RGD Reference Report - Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction. - Rat Genome Database

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Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction.

Authors: Imanaka-Yoshida, K  Hiroe, M  Nishikawa, T  Ishiyama, S  Shimojo, T  Ohta, Y  Sakakura, T  Yoshida, T 
Citation: Imanaka-Yoshida K, etal., Lab Invest. 2001 Jul;81(7):1015-24.
RGD ID: 4889618
Pubmed: PMID:11454990   (View Abstract at PubMed)

Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in tissue remodeling. TNC is not normally expressed in adults but reappears under pathologic conditions. The present study was designed to clarify the contribution of TNC to ventricular remodeling after myocardial infarction. We examined the expression of TNC after experimental myocardial infarction in the rat by immunohistochemistry and in situ hybridization. Within 24 hours of permanent coronary ligation, interstitial fibroblasts in the border zone started to express TNC mRNA. The expression of TNC was down-regulated on Day 7 and was no longer apparent by Day 14 after infarction. During the healing process, TNC protein and TNC-producing cells were found at the edges of the residual myocardium. Some of the TNC-producing cells were immunoreactive for alpha-smooth muscle actin. In culture, TNC increased the number of cardiomyocytes attached to laminin but inhibited the formation of focal contacts at costameres. The results indicate that during the acute phase after myocardial infarction, interstitial cells in the border zone synthesize TNC, which may loosen the strong adhesion of surviving cardiomyocytes to connective tissue and thereby facilitate tissue reorganization.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction  ISOTnc (Rattus norvegicus)4889618; 4889618protein:increased expression:heart and fibroblastRGD 
myocardial infarction  IEP 4889618protein:increased expression:heart and fibroblastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnc  (tenascin C)

Genes (Mus musculus)
Tnc  (tenascin C)

Genes (Homo sapiens)
TNC  (tenascin C)


Additional Information