Bag1 (BAG cochaperone 1) - Rat Genome Database

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Gene: Bag1 (BAG cochaperone 1) Rattus norvegicus
Analyze
Symbol: Bag1
Name: BAG cochaperone 1
RGD ID: 1305203
Description: Predicted to enable adenyl-nucleotide exchange factor activity; protein-folding chaperone binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of Schwann cell differentiation; regulation of apoptotic process; and response to benzene. Located in perinuclear region of cytoplasm. Biomarker of lesion of sciatic nerve. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BAG1 (BAG cochaperone 1); PARTICIPATES IN chaperone mediated autophagy pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; benzene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BAG family molecular chaperone regulator 1; BAG-1; bcl-2-associated athanogene 1; Bcl2 associated athanogene 1; BCL2-associated athanogene; Bcl2-associated athanogene 1; LOC297994
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,864,476 - 60,877,059 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,864,476 - 60,878,161 (-)EnsemblGRCr8
mRatBN7.2556,068,494 - 56,081,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,068,494 - 56,081,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,035,035 - 58,047,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,854,186 - 59,866,762 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,848,377 - 59,861,135 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,254,421 - 57,267,002 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,254,421 - 57,267,002 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,785,751 - 61,798,332 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,329,720 - 58,342,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,680,341 - 54,692,922 (-)NCBICelera
RGSC_v3.1558,329,898 - 58,342,460 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amiodarone  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
formaldehyde  (ISO)
GSK-J4  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
Mitotane  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naled  (ISO)
nickel dichloride  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrethrins  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
sarin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IBA,ISO)
membrane  (IBA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Loss of bag-1 immunoreactivity in rat brain after transient middle cerebral artery occlusion. Hayashi T, etal., Brain Res. 2000 Jan 10;852(2):496-500.
4. Overexpression and gene amplification of BAG-1L in hormone-refractory prostate cancer. Maki HE, etal., J Pathol. 2007 Aug;212(4):395-401.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. BAG-1 expression in normal and neoplastic endometrium. Moriyama T, etal., Gynecol Oncol. 2004 Aug;94(2):289-95.
7. Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer. Nadler Y, etal., Breast Cancer Res. 2008 Apr 22;10(2):R35.
8. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. Orr AL, etal., J Biol Chem. 2008 Jun 6;283(23):16027-36. doi: 10.1074/jbc.M710606200. Epub 2008 Apr 8.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury. Sawitzki B, etal., Hum Gene Ther. 2002 Aug 10;13(12):1495-504.
14. Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: the role of glycogen-synthase-kinase-3beta. Silva R, etal., Neuroscience. 2008 Mar 27;152(3):656-69. Epub 2007 Dec 23.
15. BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. Turner BC, etal., J Clin Oncol. 2001 Feb 15;19(4):992-1000.
16. Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia. Weaver CV and Liu SP, Exp Toxicol Pathol. 2008 Mar;59(5):265-72. Epub 2008 Feb 21.
17. Changes in the BAG1 expression of Schwann cells after sciatic nerve crush. Wu H, etal., J Mol Neurosci. 2013 Mar;49(3):512-22. doi: 10.1007/s12031-012-9910-6. Epub 2012 Oct 30.
18. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
19. Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding protein are controlled by withdrawal of nicotine from cultured pheochromocytoma PC12 cells. Yamada K, etal., J Neural Transm. 2005 May;112(5):633-9. Epub 2005 Mar 23.
20. A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes. Yang L, etal., J Cell Biochem. 2007 Oct 15;102(3):786-800.
21. Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer. Yang X, etal., Exp Cell Res. 1999 Feb 25;247(1):200-7.
22. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
23. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. Zhou R, etal., J Neurosci. 2005 May 4;25(18):4493-502.
Additional References at PubMed
PMID:7834747   PMID:8889548   PMID:9396724   PMID:9679980   PMID:11965493   PMID:12477932   PMID:12853476   PMID:14978028   PMID:16116448   PMID:16207813   PMID:17046197   PMID:18242589  
PMID:18793351   PMID:20516211   PMID:21630459   PMID:22526508   PMID:22647578   PMID:24318877   PMID:33025573  


