Tln1 (talin 1) - Rat Genome Database

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Gene: Tln1 (talin 1) Rattus norvegicus
Analyze
Symbol: Tln1
Name: talin 1
RGD ID: 1306247
Description: Enables integrin binding activity. Predicted to be involved in several processes, including cytoskeleton organization; integrin activation; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Predicted to be located in adherens junction. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Orthologous to human TLN1 (talin 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313494; MGC116305; talin; talin-1; Tln
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,583,730 - 62,613,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,583,731 - 62,613,687 (-)EnsemblGRCr8
mRatBN7.2557,787,670 - 57,817,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,787,943 - 57,817,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,767,874 - 59,797,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,586,690 - 61,616,546 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,558,034 - 61,588,009 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,033,635 - 59,063,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,033,636 - 59,063,592 (-)Ensemblrn6Rnor6.0
Rnor_5.0563,558,230 - 63,588,186 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,010,952 - 60,040,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,368,517 - 56,398,472 (-)NCBICelera
RGSC_v3.1560,011,137 - 60,040,820 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gallic acid  (ISO)
glucose  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nicotinic acid  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ouabain  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenol red  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IEA,ISO)
anchoring junction  (IEA)
centriolar satellite  (IEA,ISO)
cytoplasm  (IBA)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
focal adhesion  (IBA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
ruffle  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin activation. Banno A and Ginsberg MH, Biochem Soc Trans. 2008 Apr;36(Pt 2):229-34. doi: 10.1042/BST0360229.
2. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, etal., Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17.
3. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. Cerna J, etal., J Mol Biol. 2006 Oct 6;362(5):954-65. Epub 2006 Aug 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10320340   PMID:11807098   PMID:12473654   PMID:12477932   PMID:12782621   PMID:12867986   PMID:15070891   PMID:15647794   PMID:19007553   PMID:19056867   PMID:19779731   PMID:20150896  
PMID:20458337   PMID:21362503   PMID:21423176   PMID:23382103   PMID:23533145   PMID:25468996   PMID:25771432   PMID:26923917   PMID:28131823   PMID:30545799   PMID:33450132  


