Dnmt3b (DNA methyltransferase 3 beta) - Rat Genome Database

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Gene: Dnmt3b (DNA methyltransferase 3 beta) Rattus norvegicus
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Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
RGD ID: 1303274
Description: Enables chromatin binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to hyperoxia; and response to vitamin A. Predicted to be located in chromosome, centromeric region and heterochromatin. Predicted to be part of catalytic complex. Predicted to be active in nucleus. Biomarker of anxiety disorder; congenital heart disease; fetal alcohol spectrum disorder; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Orthologous to human DNMT3B (DNA methyltransferase 3 beta); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase 3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dnmt3b-ps1   Dnmt3b-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,590,777 - 162,629,313 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3162,604,037 - 162,629,313 (+)EnsemblGRCr8
mRatBN7.23142,130,588 - 142,169,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,032,579 - 146,071,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,616,397 - 154,655,021 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,356,679 - 152,395,302 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,131,541 - 149,170,061 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)Ensemblrn6Rnor6.0
Rnor_5.03155,510,828 - 155,591,435 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43144,030,737 - 144,069,265 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,873,202 - 140,910,431 (+)NCBICelera
RGSC_v3.13143,936,358 - 143,974,887 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
anxiety disorder  (IEP)
autism spectrum disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (IEP)
Craniofacial Abnormalities  (ISO)
Dysmenorrhea  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Mammary Neoplasms  (IEP)
facioscapulohumeral muscular dystrophy 4  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP)
gastric body carcinoma  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
immunodeficiency-centromeric instability-facial anomalies syndrome  (ISO)
immunodeficiency-centromeric instability-facial anomalies syndrome 1  (ISO,ISS)
Kabuki Syndrome 1  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Multiple Primary Neoplasms  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Oral Lichen Planus  (ISO)
oral squamous cell carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
skin melanoma  (ISO)
Stomach Neoplasms  (ISO)
thymoma  (ISO)
type 1 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-hydroxy-2'-deoxyguanosine  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (ISO)
DDT  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
diphenylcyclopropenone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gibberellin A3  (EXP)
glycine betaine  (ISO)
glyphosate  (EXP)
GSK-J4  (ISO)
guggulsterone  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
isorhapontigenin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
LY294002  (ISO)
malathion  (EXP)
menadione  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
PCB138  (ISO)
pelargonidin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
procyanidin B2  (ISO)
pterostilbene  (ISO)
pyrethrins  (EXP)
quartz  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tangeretin  (ISO)
tartrazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers. Azad AK, etal., Cancer. 2012 Mar 15;118(6):1554-65. doi: 10.1002/cncr.26446. Epub 2011 Aug 25.
2. Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells. Bai S, etal., J Biol Chem. 2006 May 12;281(19):13604-11. Epub 2006 Mar 14.
3. DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Bai S, etal., Mol Cell Biol. 2005 Jan;25(2):751-66.
4. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
5. The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma. Chen MF, etal., Cancer. 2012 Aug 15;118(16):4074-89. doi: 10.1002/cncr.26736. Epub 2011 Dec 27.
6. Significance of DNMT3b in oral cancer. Chen WC, etal., PLoS One. 2014 Mar 13;9(3):e89956. doi: 10.1371/journal.pone.0089956. eCollection 2014.
7. Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis. Coppede F, etal., PLoS One. 2013 Nov 19;8(11):e80846. doi: 10.1371/journal.pone.0080846. eCollection 2013.
8. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Cowin PA, etal., Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
9. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
10. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. de Vogel S, etal., Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96. doi: 10.1158/1055-9965.EPI-09-0289. Epub 2009 Oct 20.
11. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
12. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Elsner VR, etal., Exp Gerontol. 2013 Feb;48(2):136-9. doi: 10.1016/j.exger.2012.11.011. Epub 2012 Nov 30.
13. Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study. Fan H, etal., J Exp Clin Cancer Res. 2008 Jul 28;27:24. doi: 10.1186/1756-9966-27-24.
14. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
15. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
16. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Fonseca-Silva T, etal., Pathobiology. 2012;79(1):18-23. doi: 10.1159/000330171. Epub 2012 Jan 12.
17. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Guo X, etal., Mol Biol Rep. 2010 Jan;37(1):219-25. doi: 10.1007/s11033-009-9626-z. Epub 2009 Jul 22.
20. High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. Hayette S, etal., PLoS One. 2012;7(12):e51527. doi: 10.1371/journal.pone.0051527. Epub 2012 Dec 10.
21. The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer. Hernandez-Sotelo D, etal., Mol Biol Rep. 2013 Jul;40(7):4275-80. doi: 10.1007/s11033-013-2511-9. Epub 2013 May 16.