Genomics

Comparative Map Data
Bag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,864,476 - 60,877,059 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,864,476 - 60,878,161 (-)EnsemblGRCr8
mRatBN7.2556,068,494 - 56,081,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,068,494 - 56,081,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,035,035 - 58,047,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,854,186 - 59,866,762 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,848,377 - 59,861,135 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,254,421 - 57,267,002 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,254,421 - 57,267,002 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,785,751 - 61,798,332 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,329,720 - 58,342,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,680,341 - 54,692,922 (-)NCBICelera
RGSC_v3.1558,329,898 - 58,342,460 (-)NCBI
Cytogenetic Map5q22NCBI
BAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,252,471 - 33,264,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,247,820 - 33,264,720 (-)Ensemblhg38GRCh38
GRCh37933,252,469 - 33,264,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,242,469 - 33,254,761 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34933,245,025 - 33,254,737NCBI
Celera933,182,605 - 33,194,897 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,209,370 - 33,221,664 (-)NCBIHuRef
CHM1_1933,251,269 - 33,264,545 (-)NCBICHM1_1
T2T-CHM13v2.0933,271,122 - 33,283,355 (-)NCBIT2T-CHM13v2.0
Bag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,936,398 - 40,948,294 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,936,398 - 40,948,294 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38440,936,398 - 40,948,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,936,398 - 40,948,294 (-)Ensemblmm10GRCm38
MGSCv37440,883,431 - 40,895,327 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36441,125,088 - 41,136,908 (-)NCBIMGSCv36mm8
Celera440,597,072 - 40,608,972 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.67NCBI
Bag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554722,396,543 - 2,404,333 (+)Ensembl
ChiLan1.0NW_0049554722,394,317 - 2,405,199 (+)NCBIChiLan1.0ChiLan1.0
BAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,339,036 - 91,348,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,345,096 - 91,354,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,033,267 - 33,043,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,841,254 - 33,851,242 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,841,449 - 33,851,167 (-)EnsemblpanPan2panpan1.1
BAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,348,833 - 50,363,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,350,999 - 50,363,581 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1148,978,818 - 48,993,481 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01151,288,922 - 51,303,809 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,288,044 - 51,303,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,953,304 - 49,967,917 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,820,251 - 49,835,112 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,585,344 - 50,600,226 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,245,421 - 165,256,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,791,119 - 1,804,151 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,793,001 - 1,804,145 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,227,337 - 33,242,230 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11033,227,530 - 33,240,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,484,543 - 37,497,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,006,177 - 47,016,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,900,059 - 43,910,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,015,044 - 38,025,079 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473638,015,150 - 38,025,079 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bag1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,234,366 - 117,246,964 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bag1
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000011455
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
Bag1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,068,527 - 56,068,738 (+)MAPPERmRatBN7.2
Rnor_6.0557,254,455 - 57,254,665NCBIRnor6.0
Rnor_5.0561,785,785 - 61,785,995UniSTSRnor5.0
RGSC_v3.4558,329,749 - 58,329,959UniSTSRGSC3.4
Celera554,680,375 - 54,680,585UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011455   ⟹   ENSRNOP00000011455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,864,476 - 60,878,161 (-)Ensembl
mRatBN7.2 Ensembl556,068,494 - 56,081,075 (-)Ensembl
Rnor_6.0 Ensembl557,254,421 - 57,267,002 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170776   ⟹   ENSRNOP00000106198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,864,476 - 60,877,685 (-)Ensembl
RefSeq Acc Id: NM_001106647   ⟹   NP_001100117
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,864,476 - 60,877,059 (-)NCBI
mRatBN7.2556,068,494 - 56,081,075 (-)NCBI
Rnor_6.0557,254,421 - 57,267,002 (-)NCBI
Rnor_5.0561,785,751 - 61,798,332 (-)NCBI
RGSC_v3.4558,329,720 - 58,342,293 (-)RGD
Celera554,680,341 - 54,692,922 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001256084   ⟹   NP_001243013
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,864,476 - 60,877,059 (-)NCBI
mRatBN7.2556,068,494 - 56,081,075 (-)NCBI
Rnor_6.0557,254,421 - 57,267,002 (-)NCBI
Rnor_5.0561,785,751 - 61,798,332 (-)NCBI
Celera554,680,341 - 54,692,922 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100117   ⟸   NM_001106647
- Peptide Label: isoform 1L
- UniProtKB: B0K019 (UniProtKB/Swiss-Prot),   F1LRM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243013   ⟸   NM_001256084
- Peptide Label: isoform 1S
- UniProtKB: A6IIS9 (UniProtKB/TrEMBL),   A6IIS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011455   ⟸   ENSRNOT00000011455
Ensembl Acc Id: ENSRNOP00000106198   ⟸   ENSRNOT00000170776
Protein Domains
BAG   Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0K019-F1-model_v2 AlphaFold B0K019 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693639
Promoter ID:EPDNEW_R4163
Type:initiation region
Name:Bag1_1
Description:Bcl2 associated athanogene 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0557,266,987 - 57,267,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305203 AgrOrtholog
BioCyc Gene G2FUF-41584 BioCyc
Ensembl Genes ENSRNOG00000008277 Ensembl
Gene3D-CATH 1.20.58.120 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8370352 IMAGE-MGC_LOAD
InterPro BAG_chaperone_regulator UniProtKB/Swiss-Prot
  BAG_dom_sf UniProtKB/Swiss-Prot
  BAG_domain UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/Swiss-Prot
KEGG Report rno:297994 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188704 IMAGE-MGC_LOAD
NCBI Gene 297994 ENTREZGENE
PANTHER PTHR12329 UniProtKB/Swiss-Prot
  PTHR12329:SF16 UniProtKB/Swiss-Prot
Pfam BAG UniProtKB/Swiss-Prot
  ubiquitin UniProtKB/Swiss-Prot
PhenoGen Bag1 PhenoGen
PROSITE BAG UniProtKB/Swiss-Prot
  UBIQUITIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008277 RatGTEx
SMART BAG UniProtKB/Swiss-Prot
  UBQ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot
  SSF63491 UniProtKB/Swiss-Prot
UniProt A0ABK0LKM8_RAT UniProtKB/TrEMBL
  A6IIS8 ENTREZGENE, UniProtKB/TrEMBL
  A6IIS9 ENTREZGENE, UniProtKB/TrEMBL
  B0K019 ENTREZGENE, UniProtKB/Swiss-Prot
  F1LRM5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Bag1  BAG cochaperone 1  Bag1  Bcl2 associated athanogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Bag1  Bcl2 associated athanogene 1  Bag1  BCL2-associated athanogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bag1  BCL2-associated athanogene  Bag1  Bcl2-associated athanogene 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bag1  Bcl2-associated athanogene 1   Bag1_predicted  Bcl2-associated athanogene 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bag1_predicted  Bcl2-associated athanogene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED