Polg2 (DNA polymerase gamma 2, accessory subunit) - Rat Genome Database

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Gene: Polg2 (DNA polymerase gamma 2, accessory subunit) Rattus norvegicus
Analyze
Symbol: Polg2
Name: DNA polymerase gamma 2, accessory subunit
RGD ID: 1305128
Description: Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication. Predicted to act upstream of or within in utero embryonic development; mitochondrial DNA metabolic process; and mitochondrion organization. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA polymerase subunit gamma-2, mitochondrial; LOC303612; polymerase (DNA directed), gamma 2, accessory subunit; polymerase (DNA) gamma 2, accessory subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,212,303 - 92,222,849 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1092,212,304 - 92,222,726 (-)EnsemblGRCr8
mRatBN7.21091,712,586 - 91,723,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,712,586 - 91,723,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,768,140 - 96,778,559 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,231,315 - 96,241,734 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,634,688 - 91,645,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,968,836 - 94,979,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,968,836 - 94,979,259 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,714,851 - 94,724,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41096,120,205 - 96,130,221 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,379,006 - 90,389,432 (-)NCBICelera
RGSC_v3.11096,134,677 - 96,144,202 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
calcium dihydroxide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl fumarate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
estriol  (ISO)
flutamide  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
methylisothiazolinone  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Tewari S, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):492-504. doi: 10.1089/ars.2011.4333. Epub 2012 Feb 17.
Additional References at PubMed
PMID:10608893   PMID:10666468   PMID:11172710   PMID:12477932   PMID:14651853   PMID:15167897   PMID:18063578   PMID:18614015   PMID:19837034   PMID:19858216   PMID:23197651   PMID:23376485  
PMID:26123486   PMID:26446790   PMID:26554610   PMID:28430993  


Genomics

Comparative Map Data
Polg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,212,303 - 92,222,849 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1092,212,304 - 92,222,726 (-)EnsemblGRCr8
mRatBN7.21091,712,586 - 91,723,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,712,586 - 91,723,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,768,140 - 96,778,559 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,231,315 - 96,241,734 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,634,688 - 91,645,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,968,836 - 94,979,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,968,836 - 94,979,259 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,714,851 - 94,724,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41096,120,205 - 96,130,221 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,379,006 - 90,389,432 (-)NCBICelera
RGSC_v3.11096,134,677 - 96,144,202 (-)NCBI
Cytogenetic Map10q32.1NCBI
POLG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,477,785 - 64,497,054 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,477,781 - 64,497,071 (-)Ensemblhg38GRCh38
GRCh371762,473,902 - 62,493,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,904,364 - 59,923,631 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341759,904,364 - 59,923,604NCBI
Celera1756,943,739 - 56,963,326 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,923,123 - 57,942,249 (-)NCBIHuRef
CHM1_11762,537,826 - 62,557,108 (-)NCBICHM1_1
T2T-CHM13v2.01765,347,539 - 65,366,810 (-)NCBIT2T-CHM13v2.0
Polg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,659,030 - 106,670,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,659,079 - 106,670,363 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,768,204 - 106,779,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,768,253 - 106,779,537 (-)Ensemblmm10GRCm38
MGSCv3711106,629,518 - 106,640,851 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611106,584,396 - 106,595,532 (-)NCBIMGSCv36mm8
Celera11118,499,425 - 118,510,748 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.01NCBI
Polg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,376,712 - 7,396,647 (+)Ensembl
ChiLan1.0NW_0049554787,376,240 - 7,396,647 (+)NCBIChiLan1.0ChiLan1.0
POLG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,664,361 - 80,686,934 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,484,050 - 85,505,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,574,442 - 58,593,915 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,667,246 - 63,686,503 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,667,246 - 63,686,503 (-)EnsemblpanPan2panpan1.1
POLG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,258,188 - 12,298,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl912,269,990 - 12,298,272 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha913,154,464 - 13,194,209 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,921,112 - 13,960,915 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,920,748 - 13,960,815 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,867,260 - 12,907,024 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,625,825 - 14,665,713 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,627,009 - 14,666,887 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Polg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,190,704 - 14,206,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,988,368 - 5,003,922 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,988,469 - 5,004,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,582,544 - 14,601,570 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11214,582,075 - 14,601,576 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
POLG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11656,773,867 - 56,794,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1656,776,330 - 56,794,654 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607727,382,675 - 27,402,719 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624870177,239 - 204,552 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624870136,060 - 204,486 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Polg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,348,815 - 72,359,511 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Polg2
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000018394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH141897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,723,680 - 91,723,877 (+)MAPPERmRatBN7.2
Rnor_6.01094,979,932 - 94,980,128NCBIRnor6.0
Rnor_5.01094,725,632 - 94,725,828UniSTSRnor5.0
RGSC_v3.41096,130,894 - 96,131,090UniSTSRGSC3.4
Celera1090,390,105 - 90,390,301UniSTS
RH 3.4 Map10981.5UniSTS
Cytogenetic Map10q32.1UniSTS
WI-22548  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,723,528 - 91,723,752 (+)MAPPERmRatBN7.2
Rnor_6.01094,979,780 - 94,980,003NCBIRnor6.0
Rnor_5.01094,725,480 - 94,725,703UniSTSRnor5.0
RGSC_v3.41096,130,742 - 96,130,965UniSTSRGSC3.4
Celera1090,389,953 - 90,390,176UniSTS
Cytogenetic Map10q32.1UniSTS
D17S1990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,724,682 - 91,724,960 (+)MAPPERmRatBN7.2
Rnor_6.01094,980,934 - 94,981,211NCBIRnor6.0
Rnor_5.01094,726,634 - 94,726,911UniSTSRnor5.0
RGSC_v3.41096,131,896 - 96,132,173UniSTSRGSC3.4
Celera1090,391,107 - 90,391,384UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018394   ⟹   ENSRNOP00000018394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1092,212,304 - 92,222,726 (-)Ensembl
mRatBN7.2 Ensembl1091,712,586 - 91,723,008 (-)Ensembl
Rnor_6.0 Ensembl1094,968,836 - 94,979,259 (-)Ensembl
RefSeq Acc Id: NM_001107060   ⟹   NP_001100530
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,212,304 - 92,222,726 (-)NCBI
mRatBN7.21091,712,586 - 91,723,008 (-)NCBI
Rnor_6.01094,968,836 - 94,979,259 (-)NCBI
Rnor_5.01094,714,851 - 94,724,959 (-)NCBI
RGSC_v3.41096,120,205 - 96,130,221 (-)RGD
Celera1090,379,006 - 90,389,432 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269211   ⟹   XP_063125281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,212,303 - 92,222,849 (-)NCBI
RefSeq Acc Id: XM_063269212   ⟹   XP_063125282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,219,758 - 92,222,849 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100530 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125281 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06411 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018394
  ENSRNOP00000018394.3
RefSeq Acc Id: NP_001100530   ⟸   NM_001107060
- UniProtKB: D3ZYP7 (UniProtKB/TrEMBL),   A6HK56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018394   ⟸   ENSRNOT00000018394
RefSeq Acc Id: XP_063125281   ⟸   XM_063269211
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063125282   ⟸   XM_063269212
- Peptide Label: isoform X2
Protein Domains
Anticodon-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYP7-F1-model_v2 AlphaFold D3ZYP7 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305128 AgrOrtholog
BioCyc Gene G2FUF-22928 BioCyc
Ensembl Genes ENSRNOG00000013728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018394 ENTREZGENE
  ENSRNOT00000018394.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.800 UniProtKB/TrEMBL
  Bira Bifunctional Protein, Domain 2 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Anticodon-bd UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/TrEMBL
  Gly-tRNA_synthase/POLG2 UniProtKB/TrEMBL
  POLG2_C UniProtKB/TrEMBL
KEGG Report rno:303612 UniProtKB/TrEMBL
NCBI Gene 303612 ENTREZGENE
PANTHER PTHR10745 UniProtKB/TrEMBL
  PTHR10745:SF8 UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/TrEMBL
PhenoGen Polg2 PhenoGen
RatGTEx ENSRNOG00000013728 RatGTEx
Superfamily-SCOP Class II aaRS ABD-related UniProtKB/TrEMBL
  SSF55681 UniProtKB/TrEMBL
UniProt A6HK56 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYP7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Polg2  DNA polymerase gamma 2, accessory subunit  Polg2  polymerase (DNA) gamma 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Polg2  polymerase (DNA) gamma 2, accessory subunit  Polg2  polymerase (DNA directed), gamma 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Polg2  polymerase (DNA directed), gamma 2, accessory subunit   Polg2_predicted  polymerase (DNA directed), gamma 2, accessory subunit (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Polg2_predicted  polymerase (DNA directed), gamma 2, accessory subunit (predicted)      Symbol and Name status set to approved 70820 APPROVED