22. DNA methyltransferase 3B (DNMT3B -579G>T) promotor polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt. Khorshied MM and El-Ghamrawy MK, Gene. 2012 Dec 10;511(1):34-7. doi: 10.1016/j.gene.2012.09.024. Epub 2012 Sep 18.
23. Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL). Kn H, etal., Cancer Biol Ther. 2004 Oct;3(10):989-94. Epub 2004 Oct 2.
24. DNMT3B polymorphisms and risk of primary lung cancer. Lee SJ, etal., Carcinogenesis. 2005 Feb;26(2):403-9. Epub 2004 Nov 4.
25. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, etal., Genomics 2004 Jul;84(1):193-204.
26. Abnormal DNA methylation in CD4+ T cells from people with latent autoimmune diabetes in adults. Li Y, etal., Diabetes Res Clin Pract. 2011 Nov;94(2):242-8. doi: 10.1016/j.diabres.2011.07.027. Epub 2011 Aug 23.
27. [The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia]. Li Y, etal., Zhonghua Nei Ke Za Zhi. 2005 Aug;44(8):588-91.
28. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
29. Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study. Liu Z, etal., Cancer Lett. 2008 Sep 8;268(1):158-65. doi: 10.1016/j.canlet.2008.03.034. Epub 2008 May 1.
30. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
31. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
32. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Meunier L, etal., Endocrinology. 2012 Apr;153(4):1936-47. doi: 10.1210/en.2011-1109. Epub 2012 Feb 14.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
35. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
36. The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis. Nam EJ, etal., Rheumatol Int. 2010 Aug;30(10):1299-303. doi: 10.1007/s00296-009-1141-y. Epub 2009 Sep 24.
37. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Nguyen T, etal., Epigenetics. 2011 Mar;6(3):388-94. Epub 2011 Mar 1.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Park HJ, etal., Cancer Lett. 2006 Feb 28;233(2):271-8.
40. Correlations among PPARgamma, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer. Pazienza V, etal., PPAR Res. 2012;2012:461784. doi: 10.1155/2012/461784. Epub 2012 Aug 8.
41. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Cocaine represses protein phosphatase-1Cbeta through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Pol Bodetto S, etal., Neuropharmacology. 2013 Oct;73:31-40. doi: 10.1016/j.neuropharm.2013.05.005. Epub 2013 May 18.
44. Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue. Qin W, etal., Nutr Cancer. 2014;66(2):270-7. doi: 10.1080/01635581.2014.868910. Epub 2014 Jan 21.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Sharma D, etal., Mol Endocrinol. 2013 Jul;27(7):1142-52. doi: 10.1210/me.2013-1079. Epub 2013 May 13.
49. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. Su PH, etal., Oncogene. 2013 Jan 3;32(1):15-26. doi: 10.1038/onc.2012.29. Epub 2012 Feb 13.
50. Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma. Su X, etal., Oncol Rep. 2010 Mar;23(3):819-26.
51. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Tao J, etal., J Clin Immunol. 2008 Sep;28(5):432-9. doi: 10.1007/s10875-008-9223-2. Epub 2008 Aug 6.
52. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Tryndyak VP, etal., Carcinogenesis. 2006 Aug;27(8):1713-20. Epub 2006 Apr 22.
53. Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior. Wang X, etal., Mol Neurobiol. 2013 Dec;48(3):544-55. doi: 10.1007/s12035-013-8444-4. Epub 2013 Mar 26.
54. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Wu Y, etal., Fertil Steril. 2007 Jan;87(1):24-32. Epub 2006 Nov 1.
55. DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia. Xiong L, etal., FEBS J. 2012 Dec;279(23):4318-26. doi: 10.1111/febs.12021. Epub 2012 Nov 7.
56. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Xiong Y, etal., Gynecol Oncol. 2005 Mar;96(3):601-9.
57. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Xu GL, etal., Nature. 1999 Nov 11;402(6758):187-91.
58. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Zhang C, etal., Neurosci Lett. 2009 Oct 25;462(3):308-11. doi: 10.1016/j.neulet.2009.06.085. Epub 2009 Jul 2.
59. [Association of DNA methyltransferase 3B gene polymorphism with early-onset schizophrenia]. Zhang C, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Dec;27(6):697-9. doi: 10.3760/cma.j.issn.1003-9406.2010.06.022.
60. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhang Q, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Feb;31(2):92-5.
61. Association between DNA methyltransferases 3B gene polymorphisms and the susceptibility to acute myeloid leukemia in Chinese Han population. Zheng Q, etal., PLoS One. 2013 Sep 17;8(9):e74626. doi: 10.1371/journal.pone.0074626. eCollection 2013.
