NANOG (Nanog homeobox) - Rat Genome Database

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Gene: NANOG (Nanog homeobox) Canis lupus familiaris
Analyze
Symbol: NANOG
Name: Nanog homeobox
RGD ID: 12336953
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cell dedifferentiation (ortholog); cell differentiation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH colon cancer (ortholog); developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); FOUND IN chromatin (ortholog); condensed chromosome (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein NANOG
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,262,558 - 37,266,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,348,312 - 9,354,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,614,640 - 37,620,732 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12737,494,510 - 37,500,598 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,530,317 - 37,536,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,831,817 - 8,837,819 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:22772571   PMID:23016947   PMID:30032202  


Genomics

Comparative Map Data
NANOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,262,558 - 37,266,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,348,312 - 9,354,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,614,640 - 37,620,732 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12737,494,510 - 37,500,598 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,530,317 - 37,536,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,831,817 - 8,837,819 (-)NCBIUU_Cfam_GSD_1.0
NANOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,789,402 - 7,799,146 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,787,794 - 7,799,146 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,941,998 - 7,951,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,833,262 - 7,839,922 (+)NCBINCBI36Build 36hg18NCBI36
Build 34127,833,261 - 7,839,922NCBI
Celera129,520,085 - 9,526,744 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,755,619 - 7,762,294 (+)NCBIHuRef
CHM1_1127,941,303 - 7,947,961 (+)NCBICHM1_1
T2T-CHM13v2.0127,803,995 - 7,813,735 (+)NCBIT2T-CHM13v2.0
Nanog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,684,448 - 122,691,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,684,448 - 122,691,592 (+)EnsemblGRCm39 Ensembl
GRCm386122,707,489 - 122,714,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,707,489 - 122,714,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,657,586 - 122,663,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,673,114 - 122,680,252 (+)NCBIMGSCv36mm8
Celera6124,507,792 - 124,514,310 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.8NCBI
Nanog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,615,687 - 157,623,061 (+)NCBIGRCr8
mRatBN7.24155,943,737 - 155,951,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,211,480 - 162,218,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,563,349 - 186,570,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,639,759 - 156,647,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,531,906 - 155,539,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,552,995 - 222,560,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,190,786 - 159,198,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,438,699 - 159,441,754 (+)NCBI
Celera4144,763,722 - 144,771,060 (+)NCBICelera
Cytogenetic Map4q42NCBI
Nanog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554136,561,323 - 6,565,770 (+)NCBIChiLan1.0ChiLan1.0
NANOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,347,790 - 13,354,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,344,549 - 13,351,498 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,913,037 - 7,919,715 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,070,877 - 8,077,556 (+)NCBIpanpan1.1PanPan1.1panPan2
Nanog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,997,260 - 99,003,117 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936892181,834 - 187,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,932,382 - 62,939,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,931,642 - 62,939,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,798,046 - 65,843,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NANOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,813,309 - 7,820,009 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666063363,373 - 369,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248605,026,203 - 5,037,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NANOG
52 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system musculoskeletal system nervous system reproductive system
High
Medium
Low
Below cutoff 4 1 4 7

Sequence


Reference Sequences
RefSeq Acc Id: XM_038437912   ⟹   XP_038293840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02737,614,640 - 37,620,732 (+)NCBI
RefSeq Acc Id: XM_038459499   ⟹   XP_038315427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha279,348,312 - 9,354,207 (-)NCBI
RefSeq Acc Id: XM_038514321   ⟹   XP_038370249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12737,494,510 - 37,500,598 (+)NCBI
RefSeq Acc Id: XM_038576121   ⟹   XP_038432049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0278,831,817 - 8,837,819 (-)NCBI
RefSeq Acc Id: XM_038640367   ⟹   XP_038496295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02737,530,317 - 37,536,638 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038370249   ⟸   XM_038514321
RefSeq Acc Id: XP_038496295   ⟸   XM_038640367
RefSeq Acc Id: XP_038293840   ⟸   XM_038437912
- UniProtKB: A0A8C0QUR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315427   ⟸   XM_038459499
- UniProtKB: A0A8C0QUR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432049   ⟸   XM_038576121
- UniProtKB: A0A8C0QUR0 (UniProtKB/TrEMBL)
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013914 UniProtKB/TrEMBL
  ENSCAFG00030022852 UniProtKB/TrEMBL
  ENSCAFG00040021229 UniProtKB/TrEMBL
  ENSCAFG00845029777 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022072.5 UniProtKB/TrEMBL
  ENSCAFT00030042036.1 UniProtKB/TrEMBL
  ENSCAFT00040039461.1 UniProtKB/TrEMBL
  ENSCAFT00845052746 ENTREZGENE
  ENSCAFT00845052746.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
NCBI Gene NANOG ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NANOG UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0QUR0 ENTREZGENE
  A0A8C0TEJ9_CANLF UniProtKB/TrEMBL
  A0A8I3Q4J3_CANLF UniProtKB/TrEMBL