Kif5a (kinesin family member 5A) - Rat Genome Database

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Gene: Kif5a (kinesin family member 5A) Rattus norvegicus
Analyze
Symbol: Kif5a
Name: kinesin family member 5A
RGD ID: 1303035
Description: Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinesin heavy chain isoform 5A; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain; NKHC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,937,210 - 64,974,339 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl764,934,740 - 64,978,272 (-)EnsemblGRCr8
mRatBN7.2763,051,894 - 63,089,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx764,941,174 - 64,978,298 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,143,590 - 67,180,714 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,944,692 - 66,982,059 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,515,832 - 70,552,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)Ensemblrn6Rnor6.0
Rnor_5.0770,693,375 - 70,727,047 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,183,575 - 67,220,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,193,348 - 60,229,555 (-)NCBICelera
RGSC_v3.1767,204,304 - 67,241,496 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clobetasol  (ISO)
copper(II) chloride  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
L-1,4-dithiothreitol  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
phenylmercury acetate  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tebuconazole  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (EXP)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zalcitabine  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Alcina A, etal., Genes Immun. 2010 Jul;11(5):439-45. doi: 10.1038/gene.2010.30. Epub 2010 May 27.
2. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
3. Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10. Carosi L, etal., J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):702-4. doi: 10.1136/jnnp-2014-308625. Epub 2014 Oct 28.
4. Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. Danoy P, etal., Ann Rheum Dis. 2011 Oct;70(10):1793-7. doi: 10.1136/ard.2010.144576. Epub 2011 Jul 21.
5. Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Fichera M, etal., Neurology. 2004 Sep 28;63(6):1108-10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
9. Replication of European rheumatoid arthritis loci in a Pakistani population. Jalil SF, etal., J Rheumatol. 2013 Apr;40(4):401-7. doi: 10.3899/jrheum.121050. Epub 2013 Feb 1.
10. Axonal transport deficit in a KIF5A( -/- ) mouse model. Karle KN, etal., Neurogenetics. 2012 May;13(2):169-79. doi: 10.1007/s10048-012-0324-y. Epub 2012 Apr 1.
11. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Kuzma-Kozakiewicz M, etal., Neurodegener Dis. 2013;12(2):71-80. doi: 10.1159/000339529. Epub 2012 Sep 21.
12. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
13. The mitochondrial and autosomal mutation landscapes of prostate cancer. Lindberg J, etal., Eur Urol. 2013 Apr;63(4):702-8. doi: 10.1016/j.eururo.2012.11.053. Epub 2012 Dec 5.
14. Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing. Lynch DS, etal., Eur J Hum Genet. 2016 Jun;24(6):857-63. doi: 10.1038/ejhg.2015.200. Epub 2015 Sep 16.
15. Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons. Ma B, etal., Sci Rep. 2011;1:140. Epub 2011 Nov 3.
16. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. Macioce P, etal., J Cell Sci 2003 Dec 1;116(Pt 23):4847-56.
17. Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases. Melo TQ, etal., Cell Mol Neurobiol. 2013 Apr;33(3):327-35. doi: 10.1007/s10571-012-9898-z. Epub 2012 Dec 22.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness. Muglia M, etal., J Neurol Sci. 2014 Aug 15;343(1-2):218-20. doi: 10.1016/j.jns.2014.05.063. Epub 2014 Jun 5.
20. Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Nakajima K, etal., Neuron. 2012 Dec 6;76(5):945-61. doi: 10.1016/j.neuron.2012.10.012.
21. Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity. Oh JY, etal., J Cell Sci. 2013 May 1;126(Pt 9):2114-23. doi: 10.1242/jcs.125690. Epub 2013 Mar 13.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Reid E, etal., Am J Hum Genet. 2002 Nov;71(5):1189-94. Epub 2002 Sep 24.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites. Romero AM, etal., Neurotox Res. 2015 Jan;27(1):43-54. doi: 10.1007/s12640-014-9484-x. Epub 2014 Jul 15.
28. SPG10 is a rare cause of spastic paraplegia in European families. Schüle R, etal., J Neurol Neurosurg Psychiatry. 2008 May;79(5):584-7. doi: 10.1136/jnnp.2007.137596. Epub 2008 Feb 1.
29. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
30. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
31. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. Taya S, etal., J Neurosci. 2007 Jan 3;27(1):15-26.
32. Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. Tooker BC, etal., Biomarkers. 2011 Mar;16(2):181-91. doi: 10.3109/1354750X.2010.543289. Epub 2011 Jan 14.
33. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Vignali G, etal., Eur J Neurosci. 1996 Mar;8(3):536-44.
34. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat. Vignali G, etal., J Neurochem. 1997 Nov;69(5):1840-9.
Additional References at PubMed
PMID:7514426   PMID:11986669   PMID:15644324   PMID:16018997   PMID:16301330   PMID:17360631   PMID:18539120   PMID:19946888   PMID:20152113   PMID:21048148   PMID:21411631   PMID:21976701  
PMID:22539840   PMID:28886967   PMID:29476059   PMID:30053369   PMID:31904090   PMID:34348158   PMID:36214718   PMID:36862119  


Genomics

Comparative Map Data
Kif5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,937,210 - 64,974,339 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl764,934,740 - 64,978,272 (-)EnsemblGRCr8
mRatBN7.2763,051,894 - 63,089,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx764,941,174 - 64,978,298 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,143,590 - 67,180,714 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,944,692 - 66,982,059 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,515,832 - 70,552,897 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)Ensemblrn6Rnor6.0
Rnor_5.0770,693,375 - 70,727,047 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,183,575 - 67,220,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,193,348 - 60,229,555 (-)NCBICelera
RGSC_v3.1767,204,304 - 67,241,496 (-)NCBI
Cytogenetic Map7q22NCBI
KIF5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,550,044 - 57,586,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,546,026 - 57,586,633 (+)Ensemblhg38GRCh38
GRCh371257,943,827 - 57,980,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,230,114 - 56,264,821 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341256,230,113 - 56,264,821NCBI
Celera1257,599,677 - 57,634,382 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,981,745 - 55,016,257 (+)NCBIHuRef
CHM1_11257,911,685 - 57,946,386 (+)NCBICHM1_1
T2T-CHM13v2.01257,518,283 - 57,554,872 (+)NCBIT2T-CHM13v2.0
Kif5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,061,564 - 127,102,217 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,061,565 - 127,099,217 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810127,225,695 - 127,266,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,225,696 - 127,263,348 (-)Ensemblmm10GRCm38
MGSCv3710126,662,751 - 126,700,419 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610126,628,648 - 126,666,029 (-)NCBIMGSCv36mm8
Celera10129,618,645 - 129,655,868 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Kif5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,287,111 - 5,310,962 (+)Ensembl
ChiLan1.0NW_0049554585,264,274 - 5,310,962 (+)NCBIChiLan1.0ChiLan1.0
KIF5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,754,420 - 36,791,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,751,196 - 36,787,946 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,340,201 - 31,376,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,599,376 - 31,635,677 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,599,376 - 31,635,327 (-)EnsemblpanPan2panpan1.1
KIF5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,637,007 - 1,666,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,636,932 - 1,664,767 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha101,700,232 - 1,729,959 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0101,646,391 - 1,676,129 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,646,235 - 1,676,121 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,624,071 - 1,653,916 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,865,983 - 1,895,693 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,990,984 - 2,020,928 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kif5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,137,419 - 57,172,692 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,697,492 - 1,732,832 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,697,531 - 