Additional References at PubMed
PMID:9662389   PMID:10555141   PMID:11919202   PMID:11934864   PMID:14519686   PMID:15456878   PMID:16543361   PMID:17303076   PMID:17938196   PMID:18056424   PMID:18413740   PMID:18567530  
PMID:18814855   PMID:19796622   PMID:20548288   PMID:21378119   PMID:22133874   PMID:23754746   PMID:25190601   PMID:25416223   PMID:27856912   PMID:33099744   PMID:33298433   PMID:36173508  
PMID:36430472  


Genomics

Comparative Map Data
Dnmt3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,590,777 - 162,629,313 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3162,604,037 - 162,629,313 (+)EnsemblGRCr8
mRatBN7.23142,130,588 - 142,169,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,032,579 - 146,071,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,616,397 - 154,655,021 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,356,679 - 152,395,302 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,131,541 - 149,170,061 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)Ensemblrn6Rnor6.0
Rnor_5.03155,510,828 - 155,591,435 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43144,030,737 - 144,069,265 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,873,202 - 140,910,431 (+)NCBICelera
RGSC_v3.13143,936,358 - 143,974,887 (+)NCBI
Cytogenetic Map3q41NCBI
DNMT3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382032,762,385 - 32,809,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,762,385 - 32,809,359 (+)Ensemblhg38GRCh38
GRCh372031,350,191 - 31,397,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,813,852 - 30,860,823 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2028,104,119 - 28,151,087 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,137,312 - 28,184,284 (+)NCBIHuRef
CHM1_12031,253,633 - 31,300,607 (+)NCBICHM1_1
T2T-CHM13v2.02034,489,113 - 34,536,082 (+)NCBIT2T-CHM13v2.0
Dnmt3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,491,332 - 153,529,650 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,491,370 - 153,529,650 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382153,649,411 - 153,687,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,649,450 - 153,687,730 (+)Ensemblmm10GRCm38
MGSCv372153,475,190 - 153,513,466 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362153,340,895 - 153,379,168 (+)NCBIMGSCv36mm8
Celera2159,495,468 - 159,534,017 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.79NCBI
Dnmt3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,380,591 - 28,421,301 (-)Ensembl
ChiLan1.0NW_00495542228,380,595 - 28,427,012 (-)NCBIChiLan1.0ChiLan1.0
DNMT3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,453,003 - 38,499,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,446,101 - 38,493,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,049,993 - 29,096,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,169,081 - 30,215,487 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,186,069 - 30,215,487 (+)EnsemblpanPan2panpan1.1
DNMT3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,096,386 - 22,123,378 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,096,349 - 22,122,900 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2421,724,710 - 21,769,260 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02422,765,878 - 22,810,458 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,782,662 - 22,810,452 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,042,034 - 22,086,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,150,746 - 22,195,021 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,581,755 - 22,626,058 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnmt3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,116,001 - 171,139,372 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,547,620 - 19,569,406 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,547,836 - 19,570,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,345,816 - 36,386,072 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11736,345,715 - 36,386,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,282,731 - 41,322,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,128,635 - 37,176,033 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,146,538 - 37,174,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605089,724,034 - 89,772,846 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248426,450,852 - 6,475,785 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248426,450,972 - 6,505,929 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnmt3b
120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:116
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000015482
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
UniSTS:472909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,158,376 - 142,158,451 (+)MAPPERmRatBN7.2
mRatBN7.23142,195,729 - 142,195,804 (+)MAPPERmRatBN7.2
Rnor_6.03149,198,110 - 149,198,184NCBIRnor6.0
Rnor_6.03149,159,316 - 149,159,390NCBIRnor6.0
