TLN1 (talin 1) - Rat Genome Database

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Gene: TLN1 (talin 1) Pan paniscus
Analyze
Symbol: TLN1
Name: talin 1
RGD ID: 11837124
Description: ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN cell-substrate junction assembly (ortholog); cortical actin cytoskeleton organization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; integrin mediated signaling pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN adherens junction (inferred); cytoplasm (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: talin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,856,104 - 88,889,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,862,042 - 88,895,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,549,328 - 35,583,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,351,836 - 36,379,228 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,351,836 - 36,379,228 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,856,104 - 88,889,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,862,042 - 88,895,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,549,328 - 35,583,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,351,836 - 36,379,228 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,351,836 - 36,379,228 (-)Ensemblpanpan1.1panPan2
TLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,696,948 - 35,732,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,696,948 - 35,732,195 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,696,945 - 35,732,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,687,334 - 35,722,128 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,687,333 - 35,722,128NCBI
Celera935,630,882 - 35,665,942 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,652,933 - 35,688,016 (-)NCBIHuRef
CHM1_1935,697,164 - 35,732,795 (-)NCBICHM1_1
T2T-CHM13v2.0935,717,603 - 35,752,875 (-)NCBIT2T-CHM13v2.0
Tln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,531,513 - 43,562,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,531,519 - 43,562,691 (-)EnsemblGRCm39 Ensembl
GRCm38443,531,513 - 43,562,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,531,519 - 43,562,691 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,544,385 - 43,575,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,552,618 - 43,583,355 (-)NCBIMGSCv36mm8
Celera443,565,322 - 43,596,576 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Tln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,583,730 - 62,613,687 (-)NCBIGRCr8
mRatBN7.2557,787,670 - 57,817,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,787,943 - 57,817,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,767,874 - 59,797,730 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,586,690 - 61,616,546 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,558,034 - 61,588,009 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,033,635 - 59,063,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,033,636 - 59,063,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,558,230 - 63,588,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,010,952 - 60,040,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,011,137 - 60,040,820 (-)NCBI
Celera556,368,517 - 56,398,472 (-)NCBICelera
Cytogenetic Map5q22NCBI
Tln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472568,939 - 603,676 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472568,939 - 603,676 (+)NCBIChiLan1.0ChiLan1.0
TLN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,227,286 - 52,260,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,227,611 - 52,259,915 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,794,867 - 50,827,807 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,292,240 - 53,325,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,292,242 - 53,324,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,836,787 - 51,869,722 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,820,283 - 51,853,236 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,522,450 - 52,555,390 (-)NCBIUU_Cfam_GSD_1.0
Tln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,146,099 - 167,179,354 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,693,679 - 3,727,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,693,679 - 3,727,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,416,044 - 236,450,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,416,041 - 236,450,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,141,075 - 264,175,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,870,004 - 44,906,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,876,643 - 44,907,072 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,973,581 - 42,009,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,061,290 - 5,095,661 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,061,108 - 5,095,433 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000029039   ⟹   ENSPPAP00000007043
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,351,836 - 36,379,228 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000029048   ⟹   ENSPPAP00000007048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,352,037 - 36,370,054 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000029058   ⟹   ENSPPAP00000007056
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,352,290 - 36,379,192 (-)Ensembl
RefSeq Acc Id: XM_034967401   ⟹   XP_034823292
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,856,104 - 88,889,994 (+)NCBI
NHGRI_mPanPan1988,862,042 - 88,895,932 (+)NCBI
Mhudiblu_PPA_v0935,549,328 - 35,583,376 (-)NCBI
RefSeq Acc Id: XM_034967402   ⟹   XP_034823293
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,864,233 - 88,889,994 (+)NCBI
NHGRI_mPanPan1988,870,171 - 88,895,932 (+)NCBI
Mhudiblu_PPA_v0935,549,328 - 35,575,090 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034823292 (Get FASTA)   NCBI Sequence Viewer  
  XP_034823293 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000007043.1
  ENSPPAP00000007048.1
  ENSPPAP00000007056.1
Reference Protein Sequences
RefSeq Acc Id: XP_034823292   ⟸   XM_034967401
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZT34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034823293   ⟸   XM_034967402
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZT34 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000007048   ⟸   ENSPPAT00000029048
RefSeq Acc Id: ENSPPAP00000007043   ⟸   ENSPPAT00000029039
RefSeq Acc Id: ENSPPAP00000007056   ⟸   ENSPPAT00000029058
Protein Domains
FERM   I/LWEQ   Talin R4   Vinculin-binding site-containing


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000029039.1 UniProtKB/TrEMBL
  ENSPPAT00000029048.1 UniProtKB/TrEMBL
  ENSPPAT00000029058.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  I/LWEQ domain UniProtKB/TrEMBL
  Talin, central domain UniProtKB/TrEMBL
InterPro Alpha-catenin/vinculin-like_sf UniProtKB/TrEMBL
  Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_f0 UniProtKB/TrEMBL
  I/LWEQ_dom_sf UniProtKB/TrEMBL
  ILWEQ_dom UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Talin1/2-RS UniProtKB/TrEMBL
  Talin_cent UniProtKB/TrEMBL
  Talin_cent_sf UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Vinculin-bd_dom UniProtKB/TrEMBL
NCBI Gene TLN1 ENTREZGENE
PANTHER TALIN UniProtKB/TrEMBL
  TALIN-1 UniProtKB/TrEMBL
Pfam FERM_f0 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
  Talin_middle UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  VBS UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  ILWEQ UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF109880 UniProtKB/TrEMBL
  SSF109885 UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF47220 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A2R8ZQ40_PANPA UniProtKB/TrEMBL
  A0A2R8ZT34 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZT39_PANPA UniProtKB/TrEMBL