| 621719 | Caly | calcyon neuron-specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding; clathrin light chain binding (ortholog); INVOLVED IN anterograde axonal transport; positive regulation of clathrin coat assembly; positive regulation of retrograde axon cargo transport; ASSOCIATED WITH attention deficit hyperactivit y disorder; Animal Disease Models (ortholog); essential hypertension (ortholog); FOUND IN axon; cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 1 | 204292317 | 204303506 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1305520 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding; protein serine/threonine kinase activity; Notch binding (ortholog); INVOLVED IN presynaptic endocytosis; regulation of clathrin-dependent endocytosis; positive regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH tooth agenes is (ortholog); FOUND IN calyx of Held; cell leading edge; clathrin complex; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 4 | 120845012 | 121009170 | Rat | 158 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2169 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding; D1 dopamine receptor binding; heparan sulfate proteoglycan binding (ortholog); INVOLVED IN cellular response to amyloid-beta; cellular response to retinoic acid; cellular response to thyroid hormone stimulus; PARTICIPATES IN acebutolol pharmacody namics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon; calyx of Held; dendritic spine head; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol | 1 | 89700645 | 89729782 | Rat | 410 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2244 | Cacna1a | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding; high voltage-gated calcium channel activity; voltage-gated calcium channel activity; INVOLVED IN calcium ion import; calcium ion transport; chemical synaptic transmission; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodyn amics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH abnormal gait; decreased spike-wave discharge type I; ASSOCIATED WITH childhood absence epilepsy; temporal lobe epilepsy; Alternating Hemiplegia of Childhood 1 (ortholog); FOUND IN calyx of Held; neuronal cell body; perikaryon; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 19 | 40425560 | 40724810 | Rat | 389 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 69340 | Calb1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN cochlea development; l earning or memory; regulation of synaptic plasticity; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder; bilirubin metabolic disorder; Hearing Loss, Noise-Induced; FOUND IN axon; calyx of Held; cuticular plate; INTERACTS WITH (S)-nicotine; 3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid; 3H-1,2-dithiole-3-thione | 5 | 34172612 | 34199555 | Rat | 239 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359369 | Ccin | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog); INTERACTS WITH bisphenol A; cadm ium dichloride; gentamycin | 5 | 63002427 | 63004314 | Rat | 44 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1562799 | Cylc2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog ); sperm glycocalyx (ortholog); INTERACTS WITH 2-palmitoylglycerol (ortholog); aflatoxin B1 (ortholog); raloxifene (ortholog) | 5 | 70349791 | 70384673 | Rat | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359708 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); PARTICIPATES IN endocytosis pathway; ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN caly ont-weight:700;'>calyx of Held (ortholog); nucleoplasm (ortholog); presynapse (ortholog); INTERACTS WITH 2,4,6-trinitrotoluene; 2,6-dinitrotoluene; atrazine | 12 | 47490350 | 47531232 | Rat | 105 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2704 | Glra1 | glycine receptor, alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity; extracellularly glycine-gated ion channel activity; glycine binding; INVOLVED IN chloride transport; monoatomic anion transport; synaptic transmission, glycinergic; PARTICIPATES IN Inhibitory synaptic transmissi on pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held; endoplasmic reticulum; external side of plasma membrane; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; atrazine | 10 | 40128284 | 40228612 | Rat | 257 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2846 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity; heterocyclic compound binding; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; INVOLVED IN chemical synaptic transmission; drinking behavior; feeding behavior; ASSOCI ATED WITH abnormal fear/anxiety-related behavior; ASSOCIATED WITH Anorexia; anxiety disorder; Dyskinesias; FOUND IN calyx of Held; cytoplasm (ortholog); G protein-coupled serotonin receptor complex (ortholog); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine | 8 | 91395405 | 91414815 | Rat | 200 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2949 | Kcna1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN a xon development; cell communication by electrical coupling; cerebral cortex development; ASSOCIATED WITH convulsive seizures; environmentally induced seizures; ASSOCIATED WITH epilepsy with generalized tonic-clonic seizures; episodic ataxia type 1; Myokymia; FOUND IN apical plasma membrane; calyx of Held; cell surface; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrylamide | 4 | 161150378 | 161160051 | Rat | 236 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2950 | Kcna2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; kinesin binding; outward rectifier potassium channel activity; INVOLVED IN cerebral cortex development; corpus callosum development; neuronal action potential; ASSOCIATED WITH Experimental Diabetes Mellitus; autism spectru m disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN calyx of Held; glutamatergic synapse; juxtaparanode region of axon; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil | 2 | 197392746 | 197406606 | Rat | 214 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2951 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; outward rectifier potassium channel activity; voltage-gated potassium channel activity; INVOLVED IN corpus callosum development; optic nerve development; potassium ion transmembrane transport; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held; glutamatergic synapse; membrane raft; INTERACTS WITH acetamide; ammonium chloride; bisphenol A | 2 | 197320324 | 197322277 | Rat | 129 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2955 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; transmembrane transporter binding; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cellular response to xenobiotic stimulus; cerebellum development; corpu s callosum development; ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held; cell surface; dendrite; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; Ampullosporin | 1 | 106039247 | 106081034 | Rat | 171 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1589169 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity; INVOLVED IN axon development; cerebral cortex development; corpus callosum development; ASSOCIATED WITH Hyperalgesia; sciatic neuropathy; status epilepticus; FOUND IN axon; calyx of Held; cell surface; INTERACTS WITH (+)-pilocarpine; (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 197747095 | 197788467 | Rat | 130 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628848 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity; INVOLVED IN potassium ion transport; potassium ion transmembrane transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held; presynaptic membrane; clathrin coat (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride | 9 | 31326595 | 31892399 | Rat | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68417 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding; magnesium ion binding; protein kinase binding; INVOLVED IN positive regulation of calcium-mediated signaling; positive regulation of exocytosis; regulation of neuron projection development; PARTICIPATES IN calcium/calcium-mediated signaling pathwa y; FOUND IN calyx of Held; dense core granule; glutamatergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole | 3 | 34920949 | 34966554 | Rat | 132 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 708533 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity; structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-dependent activati on of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | 12 | 33383646 | 33582259 | Rat | 86 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1590079 | Tprg1l | tumor protein p63 regulated 1-like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; calcineurin-NFAT signaling cascade (ortholog); FOUND IN caly /span>x of Held; extrinsic component of synaptic vesicle membrane; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 5 | 170004577 | 170007784 | Rat | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 708563 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (orthol og); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide | 10 | 73053414 | 73083640 | Rat | 102 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628592 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding; syntaxin binding; syntaxin-1 binding; INVOLVED IN synaptic vesicle priming; chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN synaptic vesicle membrane; < span style='font-weight:700;'>calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 83127650 | 83553822 | Rat | 116 | description | gene, protein-coding, VALIDATED [RefSeq] |