| 1585012 | Osm | oncostatin M | ENCODES a protein that exhibits cytokine activity (ortholog); growth factor activity (ortholog); oncostatin-M receptor binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); negative regulation of hormone secretion (ortholog); negative regulation of meiotic nuclear division (ortholo g); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-3 signaling pathway; cytokine mediated signaling pathway; ASSOCIATED WITH Chloracne (ortholog); contact dermatitis (ortholog); COVID-19 (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 17beta-estradiol 3-benzoate | 14 | 83327202 | 83332073 | Rat | 160 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 628841 | Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | ENCODES a protein that exhibits ATP binding; calcium channel activity; calmodulin binding; INVOLVED IN calcium ion import across plasma membrane; calcium ion transmembrane transport; calcium ion transport; ASSOCIATED WITH alcohol withdrawal syndrome; cocaine abuse; cocaine dependence; FOUND IN axon terminus; dendrite; external side of plasma membrane; INTERACTS WITH (R)-camphor; (S)-nicotine; 1,2-dimethylhydrazine | 10 | 58349936 | 58375021 | Rat | 519 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3965 | Trpv2 | transient receptor potential cation channel, subfamily V, member 2 | ENCODES a protein that exhibits calcium channel activity; monoatomic cation channel activity (ortholog); INVOLVED IN negative regulation of cell population proliferation; apoptotic process (ortholog); positive regulation of axon extension (ortholog); ASSOCIATED WITH Endometrial Neoplasms (ortholog); Experimental Arthritis (ortholog); FOUND IN endomembrane system; lamellipodium; neuronal cell body; INTERACTS WITH 11-hydroxy-Delta(9)-tetrahydrocannabinol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 10 | 47772223 | 47797956 | Rat | 173 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 69337 | Trpv4 | transient receptor potential cation channel, subfamily V, member 4 | ENCODES a protein that exhibits actin binding; actin filament binding; alpha-tubulin binding; INVOLVED IN actin cytoskeleton organization; actin filament organization; calcium ion import; ASSOCIATED WITH pulmonary hypertension; amyotrophic lateral sclerosis type 5 (ortholog); Auditory Neuropathy (or tholog); FOUND IN cell surface; cortical actin cytoskeleton; cytoplasmic microtubule; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3',5'-cyclic AMP; 3-chloropropane-1,2-diol | 12 | 47599161 | 47638143 | Rat | 409 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620636 | Trpv5 | transient receptor potential cation channel, subfamily V, member 5 | ENCODES a protein that exhibits calcium channel activity; INVOLVED IN calcium ion transmembrane transport; calcium ion transport into cytosol; calcium ion homeostasis (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH gestational diabet es (ortholog); pre-eclampsia (ortholog); FOUND IN apical plasma membrane; plasma membrane; calcium channel complex (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole | 4 | 71503085 | 71531134 | Rat | 130 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1302983 | Osmr | oncostatin M receptor | ENCODES a protein that exhibits cytokine binding (ortholog); growth factor binding (ortholog); oncostatin-M receptor activity (ortholog); INVOLVED IN oncostatin-M-mediated signaling pathway (ortholog); positive regulation of cell population proliferation (ortholog); response to cytokine (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); external side of plasma membrane (ortholog); oncostatin-M receptor complex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 57634517 | 57688802 | Rat | 193 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1306528 | Hspa4l | heat shock protein family A (Hsp70) member 4 like | ENCODES a protein that exhibits ATP binding; INVOLVED IN protein folding; response to unfolded protein; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propy l-2-thiouracil | 2 | 125668346 | 125726404 | Rat | 214 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1310207 | Tmem63c | transmembrane protein 63c | ENCODES a protein that exhibits calcium-activated cation channel activity (ortholog); osmolarity-sensing monoatomic cation channel activity (ortholog); phospholipid scramblase activity (ortholog); INVOLVED IN glomerular filtration; monoatomic cation transport (o rtholog); ASSOCIATED WITH Albuminuria; focal segmental glomerulosclerosis (ortholog); hereditary spastic paraplegia 87 (ortholog); FOUND IN lysosomal membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 6 | 112398308 | 112469732 | Rat | 83 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1564042 | Ttc33 | tetratricopeptide repeat domain 33 | INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 56007377 | 56054312 | Rat | 59 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1564771 | Ddx3x | DEAD-box helicase 3, X-linked | ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); CTPase activity (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to osmotic stress (ortholog); cellular response to virus (ortholog); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); cerebellar hypoplasia (ortholog); FOUND IN glutamatergic synapse; postsynaptic density; cell leading edge (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene | X | 12152346 | 12165983 | Rat | 278 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311023 | Dysf | dysferlin | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); INVOLVED IN angiogenesis (ortholog); cellular response to osmotic stress (ortholog); fat cell differentiation (or tholog); ASSOCIATED WITH autosomal recessive limb-girdle muscular dystrophy (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2B (ortholog); autosomal recessive nonsyndromic deafness (ortholog); FOUND IN cytoplasm; cytoplasmic vesicle (ortholog); early endosome (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 4 | 118048460 | 118248273 | Rat | 222 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1582935 | Gypa | glycophorin A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN regulation of response to osmotic stress (ortholog); ASSOCIATED WITH malaria (ortholog); Skin Neoplasms (ortholog); FOUND IN ankyrin-1 complex (ortholog); external side of plasma m embrane (ortholog); plasma membrane (ortholog); INTERACTS WITH acrylamide; bisphenol A; glyphosate | 19 | 44354669 | 44370304 | Rat | 81 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311690 | Lrrc8a | leucine rich repeat containing 8 VRAC subunit A | ENCODES a protein that exhibits volume-sensitive anion channel activity; cyclic-GMP-AMP transmembrane transporter activity (ortholog); identical protein binding (ortholog); INVOLVED IN aspartate transmembrane transport; response to osmotic stress; taurine transm embrane transport; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 5 (ortholog); FOUND IN cell surface (ortholog); lysosomal membrane (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 3 | 33902299 | 33934989 | Rat | 189 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306585 | Lrrc8c | leucine rich repeat containing 8 VRAC subunit C | ENCODES a protein that exhibits volume-sensitive anion channel activity; INVOLVED IN aspartate transmembrane transport; cellular response to osmotic stress; taurine transmembrane transport; ASSOCIATED WITH multiple sclerosis (ortholog); TIMES Syndrome (ortholog) ; FOUND IN monoatomic ion channel complex; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil | 14 | 4528721 | 4621259 | Rat | 163 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309601 | Lrrc8d | leucine rich repeat containing 8 VRAC subunit D | ENCODES a protein that exhibits volume-sensitive anion channel activity; INVOLVED IN aspartate transmembrane transport; cellular response to osmotic stress; taurine transmembrane transport; FOUND IN monoatomic ion channel complex; cytoplasm (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 14 | 4335114 | 4411549 | Rat | 151 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311979 | Lrrc8e | leucine rich repeat containing 8 VRAC subunit E | ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN aspartate transmembrane transport (ortholog); cell volume homeostasis (ortholog); cellular response to osmotic stress (ortholog); ASSOCIATED WITH long QT syndrome (or tholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); lysosomal membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine | 12 | 7376103 | 7387250 | Rat | 108 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560043 | Map2k7 | mitogen activated protein kinase kinase 7 | ENCODES a protein that exhibits ATP binding; JUN kinase kinase activity; magnesium ion binding; INVOLVED IN cellular response to osmotic stress; cellular response to sorbitol; JNK cascade; PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; adenosin e signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH breast cancer (ortholog); Breast Neoplasms (ortholog); colon adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom | 12 | 7389032 | 7398377 | Rat | 251 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561602 | Nlk | nemo like kinase | ENCODES a protein that exhibits ATP binding (ortholog); DNA-binding transcription factor binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN cellular response to osmotic stress (ortholog); intracellular signal transduction (ortholog); negative regu lation of TORC1 signaling (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; mitogen activated protein kinase signaling pathway; Wnt signaling pathway; ASSOCIATED WITH myocardial infarction; Spinal Cord Injuries; Subarachnoid Hemorrhage; FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 10 | 63965432 | 64089006 | Rat | 126 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2321078 | Relb | RELB proto-oncogene, NF-kB subunit | ENCODES a protein that exhibits DNA binding; DNA-binding transcription factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to osmotic stress; antigen processing and presentation (ortholog); circadian regulation of gene expression (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH Cerebral Hemorrhage; kidney disease; muscular atrophy; FOUND IN centrosome (ortholog); chromatin (ortholog); cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 88385717 | 88413380 | Rat | 300 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 61922 | Scn7a | sodium voltage-gated channel alpha subunit 7 | ENCODES a protein that exhibits osmolarity-sensing monoatomic cation channel activity; voltage-gated channel activity; sodium channel activity (ortholog); INVOLVED IN membrane depolarization during action