Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | inflammatory bowel disease | | ISO | GIT2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:37156999 | |
|
Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | inflammatory bowel disease | | ISO | GIT2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:37156999 | |
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. | Bagrodia S, etal., J Biol Chem 1999 Aug 6;274(32):22393-400. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
4. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
5. | GOA pipeline | RGD automated data pipeline |
6. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
8. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
PMID:10942595 | PMID:17310244 | PMID:19912111 | PMID:21423176 | PMID:22606319 | PMID:23870131 | PMID:26637799 |
Git2 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GIT2 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Git2 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Git2 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GIT2 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GIT2 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Git2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GIT2 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GIT2 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Git2 (Heterocephalus glaber - naked mole-rat) |
|
.
Variants in Git2
249 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH132951 |
|
||||||||||||||||||||||||||||||||||||||||
BE120218 |
|
||||||||||||||||||||||||||||||||||||||||
AI511444 |
|
||||||||||||||||||||||||||||||||||||||||
RH139528 |
|
||||||||||||||||||||||||||||||||||||||||
RH140364 |
|
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 56 | 40 | 19 | 40 | 6 | 7 | 74 | 35 | 41 | 11 | 6 |
Low | 1 | 1 | 1 | 2 | 4 | 2 | |||||||
Below cutoff |
RefSeq Transcripts | NM_001005553 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006249442 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006249445 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006249447 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006249450 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271354 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271355 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271356 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271357 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271358 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271359 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271360 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271361 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC095845 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC081967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473973 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ235304 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000012 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000045946 ⟹ ENSRNOP00000048331 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000096072 ⟹ ENSRNOP00000086491 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000097577 ⟹ ENSRNOP00000081139 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000100352 ⟹ ENSRNOP00000093537 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000105617 ⟹ ENSRNOP00000079644 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000108942 ⟹ ENSRNOP00000080405 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | NM_001005553 ⟹ NP_001005553 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006249442 ⟹ XP_006249504 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006249445 ⟹ XP_006249507 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006249447 ⟹ XP_006249509 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006249450 ⟹ XP_006249512 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_063271354 ⟹ XP_063127424 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271355 ⟹ XP_063127425 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271356 ⟹ XP_063127426 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271357 ⟹ XP_063127427 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271358 ⟹ XP_063127428 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271359 ⟹ XP_063127429 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271360 ⟹ XP_063127430 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_063271361 ⟹ XP_063127431 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Protein RefSeqs | NP_001005553 | (Get FASTA) | NCBI Sequence Viewer |
XP_006249504 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006249507 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006249509 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006249512 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127424 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127425 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127426 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127427 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127428 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127429 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127430 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063127431 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH81967 | (Get FASTA) | NCBI Sequence Viewer |
EDM13925 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13926 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000048331 | ||
ENSRNOP00000048331.3 | |||
ENSRNOP00000079644.1 | |||
ENSRNOP00000080405.1 | |||
ENSRNOP00000081139.1 | |||
ENSRNOP00000086491 | |||
ENSRNOP00000086491.1 | |||
