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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Acc ID: CHEBI:29132
Term: N-acetyl-1,4-benzoquinone imine
Definition: A ketoimine that has formula C8H7NO2.
Chemical ID: MESH:C028473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpa1increases activityEXP 6480464CTDN-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 proteinPMID:20720158
Trpa1affects response to substanceISOTrpa1 (Mus musculus)6480464CTDTRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneiminePMID:20720158
Trpa1increases activityISOTRPA1 (Homo sapiens)6480464CTDN-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 proteinPMID:20720158
Trpa1multiple interactionsISOTRPA1 (Homo sapiens)6480464CTD2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]PMID:20720158
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