Trpa1 (transient receptor potential cation channel, subfamily A, member 1) - Rat Genome Database

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Gene: Trpa1 (transient receptor potential cation channel, subfamily A, member 1) Rattus norvegicus
Analyze
Symbol: Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
RGD ID: 1303284
Description: Enables osmolarity-sensing monoatomic cation channel activity and voltage-gated calcium channel activity. Involved in several processes, including cellular response to caffeine; cellular response to carbon dioxide; and positive regulation of transport. Located in apical plasma membrane and axon. Used to study asthma; diabetic neuropathy; and overactive bladder syndrome. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1); INTERACTS WITH 3-phenylprop-2-enal; 4-hydroxynon-2-enal; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ANKTM1; ankyrin-like with transmembrane domains protein 1; transient receptor potential cation channel subfamily A member 1; wasabi receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Trpa1em1Kcrd ; Trpa1em1Gne
Genetic Models: SD-Trpa1em1Gne ; W-Trpa1em1Kcrd
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,163,060 - 9,217,325 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl59,163,060 - 9,217,325 (+)EnsemblGRCr8
mRatBN7.254,379,862 - 4,434,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,379,999 - 4,433,570 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx56,513,645 - 6,566,735 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.058,152,548 - 8,205,642 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.057,846,752 - 7,899,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.053,783,247 - 3,836,485 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl53,783,247 - 3,836,485 (+)Ensemblrn6Rnor6.0
Rnor_5.053,764,339 - 3,818,781 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.453,531,163 - 3,584,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera53,971,809 - 4,024,939 (+)NCBICelera
RGSC_v3.153,531,162 - 3,584,401 (+)NCBI
Cytogenetic Map5q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibutyrin  (ISO)
1,2-dichloroethane  (ISO)
1,2-naphthoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1-naphthol  (ISO)
1-nitronaphthalene  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
2,3-Dicresol  (ISO)
2,4-di-tert-butylphenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-xylenol  (ISO)
2,5-xylenol  (ISO)
2,6-Dimethylphenol  (ISO)
2-ethylhexan-1-ol  (ISO)
2-Ethylphenol  (ISO)
2-Methoxy-4-methylphenol  (ISO)
3,4-xylenol  (ISO)
3,5-xylenol  (ISO)
3-Ethylphenol  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4-ethylphenol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
8-Br-cAMP  (ISO)
A-967079  (ISO)
acetophenone  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Agathic acid  (ISO)
allethrin  (EXP)
allicin  (EXP,ISO)
allyl isothiocyanate  (EXP,ISO)
amiloride  (ISO)
arachidonic acid  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
atropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Cannabichromene  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
Cannabidivarin  (ISO)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
carbon dioxide  (EXP)
carvacrol  (EXP,ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
citronellal  (ISO)
coniferyl aldehyde  (ISO)
crotonaldehyde  (EXP,ISO)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
edelfosine  (ISO)
entinostat  (ISO)
eugenol  (EXP)
fenvalerate  (EXP)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
gadolinium atom  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glycerol  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isocyanates  (ISO)
isopentenyl diphosphate  (ISO)
L-1,4-dithiothreitol  (ISO)
Lasiocarpine  (ISO)
lidocaine  (EXP,ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
mechlorethamine  (ISO)
menadione  (ISO)
methylglyoxal  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
naphthalene  (ISO)
nonivamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-methoxybenzaldehyde  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrocrocin  (ISO)
propane-1,2-diol  (ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (ISO)
resiniferatoxin  (EXP)
ruthenium red  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
safranal  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
styrene  (ISO)
tributyrin  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
WIN 55212-2  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transmembrane import into cytosol  (IBA,IDA,IMP)
calcium ion transmembrane transport  (IEA,ISO,ISS)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to caffeine  (IEP)
cellular response to carbon dioxide  (IDA)
cellular response to cold  (IMP)
cellular response to food  (IEA,ISO)
cellular response to heat  (IMP)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to oxygen-containing compound  (IEA)
cellular response to stress  (IEA)
cellular response to toxic substance  (IEA,ISO)
detection of chemical stimulus involved in sensory perception of pain  (IBA,ISO)
detection of mechanical stimulus involved in sensory perception  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of monoatomic anion transport  (IMP)
protein homotetramerization  (IEA,ISO,ISS)
regulation of blood circulation  (IMP)
regulation of neuronal action potential  (IMP)
response to cold  (IEA,ISO,ISS)
response to hydrogen peroxide  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (IEA,ISO,ISS)
system process  (IEA)
thermoception  (IBA,ISO)
transmembrane transport  (IEA)
urinary bladder smooth muscle contraction  (IMP)

Cellular Component
apical plasma membrane  (IDA)
axon  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
stereocilium bundle  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Andrade EL, etal., Am J Physiol Renal Physiol. 2011 May;300(5):F1223-34. doi: 10.1152/ajprenal.00535.2010. Epub 2011 Mar 2.
2. Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels. Bianchi BR, etal., J Pharmacol Exp Ther. 2012 May;341(2):360-8. doi: 10.1124/jpet.111.189902. Epub 2012 Feb 7.
3. Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. Cao DS, etal., PLoS One. 2012;7(5):e38005. doi: 10.1371/journal.pone.0038005. Epub 2012 May 31.
4. TRPA1 contributes to cold hypersensitivity. del Camino D, etal., J Neurosci. 2010 Nov 10;30(45):15165-74. doi: 10.1523/JNEUROSCI.2580-10.2010.
5. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Eid SR, etal., Mol Pain. 2008 Oct 27;4:48. doi: 10.1186/1744-8069-4-48.
6. Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Ji G, etal., Neuroscience. 2008 Jun 26;154(3):1054-66. doi: 10.1016/j.neuroscience.2008.04.039. Epub 2008 May 2.
7. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Jordt SE, etal., Nature 2004 Jan 15;427(6971):260-5. Epub 2004 Jan 07.
8. Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon. Kaji I, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G690-701. doi: 10.1152/ajpgi.00289.2011. Epub 2011 Dec 29.
9. Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Koivisto A, etal., Pharmacol Res. 2012 Jan;65(1):149-58. doi: 10.1016/j.phrs.2011.10.006. Epub 2011 Nov 23.
10. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Kojima R, etal., Eur J Pharmacol. 2014 Jan 15;723:288-93. doi: 10.1016/j.ejphar.2013.11.020. Epub 2013 Nov 28.
11. P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors. Krimon S, etal., Pharmacol Biochem Behav. 2013 Nov;112:49-55. doi: 10.1016/j.pbb.2013.09.017. Epub 2013 Oct 9.
12. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. McGaraughty S, etal., Mol Pain. 2010 Mar 5;6:14. doi: 10.1186/1744-8069-6-14.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma. Reese RM, etal., Sci Rep. 2020 Jan 22;10(1):979. doi: 10.1038/s41598-020-57936-5.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. Staruschenko A, etal., J Biol Chem. 2010 May 14;285(20):15167-77. doi: 10.1074/jbc.M110.106153. Epub 2010 Mar 15.
20. Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats. Vermeulen W, etal., Eur J Pharmacol. 2013 Jan 5;698(1-3):404-12. doi: 10.1016/j.ejphar.2012.10.014. Epub 2012 Oct 23.
21. Warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Wang S, etal., Mol Pain. 2012 Mar 29;8:22. doi: 10.1186/1744-8069-8-22.
22. TRPA1 is a component of the nociceptive response to CO2. Wang YY, etal., J Neurosci. 2010 Sep 29;30(39):12958-63. doi: 10.1523/JNEUROSCI.2715-10.2010.
23. Transient receptor potential A1 mediates an osmotically activated ion channel. Zhang XF, etal., Eur J Neurosci. 2008 Feb;27(3):605-11. doi: 10.1111/j.1460-9568.2008.06030.x.
