RGD Reference Report - Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis. - Rat Genome Database

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Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.

Authors: Osada, S  Suzuki, S  Yoshimi, C  Matsumoto, M  Shirai, T  Takahashi, S  Imagawa, M 
Citation: Osada S, etal., Oncol Rep. 2013 Oct;30(4):1669-74. doi: 10.3892/or.2013.2651. Epub 2013 Aug 2.
RGD ID: 9586718
Pubmed: PMID:23912631   (View Abstract at PubMed)
DOI: DOI:10.3892/or.2013.2651   (Journal Full-text)

Aberrant expression of regulators for epigenetics is involved in tumorigenesis. There is an urgent need to identify and characterize regulators concerned with epigenetics in the early stages of hepatocarcinogenesis. In the present study, we found that the expression of coactivator-associated arginine methyltransferase 1 (CARM1), a histone methyltransferase that functions as a cofactor for nuclear hormone receptors and several transcription factors, was elevated in adenomas and aberrant in carcinomas during hepatocellular carcinogenesis. In addition to RNA expression, immunohistochemical staining of liver sections revealed that CARM1 was highly expressed in the nucleus of tumor marker glutathione S-transferase placental form (GST-P)-positive foci. Neoplastic transformation of GST-P-positive foci guides the formation of hepatocellular carcinomas. CARM1 expression was not elevated in GST-P-negative regions. Furthermore, a luciferase reporter analysis revealed that CARM1 activated the Gst-p promoter in H4IIE, a hepatocellular carcinoma cell line. This activation was mediated by the enhancer element responsible for the carcinogenic-specific expression of Gst-p and nuclear factor E2-related factor 2. Knockdown of Carm1 by shRNA in H4IIE cells inhibited cell proliferation. These findings suggest that aberrantly expressed CARM1 in tumor marker-positive cells promotes tumorigenesis in the early stages of hepatocarcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular adenoma  ISOCarm1 (Rattus norvegicus)9586718; 9586718mRNA and protein:increased expression:liver:RGD 
hepatocellular adenoma  IEP 9586718mRNA and protein:increased expression:liver:RGD 
hepatocellular carcinoma  ISOCarm1 (Rattus norvegicus)9586718; 9586718mRNA and protein:increased expression:liver:RGD 
hepatocellular carcinoma  IEP 9586718mRNA and protein:increased expression:liver:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Carm1  (coactivator-associated arginine methyltransferase 1)

Genes (Mus musculus)
Carm1  (coactivator-associated arginine methyltransferase 1)

Genes (Homo sapiens)
CARM1  (coactivator associated arginine methyltransferase 1)


Additional Information