Smad6 (SMAD family member 6) - Rat Genome Database

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Gene: Smad6 (SMAD family member 6) Rattus norvegicus
Analyze
Symbol: Smad6
Name: SMAD family member 6
RGD ID: 1305069
Description: Predicted to enable several functions, including SMAD binding activity; signaling receptor binding activity; and transcription regulator inhibitor activity. Involved in response to estrogen. Predicted to be located in nucleus. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in cytoplasm. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis 7; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; endocytosis pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC367100; MAD homolog 6; MAD homolog 6 (Drosophila); mothers against decapentaplegic homolog 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,345,457 - 73,414,985 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,345,460 - 73,414,149 (-)EnsemblGRCr8
mRatBN7.2864,450,114 - 64,519,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,450,114 - 64,519,763 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,964,906 - 70,033,580 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,237,362 - 68,306,026 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,107,492 - 66,176,160 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,897,746 - 68,967,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,898,296 - 68,966,108 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,608,372 - 68,677,705 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,144,395 - 68,214,652 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,858,003 - 63,926,291 (-)NCBICelera
RGSC_v3.1868,163,448 - 68,232,779 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
epoxiconazole  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
galangin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
icariin  (ISO)
iloprost  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
neomycin  (ISO)
octreotide  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pasireotide  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration. Brodin G, etal., Cancer Res. 1999 Jun 1;59(11):2731-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis. Uchida K, etal., Mol Cell Biol Res Commun. 2000 Aug;4(2):98-105.
13. MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells. Wang CJ, etal., Life Sci. 2020 Feb 1;242:117205. doi: 10.1016/j.lfs.2019.117205. Epub 2019 Dec 23.
14. Mutation analysis of the Smad6 and Smad7 gene in human ovarian cancers. Wang D, etal., Int J Oncol. 2000 Dec;17(6):1087-91.
15. [Changes of bone morphogenetic protein-7 and inhibitory Smad expression in streptozotocin-induced diabetic nephropathy rat kidney.] Yang Q, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):190-6.
16. TGF-beta, BMPS, and their signal transducing mediators, Smads, in rat fracture healing. Yu Y, etal., J Biomed Mater Res 2002 Jun 5;60(3):392-7.
Additional References at PubMed
PMID:9256479   PMID:9436979   PMID:10655064   PMID:11278251   PMID:14656760   PMID:16491121   PMID:16886151   PMID:19047146   PMID:19193853   PMID:21145505   PMID:21542012   PMID:21718693  
PMID:22275001   PMID:22581061   PMID:23455153   PMID:23610558   PMID:24446200   PMID:25651742   PMID:25807483   PMID:30135141   PMID:34449013   PMID:35917232  


