RGD Reference Report - Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. - Rat Genome Database

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Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains.

Authors: Conti, LH  Jirout, M  Breen, L  Vanella, JJ  Schork, NJ  Printz, MP 
Citation: Conti LH, etal., Behav Genet 2004 Jan;34(1):93-103.
RGD ID: 737695
Pubmed: PMID:14739700   (View Abstract at PubMed)
DOI: DOI:10.1023/B:BEGE.0000009479.02183.1f   (Journal Full-text)

Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait, the trait will be continuously distributed and be amenable to detection of associations between allelic variation at specific chromosomal loci and the phenotypes being studied via quantitative trait loci (QTL) mapping. The elevated plus-maze test provides quantitative measures of both anxiety-like and locomotion phenotypes. Using this test, we assessed four phenotypes in a set of 22 rat recombinant inbred (RI) strains derived from Brown Norway (BN. Lx /Cub) and Spontaneously Hypertensive rat (SHR/Ola) progenitors. QTL analyses were used to determine whether allelic variation at specific chromosomal loci contribute significantly to RI strain-dependent variance in each phenotype. Significant QTL for an anxiety phenotype were found on chromosomes 2, 5, 6, and 7. For a phenotype reflecting both anxiety and locomotion, QTL were found on chromosomes 2, 7, and 8, while for a locomotion phenotype, significant QTL were found on chromosomes 3 and 18.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder  IAGP 737695; 737695; 737695; 737695; 737695; 737695; 737695; 737695; 737695 RGD 
anxiety disorder MODEL: spontaneousIAGP 737695compared to SHR/Ola strainRGD 
Hyperkinesis  IDA 737695; 737695 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Anxrr10  (Anxiety related response QTL 10)
Anxrr11  (Anxiety related response QTL 11)
Anxrr3  (Anxiety related response QTL 3)
Anxrr4  (Anxiety related response QTL 4)
Anxrr5  (Anxiety related response QTL 5)
Anxrr6  (Anxiety related response QTL 6)
Anxrr7  (Anxiety related response QTL 7)
Anxrr8  (Anxiety related response QTL 8)
Anxrr9  (Anxiety related response QTL 9)

Strains
BN-Lx/Cub  (Brown Norway with polydactyly-luxate)
SHR/Ola  (NA)

Objects referenced in this article
Gene Arr3 arrestin 3 Rattus norvegicus

Additional Information