RGD Reference Report - Peripheral blood monocyte subsets predict antiviral response in chronic hepatitis C. - Rat Genome Database

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Peripheral blood monocyte subsets predict antiviral response in chronic hepatitis C.

Authors: Rodriguez-Munoz, Y  Martin-Vilchez, S  Lopez-Rodriguez, R  Hernandez-Bartolome, A  Trapero-Marugan, M  Borque, MJ  Moreno-Otero, R  Sanz-Cameno, P 
Citation: Rodriguez-Munoz Y, etal., Aliment Pharmacol Ther. 2011 Oct;34(8):960-71. doi: 10.1111/j.1365-2036.2011.04807.x. Epub 2011 Aug 17.
RGD ID: 6892709
Pubmed: PMID:21848603   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2036.2011.04807.x   (Journal Full-text)

BACKGROUND: Hepatitis C virus infection evolves into chronic progressive liver disease in a significant percentage of patients. Monocytes constitute a diverse group of myeloid cells that mediate innate and adaptive immune response. In addition to proinflammatory CD16+ monocytes, a Tie-2+ subgroup - Tie-2 expressing monocytes (TEMs) - that has robust proangiogenic potential has been recently defined. AIM: To study the heterogeneity of peripheral blood monocytes in chronic hepatitis C (CHC) patients and to examine their proposed pathophysiological roles on disease progression and response to antiviral therapy. METHODS: We studied CD16+ and Tie-2+ peripheral monocyte subpopulations in 21 healthy subjects and 39 CHC patients in various stages of disease and responses to antiviral treatment using flow cytometry. Expression profiles of proangiogenic and tissue remodelling factors in monocyte supernatants were measured using ELISA and protein arrays. Intrahepatic expression of CD14, CD31 and Tie-2 was analysed using immunofluorescence. RESULTS: Increases of certain peripheral monocyte subsets were observed in the blood of CHC patients, wherein those cells with proinflammatory (CD16+) or proangiogenic (TEMs) potential expanded (P < 0.005, both). Notably, TEMs were significantly increased in nonresponders, particularly those with lower CD16 expression. In addition, many angiogenic factors were differentially expressed by peripheral monocytes from control or CHC patients, such as angiopoietin-1 and angiogenin (P < 0.05). Interestingly, intrahepatic TEMs were distinguished within portal infiltrates of CHC patients. CONCLUSIONS: These findings suggest for the first time the relevance of peripheral monocytes phenotypes for the achievement of response to treatment. Hence, the study of monocyte subset regulation might effect improved CHC prognoses and adjuvant therapies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Hepatitis C  IEP 6892709 RGD 
Chronic Hepatitis C  ISOANG (Homo sapiens)6892709; 6892709 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ang  (angiogenin)

Genes (Mus musculus)
Ang  (angiogenin, ribonuclease, RNase A family, 5)

Genes (Homo sapiens)
ANG  (angiogenin)


Additional Information