Tomm70 (translocase of outer mitochondrial membrane 70) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tomm70 (translocase of outer mitochondrial membrane 70) Rattus norvegicus
Analyze
Symbol: Tomm70
Name: translocase of outer mitochondrial membrane 70
RGD ID: 1303049
Description: Predicted to enable mitochondrion targeting sequence binding activity and molecular adaptor activity. Predicted to contribute to protein transmembrane transporter activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein targeting to mitochondrion; and response to thyroxine. Located in mitochondrial outer membrane. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70); PARTICIPATES IN alpha-helical insertion pathway of mitochondrial protein import; beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC112570; mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; TOM70; Tomm70a; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); translocase of outer mitochondrial membrane 70 homolog A (yeast); translocase of outer mitochondrial membrane protein 70
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tomm70-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,847,837 - 56,886,302 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,846,334 - 56,886,320 (-)EnsemblGRCr8
mRatBN7.21143,378,719 - 43,417,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,377,216 - 43,417,202 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1152,153,913 - 52,192,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,815,517 - 44,853,943 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,939,611 - 43,978,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,477,053 - 45,511,409 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,480,250 - 45,510,961 (-)Ensemblrn6Rnor6.0
Rnor_5.01148,669,804 - 48,706,365 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,302,535 - 44,341,250 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1143,168,344 - 43,206,551 (-)NCBICelera
RGSC_v3.11144,360,417 - 44,398,702 (-)NCBI
Cytogenetic Map11q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
morphine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Alvarez-Dolado M, etal., J Neurochem. 1999 Dec;73(6):2240-9.
2. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
3. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Giorgianni F, etal., Mol Cell Biochem. 2014 Apr;389(1-2):159-67. doi: 10.1007/s11010-013-1937-7. Epub 2014 Jan 7.
6. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
7. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Li J, etal., Cell Res. 2014 Aug;24(8):977-93. doi: 10.1038/cr.2014.94. Epub 2014 Jul 15.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM and Kowluru RA, Diabetes Metab Res Rev. 2013 Mar;29(3):204-13. doi: 10.1002/dmrr.2384.
12. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13. Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. Suzuki H, etal., J Cell Sci 2002 May 1;115(Pt 9):1895-905.
14. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:18570454   PMID:18614015   PMID:19946888   PMID:20531390   PMID:22871113   PMID:23303939   PMID:27919679   PMID:31505169   PMID:32357304  


