Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ephb3 | Rat | (S)-nicotine | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of EPHB3 mRNA | CTD | PMID:18247414 | Ephb3 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Ephb3 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EPHB3 mRNA | CTD | PMID:22206623 | Ephb3 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of EPHB3 mRNA | CTD | PMID:30723492 | Ephb3 | Rat | 15-acetyldeoxynivalenol | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | 15-acetyldeoxynivalenol results in increased expression of EPHB3 mRNA | CTD | PMID:23792671 | Ephb3 | Rat | 17beta-estradiol | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of EPHB3 mRNA | CTD | PMID:36828454 | Ephb3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPHB3 mRNA | CTD | PMID:19933214 | Ephb3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPHB3 mRNA | CTD | PMID:32109520 | Ephb3 | Rat | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of EPHB3 mRNA | CTD | PMID:17982090 | Ephb3 | Rat | 2-naphthylamine | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | 2-Naphthylamine results in increased expression of EPHB3 mRNA | CTD | PMID:18247414 | Ephb3 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of EPHB3 mRNA | CTD | PMID:25172293 | Ephb3 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EPHB3 mRNA | CTD | PMID:20188158 | Ephb3 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Ephb3 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of EPHB3 promoter | CTD | PMID:33297965 | Ephb3 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Ephb3 (Mus musculus) | 6480464 | bisphenol S affects the methylation of EPHB3 gene | CTD | PMID:31683443 | Ephb3 | Rat | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of EPHB3 mRNA | CTD | PMID:24780913 | Ephb3 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of EPHB3 mRNA | CTD | PMID:24780913 | Ephb3 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EPHB3 mRNA | CTD | PMID:23630614 | Ephb3 | Rat | all-trans-retinoic acid | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EPHB3 mRNA | CTD | PMID:23724009 | Ephb3 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of EPHB3 mRNA | CTD | PMID:35163327 | Ephb3 | Rat | antirheumatic drug | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EPHB3 mRNA | CTD | PMID:24449571 | Ephb3 | Rat | arsane | affects methylation | ISO | EPHB3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EPHB3 gene | CTD | PMID:25304211 | Ephb3 | Rat | arsenic atom | affects methylation | ISO | EPHB3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EPHB3 gene | CTD | PMID:25304211 | Ephb3 | Rat | atrazine | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Atrazine results in increased expression of EPHB3 mRNA | CTD | PMID:22378314 | Ephb3 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of EPHB3 gene | CTD | PMID:35440735 | Ephb3 | Rat | benzatropine | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein | CTD | PMID:34122009 | Ephb3 | Rat | benzo[a]pyrene | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of EPHB3 mRNA | CTD | PMID:18247414 | Ephb3 | Rat | benzo[a]pyrene | increases methylation | ISO | EPHB3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EPHB3 promoter | CTD | PMID:27901495 | Ephb3 | Rat | beta-lapachone | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of EPHB3 mRNA | CTD | PMID:38218311 | Ephb3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPHB3 mRNA | CTD | PMID:25181051|PMID:33296240|PMID:34947998 | Ephb3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EPHB3 mRNA | CTD | PMID:41034487 | Ephb3 | Rat | bisphenol A | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of EPHB3 mRNA | CTD | PMID:32156529 | Ephb3 | Rat | bisphenol A | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EPHB3 gene | CTD | PMID:31601247 | Ephb3 | Rat | bisphenol A | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EPHB3 mRNA | CTD | PMID:27685785|PMID:36828454 | Ephb3 | Rat | butanal | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of EPHB3 mRNA | CTD | PMID:26079696 | Ephb3 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of EPHB3 mRNA | CTD | PMID:19167457 | Ephb3 | Rat | cadmium atom | multiple interactions | ISO | Ephb3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EPHB3 more ... | CTD | PMID:37325564 | Ephb3 | Rat | cadmium dichloride | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of EPHB3 mRNA | CTD | PMID:38568856 | Ephb3 | Rat | cadmium dichloride | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of EPHB3 mRNA | CTD | PMID:38174414 | Ephb3 | Rat | cadmium dichloride | multiple interactions | ISO | Ephb3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EPHB3 more ... | CTD | PMID:37325564 | Ephb3 | Rat | carbon nanotube | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of EPHB3 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Ephb3 | Rat | chromium(6+) | affects expression | ISO | Ephb3 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of EPHB3 mRNA | CTD | PMID:28472532 | Ephb3 | Rat | cisplatin | multiple interactions | ISO | Ephb3 (Mus musculus) | 6480464 | [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of more ... | CTD | PMID:23625948 | Ephb3 | Rat | cisplatin | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of EPHB3 mRNA | CTD | PMID:27392435 | Ephb3 | Rat | cisplatin | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of EPHB3 mRNA | CTD | PMID:27392435 | Ephb3 | Rat | clozapine | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Clozapine results in increased expression of EPHB3 protein | CTD | PMID:34122009 | Ephb3 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of EPHB3 mRNA | CTD | PMID:15691709 | Ephb3 | Rat | copper(II) chloride | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of EPHB3 mRNA | CTD | PMID:38568856 | Ephb3 | Rat | Cuprizon | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein | CTD | PMID:34122009 | Ephb3 | Rat | DDE | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of EPHB3 mRNA | CTD | PMID:38568856 | Ephb3 | Rat | dibutyl phthalate | affects expression | EXP | | 6480464 | Dibutyl Phthalate affects the expression of EPHB3 mRNA | CTD | PMID:30934153 | Ephb3 | Rat | dorsomorphin | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Ephb3 | Rat | doxorubicin | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of EPHB3 mRNA | CTD | PMID:29803840 | Ephb3 | Rat | doxorubicin | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of EPHB3 mRNA | CTD | PMID:39631538 | Ephb3 | Rat | ethanol | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Ethanol results in increased expression of EPHB3 mRNA | CTD | PMID:30319688 | Ephb3 | Rat | folic acid | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Folic Acid results in increased expression of EPHB3 mRNA | CTD | PMID:25629700 | Ephb3 | Rat | folic acid | multiple interactions | ISO | Ephb3 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EPHB3 mRNA | CTD | PMID:22206623 | Ephb3 | Rat | fulvestrant | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EPHB3 gene | CTD | PMID:31601247 | Ephb3 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of EPHB3 mRNA | CTD | PMID:27387713 | Ephb3 | Rat | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of EPHB3 gene | CTD | PMID:27387713 | Ephb3 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of EPHB3 mRNA | CTD | PMID:33387578 | Ephb3 | Rat | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of EPHB3 mRNA | CTD | PMID:11578147 | Ephb3 | Rat | lipopolysaccharide | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of EPHB3 mRNA | CTD | PMID:35811015 | Ephb3 | Rat | lipopolysaccharide | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of EPHB3 mRNA | CTD | PMID:35811015 | Ephb3 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of EPHB3 gene | CTD | PMID:35440735 | Ephb3 | Rat | methylisothiazolinone | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of EPHB3 mRNA | CTD | PMID:31629900 | Ephb3 | Rat | N-methyl-N'-nitro-N-nitrosoguanidine | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Methylnitronitrosoguanidine results in decreased expression of EPHB3 mRNA | CTD | PMID:12634122 | Ephb3 | Rat | nicotine | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of EPHB3 mRNA | CTD | PMID:18247414 | Ephb3 | Rat | okadaic acid | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of EPHB3 mRNA | CTD | PMID:38832940 | Ephb3 | Rat | paracetamol | affects expression | ISO | Ephb3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of EPHB3 mRNA | CTD | PMID:17562736 | Ephb3 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of EPHB3 mRNA | CTD | PMID:33387578 | Ephb3 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of EPHB3 mRNA | CTD | PMID:35163327 | Ephb3 | Rat | ponatinib | decreases activity | ISO | EPHB3 (Homo sapiens) | 6480464 | ponatinib results in decreased activity of EPHB3 protein | CTD | PMID:19878872 | Ephb3 | Rat | potassium dichromate | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of EPHB3 mRNA | CTD | PMID:23608068 | Ephb3 | Rat | propanal | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of EPHB3 mRNA | CTD | PMID:26079696 | Ephb3 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of EPHB3 mRNA | CTD | PMID:35811015 | Ephb3 | Rat | SB 431542 | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Ephb3 | Rat | silicon dioxide | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of EPHB3 mRNA | CTD | PMID:25895662 | Ephb3 | Rat | sodium arsenite | affects methylation | ISO | EPHB3 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of EPHB3 gene | CTD | PMID:28589171 | Ephb3 | Rat | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of EPHB3 mRNA | CTD | PMID:19281266 | Ephb3 | Rat | sunitinib | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EPHB3 mRNA | CTD | PMID:31533062 | Ephb3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of EPHB3 mRNA | CTD | PMID:34492290 | Ephb3 | Rat | titanium dioxide | decreases methylation | ISO | Ephb3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of EPHB3 promoter | CTD | PMID:35295148 | Ephb3 | Rat | titanium dioxide | increases methylation | ISO | Ephb3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of EPHB3 gene | CTD | PMID:35295148 | Ephb3 | Rat | Tributyltin oxide | increases expression | ISO | Ephb3 (Mus musculus) | 6480464 | bis(tri-n-butyltin)oxide results in increased expression of EPHB3 mRNA | CTD | PMID:18958704 | Ephb3 | Rat | trichloroethene | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | Trichloroethylene results in decreased expression of EPHB3 mRNA | CTD | PMID:15363585 | Ephb3 | Rat | triptonide | decreases expression | ISO | Ephb3 (Mus musculus) | 6480464 | triptonide results in decreased expression of EPHB3 mRNA | CTD | PMID:33045310 | Ephb3 | Rat | urethane | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Urethane results in increased expression of EPHB3 mRNA | CTD | PMID:28818685 | Ephb3 | Rat | valproic acid | affects expression | ISO | Ephb3 (Mus musculus) | 6480464 | Valproic Acid affects the expression of EPHB3 mRNA | CTD | PMID:17292431 | Ephb3 | Rat | valproic acid | increases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPHB3 mRNA | CTD | PMID:24383497|PMID:26272509 | Ephb3 | Rat | valproic acid | multiple interactions | ISO | EPHB3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Ephb3 | Rat | zearalenone | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | Zearalenone results in decreased expression of EPHB3 mRNA | CTD | PMID:36828454 | Ephb3 | Rat | zoledronic acid | decreases expression | ISO | EPHB3 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of EPHB3 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||





