Genomics

Comparative Map Data
Smad6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,345,457 - 73,414,985 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,345,460 - 73,414,149 (-)EnsemblGRCr8
mRatBN7.2864,450,114 - 64,519,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,450,114 - 64,519,763 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,964,906 - 70,033,580 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,237,362 - 68,306,026 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,107,492 - 66,176,160 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,897,746 - 68,967,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,898,296 - 68,966,108 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,608,372 - 68,677,705 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,144,395 - 68,214,652 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,858,003 - 63,926,291 (-)NCBICelera
RGSC_v3.1868,163,448 - 68,232,779 (-)NCBI
Cytogenetic Map8q24NCBI
SMAD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381566,702,236 - 66,782,849 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1566,702,236 - 66,782,849 (+)Ensemblhg38GRCh38
GRCh371566,994,574 - 67,075,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,781,688 - 64,861,380 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341564,781,723 - 64,861,380NCBI
Celera1543,882,942 - 43,962,620 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,830,247 - 43,909,482 (+)NCBIHuRef
CHM1_11567,112,770 - 67,192,414 (+)NCBICHM1_1
T2T-CHM13v2.01564,524,017 - 64,604,653 (+)NCBIT2T-CHM13v2.0
Smad6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,860,358 - 63,929,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,860,358 - 63,929,341 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38963,953,076 - 64,022,085 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,953,076 - 64,022,059 (-)Ensemblmm10GRCm38
MGSCv37963,800,883 - 63,869,866 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36963,751,143 - 63,819,327 (-)NCBIMGSCv36mm8
Celera961,176,785 - 61,248,052 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.4NCBI
Smad6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554509,005,332 - 9,070,790 (-)NCBIChiLan1.0ChiLan1.0
SMAD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,954,503 - 56,034,004 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,126,630 - 60,206,563 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01545,648,709 - 45,728,821 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,923,356 - 64,001,607 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,923,379 - 64,001,154 (+)EnsemblpanPan2panpan1.1
SMAD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,938,908 - 31,014,259 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,937,849 - 31,014,583 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3030,868,681 - 30,945,004 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03031,135,483 - 31,212,132 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,133,955 - 31,211,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,064,510 - 31,140,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,124,002 - 31,200,323 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,365,990 - 31,442,355 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Smad6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,933,410 - 109,008,484 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,781,549 - 26,856,571 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,781,420 - 26,856,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,656,887 - 164,735,704 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11164,652,602 - 164,735,084 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,396,037 - 182,478,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,760,117 - 16,841,286 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,759,260 - 16,840,240 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048124,628,125 - 124,709,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,042,904 - 6,107,860 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247816,043,183 - 6,108,959 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Smad6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1858,258,431 - 58,327,647 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Smad6
289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:91
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000012155
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
RH130848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,522,116 - 64,522,303 (+)MAPPERmRatBN7.2
Rnor_6.0868,969,720 - 68,969,906NCBIRnor6.0
Rnor_5.0868,680,243 - 68,680,429UniSTSRnor5.0
RGSC_v3.4868,216,313 - 68,216,499UniSTSRGSC3.4
Celera863,929,903 - 63,930,089UniSTS
RH 3.4 Map8808.4UniSTS
Cytogenetic Map8q24UniSTS
AU046917  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,478,388 - 64,478,554 (+)MAPPERmRatBN7.2
Rnor_6.0868,926,013 - 68,926,176NCBIRnor6.0
Rnor_5.0868,636,639 - 68,636,802UniSTSRnor5.0
RGSC_v3.4868,172,604 - 68,172,767UniSTSRGSC3.4
Celera863,885,638 - 63,885,801UniSTS
Cytogenetic Map8q24UniSTS
AU046916  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,478,388 - 64,478,556 (+)MAPPERmRatBN7.2
Rnor_6.0868,926,013 - 68,926,178NCBIRnor6.0
Rnor_5.0868,636,639 - 68,636,804UniSTSRnor5.0
RGSC_v3.4868,172,604 - 68,172,769UniSTSRGSC3.4
Celera863,885,638 - 63,885,803UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 59 59 6 323 159 11 139 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000012155   ⟹   ENSRNOP00000012155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,345,460 - 73,414,149 (-)Ensembl
mRatBN7.2 Ensembl864,450,114 - 64,519,763 (-)Ensembl
Rnor_6.0 Ensembl868,898,296 - 68,966,108 (-)Ensembl
RefSeq Acc Id: NM_001109002   ⟹   NP_001102472
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,345,460 - 73,414,149 (-)NCBI
mRatBN7.2864,450,117 - 64,518,841 (-)NCBI
Rnor_6.0868,898,291 - 68,966,108 (-)NCBI
Rnor_5.0868,608,372 - 68,677,705 (-)NCBI
RGSC_v3.4868,144,395 - 68,214,652 (-)RGD
Celera863,858,003 - 63,926,291 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243242   ⟹   XP_006243304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,345,457 - 73,414,985 (-)NCBI
mRatBN7.2864,450,114 - 64,519,673 (-)NCBI
Rnor_6.0868,897,746 - 68,967,221 (-)NCBI
Rnor_5.0868,608,372 - 68,677,705 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102472 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012155
  ENSRNOP00000012155.8
RefSeq Acc Id: NP_001102472   ⟸   NM_001109002
- UniProtKB: D3ZAQ2 (UniProtKB/TrEMBL),   A6J5A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243304   ⟸   XM_006243242
- Peptide Label: isoform X1
- UniProtKB: D3ZAQ2 (UniProtKB/TrEMBL),   A6J5A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012155   ⟸   ENSRNOT00000012155
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAQ2-F1-model_v2 AlphaFold D3ZAQ2 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305069 AgrOrtholog
BioCyc Gene G2FUF-30123 BioCyc
Ensembl Genes ENSRNOG00000009173 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012155 ENTREZGENE
  ENSRNOT00000012155.9 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
KEGG Report rno:367100 UniProtKB/TrEMBL
NCBI Gene 367100 ENTREZGENE
PANTHER Dwarfin UniProtKB/TrEMBL
  MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PhenoGen Smad6 PhenoGen
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009173 RatGTEx
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP MAD_MH1 UniProtKB/TrEMBL
  SMAD_FHA UniProtKB/TrEMBL
UniProt A6J5A7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAQ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad6  SMAD family member 6  Smad6  MAD homolog 6 (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Smad6  MAD homolog 6 (Drosophila)   Smad6_predicted  MAD homolog 6 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Smad6_predicted  MAD homolog 6 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED