Nanog (Nanog homeobox) - Rat Genome Database

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Gene: Nanog (Nanog homeobox) Rattus norvegicus
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Symbol: Nanog
Name: Nanog homeobox
RGD ID: 1303178
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and lysine-acetylated histone binding activity. Involved in several processes, including cellular response to erythropoietin; cellular response to rapamycin; and multidimensional cell growth. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromatin and nucleus. Used to study colon cancer. Orthologous to several human genes including NANOG (Nanog homeobox); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein NANOG
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WIC-Tg(Nanog-YFP*)1Utr  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,615,687 - 157,623,061 (+)NCBIGRCr8
mRatBN7.24155,943,737 - 155,951,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,211,480 - 162,218,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,563,349 - 186,570,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,639,759 - 156,647,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,531,906 - 155,539,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,552,995 - 222,560,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,190,786 - 159,198,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,438,699 - 159,441,754 (+)NCBI
Celera4144,763,722 - 144,771,060 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
NanogRatcolon cancer treatmentIDA 7240527 RGD 
NanogRatParkinson's disease treatmentISONanog (Mus musculus)9681444mouse gene in a rat model more ...RGD 
NanogRatteratoma severityISONanog (Mus musculus)9681441mouse gene in a rat Myocardial Infarction model and protein:decreased expression:embryonic stem cellRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NanogRatdevelopmental and epileptic encephalopathy 21  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 21ClinVarPMID:18712838 more ...
NanogRatHyperphosphatemic Familial Tumoral Calcinosis 1  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Tumoral calcinosis more ...ClinVarPMID:25378588 and PMID:29389098
NanogRatKlippel-Feil syndrome 3  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Klippel-Feil syndrome 3 and autosomal dominantClinVarPMID:28492532
NanogRatlymphoproliferative syndrome 2  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 2ClinVarPMID:28492532
NanogRatperoxisome biogenesis disorder 2B  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder 2BClinVarPMID:18712838 more ...
NanogRatTemtamy syndrome  ISONANOG (Homo sapiens)8554872ClinVar Annotator: match by term: Temtamy syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
NanogRatGerm Cell and Embryonal Neoplasms  ISONANOG (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16168501
NanogRatNeoplastic Cell Transformation  ISONANOG (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29626521

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Object Symbol
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Original Reference(s)
NanogRat(+)-catechin multiple interactionsISONANOG (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NANOG mRNACTDPMID:24763279
NanogRat(20S)-ginsenoside Rg3 decreases expressionISONANOG (Homo sapiens)6480464ginsenoside Rg3 results in decreased expression of NANOG mRNACTDPMID:31916386
NanogRat(S)-naringenin decreases expressionISONANOG (Homo sapiens)6480464naringenin results in decreased expression of NANOG proteinCTDPMID:27468969
NanogRat(S)-nicotine increases expressionISONANOG (Homo sapiens)6480464Nicotine results in increased expression of NANOG mRNA and Nicotine results in increased expression of NANOG proteinCTDPMID:23219715
NanogRat(S)-nicotine increases expressionISONanog (Mus musculus)6480464Nicotine results in increased expression of NANOG proteinCTDPMID:31507073
NanogRat(S)-nicotine multiple interactionsISONANOG (Homo sapiens)6480464[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein and SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]CTDPMID:23219715 and PMID:30259641
NanogRat(S)-ropivacaine decreases expressionISONANOG (Homo sapiens)6480464Ropivacaine results in decreased expression of NANOG proteinCTDPMID:36124980
NanogRat1,2-dichloroethane decreases expressionISONanog (Mus musculus)6480464ethylene dichloride results in decreased expression of NANOG mRNACTDPMID:28189721 and PMID:28960355
NanogRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of NANOG mRNACTDPMID:27840820
NanogRat17beta-estradiol increases expressionISONANOG (Homo sapiens)6480464Estradiol results in increased expression of NANOG mRNA and Estradiol results in increased expression of NANOG proteinCTDPMID:23391485 and PMID:34719554
NanogRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISONanog (Mus musculus)64804642 more ...CTDPMID:34547414
NanogRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONanog (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NANOG mRNACTDPMID:24058054
NanogRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NANOG mRNACTDPMID:33387578
NanogRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONANOG (Homo sapiens)6480464N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NANOG mRNA]CTDPMID:30203000
NanogRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONANOG (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of NANOG mRNACTDPMID:30203000
NanogRat2,4-di-tert-butylphenol multiple interactionsISONANOG (Homo sapiens)6480464[Chir 99021 co-treated with 2 and 4-di-tert-butylphenol] results in increased expression of NANOG mRNACTDPMID:36682590
NanogRat2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactionsISONANOG (Homo sapiens)6480464[Verapamil co-treated with kaempferol] results in decreased expression of NANOG mRNA and [Verapamil co-treated with kaempferol] results in decreased expression of NANOG proteinCTDPMID:35063459
NanogRat2-methoxy-17beta-estradiol multiple interactionsISONanog (Mus musculus)64804642-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]CTDPMID:25822711
NanogRat3,5,6-trichloro-2-pyridinol decreases expressionISONanog (Mus musculus)64804643 more ...CTDPMID:23220036
NanogRat3,5,6-trichloropyridine-2-one decreases expressionISONanog (Mus musculus)64804643 more ...CTDPMID:23220036

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Biological Process
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Original Reference(s)
NanogRatBMP signaling pathway acts_upstream_ofIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatBMP signaling pathway acts_upstream_ofISONanog (Mus musculus)1624291 PMID:16801560RGDPMID:16801560
NanogRatcell dedifferentiation involved_inISONanog (Mus musculus)1624291 PMID:23040477RGDPMID:23040477
NanogRatcell dedifferentiation involved_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatcell differentiation involved_inISONANOG (Homo sapiens)1624291 PMID:16501172RGDPMID:16501172
NanogRatcell differentiation involved_inIBAFB:FBgn0000529 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NanogRatcellular response to erythropoietin  IEP 9589810 RGD 
NanogRatcellular response to rapamycin  IEP 9589808 RGD 
NanogRatembryonic pattern specification involved_inISONanog (Mus musculus)1624291 PMID:15108323RGDPMID:15108323
NanogRatembryonic pattern specification involved_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatendodermal cell fate specification acts_upstream_of_or_withinISONANOG (Homo sapiens)1624291 PMID:20713518RGDPMID:20713518
NanogRatgene expression involved_inISONanog (Mus musculus)1624291 PMID:17267691 and PMID:26005002RGDPMID:17267691 and PMID:26005002
NanogRatgene expression involved_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatgonad development involved_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatgonad development involved_inISONanog (Mus musculus)1624291 PMID:15108323RGDPMID:15108323
NanogRatmesodermal cell fate commitment acts_upstream_of_or_withinISONanog (Mus musculus)1624291MGI:109452 PMID:16801560RGDPMID:16801560
NanogRatmesodermal cell fate commitment acts_upstream_ofIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatmesodermal cell fate commitment acts_upstream_ofISONanog (Mus musculus)1624291MGI:109452 PMID:16801560RGDPMID:16801560
NanogRatmultidimensional cell growth  IEP 9589809 RGD 
NanogRatnegative regulation of BMP signaling pathway acts_upstream_of_or_withinISONanog (Mus musculus)1624291 PMID:16801560RGDPMID:16801560
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Cellular Component
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Object Symbol
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Original Reference(s)
NanogRatchromatin is_active_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatchromatin is_active_inISONanog (Mus musculus)1624291 PMID:23798425RGDPMID:23798425
NanogRatcondensed chromosome NOT|located_inISONanog (Mus musculus)1624291 PMID:27723719RGDPMID:27723719
NanogRatintracellular membrane-bounded organelle located_inISONANOG (Homo sapiens) more ...1624291 RGDGO_REF:0000052
NanogRatnucleolus located_inISONANOG (Homo sapiens)1624291 PMID:20458727RGDPMID:20458727
NanogRatnucleoplasm located_inISONanog (Mus musculus)1624291 PMID:21076177RGDPMID:21076177
NanogRatnucleoplasm located_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatnucleoplasm located_inISONANOG (Homo sapiens) more ...1624291 RGDGO_REF:0000052
NanogRatnucleus located_inISONANOG (Homo sapiens)1624291 PMID:18932205RGDPMID:18932205
NanogRatnucleus located_inIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
NanogRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
NanogRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
NanogRatnucleus located_inISONanog (Mus musculus)1624291 PMID:15582778 more ...RGDPMID:15582778 more ...
NanogRatnucleus is_active_inISONanog (Mus musculus)1624291 PMID:23798425RGDPMID:23798425
NanogRatnucleus located_inIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
NanogRatchromatin binding enablesISONanog (Mus musculus)1624291 PMID:18467660RGDPMID:18467660
NanogRatchromatin binding enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatDNA binding enablesISONANOG (Homo sapiens)1624291 PMID:16153702 and PMID:19427902RGDPMID:16153702 and PMID:19427902
NanogRatDNA binding enablesIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
NanogRatDNA binding enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-03711600115GO_REF:0000043UniProtGO_REF:0000043
NanogRatDNA binding enablesISONanog (Mus musculus)1624291 PMID:12787504 more ...RGDPMID:12787504 more ...
NanogRatDNA binding enablesIEAInterPro:IPR0013561600115GO_REF:0000002InterProGO_REF:0000002
NanogRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONanog (Mus musculus)1624291 PMID:18957414RGDPMID:18957414
NanogRatDNA-binding transcription factor activity enablesISONanog (Mus musculus)1624291 PMID:22988117RGDPMID:22988117
NanogRatDNA-binding transcription factor activity enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatDNA-binding transcription factor activity enablesISONANOG (Homo sapiens)1624291 PMID:16153702RGDPMID:16153702
NanogRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:101926 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NanogRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR0179701600115GO_REF:0000002InterProGO_REF:0000002
NanogRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISONanog (Mus musculus)1624291 PMID:22988117RGDPMID:22988117
NanogRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
NanogRatidentical protein binding enablesISONanog (Mus musculus) and PR:Q80Z64-11624291UniProtKB:Q80Z64-1 and PMID:18436640RGDPMID:18436640
NanogRatlysine-acetylated histone binding enablesISONanog (Mus musculus)1624291 PMID:23798425RGDPMID:23798425
NanogRatlysine-acetylated histone binding enablesIEAUniProtKB:Q80Z64 and ensembl:ENSMUSP000000125401600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
NanogRatDNA modification pathway   ISONANOG (Homo sapiens)8695944 RGD 

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#
Reference Title
Reference Citation
1. Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells. Chang MY, etal., PLoS One. 2010 Mar 24;5(3):e9838. doi: 10.1371/journal.pone.0009838.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. Nanog attenuates lipopolysaccharide-induced inflammatory responses by blocking nuclear factor-kappaB transcriptional activity in BV-2 cells. Duan Z, etal., Neuroreport. 2013 Sep 11;24(13):718-23. doi: 10.1097/WNR.0b013e328363fd67.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. Han S, etal., J Genet Genomics. 2012 Dec 20;39(12):633-41. doi: 10.1016/j.jgg.2012.08.006. Epub 2012 Nov 21.
6. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Hart AH, etal., Dev Dyn 2004 May;230(1):187-98.
7. Chronic high dose intraperitoneal bisphenol A (BPA) induces substantial histological and gene expression alterations in rat penile tissue without impairing erectile function. Kovanecz I, etal., J Sex Med. 2013 Dec;10(12):2952-66. doi: 10.1111/jsm.12336. Epub 2013 Oct 17.
8. Tumourigenesis in the infarcted rat heart is eliminated through differentiation and enrichment of the transplanted embryonic stem cells. Lin Q, etal., Eur J Heart Fail. 2010 Nov;12(11):1179-85. doi: 10.1093/eurjhf/hfq144. Epub 2010 Sep 3.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Parasramka MA, etal., Mol Nutr Food Res. 2012 Aug;56(8):1259-69. doi: 10.1002/mnfr.201200117. Epub 2012 May 29.
11. Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Pospelova TV, etal., Cell Cycle. 2013 Dec 15;12(24):3841-51. doi: 10.4161/cc.27396. Epub 2013 Dec 2.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sites. Singh AK, etal., Cell Tissue Res. 2008 Jan 15;.
16. Expression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium. Song N, etal., Cell Prolif. 2010 Feb;43(1):49-55. doi: 10.1111/j.1365-2184.2009.00653.x. Epub 2009 Oct 21.
17. Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis. Song Y, etal., Reprod Biol Endocrinol. 2014 May 18;12:42. doi: 10.1186/1477-7827-12-42.
18. Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection. Tripathy D, etal., CNS Neurosci Ther. 2014 Aug;20(8):717-27. doi: 10.1111/cns.12295. Epub 2014 Jun 21.
19. Effect of Recombinant Human Erythropoietin On the Stemness of Bone Marrow-derived Mesenchymal Stem Cells in vitro. Ye L, etal., Int J Stem Cells. 2010 May;3(2):175-82.
20. Nanog and beta-catenin: a new convergence point in EpSC proliferation and differentiation. Yin D, etal., Int J Mol Med. 2012 Apr;29(4):587-92. doi: 10.3892/ijmm.2011.871. Epub 2011 Dec 29.
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PMID:12787504   PMID:12787505   PMID:15582778   PMID:15788452   PMID:16153702   PMID:16259959   PMID:16501172   PMID:16518401   PMID:16767105   PMID:16801560   PMID:16894029   PMID:17938240  
PMID:17940068   PMID:18388306   PMID:18400104   PMID:18425773   PMID:18436640   PMID:18448678   PMID:18467660   PMID:18932205   PMID:18957414   PMID:19427902   PMID:19796622   PMID:20123909  
PMID:20458727   PMID:20713518   PMID:20720539   PMID:20937355   PMID:21062744   PMID:21076177   PMID:21146513   PMID:21385842   PMID:22988117   PMID:23040477   PMID:23287475   PMID:23708658  
PMID:23824537   PMID:24036311   PMID:24268575   PMID:24515304   PMID:25304966   PMID:25335925   PMID:25397698   PMID:25633057   PMID:25825768   PMID:26707878   PMID:27723719   PMID:32471175  
PMID:34758295  



Nanog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,615,687 - 157,623,061 (+)NCBIGRCr8
mRatBN7.24155,943,737 - 155,951,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,211,480 - 162,218,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,563,349 - 186,570,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,639,759 - 156,647,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,531,906 - 155,539,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,552,995 - 222,560,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,190,786 - 159,198,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,438,699 - 159,441,754 (+)NCBI
Celera4144,763,722 - 144,771,060 (+)NCBICelera
Cytogenetic Map4q42NCBI
NANOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,789,402 - 7,799,146 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,787,794 - 7,799,146 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,941,998 - 7,951,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,833,262 - 7,839,922 (+)NCBINCBI36Build 36hg18NCBI36
Build 34127,833,261 - 7,839,922NCBI
Celera129,520,085 - 9,526,744 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,755,619 - 7,762,294 (+)NCBIHuRef
CHM1_1127,941,303 - 7,947,961 (+)NCBICHM1_1
T2T-CHM13v2.0127,803,995 - 7,813,735 (+)NCBIT2T-CHM13v2.0
Nanog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,684,448 - 122,691,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,684,448 - 122,691,592 (+)EnsemblGRCm39 Ensembl
GRCm386122,707,489 - 122,714,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,707,489 - 122,714,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,657,586 - 122,663,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,673,114 - 122,680,252 (+)NCBIMGSCv36mm8
Celera6124,507,792 - 124,514,310 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.8NCBI
Nanog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554136,561,323 - 6,565,770 (+)NCBIChiLan1.0ChiLan1.0
NANOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,347,790 - 13,354,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,344,549 - 13,351,498 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,913,037 - 7,919,715 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,070,877 - 8,077,556 (+)NCBIpanpan1.1PanPan1.1panPan2
NANOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,262,558 - 37,266,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,348,312 - 9,354,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,614,640 - 37,620,732 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,614,640 - 37,620,302 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,494,510 - 37,500,598 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,530,317 - 37,536,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,831,817 - 8,837,819 (-)NCBIUU_Cfam_GSD_1.0
Nanog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,997,260 - 99,003,117 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936892181,834 - 187,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,932,382 - 62,939,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,931,642 - 62,939,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,798,046 - 65,843,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NANOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,813,309 - 7,820,009 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666063363,373 - 369,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248605,026,203 - 5,037,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nanog
37 total Variants

