RGD Reference Report - Talins and kindlins: partners in integrin-mediated adhesion. - Rat Genome Database

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Talins and kindlins: partners in integrin-mediated adhesion.

Authors: Calderwood, DA  Campbell, ID  Critchley, DR 
Citation: Calderwood DA, etal., Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17.
RGD ID: 7349373
Pubmed: PMID:23860236   (View Abstract at PubMed)
PMCID: PMC4116690   (View Article at PubMed Central)
DOI: DOI:10.1038/nrm3624   (Journal Full-text)

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix (or cellular counter-receptors) and intracellular cytoskeletal and signalling networks, enabling cells to sense and respond to their chemical and physical environment. Talins and kindlins, two families of FERM-domain proteins, bind the cytoplasmic tail of integrins, recruit cytoskeletal and signalling proteins involved in mechanotransduction and synergize to activate integrin binding to extracellular ligands. New data reveal the domain structure of full-length talin, provide insights into talin-mediated integrin activation and show that RIAM recruits talin to the plasma membrane, whereas vinculin stabilizes talin in cell-matrix junctions. How kindlins act is less well-defined, but disease-causing mutations show that kindlins are also essential for integrin activation, adhesion, cell spreading and signalling.

Objects Annotated

Genes (Rattus norvegicus)
Fblim1  (filamin binding LIM protein 1)
Fermt1  (FERM domain containing kindlin 1)
Fermt2  (FERM domain containing kindlin 2)
Fermt3  (FERM domain containing kindlin 3)
Itgb1bp1  (integrin subunit beta 1 binding protein 1)
Krit1  (KRIT1, ankyrin repeat containing)
Sharpin  (SHANK-associated RH domain interactor)
Tln1  (talin 1)
Tln2  (talin 2)

Genes (Mus musculus)
Fblim1  (filamin binding LIM protein 1)
Fermt1  (fermitin family member 1)
Fermt2  (fermitin family member 2)
Fermt3  (fermitin family member 3)
Itgb1bp1  (integrin beta 1 binding protein 1)
Krit1  (KRIT1, ankyrin repeat containing)
Sharpin  (SHANK-associated RH domain interacting protein)
Tln1  (talin 1)
Tln2  (talin 2)

Genes (Homo sapiens)
FBLIM1  (filamin binding LIM protein 1)
FERMT1  (FERM domain containing kindlin 1)
FERMT2  (FERM domain containing kindlin 2)
FERMT3  (FERM domain containing kindlin 3)
ITGB1BP1  (integrin subunit beta 1 binding protein 1)
KRIT1  (KRIT1 ankyrin repeat containing)
SHARPIN  (SHANK associated RH domain interactor)
TLN1  (talin 1)
TLN2  (talin 2)


Additional Information