copy number loss not provided [RCV000682875] Chr7:75082354..76007380 [GRCh37]
Chr7:7q11.23		 likely pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:75155747-75445377)x3 copy number gain not provided [RCV000746815] Chr7:75155747..75445377 [GRCh37]
Chr7:7q11.23		 benign
NM_001371938.1(CCL26):c.74-10T>C single nucleotide variant not provided [RCV000923814] Chr7:75772013 [GRCh38]
Chr7:75401331 [GRCh37]
Chr7:7q11.23		 likely benign
GRCh37/hg19 7q11.23(chr7:72744494-76038818) copy number loss Williams syndrome [RCV000767638] Chr7:72744494..76038818 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:72621722-76007380)x1 copy number loss not provided [RCV001005967] Chr7:72621722..76007380 [GRCh37]
Chr7:7q11.23		 pathogenic
GRCh37/hg19 7q11.23(chr7:75076890-76007283)x3 copy number gain not provided [RCV000849303] Chr7:75076890..76007283 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q11.23(chr7:75233243-76007283)x3 copy number gain not provided [RCV000849638] Chr7:75233243..76007283 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75091878-76117614)x1 copy number loss not provided [RCV000848509] Chr7:75091878..76117614 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75091880-75951903)x3 copy number gain not provided [RCV002472796] Chr7:75091880..75951903 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:72403117-76709600)x1 copy number loss not provided [RCV001258798] Chr7:72403117..76709600 [GRCh37]
Chr7:7q11.23		 pathogenic
NC_000007.14:g.(75058300_?)_(?_79083658)del deletion Distal 7q11.23 microdeletion syndrome [RCV001839073] Chr7:75058300..79083658 [GRCh38]
Chr7:7q11.23-21.11		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75085014-76007380)x1 copy number loss not provided [RCV002472641] Chr7:75085014..76007380 [GRCh37]
Chr7:7q11.23		 likely pathogenic
GRCh37/hg19 7q11.23(chr7:75146858-75995207)x3 copy number gain not provided [RCV002473454] Chr7:75146858..75995207 [GRCh37]
Chr7:7q11.23		 uncertain significance
NM_001371938.1(CCL26):c.143G>A (p.Arg48Gln) single nucleotide variant Inborn genetic diseases [RCV002973251] Chr7:75771934 [GRCh38]
Chr7:75401252 [GRCh37]
Chr7:7q11.23		 likely benign
NM_001371938.1(CCL26):c.80G>T (p.Ser27Ile) single nucleotide variant Inborn genetic diseases [RCV002772286] Chr7:75771997 [GRCh38]
Chr7:75401315 [GRCh37]
Chr7:7q11.23		 uncertain significance
NM_001371938.1(CCL26):c.178C>T (p.Arg60Trp) single nucleotide variant Inborn genetic diseases [RCV002644882] Chr7:75771899 [GRCh38]
Chr7:75401217 [GRCh37]
Chr7:7q11.23		 uncertain significance
NM_001371938.1(CCL26):c.275A>C (p.Lys92Thr) single nucleotide variant Inborn genetic diseases [RCV003383534] Chr7:75769703 [GRCh38]
Chr7:75399021 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:75148973-75591416)x3 copy number gain not provided [RCV003484685] Chr7:75148973..75591416 [GRCh37]
Chr7:7q11.23		 uncertain significance
GRCh37/hg19 7q11.23(chr7:72732819-76003862)x3 copy number gain not specified [RCV003986700] Chr7:72732819..76003862 [GRCh37]
Chr7:7q11.23		 pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR25hsa-miR-25-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22431589