ENSRNOP00000093537.1 | |||
GenBank Protein | Q66H91 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001005553 ⟸ NM_001005553 |
- UniProtKB: | Q66H91 (UniProtKB/TrEMBL), A0A8L2UM41 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006249507 ⟸ XM_006249445 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A8I6A5F6 (UniProtKB/TrEMBL), A0A8L2UM41 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006249512 ⟸ XM_006249450 |
- Peptide Label: | isoform X11 |
- UniProtKB: | A0A8I6G6J8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006249504 ⟸ XM_006249442 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8L2UM41 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006249509 ⟸ XM_006249447 |
- Peptide Label: | isoform X9 |
- UniProtKB: | A0A8I6G6J8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000048331 ⟸ ENSRNOT00000045946 |
RefSeq Acc Id: | ENSRNOP00000081139 ⟸ ENSRNOT00000097577 |
RefSeq Acc Id: | ENSRNOP00000086491 ⟸ ENSRNOT00000096072 |
RefSeq Acc Id: | ENSRNOP00000080405 ⟸ ENSRNOT00000108942 |
RefSeq Acc Id: | ENSRNOP00000079644 ⟸ ENSRNOT00000105617 |
RefSeq Acc Id: | ENSRNOP00000093537 ⟸ ENSRNOT00000100352 |
RefSeq Acc Id: | XP_063127431 ⟸ XM_063271361 |
- Peptide Label: | isoform X12 |
RefSeq Acc Id: | XP_063127429 ⟸ XM_063271359 |
- Peptide Label: | isoform X8 |
- UniProtKB: | A0A8I5ZRU3 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063127424 ⟸ XM_063271354 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | XP_063127425 ⟸ XM_063271355 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_063127427 ⟸ XM_063271357 |
- Peptide Label: | isoform X6 |
RefSeq Acc Id: | XP_063127426 ⟸ XM_063271356 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_063127428 ⟸ XM_063271358 |
- Peptide Label: | isoform X7 |
RefSeq Acc Id: | XP_063127430 ⟸ XM_063271360 |
- Peptide Label: | isoform X10 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q66H91-F1-model_v2 | AlphaFold | Q66H91 | 1-759 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13698707 | ||||||||
Promoter ID: | EPDNEW_R9232 | ||||||||
Type: | initiation region | ||||||||
Name: | Git2_1 | ||||||||
Description: | GIT ArfGAP 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
Database | Acc Id | Source(s) |
AGR Gene | RGD:1359708 | AgrOrtholog |
BioCyc Gene | G2FUF-18959 | BioCyc |
Ensembl Genes | ENSRNOG00000001190 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000045946 | ENTREZGENE |
ENSRNOT00000045946.4 | UniProtKB/TrEMBL | |
ENSRNOT00000096072.1 | UniProtKB/TrEMBL | |
ENSRNOT00000097577.1 | UniProtKB/TrEMBL | |
ENSRNOT00000100352.1 | UniProtKB/TrEMBL | |
ENSRNOT00000105617.1 | UniProtKB/TrEMBL | |
ENSRNOT00000108942.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.220.150 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
1.20.5.170 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
1.25.40.20 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Nucleotidyltransferases domain 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7125406 | IMAGE-MGC_LOAD |
InterPro | Ankyrin_rpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ankyrin_rpt-contain_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ARFGAP/RecO | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ArfGAP_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ArfGAP_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT1/2_CC | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT1_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT_SHD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:304546 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:94099 | IMAGE-MGC_LOAD |
NCBI Gene | 304546 | ENTREZGENE |
PANTHER | ARF GTPASE-ACTIVATING PROTEIN GIT2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Ank_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ArfGap | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT1_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT_CC | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT_SHD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Git2 | PhenoGen |
PRINTS | REVINTRACTNG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | ANK_REP_REGION | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ANK_REPEAT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ARFGAP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000001190 | RatGTEx |
SMART | ANK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ArfGap | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GIT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF48403 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF57863 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I5ZN29_RAT | UniProtKB/TrEMBL |
A0A8I5ZRU3 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6A5F6 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6ALK4_RAT | UniProtKB/TrEMBL | |
A0A8I6G6J8 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8L2UM41 | ENTREZGENE, UniProtKB/TrEMBL | |
A6J1Y6_RAT | UniProtKB/TrEMBL | |
A6J1Y7_RAT | UniProtKB/TrEMBL | |
GIT2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2016-03-22 | Git2 | GIT ArfGAP 2 | Git2 | G protein-coupled receptor kinase interacting ArfGAP 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-10-23 | Git2 | G protein-coupled receptor kinase interacting ArfGAP 2 | Git2 | G protein-coupled receptor kinase-interactor 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2006-03-30 | Git2 | G protein-coupled receptor kinase-interactor 2 | MGC94099 | similar to Git2 protein | Symbol and Name updated | 1299863 | APPROVED |
2005-07-29 | MGC94099 | similar to Git2 protein | Symbol and Name status set to provisional | 70820 | PROVISIONAL |