Genomics

Comparative Map Data
Tln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,583,730 - 62,613,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,583,731 - 62,613,687 (-)EnsemblGRCr8
mRatBN7.2557,787,670 - 57,817,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,787,943 - 57,817,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,767,874 - 59,797,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,586,690 - 61,616,546 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,558,034 - 61,588,009 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,033,635 - 59,063,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,033,636 - 59,063,592 (-)Ensemblrn6Rnor6.0
Rnor_5.0563,558,230 - 63,588,186 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,010,952 - 60,040,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,368,517 - 56,398,472 (-)NCBICelera
RGSC_v3.1560,011,137 - 60,040,820 (-)NCBI
Cytogenetic Map5q22NCBI
TLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,696,948 - 35,732,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,696,948 - 35,732,195 (-)Ensemblhg38GRCh38
GRCh37935,696,945 - 35,732,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,687,334 - 35,722,128 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34935,687,333 - 35,722,128NCBI
Celera935,630,882 - 35,665,942 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,652,933 - 35,688,016 (-)NCBIHuRef
CHM1_1935,697,164 - 35,732,795 (-)NCBICHM1_1
T2T-CHM13v2.0935,717,603 - 35,752,875 (-)NCBIT2T-CHM13v2.0
Tln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,531,513 - 43,562,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,531,519 - 43,562,691 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38443,531,513 - 43,562,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,531,519 - 43,562,691 (-)Ensemblmm10GRCm38
MGSCv37443,544,385 - 43,575,455 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36443,552,618 - 43,583,355 (-)NCBIMGSCv36mm8
Celera443,565,322 - 43,596,576 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Tln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472568,939 - 603,676 (+)Ensembl
ChiLan1.0NW_004955472568,939 - 603,676 (+)NCBIChiLan1.0ChiLan1.0
TLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,856,104 - 88,889,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,862,042 - 88,895,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,549,328 - 35,583,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,351,836 - 36,379,228 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,351,836 - 36,379,228 (-)EnsemblpanPan2panpan1.1
TLN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,227,286 - 52,260,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,227,611 - 52,259,915 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1150,794,867 - 50,827,807 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01153,292,240 - 53,325,176 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,292,242 - 53,324,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,836,787 - 51,869,722 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,820,283 - 51,853,236 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,522,450 - 52,555,390 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,146,099 - 167,179,354 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,693,679 - 3,727,098 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,693,679 - 3,727,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,416,044 - 236,450,922 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11236,416,041 - 236,450,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,141,075 - 264,175,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,870,004 - 44,906,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,876,643 - 44,907,072 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603841,973,581 - 42,009,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,061,290 - 5,095,661 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248685,061,108 - 5,095,433 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tln1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v112,934,685 - 2,964,721 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tln1
308 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:145
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000022400
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH130044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,814,700 - 57,814,894 (+)MAPPERmRatBN7.2
Rnor_6.0559,060,393 - 59,060,586NCBIRnor6.0
Rnor_5.0563,584,987 - 63,585,180UniSTSRnor5.0
RGSC_v3.4560,037,709 - 60,037,902UniSTSRGSC3.4
Celera556,395,273 - 56,395,466UniSTS
RH 3.4 Map5393.7UniSTS
Cytogenetic Map5q22UniSTS
RH140058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,791,576 - 57,791,768 (+)MAPPERmRatBN7.2
Rnor_6.0559,037,270 - 59,037,461NCBIRnor6.0
Rnor_5.0563,561,864 - 63,562,055UniSTSRnor5.0
RGSC_v3.4560,014,586 - 60,014,777UniSTSRGSC3.4
Celera556,372,151 - 56,372,342UniSTS
RH 3.4 Map5392.6UniSTS
Cytogenetic Map5q22UniSTS
MARC_9998-9999:997196716:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,808,270 - 57,809,552 (+)MAPPERmRatBN7.2
Rnor_6.0559,053,963 - 59,055,244NCBIRnor6.0
Rnor_5.0563,578,557 - 63,579,838UniSTSRnor5.0
RGSC_v3.4560,031,279 - 60,032,560UniSTSRGSC3.4
Celera556,388,843 - 56,390,124UniSTS
Cytogenetic Map5q22UniSTS
PMC114562P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8562,613,811 - 62,614,227 (+)Marker Load Pipeline
mRatBN7.2557,818,024 - 57,818,440 (+)MAPPERmRatBN7.2
Rnor_6.0559,063,717 - 59,064,132NCBIRnor6.0
Rnor_5.0563,588,311 - 63,588,726UniSTSRnor5.0
RGSC_v3.4560,041,033 - 60,041,448UniSTSRGSC3.4
Celera556,398,597 - 56,399,012UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022400   ⟹   ENSRNOP00000022401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,583,731 - 62,613,687 (-)Ensembl
mRatBN7.2 Ensembl557,787,943 - 57,817,900 (-)Ensembl
Rnor_6.0 Ensembl559,033,636 - 59,063,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107665   ⟹   ENSRNOP00000089335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,583,731 - 62,613,687 (-)Ensembl
mRatBN7.2 Ensembl557,787,943 - 57,817,900 (-)Ensembl
RefSeq Acc Id: NM_001039025   ⟹   NP_001034114
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,583,731 - 62,613,687 (-)NCBI
mRatBN7.2557,787,943 - 57,817,900 (-)NCBI
Rnor_6.0559,033,636 - 59,063,592 (-)NCBI
Rnor_5.0563,558,230 - 63,588,186 (-)NCBI
RGSC_v3.4560,010,952 - 60,040,908 (-)RGD
Celera556,368,517 - 56,398,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287730   ⟹   XP_063143800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,583,730 - 62,607,819 (-)NCBI
RefSeq Acc Id: NP_001034114   ⟸   NM_001039025
- UniProtKB: G3V852 (UniProtKB/TrEMBL),   A6IJ32 (UniProtKB/TrEMBL),   A6IJ31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022401   ⟸   ENSRNOT00000022400
Ensembl Acc Id: ENSRNOP00000089335   ⟸   ENSRNOT00000107665
RefSeq Acc Id: XP_063143800   ⟸   XM_063287730
- Peptide Label: isoform X1
- UniProtKB: A6IJ31 (UniProtKB/TrEMBL),   A0A8I6ABG6 (UniProtKB/TrEMBL)
Protein Domains
FERM   I/LWEQ   Talin 1-like rod-segment   Talin IBS2B   Talin R4   Talin-1/2 VBS2   Vinculin-binding site-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V852-F1-model_v2 AlphaFold G3V852 1-2541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693678
Promoter ID:EPDNEW_R4203
Type:initiation region
Name:Tln1_1
Description:talin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,063,327 - 59,063,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306247 AgrOrtholog
BioCyc Gene G2FUF-41505 BioCyc
Ensembl Genes ENSRNOG00000016630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022400 ENTREZGENE
  ENSRNOT00000022400.7 UniProtKB/TrEMBL
  ENSRNOT00000107665 ENTREZGENE
  ENSRNOT00000107665.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  I/LWEQ domain UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Talin, central domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7373937 IMAGE-MGC_LOAD
  IMAGE:7374352 IMAGE-MGC_LOAD
InterPro Alpha-catenin/vinculin-like_sf UniProtKB/TrEMBL
  Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_f0 UniProtKB/TrEMBL
  I/LWEQ_dom_sf UniProtKB/TrEMBL
  ILWEQ UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Talin1/2-RS UniProtKB/TrEMBL
  Talin1/2_VBS2 UniProtKB/TrEMBL
  Talin_cent UniProtKB/TrEMBL
  Talin_cent_sf UniProtKB/TrEMBL
  Talin_IBS2B UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  TLN1-like_RS UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  Vinculin-bd_dom UniProtKB/TrEMBL
KEGG Report rno:313494 UniProtKB/TrEMBL
MGC_CLONE MGC:116305 IMAGE-MGC_LOAD
  MGC:125179 IMAGE-MGC_LOAD
NCBI Gene 313494 ENTREZGENE
PANTHER TALIN UniProtKB/TrEMBL
  TALIN-1 UniProtKB/TrEMBL
Pfam FERM_f0 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  Talin_IBS2B UniProtKB/TrEMBL
  Talin_middle UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  Talin_VBS2 UniProtKB/TrEMBL
  TLN1-like_RS UniProtKB/TrEMBL
  VBS UniProtKB/TrEMBL
PhenoGen Tln1 PhenoGen
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016630 RatGTEx
SMART B41 UniProtKB/TrEMBL
  ILWEQ UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF109885 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  Talin_cent UniProtKB/TrEMBL
  Vinculin/catenin UniProtKB/TrEMBL
UniProt A0A8I6ABG6 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ31 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ32 ENTREZGENE, UniProtKB/TrEMBL
  G3V852 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7U7_RAT UniProtKB/TrEMBL
  Q498D4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tln1  talin 1  Tln  talin  Symbol and Name updated 1299863 APPROVED
2005-12-06 Tln  talin  Tln_predicted  talin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tln_predicted  talin (predicted)      Symbol and Name status set to approved 70820 APPROVED