Genomics

Comparative Map Data
Tomm70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,847,837 - 56,886,302 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,846,334 - 56,886,320 (-)EnsemblGRCr8
mRatBN7.21143,378,719 - 43,417,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,377,216 - 43,417,202 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1152,153,913 - 52,192,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,815,517 - 44,853,943 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,939,611 - 43,978,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,477,053 - 45,511,409 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,480,250 - 45,510,961 (-)Ensemblrn6Rnor6.0
Rnor_5.01148,669,804 - 48,706,365 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,302,535 - 44,341,250 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1143,168,344 - 43,206,551 (-)NCBICelera
RGSC_v3.11144,360,417 - 44,398,702 (-)NCBI
Cytogenetic Map11q12NCBI
TOMM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,363,431 - 100,401,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,363,431 - 100,401,111 (-)Ensemblhg38GRCh38
GRCh373100,082,275 - 100,119,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,564,997 - 101,602,915 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343101,564,998 - 101,602,915NCBI
Celera398,473,164 - 98,511,084 (-)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,450,096 - 97,488,049 (-)NCBIHuRef
CHM1_13100,045,331 - 100,083,272 (-)NCBICHM1_1
T2T-CHM13v2.03103,068,774 - 103,106,448 (-)NCBIT2T-CHM13v2.0
Tomm70a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,942,077 - 56,974,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,942,066 - 56,977,068 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381657,121,714 - 57,154,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,121,703 - 57,156,705 (+)Ensemblmm10GRCm38
MGSCv371657,121,827 - 57,154,643 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361657,043,073 - 57,075,889 (+)NCBIMGSCv36mm8
Celera1657,455,013 - 57,487,868 (+)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
Tomm70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554271,876,222 - 1,908,737 (-)Ensembl
ChiLan1.0NW_0049554271,874,277 - 1,908,245 (-)NCBIChiLan1.0ChiLan1.0
TOMM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,306,633 - 98,344,497 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,311,415 - 98,348,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,459,180 - 97,497,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,139,473 - 104,177,061 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,139,473 - 104,178,074 (-)EnsemblpanPan2panpan1.1
TOMM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,976,322 - 7,009,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,976,934 - 7,009,594 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,114,753 - 7,148,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tomm70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602150,008,687 - 150,042,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366302,906,581 - 2,940,608 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366302,906,573 - 2,938,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13158,577,379 - 158,628,262 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113158,577,026 - 158,629,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213168,193,917 - 168,218,856 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12280,477,429 - 80,516,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2280,477,872 - 80,516,670 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604186,056,352 - 86,094,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478913,792,049 - 13,829,104 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478913,792,434 - 13,828,403 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tomm70
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1441,232,594 - 41,265,459 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tomm70
174 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:119
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000002238
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
BF410432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,417,853 - 43,418,071 (+)MAPPERmRatBN7.2
Rnor_6.01145,511,794 - 45,512,011NCBIRnor6.0
Rnor_5.01148,707,061 - 48,707,278UniSTSRnor5.0
RGSC_v3.41144,341,946 - 44,342,163UniSTSRGSC3.4
Celera1143,207,247 - 43,207,464UniSTS
RH 3.4 Map11325.3UniSTS
Cytogenetic Map11q12UniSTS
RH125842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2650,124,978 - 50,125,223 (+)MAPPERmRatBN7.2
mRatBN7.21143,378,778 - 43,379,023 (+)MAPPERmRatBN7.2
Rnor_6.0652,822,334 - 52,822,578NCBIRnor6.0
Rnor_6.01145,477,113 - 45,477,358NCBIRnor6.0
Rnor_5.0662,442,457 - 62,442,701UniSTSRnor5.0
RGSC_v3.41144,302,595 - 44,302,839UniSTSRGSC3.4
Celera649,307,483 - 49,307,727UniSTS
Celera1143,168,404 - 43,168,648UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map11q12UniSTS
AI029154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,377,273 - 43,377,477 (+)MAPPERmRatBN7.2
Rnor_6.01145,475,608 - 45,475,811NCBIRnor6.0
Rnor_5.01148,668,359 - 48,668,562UniSTSRnor5.0
RGSC_v3.41144,301,090 - 44,301,293UniSTSRGSC3.4
Celera1143,166,899 - 43,167,102UniSTS
RH 3.4 Map11325.3UniSTS
Cytogenetic Map11q12UniSTS
Tomm70a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2650,125,428 - 50,126,335 (+)MAPPERmRatBN7.2
Rnor_6.0652,822,784 - 52,823,690NCBIRnor6.0
Rnor_5.0662,442,907 - 62,443,813UniSTSRnor5.0
RGSC_v3.4651,873,209 - 51,874,115UniSTSRGSC3.4
Celera649,307,933 - 49,308,839UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002238   ⟹   ENSRNOP00000002238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1156,846,334 - 56,886,320 (-)Ensembl
mRatBN7.2 Ensembl1143,377,216 - 43,417,202 (-)Ensembl
Rnor_6.0 Ensembl1145,480,250 - 45,510,961 (-)Ensembl
RefSeq Acc Id: NM_212519   ⟹   NP_997684
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,847,837 - 56,886,276 (-)NCBI
mRatBN7.21143,378,719 - 43,417,158 (-)NCBI
Rnor_6.01145,477,053 - 45,511,098 (-)NCBI
Rnor_5.01148,669,804 - 48,706,365 (-)NCBI
RGSC_v3.41144,302,535 - 44,341,250 (-)RGD
Celera1143,168,344 - 43,206,551 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768645   ⟹   XP_008766867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,854,467 - 56,886,302 (-)NCBI
mRatBN7.21143,385,372 - 43,417,166 (-)NCBI
Rnor_6.01145,483,825 - 45,511,408 (-)NCBI
Sequence:
RefSeq Acc Id: NP_997684   ⟸   NM_212519
- UniProtKB: Q75Q39 (UniProtKB/Swiss-Prot),   A6IQN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766867   ⟸   XM_008768645
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002238   ⟸   ENSRNOT00000002238

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q75Q39-F1-model_v2 AlphaFold Q75Q39 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303049 AgrOrtholog
BioCyc Gene G2FUF-21537 BioCyc
Ensembl Genes ENSRNOG00000001640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002238 ENTREZGENE
  ENSRNOT00000002238.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099109 IMAGE-MGC_LOAD
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:304017 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112570 IMAGE-MGC_LOAD
NCBI Gene 304017 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/Swiss-Prot
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/Swiss-Prot
Pfam TPR_1 UniProtKB/Swiss-Prot
  TPR_6 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen Tomm70 PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001640 RatGTEx
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP Protein prenylyltransferase UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
UniProt A6IQN3 ENTREZGENE, UniProtKB/TrEMBL
  Q75Q39 ENTREZGENE
  R9PXR4_RAT UniProtKB/TrEMBL
  TOM70_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm70  translocase of outer mitochondrial membrane 70  Tomm70a  translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Tomm70a  translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)  Tomm70a  translocase of outer mitochondrial membrane 70 homolog A (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tomm70a  translocase of outer mitochondrial membrane 70 homolog A (yeast)    translocase of outer mitochondrial membrane 70 homolog A  Name updated 1299863 APPROVED
2005-01-06 Tomm70a  translocase of outer mitochondrial membrane 70 homolog A  TOM70  TOM70 protein  Symbol and Name updated 1299863 APPROVED