Additional References at PubMed
PMID:12654248   PMID:15483558   PMID:15843607   PMID:16110328   PMID:16304633   PMID:16546170   PMID:16564016   PMID:16595689   PMID:16630838   PMID:16675144   PMID:16831854   PMID:17329204  
PMID:17517374   PMID:17571167   PMID:17584831   PMID:17588549   PMID:17943255   PMID:18272293   PMID:18297068   PMID:18398506   PMID:18463259   PMID:18598259   PMID:19158342   PMID:19211797  
PMID:19237591   PMID:19299646   PMID:19348834   PMID:19371346   PMID:19419422   PMID:19464796   PMID:19491712   PMID:19629446   PMID:19812688   PMID:19961905   PMID:20034057   PMID:20133428  
PMID:20167675   PMID:20182791   PMID:20497466   PMID:20547126   PMID:20588026   PMID:20717636   PMID:21076024   PMID:21316356   PMID:21619614   PMID:21653898   PMID:21868092   PMID:22588108  
PMID:22721614   PMID:22740698   PMID:22809691   PMID:22865090   PMID:22928941   PMID:23098993   PMID:23133534   PMID:23222658   PMID:23293814   PMID:23384628   PMID:23521647   PMID:23603259  
PMID:23707800   PMID:23784920   PMID:23832015   PMID:23842678   PMID:23846257   PMID:23873754   PMID:23916509   PMID:23918657   PMID:23959730   PMID:24071625   PMID:24358160   PMID:24607781  
PMID:24780252   PMID:25484020   PMID:25605129   PMID:25639234   PMID:25765567   PMID:25855297   PMID:25858491   PMID:25884403   PMID:25889103   PMID:25896791   PMID:26046936   PMID:26172081  
PMID:26274042   PMID:26393428   PMID:26567040   PMID:26643912   PMID:26888187   PMID:26922555   PMID:26935999   PMID:27236325   PMID:27411353   PMID:27497709   PMID:27589700   PMID:27748654  
PMID:27752892   PMID:27904941   PMID:28017670   PMID:28032561   PMID:28103292   PMID:28370084   PMID:28640016   PMID:28698251   PMID:28710476   PMID:29428952   PMID:29537196   PMID:29777700  
PMID:30236550   PMID:30510606   PMID:31016687   PMID:31144562   PMID:31257266   PMID:31531184   PMID:31866360   PMID:32035165   PMID:32484015   PMID:32572784   PMID:32708653   PMID:33232544  
PMID:33534373   PMID:33957206   PMID:34082374   PMID:35236901   PMID:35384152   PMID:35446172   PMID:35973467   PMID:36040506   PMID:36116068   PMID:36494916   PMID:36768836   PMID:36881283  
PMID:37219522   PMID:37298451   PMID:37380112   PMID:37542841   PMID:38010891   PMID:38325845   PMID:38574849   PMID:38615746  


Genomics

Comparative Map Data
Trpa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,163,060 - 9,217,325 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl59,163,060 - 9,217,325 (+)EnsemblGRCr8
mRatBN7.254,379,862 - 4,434,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,379,999 - 4,433,570 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx56,513,645 - 6,566,735 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.058,152,548 - 8,205,642 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.057,846,752 - 7,899,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.053,783,247 - 3,836,485 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl53,783,247 - 3,836,485 (+)Ensemblrn6Rnor6.0
Rnor_5.053,764,339 - 3,818,781 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.453,531,163 - 3,584,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera53,971,809 - 4,024,939 (+)NCBICelera
RGSC_v3.153,531,162 - 3,584,401 (+)NCBI
Cytogenetic Map5q11NCBI
TRPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38872,021,250 - 72,090,010 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl872,019,608 - 72,089,998 (-)Ensemblhg38GRCh38
GRCh37872,933,485 - 72,987,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36873,096,040 - 73,150,373 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34873,096,039 - 73,150,373NCBI
Celera868,932,963 - 68,987,289 (-)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef868,428,222 - 68,482,529 (-)NCBIHuRef
CHM1_1872,986,840 - 73,041,189 (-)NCBICHM1_1
T2T-CHM13v2.0872,456,370 - 72,525,074 (-)NCBIT2T-CHM13v2.0
Trpa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,942,868 - 14,989,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,942,872 - 14,989,086 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38114,872,644 - 14,918,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,872,648 - 14,918,862 (-)Ensemblmm10GRCm38
MGSCv37114,862,729 - 14,908,943 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36114,857,862 - 14,904,076 (-)NCBIMGSCv36mm8
Celera114,822,489 - 14,871,741 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.5NCBI
Trpa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554447,876,429 - 7,921,372 (+)Ensembl
ChiLan1.0NW_0049554447,876,284 - 7,922,010 (+)NCBIChiLan1.0ChiLan1.0
TRPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2787,759,979 - 87,813,795 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1863,389,306 - 63,443,548 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0868,551,685 - 68,605,336 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1870,208,697 - 70,262,802 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl870,210,352 - 70,262,627 (-)EnsemblpanPan2panpan1.1
TRPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12920,951,736 - 21,000,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2920,951,716 - 21,001,208 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2921,214,374 - 21,266,355 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02921,050,161 - 21,102,458 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2921,050,159 - 21,111,731 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12921,102,449 - 21,154,677 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02921,151,285 - 21,203,541 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02921,431,610 - 21,483,919 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530358,307,190 - 58,354,763 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366481,094,460 - 1,141,394 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366481,094,460 - 1,141,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl463,508,104 - 63,558,484 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1463,493,374 - 63,558,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2469,132,584 - 69,265,553 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236955
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1867,698,067 - 67,754,407 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl867,698,786 - 67,751,885 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603973,636,128 - 73,694,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474418,997,462 - 19,042,227 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474418,997,273 - 19,042,838 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Trpa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11149,359,312 - 149,407,510 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trpa1
389 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:104
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000009874
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat


Genetic Models
This gene Trpa1 is modified in the following models/strains:
SD-Trpa1em1Gne     W-Trpa1em1Kcrd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 38 108 24 30 4 19 4 3 141 69 1 99 51 70 26 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000009874   ⟹   ENSRNOP00000009874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,163,060 - 9,217,325 (+)Ensembl
mRatBN7.2 Ensembl54,379,999 - 4,433,570 (+)Ensembl
Rnor_6.0 Ensembl53,783,247 - 3,836,485 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118200   ⟹   ENSRNOP00000092038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,163,060 - 9,217,325 (+)Ensembl
mRatBN7.2 Ensembl54,379,999 - 4,433,570 (+)Ensembl
RefSeq Acc Id: NM_207608   ⟹   NP_997491
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,163,060 - 9,217,325 (+)NCBI
mRatBN7.254,379,862 - 4,434,133 (+)NCBI
Rnor_6.053,783,247 - 3,836,485 (+)NCBI
Rnor_5.053,764,339 - 3,818,781 (+)NCBI
RGSC_v3.453,531,163 - 3,584,401 (+)RGD
Celera53,971,809 - 4,024,939 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS78661 (Get FASTA)   NCBI Sequence Viewer  
  EDM11520 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009874
  ENSRNOP00000009874.2
  ENSRNOP00065013360
GenBank Protein Q6RI86 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997491   ⟸   NM_207608
- UniProtKB: Q6RI86 (UniProtKB/Swiss-Prot),   F1LRH9 (UniProtKB/TrEMBL),   A0A8I6AD92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009874   ⟸   ENSRNOT00000009874
Ensembl Acc Id: ENSRNOP00000092038   ⟸   ENSRNOT00000118200
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6RI86-F1-model_v2 AlphaFold Q6RI86 1-1125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303284 AgrOrtholog
BioCyc Gene G2FUF-42283 BioCyc
Ensembl Genes ENSRNOG00000007354 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065010758 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009874 ENTREZGENE
  ENSRNOT00000009874.3 UniProtKB/Swiss-Prot
  ENSRNOT00065017425 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  TRP_cation_channel UniProtKB/Swiss-Prot
KEGG Report rno:312896 UniProtKB/Swiss-Prot
NCBI Gene 312896 ENTREZGENE
PANTHER ION_TRANS DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Trpa1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007354 RatGTEx
  ENSRNOG00065010758 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A8I6AD92 ENTREZGENE, UniProtKB/TrEMBL
  A6JFC4_RAT UniProtKB/TrEMBL
  F1LRH9 ENTREZGENE
  Q6RI86 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1LRH9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Trpa1  transient receptor potential cation channel, subfamily A, member 1    transient receptor potential cation channel subfamily A member 1  Name updated 1299863 APPROVED
2005-07-14 Trpa1  transient receptor potential cation channel subfamily A member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains member of the transient receptor ion channel family 1303969
gene_drugs activated by tetrahydrocannabinol and cannabinol; but does not appear to be activated by endocannabinoids 1303969
gene_expression expressed in trigeminal ganglial neurons 1303969