Rnor_5.03155,576,334 - 155,576,408UniSTSRnor5.0
Rnor_5.03155,538,611 - 155,538,685UniSTSRnor5.0
RGSC_v3.43144,058,520 - 144,058,594UniSTSRGSC3.4
RGSC_v3.43144,097,377 - 144,097,451UniSTSRGSC3.4
Celera3140,937,252 - 140,937,326UniSTS
Celera3140,899,686 - 140,899,760UniSTS
Cytogenetic Map3q41UniSTS
UniSTS:525685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,153,093 - 142,154,418 (+)MAPPERmRatBN7.2
Rnor_6.03149,154,033 - 149,155,357NCBIRnor6.0
Rnor_5.03155,533,328 - 155,534,652UniSTSRnor5.0
RGSC_v3.43144,053,237 - 144,054,561UniSTSRGSC3.4
Celera3140,894,403 - 140,895,727UniSTS
Cytogenetic Map3q41UniSTS
UniSTS:525686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,165,241 - 142,165,985 (+)MAPPERmRatBN7.2
mRatBN7.23142,205,382 - 142,206,153 (+)MAPPERmRatBN7.2
Rnor_6.03149,207,898 - 149,208,668NCBIRnor6.0
Rnor_6.03149,166,179 - 149,166,922NCBIRnor6.0
Rnor_5.03155,586,122 - 155,586,892UniSTSRnor5.0
Rnor_5.03155,545,474 - 155,546,217UniSTSRnor5.0
RGSC_v3.43144,065,383 - 144,066,126UniSTSRGSC3.4
RGSC_v3.43144,107,027 - 144,107,797UniSTSRGSC3.4
Celera3140,946,902 - 140,947,672UniSTS
Celera3140,906,549 - 140,907,292UniSTS
Cytogenetic Map3q41UniSTS
Dnmt3b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23142,159,601 - 142,159,993 (+)MAPPERmRatBN7.2
Rnor_6.03149,160,541 - 149,160,932NCBIRnor6.0
Rnor_5.03155,539,836 - 155,540,227UniSTSRnor5.0
RGSC_v3.43144,059,745 - 144,060,136UniSTSRGSC3.4
Celera3140,900,911 - 140,901,302UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 162 91 90 59 90 59 6 351 189 11 141 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015482   ⟹   ENSRNOP00000015482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)Ensembl
Rnor_6.0 Ensembl3149,144,795 - 149,168,760 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090321   ⟹   ENSRNOP00000070758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,130,592 - 142,168,823 (+)Ensembl
Rnor_6.0 Ensembl3149,131,785 - 149,208,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097170   ⟹   ENSRNOP00000096797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3162,604,037 - 162,629,313 (+)Ensembl
mRatBN7.2 Ensembl3142,130,592 - 142,169,124 (+)Ensembl
RefSeq Acc Id: NM_001396349   ⟹   NP_001383278
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83162,590,777 - 162,629,313 (+)NCBI
mRatBN7.23142,130,588 - 142,169,128 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001383278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE52319 (Get FASTA)   NCBI Sequence Viewer  
  EDL85992 (Get FASTA)   NCBI Sequence Viewer  
  EDL85993 (Get FASTA)   NCBI Sequence Viewer  
  EDL85994 (Get FASTA)   NCBI Sequence Viewer  
  EDL85995 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000096797
  ENSRNOP00000096797.2
Ensembl Acc Id: ENSRNOP00000070758   ⟸   ENSRNOT00000090321
Ensembl Acc Id: ENSRNOP00000015482   ⟸   ENSRNOT00000015482
Ensembl Acc Id: ENSRNOP00000096797   ⟸   ENSRNOT00000097170
RefSeq Acc Id: NP_001383278   ⟸   NM_001396349
- UniProtKB: A0A8I6AVL3 (UniProtKB/TrEMBL),   A6KHW2 (UniProtKB/TrEMBL),   F1LQ40 (UniProtKB/TrEMBL),   Q1LZ51 (UniProtKB/TrEMBL)
Protein Domains
PHD-type   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1LZ51-F1-model_v2 AlphaFold Q1LZ51 1-859 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303274 AgrOrtholog
BioCyc Gene G2FUF-47210 BioCyc
Ensembl Genes ENSRNOG00000010625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097170 ENTREZGENE
  ENSRNOT00000097170.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  PWWP, helical domain UniProtKB/TrEMBL
InterPro ADD UniProtKB/TrEMBL
  C5-Methyltransferase UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  DNMT3_ADD UniProtKB/TrEMBL
  DNMT3_ADD_PHD UniProtKB/TrEMBL
  DNMT3B UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
NCBI Gene 444985 ENTREZGENE
PANTHER DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B UniProtKB/TrEMBL
  DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/TrEMBL
Pfam ADD_DNMT3 UniProtKB/TrEMBL
  ADDz_Dnmt3b UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
PhenoGen Dnmt3b PhenoGen
PROSITE ADD UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010625 RatGTEx
SMART PWWP UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8I6AVL3 ENTREZGENE, UniProtKB/TrEMBL
  A6KHW2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ40 ENTREZGENE
  Q1LZ51 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LQ40 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Dnmt3b  DNA methyltransferase 3 beta  Dnmt3b  DNA (cytosine-5-)-methyltransferase 3 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Dnmt3b  DNA (cytosine-5-)-methyltransferase 3 beta  Dnmt3b  DNA methyltransferase 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Dnmt3b  DNA methyltransferase 3B      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Dnmt3b  DNA methyltransferase 3B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mouse homolog is expressed in oocytes 1304004