1,730,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,816,854 - 22,851,973 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,813,617 - 22,851,976 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KIF5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,458,795 - 53,493,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,467,068 - 192,505,360 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,375,774 - 10,409,566 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480210,375,132 - 10,409,575 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kif5a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11205,662,572 - 205,698,578 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kif5a
164 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:595
Count of miRNA genes:263
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000007721
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
BF388221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,050,720 - 63,050,898 (+)MAPPERmRatBN7.2
Rnor_6.0770,514,659 - 70,514,836NCBIRnor6.0
Rnor_5.0770,692,202 - 70,692,379UniSTSRnor5.0
RGSC_v3.4767,182,402 - 67,182,579UniSTSRGSC3.4
Celera760,192,175 - 60,192,352UniSTS
Cytogenetic Map7q22UniSTS
Kif5a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,056,621 - 63,058,321 (+)MAPPERmRatBN7.2
Rnor_6.0770,520,496 - 70,522,195NCBIRnor6.0
Rnor_5.0770,694,646 - 70,696,345UniSTSRnor5.0
RGSC_v3.4767,188,357 - 67,190,056UniSTSRGSC3.4
Celera760,196,964 - 60,198,663UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 67 163 91 90 59 89 59 6 338 189 10 142 71 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007721   ⟹   ENSRNOP00000007721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl764,934,740 - 64,978,272 (-)Ensembl
mRatBN7.2 Ensembl763,049,424 - 63,092,858 (-)Ensembl
Rnor_6.0 Ensembl770,513,343 - 70,556,827 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080594   ⟹   ENSRNOP00000071539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl764,934,740 - 64,974,379 (-)Ensembl
mRatBN7.2 Ensembl763,049,424 - 63,089,064 (-)Ensembl
Rnor_6.0 Ensembl770,515,832 - 70,552,897 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112903   ⟹   ENSRNOP00000095825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl764,934,740 - 64,974,379 (-)Ensembl
mRatBN7.2 Ensembl763,049,424 - 63,089,064 (-)Ensembl
RefSeq Acc Id: NM_212523   ⟹   NP_997688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,937,210 - 64,974,339 (-)NCBI
mRatBN7.2763,051,894 - 63,089,024 (-)NCBI
Rnor_6.0770,515,832 - 70,552,897 (-)NCBI
Rnor_5.0770,693,375 - 70,727,047 (-)NCBI
RGSC_v3.4767,183,575 - 67,220,766 (-)RGD
Celera760,193,348 - 60,229,555 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997688 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS45402 (Get FASTA)   NCBI Sequence Viewer  
  EDM16486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071539
GenBank Protein Q6QLM7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997688   ⟸   NM_212523
- UniProtKB: Q6QLM7 (UniProtKB/Swiss-Prot),   A0A0G2K0Q2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071539   ⟸   ENSRNOT00000080594
Ensembl Acc Id: ENSRNOP00000007721   ⟸   ENSRNOT00000007721
Ensembl Acc Id: ENSRNOP00000095825   ⟸   ENSRNOT00000112903
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QLM7-F1-model_v2 AlphaFold Q6QLM7 1-1027 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695254
Promoter ID:EPDNEW_R5779
Type:initiation region
Name:Kif5a_1
Description:kinesin family member 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,552,915 - 70,552,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303035 AgrOrtholog
BioCyc Gene G2FUF-33757 BioCyc
Ensembl Genes ENSRNOG00000005299 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080594 ENTREZGENE
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.1590 UniProtKB/Swiss-Prot
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:314906 UniProtKB/Swiss-Prot
NCBI Gene 314906 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot
  KINESIN FAMILY MEMBER 5A UniProtKB/Swiss-Prot
Pfam Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif5a PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005299 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K0Q2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APJ1_RAT UniProtKB/TrEMBL
  A6HQT6_RAT UniProtKB/TrEMBL
  F1M8F2_RAT UniProtKB/TrEMBL
  KIF5A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kif5a  kinesin family member 5A      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Kif5a  kinesin family member 5A      Symbol and Name status set to provisional 70820 PROVISIONAL