Predicted Target Of
Summary Value
Count of predictions:530
Count of miRNA genes:255
Interacting mature miRNAs:264
Transcripts:ENST00000005180, ENST00000394905
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D7S1500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37775,419,201 - 75,419,285UniSTSGRCh37
GRCh37775,419,274 - 75,419,637UniSTSGRCh37
Celera770,286,949 - 70,287,033UniSTS
Celera770,287,022 - 70,287,397UniSTS
Cytogenetic Map7q11.23UniSTS
HuRef770,505,618 - 70,506,001UniSTS
HuRef770,505,545 - 70,505,629UniSTS
CRA_TCAGchr7v2774,752,265 - 74,752,349UniSTS
CRA_TCAGchr7v2774,752,338 - 74,752,701UniSTS
Marshfield Genetic Map786.12RGD
D7S1500  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q11.23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 20 36 147 9 12 9 384 11 423 4 154 56 2 1 16 280
Low 1525 1435 890 130 318 87 2821 893 722 211 976 1028 50 1143 1514 2
Below cutoff 775 1005 470 277 560 199 885 1023 1634 152 247 399 81 43 772 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_015989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA926779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB010447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB016542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF096296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF124601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF142434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG211121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000005180   ⟹   ENSP00000005180
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl775,769,538 - 75,772,211 (-)Ensembl
RefSeq Acc Id: ENST00000394905   ⟹   ENSP00000378365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl775,769,533 - 75,789,896 (-)Ensembl
RefSeq Acc Id: NM_001371936   ⟹   NP_001358865
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,769,538 - 75,791,597 (-)NCBI
T2T-CHM13v2.0777,056,610 - 77,078,673 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001371938   ⟹   NP_001358867
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,769,538 - 75,772,211 (-)NCBI
T2T-CHM13v2.0777,056,610 - 77,059,281 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006072   ⟹   NP_006063
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,769,524 - 75,789,746 (-)NCBI
GRCh37775,398,842 - 75,419,064 (-)ENTREZGENE
Build 36775,236,778 - 75,257,000 (-)NCBI Archive
HuRef770,484,790 - 70,505,408 (-)ENTREZGENE
CHM1_1775,328,822 - 75,349,108 (-)NCBI
T2T-CHM13v2.0777,056,596 - 77,076,794 (-)NCBI
CRA_TCAGchr7v2774,731,906 - 74,752,128 (-)ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006063   ⟸   NM_006072
- Peptide Label: precursor
- UniProtKB: A0N0Q5 (UniProtKB/Swiss-Prot),   Q52LV8 (UniProtKB/Swiss-Prot),   Q9Y258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001358865   ⟸   NM_001371936
- Peptide Label: precursor
- UniProtKB: Q9Y258 (UniProtKB/Swiss-Prot),   A0N0Q5 (UniProtKB/Swiss-Prot),   Q52LV8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001358867   ⟸   NM_001371938
- Peptide Label: precursor
- UniProtKB: Q9Y258 (UniProtKB/Swiss-Prot),   A0N0Q5 (UniProtKB/Swiss-Prot),   Q52LV8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSP00000005180   ⟸   ENST00000005180
RefSeq Acc Id: ENSP00000378365   ⟸   ENST00000394905

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y258-F1-model_v2 AlphaFold Q9Y258 1-94 view protein structure

Promoters
RGD ID:7210843
Promoter ID:EPDNEW_H11166
Type:initiation region
Name:CCL26_1
Description:C-C motif chemokine ligand 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11167  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,772,211 - 75,772,271EPDNEW
RGD ID:7210841
Promoter ID:EPDNEW_H11167
Type:initiation region
Name:CCL26_2
Description:C-C motif chemokine ligand 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11166  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,772,357 - 75,772,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10625 AgrOrtholog
COSMIC CCL26 COSMIC
Ensembl Genes ENSG00000006606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000005180 ENTREZGENE
  ENST00000005180.9 UniProtKB/Swiss-Prot
  ENST00000394905 ENTREZGENE
  ENST00000394905.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000006606 GTEx
HGNC ID HGNC:10625 ENTREZGENE
Human Proteome Map CCL26 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:10344 UniProtKB/Swiss-Prot
NCBI Gene 10344 ENTREZGENE
OMIM 604697 OMIM
PANTHER C-C MOTIF CHEMOKINE 26 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35557 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0N0Q5 ENTREZGENE
  CCL26_HUMAN UniProtKB/Swiss-Prot
  Q52LV8 ENTREZGENE
  Q9Y258 ENTREZGENE
UniProt Secondary A0N0Q5 UniProtKB/Swiss-Prot
  Q52LV8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL26  C-C motif chemokine ligand 26  CCL26  chemokine (C-C motif) ligand 26  Symbol and/or name change 5135510 APPROVED