potential; neuronal action potential; sodium ion homeosta sis; ASSOCIATED WITH brain infarction; autistic disorder (ortholog); FOUND IN voltage-gated sodium channel complex; glial cell projection (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 71743873 | 71846454 | Rat | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735108 | Serpinb6a | serpin family B member 6A | ENCODES a protein that exhibits protease binding (ortholog); serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN cellular response to osmotic stress (ortholog); sensory perception of sound (ortholog); ASSOCIATED WITH autosomal recessive nonsyndr omic deafness 91 (ortholog); Hearing Loss (ortholog); Usher syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); serine protease inhibitor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol | 17 | 31076811 | 31195035 | Rat | 145 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 69352 | Slc6a18 | solute carrier family 6 member 18 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); neutral L-amino acid transmembrane transporter activity (ortholog); neutral L-amino acid:sodium:chloride symporter activity (ortholog); INVOLVED IN hyperosmotic response; a mino acid transmembrane transport (ortholog); amino acid transport (ortholog); ASSOCIATED WITH hypertension (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A | 1 | 31436577 | 31450478 | Rat | 88 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306829 | Tmem63a | transmembrane protein 63a | ENCODES a protein that exhibits mechanosensitive monoatomic ion channel activity (ortholog); osmolarity-sensing monoatomic cation channel activity (ortholog); phospholipid scramblase activity (ortholog); INVOLVED IN lysosome organization (ortholog); surfactant s ecretion (ortholog); ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 19 (ortholog); FOUND IN centriolar satellite (ortholog); early endosome membrane (ortholog); lysosomal membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 13 | 95194323 | 95227944 | Rat | 119 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303284 | Trpa1 | transient receptor potential cation channel, subfamily A, member 1 | ENCODES a protein that exhibits osmolarity-sensing monoatomic cation channel activity; voltage-gated calcium channel activity; calcium channel activity (ortholog); INVOLVED IN calcium ion transmembrane import into cytosol; cellular response to caffeine; cellular response to carbon dioxide; ASSOCIATED WITH Abdominal Pain; asthma; Cold Hypersensitivity; FOUND IN apical plasma membrane; axon; plasma membrane (ortholog); INTERACTS WITH 3-phenylprop-2-enal; 4-hydroxynon-2-enal; aconitine | 5 | 9163060 | 9217325 | Rat | 320 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1593169 | Tsc22d2 | TSC22 domain family, member 2 | INVOLVED IN negative regulation of cell cycle (ortholog); response to osmotic stress (ortholog); ASSOCIATED WITH keratoconus (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 144796760 | 144847930 | Rat | 100 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3935 | Ugt1a1 | UDP glucuronosyltransferase family 1 member A1 | ENCODES a protein that exhibits enzyme binding; glucuronosyltransferase activity; enzyme inhibitor activity (ortholog); INVOLVED IN acute-phase response; animal organ regeneration; biphenyl catabolic process; PARTICIPATES IN axitinib pharmacokinetics pathway; codeine and morphine pharmacodynamics pa thway; codeine and morphine pharmacokinetics pathway; ASSOCIATED WITH abnormal renal water reabsorption; decreased mean corpuscular volume; decreased urine osmolality; ASSOCIATED WITH bilirubin metabolic disorder; Crigler-Najjar syndrome; hyperthyroidism; FOUND IN cytochrome complex; endoplasmic reticulum; endoplasmic reticulum chaperone complex (ortholog); INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-naphthyl isothiocyanate | 9 | 96249143 | 96256264 | Rat | 819 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 13432064 | Ugt1a1j | UDP glucuronosyltransferase family 1 member A1, jaundice mutant | ASSOCIATED WITH abnormal renal water reabsorption; decreased mean corpuscular volume; decreased urine osmolality; ASSOCIATED WITH bilirubin metabolic disorder; Jaundice; Polyuria | | | | Rat | 13 | description | gene, allele |
| 1309519 | Zfand1 | zinc finger AN1-type containing 1 | ENCODES a protein that exhibits proteasome binding (ortholog); INVOLVED IN cellular response to arsenite ion (ortholog); cellular response to heat (ortholog); cellular response to osmotic stress (ortholog); FOUND IN cytoplasmic stress granule (ortholog); INTERAC TS WITH bisphenol A; paracetamol; thioacetamide | 2 | 93351918 | 93364959 | Rat | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 69335 | Trpv6 | transient receptor potential cation channel, subfamily V, member 6 | ENCODES a protein that exhibits calcium channel activity; identical protein binding; calmodulin binding (ortholog); INVOLVED IN calcium ion import; calcium ion import across plasma membrane; calcium ion transmembrane transport; PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated sign aling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); gestational diabetes (ortholog); FOUND IN calcium channel complex (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 71474006 | 71489667 | Rat | 212 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |