RGD Reference Report - Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. - Rat Genome Database

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Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles.

Authors: Markovic, M  Miljkovic, D  Momcilovic, M  Popadic, D  Miljkovic, Z  Savic, E  Ramic, Z  Mostarica Stojkovic, M 
Citation: Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
RGD ID: 4831840
Pubmed: PMID:19233473   (View Abstract at PubMed)
DOI: DOI:10.1016/j.molimm.2009.01.012   (Journal Full-text)

Albino Oxford (AO) rats are resistant to induction of experimental autoimmune encephalomyelitis (EAE), in contrast to susceptible Dark Agouti (DA) rats. We have previously shown that draining lymph node cells (DLNC) obtained from immunized DA rats before the onset of the clinical disease produced more interferon (IFN)-gamma and interleukin (IL)-17 (signature cytokines of T(H)1 and T(H)17 responses, respectively) compared to DLNC from AO rats. In this study, we extend our analysis to entire induction phase of EAE with the emphasis on the T(H)1 and T(H)17-inducing cytokines. As a result, we show that throughout the inductive phase of the disease DLNC of DA rats, not only expressed higher levels of IFN-gamma and IL-17, but also of T(H)1-inducing cytokine-IL-12. As for T(H)17-inducing cytokines, DLNC of DA rats expressed more mRNA for p19, specific subunit of IL-23, but the expression of transforming growth factor (TGF)-beta in both strains was similar. Interestingly, the analysis of IL-6 expression revealed striking difference: while all DA DLNC were positive for IL-6 mRNA, cells from none of AO rats expressed detectable levels of mRNA for this cytokine. Taken together, our data suggest that the differential regulation of production of T(H)1 and T(H)17 cytokines, and IL-6 in particular, during the induction phase of disease could be responsible for the discrepancy in susceptibility to EAE between these two rat strains.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis  ISOIl12b (Rattus norvegicus)4831840; 4831840mRNA and protein:increased expression:lymph nodeRGD 
Experimental Autoimmune Encephalomyelitis  ISOIl17a (Rattus norvegicus)4831840; 4831840mRNA and protein:increased expression:lymph nodeRGD 
Experimental Autoimmune Encephalomyelitis  IEP 4831840; 4831840mRNA and protein:increased expression:lymph nodeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il12b  (interleukin 12B)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il12b  (interleukin 12b)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL12B  (interleukin 12B)
IL17A  (interleukin 17A)


Additional Information