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:98
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000060937
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat

1 to 10 of 39 rows

The following Strains have been annotated to Nanog




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 16 40 52 51 20 25 20 6 113 63 20 13 48 31



Ensembl Acc Id: ENSRNOT00000060937   ⟹   ENSRNOP00000063016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)Ensembl
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077245   ⟹   ENSRNOP00000071020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4155,532,109 - 155,538,052 (+)Ensembl
RefSeq Acc Id: NM_001100781   ⟹   NP_001094251
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,615,687 - 157,623,061 (+)NCBI
mRatBN7.24155,943,737 - 155,951,116 (+)NCBI
Rnor_6.04155,531,906 - 155,539,268 (+)NCBI
Rnor_5.04222,552,995 - 222,560,653 (+)NCBI
RGSC_v3.44159,190,786 - 159,198,160 (+)RGD
Celera4144,763,722 - 144,771,060 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237310   ⟹   XP_006237372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,615,781 - 157,622,022 (+)NCBI
mRatBN7.24155,943,906 - 155,950,010 (+)NCBI
Rnor_6.04155,532,109 - 155,538,091 (+)NCBI
Rnor_5.04222,552,995 - 222,560,653 (+)NCBI
Sequence:
Protein RefSeqs NP_001094251 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237372 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD20664 (Get FASTA)   NCBI Sequence Viewer  
  BAF91940 (Get FASTA)   NCBI Sequence Viewer  
  EDM01982 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063016
  ENSRNOP00000063016.1
RefSeq Acc Id: NP_001094251   ⟸   NM_001100781
- UniProtKB: D3ZS29 (UniProtKB/TrEMBL),   A6ILF7 (UniProtKB/TrEMBL),   A8QWW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237372   ⟸   XM_006237310
- Peptide Label: isoform X1
- UniProtKB: A8QWW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071020   ⟸   ENSRNOT00000077245
Ensembl Acc Id: ENSRNOP00000063016   ⟸   ENSRNOT00000060937
Homeobox

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS29-F1-model_v2 AlphaFold D3ZS29 1-312 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-43146 BioCyc
Ensembl Genes ENSRNOG00000008368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060937 ENTREZGENE
  ENSRNOT00000060937.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Distal-less_Homeobox_TF UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:414065 UniProtKB/TrEMBL
NCBI Gene 414065 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NANOG UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Nanog PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008368 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6ILF7 ENTREZGENE, UniProtKB/TrEMBL
  A8QWW8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS29 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Nanog  Nanog homeobox      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Nanog  Nanog homeobox      Symbol and Name status set to provisional 70820 PROVISIONAL